Timo Erkinjuntti

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. ncbi Neuropsychological functions in variant Alzheimer's disease with spastic paraparesis
    Auli Verkkoniemi
    Department of Clinical Neurosciences, Helsinki University Central Hospital, Helsinki FIN-00290, Finland
    J Neurol Sci 218:29-37. 2004
  2. ncbi Subcortical ischemic vascular disease and dementia
    Timo Erkinjuntti
    Department of Neurology, University of Helsinki, Helsinki, Finland
    Int Psychogeriatr 15:23-6. 2003
  3. ncbi Structure out of chaos: functional brain network analysis with EEG, MEG, and functional MRI
    Elisabeth C W van Straaten
    Department of Clinical Neurophysiology and MEG Centre, VU University Medical Centre, Amsterdam, The Netherlands
    Eur Neuropsychopharmacol 23:7-18. 2013
  4. ncbi Disturbed oscillatory brain dynamics in subcortical ischemic vascular dementia
    Elisabeth C W van Straaten
    Department of Clinical Neurophysiology, VU University Medical Center, De Boelelaan 1118, Amsterdam, 1081 HV, Netherlands
    BMC Neurosci 13:85. 2012
  5. ncbi Periventricular white matter hyperintensities increase the likelihood of progression from amnestic mild cognitive impairment to dementia
    Elisabeth C W van Straaten
    Dept of Neurology and Alzheimer Center, VU Medical Center, De Boelelaan 1117, 7057, 1007 MB, Amsterdam, The Netherlands
    J Neurol 255:1302-8. 2008
  6. ncbi Impact of white matter hyperintensities scoring method on correlations with clinical data: the LADIS study
    Elisabeth C W van Straaten
    Department of Neurology and Alzheimer Center, VU Medical Center, Amsterdam, The Netherlands
    Stroke 37:836-40. 2006
  7. ncbi Operational definitions for the NINDS-AIREN criteria for vascular dementia: an interobserver study
    Elisabeth C W van Straaten
    Department of Neurology and Alzheimer Center, VU Medical Center, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam, Netherlands
    Stroke 34:1907-12. 2003
  8. ncbi On the etiology of incident brain lacunes: longitudinal observations from the LADIS study
    Alida A Gouw
    Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Stroke 39:3083-5. 2008
  9. ncbi Progression of white matter hyperintensities and incidence of new lacunes over a 3-year period: the Leukoaraiosis and Disability study
    Alida A Gouw
    Department of Neurology, Alzheimer Center and Image Analysis Center, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Stroke 39:1414-20. 2008
  10. ncbi Small vessel disease and general cognitive function in nondisabled elderly: the LADIS study
    Wiesje M van der Flier
    Alzheimer Center, Department of Neurology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Stroke 36:2116-20. 2005

Collaborators

Detail Information

Publications44

  1. ncbi Neuropsychological functions in variant Alzheimer's disease with spastic paraparesis
    Auli Verkkoniemi
    Department of Clinical Neurosciences, Helsinki University Central Hospital, Helsinki FIN-00290, Finland
    J Neurol Sci 218:29-37. 2004
    ..However, all these early-onset patients (age range 43-63 years) with a deletion mutation of PS-1 gene showed prominent memory impairment and deficits in visuoconstructive and intellectual functions...
  2. ncbi Subcortical ischemic vascular disease and dementia
    Timo Erkinjuntti
    Department of Neurology, University of Helsinki, Helsinki, Finland
    Int Psychogeriatr 15:23-6. 2003
    ..Further empirical research is needed to refine the syndrome and stages and validate the brain imaging criteria, as well as to detail the natural history and outcomes of SIVD...
  3. ncbi Structure out of chaos: functional brain network analysis with EEG, MEG, and functional MRI
    Elisabeth C W van Straaten
    Department of Clinical Neurophysiology and MEG Centre, VU University Medical Centre, Amsterdam, The Netherlands
    Eur Neuropsychopharmacol 23:7-18. 2013
    ..Moreover, the results that have been reported in this respect in the last years, in healthy brains as well as in functional brain networks of subjects with a neurological or psychiatrical disease, will be reviewed...
  4. ncbi Disturbed oscillatory brain dynamics in subcortical ischemic vascular dementia
    Elisabeth C W van Straaten
    Department of Clinical Neurophysiology, VU University Medical Center, De Boelelaan 1118, Amsterdam, 1081 HV, Netherlands
    BMC Neurosci 13:85. 2012
    ....
  5. ncbi Periventricular white matter hyperintensities increase the likelihood of progression from amnestic mild cognitive impairment to dementia
    Elisabeth C W van Straaten
    Dept of Neurology and Alzheimer Center, VU Medical Center, De Boelelaan 1117, 7057, 1007 MB, Amsterdam, The Netherlands
    J Neurol 255:1302-8. 2008
    ..The influence of WMH on progression of aMCI to Alzheimer's disease (AD) is less clear...
  6. ncbi Impact of white matter hyperintensities scoring method on correlations with clinical data: the LADIS study
    Elisabeth C W van Straaten
    Department of Neurology and Alzheimer Center, VU Medical Center, Amsterdam, The Netherlands
    Stroke 37:836-40. 2006
    ..Associations may depend on the method used for measuring WMH. We investigated the ability of different WMH scoring methods to detect differences in WMH load between groups with and without symptoms...
  7. ncbi Operational definitions for the NINDS-AIREN criteria for vascular dementia: an interobserver study
    Elisabeth C W van Straaten
    Department of Neurology and Alzheimer Center, VU Medical Center, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam, Netherlands
    Stroke 34:1907-12. 2003
    ..The purposes of our study were to operationalize the radiological part of the NINDS-AIREN criteria and to assess the effect of this operationalization on interobserver agreement...
  8. ncbi On the etiology of incident brain lacunes: longitudinal observations from the LADIS study
    Alida A Gouw
    Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Stroke 39:3083-5. 2008
    ..We investigated regional differences in MRI characteristics and risk factor profiles of incident lacunes over a 3-year period...
  9. ncbi Progression of white matter hyperintensities and incidence of new lacunes over a 3-year period: the Leukoaraiosis and Disability study
    Alida A Gouw
    Department of Neurology, Alzheimer Center and Image Analysis Center, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Stroke 39:1414-20. 2008
    ..We studied the natural course of white matter hyperintensities (WMH) and lacunes, the main MRI representatives of small vessel disease, over time and evaluated possible predictors for their development...
  10. ncbi Small vessel disease and general cognitive function in nondisabled elderly: the LADIS study
    Wiesje M van der Flier
    Alzheimer Center, Department of Neurology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Stroke 36:2116-20. 2005
    ..We investigated the independent contribution of WMH and lacunes to general cognitive function in a group of independently living elderly with varying degrees of small vessel disease...
  11. ncbi Reliability and sensitivity of visual scales versus volumetry for evaluating white matter hyperintensity progression
    A A Gouw
    Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Cerebrovasc Dis 25:247-53. 2008
    ..However, the most suitable method for measuring WMH progression has not been established yet. We compared the reliability and sensitivity of cross-sectional and longitudinal visual scales with volumetry for measuring WMH progression...
  12. ncbi Vascular burden of the brain
    Barry Reisberg
    Int Psychogeriatr 15:7-10. 2003
  13. ncbi Age, hypertension, and lacunar stroke are the major determinants of the severity of age-related white matter changes. The LADIS (Leukoaraiosis and Disability in the Elderly) Study
    Anna Maria Basile
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy, and Department of Neurology, , Paris, France
    Cerebrovasc Dis 21:315-22. 2006
    ..CONCLUSIONS: The LADIS Study confirms that age, hypertension and lacunar strokes are the major determinants of ARWMC. Smoking and hypercholesterolemia provide additional risk...
  14. ncbi White matter hyperintensities rather than lacunar infarcts are associated with depressive symptoms in older people: the LADIS study
    Michael J Firbank
    Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Am J Geriatr Psychiatry 14:834-41. 2006
    ..CONCLUSIONS: The results suggest that in this population of nondisabled older people, WMH have a greater influence on depressive symptoms than infarcts...
  15. ncbi Corpus callosum atrophy is associated with mental slowing and executive deficits in subjects with age-related white matter hyperintensities: the LADIS Study
    Hanna Jokinen
    Department of Psychology, University of Helsinki, Helsinki, Finland
    J Neurol Neurosurg Psychiatry 78:491-6. 2007
    ..Previous research has indicated that corpus callosum atrophy is associated with global cognitive decline in neurodegenerative diseases, but few studies have investigated specific cognitive functions...
  16. ncbi Risk of rapid global functional decline in elderly patients with severe cerebral age-related white matter changes: the LADIS study
    Domenico Inzitari
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Arch Intern Med 167:81-8. 2007
    ..The LADIS (LeukoAraiosis and DISability) Study primarily aims to assess ARWMCs as a determinant of global functional decline in the elderly population...
  17. ncbi Comparison of the Alzheimer's Disease Assessment Scale Cognitive Subscale and the Vascular Dementia Assessment Scale in differentiating elderly individuals with different degrees of white matter changes. The LADIS Study
    Raija Ylikoski
    Memory Research Unit, Department of Neurology, University of Helsinki, Helsinki, Finland
    Dement Geriatr Cogn Disord 24:73-81. 2007
    ..The objective of this study was to compare the results of the two scales among subjects with various degrees of white matter hyperintensities (WMHs)...
  18. ncbi White matter lesions are related to impaired instrumental activities of daily living poststroke
    Tarja Ilona Pohjasvaara
    Department of Neurology, Helsinki Medical Imaging Center, Helsinki University Central Hospital, Helsinki, Finland
    J Stroke Cerebrovasc Dis 16:251-8. 2007
    ..We sought to examine the role of WMLs and their extent, in regard to basic ADL, instrumental ADL (IADL), and cognitive functions, in a large well-defined cohort examined 3 months after an ischemic stroke...
  19. ncbi Vascular cognitive impairment
    John T O'Brien
    Institute for Aging and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    Lancet Neurol 2:89-98. 2003
    ..Clinical trials in vascular cognitive impairment are in their infancy but support the value of therapeutic interventions for symptomatic treatment...
  20. ncbi Differential impact of cerebral white matter changes, diabetes, hypertension and stroke on cognitive performance among non-disabled elderly. The LADIS study
    Ana Verdelho
    Neurology Department, Centro de Estudos Egas Moniz, Santa Maria Hospital, Lisbon, Portugal
    J Neurol Neurosurg Psychiatry 78:1325-30. 2007
    ..Our aim was to study the influence of vascular risk factors and ARWMC on the neuropsychological performance of an independent elderly population, to see if vascular risk factors impair cognition in addition to the effects of ARWMC...
  21. ncbi Galantamine in the treatment of cognitive decline in patients with vascular dementia or Alzheimer's disease with cerebrovascular disease
    Gary Small
    Department of Psychiatry and Biobehavioral Sciences and Neuropsychiatric Institute, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90024, USA
    CNS Drugs 17:905-14. 2003
    ....
  22. ncbi An open-label extension trial of galantamine in patients with probable vascular dementia and mixed dementia
    Timo Erkinjuntti
    Department of Clinical Neurosciences, Helsinki University Central Hospital, Helsinki, Finland
    Clin Ther 25:1765-82. 2003
    ....
  23. ncbi Subcortical ischaemic vascular dementia
    Gustavo C Roman
    University of Texas at San Antonio and the Audie L Murphy Memorial Veterans Hospital, San Antonio, Texas 78284 7883, USA
    Lancet Neurol 1:426-36. 2002
    ..Treatment is symptomatic and prevention requires control of treatable risk factors...
  24. ncbi Vascular dementia
    Timo Erkinjuntti
    Department of Neurology, University of Helsinki, Helsinki, Finland
    Semin Clin Neuropsychiatry 8:37-45. 2003
    ..Attempts to treat VaD had varying degrees of success, but it now appears that many forms of VCI might be preventable, especially with good control of vascular risk factors in middle age...
  25. ncbi Treatment options: the latest evidence with galantamine (Reminyl)
    Timo Erkinjuntti
    Memory Research Unit, Department of Clinical Neurosciences, Helsinki University Central Hospital, P O Box 300, 00029 HYKS, Finland
    J Neurol Sci 203:125-30. 2002
    ..Galantamine therefore has potential to benefit a wide range of patients with dementia in the clinic...
  26. ncbi Emerging therapies for vascular dementia and vascular cognitive impairment
    Timo Erkinjuntti
    Helsinki University Central Hospital, Helsinki, Finland
    Stroke 35:1010-7. 2004
    ..CONCLUSIONS: From a public health viewpoint, recognition of VCI before the development of dementia and correction of vascular burden on the brain may lead to a global decrease of incident dementia...
  27. ncbi Treatment of vascular dementia-evidence from clinical trials with cholinesterase inhibitors
    Timo Erkinjuntti
    Helsinki University Central Hospital, Finland
    Neurol Res 26:603-5. 2004
    ..Controlled clinical trials with donepezil, galantamine, and rivastigmine in VaD, as well as in patients with AD plus CVD, have demonstrated improvement in cognition, behavior and activities of daily living...
  28. ncbi Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trial
    Timo Erkinjuntti
    Department of Clinical Neurosciences, Helsinki University Central Hospital, Helsinki, Finland
    Lancet 359:1283-90. 2002
    ..We investigated the effects of galantamine in patients with a diagnosis of probable vascular dementia or Alzheimer's disease combined with cerebrovascular disease...
  29. ncbi Impact of age-related cerebral white matter changes on the transition to disability -- the LADIS study: rationale, design and methodology
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Neuroepidemiology 24:51-62. 2005
    ..The study results may also help to standardize, on an international basis, tools and criteria to identify early stages of disability...
  30. ncbi Development of a neuropsychological battery for the Leukoaraiosis and Disability in the Elderly Study (LADIS): experience and baseline data
    Sofia Madureira
    Servico de Neurologia, Centro de Estudos Egas Moniz, Hospital de Santa Maria, Lisboa, Portugal
    Neuroepidemiology 27:101-16. 2006
    ..In the LADIS population baseline data, older age and lower educational levels negatively influence neuropsychological performance...
  31. ncbi Depression-executive dysfunction syndrome in stroke patients
    Risto Vataja
    Memory Research Unit, Department of Neurology, Helsinki University Central Hospital, P.O. Box 300, FIN-00029 HUS, Finland
    Am J Geriatr Psychiatry 13:99-107. 2005
    ..CONCLUSIONS: DES is a valid concept and may define a subgroup of poststroke patients with frontal-subcortical pathology and with distinct prognosis and treatment options...
  32. ncbi Generalized anxiety disorders three to four months after ischemic stroke
    Antero Leppävuori
    Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland
    Cerebrovasc Dis 16:257-64. 2003
    ..The main objective of our study was to detail the frequency and clinical determinants of poststroke generalized anxiety disorders in a large, well-defined stroke cohort...
  33. ncbi [Cognition disorders after cerebrovascular accidents]
    Tarja Pohjasvaara
    HUS, HYKS Neuroklinikka 00029 HUS, Lohjan aluesairaala 08100 Lohja
    Duodecim 118:593-9. 2002
  34. ncbi Segmentation of age-related white matter changes in a clinical multi-center study
    Tim B Dyrby
    Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Hvidovre, Denmark
    Neuroimage 41:335-45. 2008
    ..Expert knowledge not available to the neural networks was a minor source of discrepancy, while variation in MR scan quality constituted the largest source of error...
  35. ncbi Vascular cognitive deterioration and stroke
    Timo Erkinjuntti
    Department of Neurology, University of Helsinki, Helsinki, Finland
    Cerebrovasc Dis 24:189-94. 2007
    ..Whilst CVD is preventable and treatable, it is clearly a major factor in the prevalence of cognitive impairment in the elderly worldwide...
  36. ncbi Subcortical vascular dementia
    Timo Erkinjuntti
    Memory Research Unit, Department of Clinical Neurosciences, University of Helsinki, Finland
    Cerebrovasc Dis 13:58-60. 2002
    ..Subcortical VaD is expected to show a more predictable clinical picture, natural history, outcome and treatment responses...
  37. ncbi Management of patients with Alzheimer's disease plus cerebrovascular disease: 12-month treatment with galantamine
    Roger Bullock
    Kingshill Research Centre, Victoria Hospital, Swindon, UK
    Dement Geriatr Cogn Disord 17:29-34. 2004
    ..The results of this subgroup analysis indicate that galantamine is effective for long-term maintenance of the cognitive function in patients with AD + CVD and is safe and well tolerated in this patient population...
  38. ncbi Smoking and the platelet fibrinogen receptor glycoprotein IIb/IIIA PlA1/A2 polymorphism interact in the risk of lacunar stroke and midterm survival
    Niku K J Oksala
    Division of Vascular Surgery, Department of Surgery, Tampere University Hospital, Tampere, Finland
    Stroke 38:50-5. 2007
    ..The platelet fibrinogen receptor glycoprotein (Gp) IIb/IIIa Pl(A1/A2) polymorphism affects the binding of platelets to fibrinogen and is suggested to interact with smoking...
  39. ncbi Clinical features of MRI-defined subcortical vascular disease
    Tarja Pohjasvaara
    Department of Neurology, Memory Research Unit, Helsinki University Central Hospital, Helsinki, Finland
    Alzheimer Dis Assoc Disord 17:236-42. 2003
    ..05, 95% confidence interval 1.02-1.09) related to SIVD. CONCLUSIONS: The most significant clinical features of MRI-defined SIVD were found to be apractic-atactic gait, impaired ADL functions, and depression...
  40. ncbi Relationship between periventricular and deep white matter lesions and depressive symptoms in older people. The LADIS Study
    Mani S Krishnan
    Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 21:983-9. 2006
    ..However, it remains controversial as to whether PVL, DWML, or both are most strongly associated with depression and this was the aim of the current study...
  41. ncbi Treatment of vascular dementia--evidence from clinical trials with cholinesterase inhibitors
    Timo Erkinjuntti
    Helsinki University Central Hospital, Helsinki, Finland
    J Neurol Sci 226:63-6. 2004
    ..Controlled clinical trials with donepezil, galantamine and rivastigmine in VaD, as well as in patients with AD plus CVD, have demonstrated improvements in cognition, behavior and activities of daily living...
  42. ncbi Leukoaraiosis predicts hidden global functioning impairment in nondisabled older people: the LADIS (Leukoaraiosis and Disability in the Elderly) Study
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    J Am Geriatr Soc 54:1095-101. 2006
    ..To determine whether leukoaraiosis severity is independently associated with differences in global functioning in nondisabled elderly patients...
  43. ncbi Classification and subtypes of vascular dementia
    Anders Wallin
    Goteborg University, Institute of Clinical Neuroscience, Sahlgrenska University Hospital, Molndal, Sweden
    Int Psychogeriatr 15:27-37. 2003
    ..Subcortical VaD has a relatively homogeneous clinical picture for which detailed criteria are suggested. AD + VaD is more difficult to identify but is possible, sometimes with the aid of neuroimaging and/or biological markers...
  44. ncbi White matter hyperintensities and depression--preliminary results from the LADIS study
    Michael J Firbank
    Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 20:674-9. 2005
    ..CONCLUSIONS: The results suggest that WMH play a role in increasing depressive symptoms, even when perceived quality of life is controlled for as a possible mediating factor...