Research Topics
Species | M G DikSummaryAffiliation: VU University Medical Center Country: The Netherlands Publications
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Detail Information
Publications
Serum inflammatory proteins and cognitive decline in older personsM G Dik
Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
Neurology 64:1371-7. 2005..To assess whether serum levels of the inflammatory proteins alpha(1)-antichymotrypsin (ACT), C-reactive protein (CRP), interleukin-6 (IL-6), and albumin are associated with cognitive decline in older persons...
Contribution of metabolic syndrome components to cognition in older individualsMiranda G Dik
EMGO Institute, VU University Medical Center, 1081 BT Amsterdam, The Netherlands
Diabetes Care 30:2655-60. 2007..However, it is not known what the roles of the individual components of the metabolic syndrome on cognition are...
Total cholesterol and oxysterols: early markers for cognitive decline in elderly?T N Van den Kommer
Longitudinal Aging Study Amsterdam, EMGO Institute, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
Neurobiol Aging 30:534-45. 2009..002) and memory functioning (p=.045). The results implicate that lower total cholesterol may be considered as a frailty marker, predictive of lower cognitive functioning in elderly...
Development of classification models for early identification of persons at risk for persistent cognitive declineT N Van den Kommer
Longitudinal Aging Study Amsterdam and EMGO Institute, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
J Neurol 255:1486-94. 2008..To develop two classification models for use in primary care to aid early identification of persons at risk for persistent cognitive decline...
Homocysteine and inflammation: predictors of cognitive decline in older persons?T N Van den Kommer
Longitudinal Aging Study Amsterdam and EMGO Institute, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
Neurobiol Aging 31:1700-9. 2010..The results implicate that a combination of both risk factors may be used as a marker for cognitive impairment...
Inflammatory markers in late-life depression: results from a population-based studyM A Bremmer
Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
J Affect Disord 106:249-55. 2008..The association between inflammation and depression may depend on the presence of specific chronic diseases or be relevant in specific sub-groups of depressed patients only...
Effects of gender and age on the association of apolipoprotein E epsilon4 with bone mineral density, bone turnover and the risk of fractures in older peopleS M F Pluijm
Institute for Research in Extramural Medicine EMGO Institute, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
Osteoporos Int 13:701-9. 2002....
Distribution of APOE genotypes in a memory clinic cohortW M van der Flier
Alzheimer Center, Department of Neurology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
Dement Geriatr Cogn Disord 25:433-8. 2008..To describe the distribution of apolipoprotein E (APOE) genotypes in a cohort of memory clinic patients...
Memory complaints and APOE-epsilon4 accelerate cognitive decline in cognitively normal elderlyM G Dik
Institute for Research in Extramural Medicine EMGO Institute, Academic Hospital, Vrije Universiteit, Amsterdam, The Netherlands
Neurology 57:2217-22. 2001..To investigate to what extent subjective memory complaints and APOE-epsilon4 allele carriage predict future cognitive decline in cognitively intact elderly persons, by evaluating both their separate and combined effects...
[Predictors of dementia, the construction of classification trees]H C Comijs
EMGO institute LASA, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam
Tijdschr Gerontol Geriatr 37:237-42. 2006..In persons without memory complaints, persons with cardiovascular diseases or diabetes were at increased risk of dementia. Further research is necessary before these classification trees can be implemented in general health care...
Memory complaints; the association with psycho-affective and health problems and the role of personality characteristics. A 6-year follow-up studyH C Comijs
Institute for Research in Extramural Medicine EMGO and the Department of Psychiatry, Vrije Universiteit, Amsterdam, The Netherlands
J Affect Disord 72:157-65. 2002..Furthermore, it is investigated whether personality characteristics have a modifying effect on the association of memory complaints with depressive and anxiety symptoms and physical health...
[Stroke patients in need of long-term nursing home care. Who are they? What are their problems? Which care do they receive?]M Smalbrugge
Afdeling verpleeghuisgeneskunde EMGO, VU Medisch Centrum, Amsterdam
Tijdschr Gerontol Geriatr 39:193-201. 2008..We are poorly informed about the demographic and clinical characteristics and about the care problems and received care of these patients. This study aims to provide a first description of these characteristics in this group of patients...
The impact of change in cognitive functioning and cognitive decline on disability, well-being, and the use of healthcare services in older persons. Results of Longitudinal Aging Study AmsterdamHannie C Comijs
Institute for Research in Extramural Medicine and Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
Dement Geriatr Cogn Disord 19:316-23. 2005..With the aging of the population, the number of persons with cognitive impairment is likely to increase, and appropriate services should be available to them...
Somatic chronic diseases and 6-year change in cognitive functioning among older personsHannie C Comijs
Department of Psychiatry, EMGO Institute, LASA, VU University Medical Center, Van der Boechorststraat, BT Amsterdam, The Netherlands
Arch Gerontol Geriatr 48:191-6. 2009..These findings further stress that careful clinical evaluation of cognitive functioning in older persons with these diseases is required in order to provide adequate care...
Inflammatory markers in AD and MCI patients with different biomarker profilesAlie Schuitemaker
Department of Neurology Alzheimer Center, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
Neurobiol Aging 30:1885-9. 2009..The aim of this study was to demonstrate the involvement of the inflammatory proteins IL-6, ACT and CRP early in the pathology process of AD in patients with mild cognitive impairment (MCI) and AD...
The course of cognitive decline in older persons: results from the longitudinal aging study amsterdamHannie C Comijs
Department of Psychiatry, Institute for Research in Extramural Medicine EMGO Institute of the VU University Medical Center, Amsterdam, The Netherlands
Dement Geriatr Cogn Disord 17:136-42. 2004..Of this group, 44% recovered from cognitive decline or stayed stable in the next 3 years. Especially older age, memory complaints and an increase of cardiovascular diseases at follow-up predict further deterioration...
Late-life depression, cortisol, and the metabolic syndromeNicole Vogelzangs
Department of Psychiatry, VU University Medical Center, A J Ernststraat 887, Amsterdam, The Netherlands
Am J Geriatr Psychiatry 17:716-21. 2009..This study investigated cross-sectionally whether depression and high-cortisol levels increased the odds of metabolic syndrome in an older community-based sample...
Insulin-like growth factor I (IGF-I) and cognitive decline in older personsMiranda G Dik
Institute for Research in Extramural Medicine EMGO Institute, VU University Medical Center, 1081 BT, Amsterdam, The Netherlands
Neurobiol Aging 24:573-81. 2003..78; 95% CI, 1.19-2.68). In summary, this study suggests that IGF-I levels below 9.4 nmol/l are negatively associated with both the level and decline of information processing speed...
Classification models for early identification of persons at risk for dementia in primary care: an evaluation in a sample aged 80 years and olderTessa N van den Kommer
Longitudinal Aging Study Amsterdam and the EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands tn vandenkommer vumc nl
Dement Geriatr Cogn Disord 28:567. 2009..To evaluate previously developed classification models to make implementation in primary care possible and aid early identification of persons at risk for dementia...
Unhealthy lifestyles during the life course: association with physical decline in late lifeSaskia M Pluijm
Institute for Research in Extramural Medicine EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
Aging Clin Exp Res 19:75-83. 2007....
