Michaela Diamant

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. pmc Cerebral blood flow and glucose metabolism in healthy volunteers measured using a high-resolution PET scanner
    Marc C Huisman
    Diabetes Center Department of Internal Medicine, VU University Medical Center, Amsterdam, 1081, HV, The Netherlands
    EJNMMI Res 2:63. 2012
  2. pmc Safety and efficacy of once-weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes over 84 weeks
    Michaela Diamant
    Diabetes Center, VU Medical Center, Amsterdam, The Netherlands
    Diabetes Care 35:683-9. 2012
  3. pmc Effect of additional treatment with EXenatide in patients with an Acute Myocardial Infarction (EXAMI): study protocol for a randomized controlled trial
    Martijn Scholte
    Department of Cardiology, VU University Medical Center, De Boelelaan 11171081 HV Amsterdam, The Netherlands
    Trials 12:240. 2011
  4. pmc Altered myocardial substrate metabolism is associated with myocardial dysfunction in early diabetic cardiomyopathy in rats: studies using positron emission tomography
    Charissa E van den Brom
    Department of Endocrinology, Diabetes Centre, VU University Medical Centre, Amsterdam, The Netherlands
    Cardiovasc Diabetol 8:39. 2009
  5. ncbi request reprint The metabolic syndrome and endothelial dysfunction: common highway to type 2 diabetes and CVD
    Michaela Diamant
    Department of Endocrinology Diabetes Center, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Curr Diab Rep 6:279-86. 2006
  6. ncbi request reprint [Analogs of glucagon-like peptide-1 (GLP-1): an old concept as a new treatment of patients with diabetes mellitus type 2]
    M Diamant
    VU Medisch Centrum, afd Endocrinologie Diabetescentrum, Postbus 7057, 1007 MB Amsterdam
    Ned Tijdschr Geneeskd 148:1912-7. 2004
  7. ncbi request reprint Brain insulin signalling in the regulation of energy balance and peripheral metabolism
    Michaela Diamant
    Department of Endocrinology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Ideggyogy Sz 60:97-108. 2007
  8. ncbi request reprint [Cellular microparticles and blood-vessel damage. II. Functional characteristics and clinical significance]
    M Diamant
    VU Medisch Centrum, afd Endocrinologie Diabetescentrum, Postbus 7057, 1007 MB Amsterdam
    Ned Tijdschr Geneeskd 148:1380-4. 2004
  9. ncbi request reprint [Cellular microparticles and blood-vessel damage. I. Structure, detection and origin]
    M Diamant
    VU Medisch Centrum, afd Endocrinologie Diabetescentrum, Postbus 7057, 1007 MB Amsterdam
    Ned Tijdschr Geneeskd 148:1376-80. 2004
  10. doi request reprint Once weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes (DURATION-3): an open-label randomised trial
    Michaela Diamant
    Diabetes Centre, VU University Medical Centre, Amsterdam, Netherlands
    Lancet 375:2234-43. 2010

Detail Information

Publications116 found, 100 shown here

  1. pmc Cerebral blood flow and glucose metabolism in healthy volunteers measured using a high-resolution PET scanner
    Marc C Huisman
    Diabetes Center Department of Internal Medicine, VU University Medical Center, Amsterdam, 1081, HV, The Netherlands
    EJNMMI Res 2:63. 2012
    ..abstract:..
  2. pmc Safety and efficacy of once-weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes over 84 weeks
    Michaela Diamant
    Diabetes Center, VU Medical Center, Amsterdam, The Netherlands
    Diabetes Care 35:683-9. 2012
    ..This 84-week extension study assessed the long-term safety and efficacy of EQW versus IG...
  3. pmc Effect of additional treatment with EXenatide in patients with an Acute Myocardial Infarction (EXAMI): study protocol for a randomized controlled trial
    Martijn Scholte
    Department of Cardiology, VU University Medical Center, De Boelelaan 11171081 HV Amsterdam, The Netherlands
    Trials 12:240. 2011
    ....
  4. pmc Altered myocardial substrate metabolism is associated with myocardial dysfunction in early diabetic cardiomyopathy in rats: studies using positron emission tomography
    Charissa E van den Brom
    Department of Endocrinology, Diabetes Centre, VU University Medical Centre, Amsterdam, The Netherlands
    Cardiovasc Diabetol 8:39. 2009
    ..The purpose of the present study was to study in a rat model of early DCM, in vivo changes in myocardial substrate metabolism and their association with myocardial function...
  5. ncbi request reprint The metabolic syndrome and endothelial dysfunction: common highway to type 2 diabetes and CVD
    Michaela Diamant
    Department of Endocrinology Diabetes Center, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Curr Diab Rep 6:279-86. 2006
    ..This review focuses on the mechanisms linking ED to the metabolic syndrome, T2D, and CVD, and the possible therapies that may improve ED and reduce T2D and CVD risk...
  6. ncbi request reprint [Analogs of glucagon-like peptide-1 (GLP-1): an old concept as a new treatment of patients with diabetes mellitus type 2]
    M Diamant
    VU Medisch Centrum, afd Endocrinologie Diabetescentrum, Postbus 7057, 1007 MB Amsterdam
    Ned Tijdschr Geneeskd 148:1912-7. 2004
    ..Enhancement of incretin action seems a rational and promising option for the treatment of type-2 diabetes...
  7. ncbi request reprint Brain insulin signalling in the regulation of energy balance and peripheral metabolism
    Michaela Diamant
    Department of Endocrinology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Ideggyogy Sz 60:97-108. 2007
    ....
  8. ncbi request reprint [Cellular microparticles and blood-vessel damage. II. Functional characteristics and clinical significance]
    M Diamant
    VU Medisch Centrum, afd Endocrinologie Diabetescentrum, Postbus 7057, 1007 MB Amsterdam
    Ned Tijdschr Geneeskd 148:1380-4. 2004
    ..In view of their functional properties, cellular microparticles may be a missing link between cellular and plasmatic processes underlying atherosclerotic blood-vessel damage...
  9. ncbi request reprint [Cellular microparticles and blood-vessel damage. I. Structure, detection and origin]
    M Diamant
    VU Medisch Centrum, afd Endocrinologie Diabetescentrum, Postbus 7057, 1007 MB Amsterdam
    Ned Tijdschr Geneeskd 148:1376-80. 2004
    ..Elevated numbers of microparticles can be found in a wide variety of diseases, all of which are associated with hypercoagulability and blood-vessel damage, thus suggesting their role in the pathogenesis of vascular disease...
  10. doi request reprint Once weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes (DURATION-3): an open-label randomised trial
    Michaela Diamant
    Diabetes Centre, VU University Medical Centre, Amsterdam, Netherlands
    Lancet 375:2234-43. 2010
    ..We aimed to test the hypothesis that improvement in haemoglobin A(1c) (HbA(1c)) achieved with once weekly exenatide was superior to that achieved with insulin glargine titrated to glucose targets...
  11. ncbi request reprint Cellular microparticles: new players in the field of vascular disease?
    M Diamant
    Department of Endocrinology Diabetes Centre, VU University Medical Centre, Amsterdam, The Netherlands
    Eur J Clin Invest 34:392-401. 2004
    ..In view of their functional properties, cell-derived microparticles may be an important intermediate in the cascade of cellular and plasmatic dysfunctions underlying the process of atherogenesis...
  12. doi request reprint Do nutrient-gut-microbiota interactions play a role in human obesity, insulin resistance and type 2 diabetes?
    M Diamant
    Diabetes Centre, VU University Medical Centre, Amsterdam, The Netherlands
    Obes Rev 12:272-81. 2011
    ..Large-scale intervention trials, investigating the potential benefit of prebiotics and probiotics in improving cardiometabolic health in high-risk populations, are eagerly awaited...
  13. ncbi request reprint The association between abdominal visceral fat and carotid stiffness is mediated by circulating inflammatory markers in uncomplicated type 2 diabetes
    Michaela Diamant
    Department of Endocrinology Diabetes Center, VU University Medical Center, De Boelelaan 1117, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    J Clin Endocrinol Metab 90:1495-501. 2005
    ....
  14. ncbi request reprint Diastolic dysfunction is associated with altered myocardial metabolism in asymptomatic normotensive patients with well-controlled type 2 diabetes mellitus
    Michaela Diamant
    Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
    J Am Coll Cardiol 42:328-35. 2003
    ..This study evaluated myocardial function in relation to high-energy phosphate (HEP) metabolism in asymptomatic patients with uncomplicated type 2 diabetes mellitus using magnetic resonance (MR) techniques...
  15. ncbi request reprint Thiazolidinediones in type 2 diabetes mellitus: current clinical evidence
    Michaela Diamant
    Department of Endocrinology, Diabetes Centre, VU University Medical Centre, Amsterdam, The Netherlands
    Drugs 63:1373-405. 2003
    ..Long-term efficacy and surveillance of this promising class of drugs in patients, however, still need to be demonstrated in outcome trials...
  16. ncbi request reprint Elevated numbers of tissue-factor exposing microparticles correlate with components of the metabolic syndrome in uncomplicated type 2 diabetes mellitus
    Michaela Diamant
    Department of Endocrinology Diabetes Center, VU University Medical Center, Amsterdam, The Netherlands
    Circulation 106:2442-7. 2002
    ..We characterized circulating microparticles both in patients with uncomplicated, well-regulated type 2 diabetes and in healthy subjects, as well as their relationship with coagulation and metabolic control...
  17. doi request reprint Myocardial steatosis is an independent predictor of diastolic dysfunction in type 2 diabetes mellitus
    Luuk J Rijzewijk
    Department of Endocrinology, VU University Medical Center, Amsterdam, The Netherlands
    J Am Coll Cardiol 52:1793-9. 2008
    ....
  18. doi request reprint Pioglitazone improves cardiac function and alters myocardial substrate metabolism without affecting cardiac triglyceride accumulation and high-energy phosphate metabolism in patients with well-controlled type 2 diabetes mellitus
    Rutger W van der Meer
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    Circulation 119:2069-77. 2009
    ..We determined the effects of pioglitazone on myocardial function in relation to cardiac high-energy phosphate, glucose, and fatty acid metabolism and triglyceride content in T2DM patients...
  19. doi request reprint One-year treatment with exenatide vs. insulin glargine: effects on postprandial glycemia, lipid profiles, and oxidative stress
    Mathijs C Bunck
    Department of Internal Medicine, Section of Endocrinology, Diabetes Center, VU University Medical Center, Amsterdam, The Netherlands
    Atherosclerosis 212:223-9. 2010
    ..The objective of the present study was to investigate the effects of one-year treatment with exenatide or Insulin Glargine, followed by a 5-week off-drug period, on postprandial lipidaemia, glycaemia and measures of oxidative stress...
  20. pmc Diabetic cardiomyopathy in Zucker diabetic fatty rats: the forgotten right ventricle
    Charissa E van den Brom
    Department of Internal Medicine Diabetes Centre, VU University Medical Centre, Amsterdam, The Netherlands
    Cardiovasc Diabetol 9:25. 2010
    ..The purpose of the present study was to investigate whether LV changes are paralleled by RV alterations in a rat model of diabetes...
  21. pmc Liver fat content in type 2 diabetes: relationship with hepatic perfusion and substrate metabolism
    Luuk J Rijzewijk
    Diabetes Center, VU University Medical Center, Amsterdam, The Netherlands
    Diabetes 59:2747-54. 2010
    ..The aim of the current study was to assess hepatic parenchymal perfusion, together with glucose and fatty acid metabolism, in relation to hepatic triglyceride content...
  22. ncbi request reprint Identifying the metabolic syndrome in obese children and adolescents: do age and definition matter?
    Mariska van Vliet
    Department of Endocrinology Diabetes Centre, VU University Medical Centre, De Boelelaan 1118, 1081HV Amsterdam, The Netherlands
    Curr Clin Pharmacol 4:233-8. 2009
    ..To assess the prevalence of the metabolic syndrome (MetS) in overweight/obese children and adolescents of an out-patient clinic, and to compare two definitions of MetS in adolescents...
  23. doi request reprint Determinants of postprandial triglyceride and glucose responses after two consecutive fat-rich or carbohydrate-rich meals in normoglycemic women and in women with type 2 diabetes mellitus: the Hoorn Prandial Study
    Marjan Alssema
    EMGO Institute, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Metabolism 57:1262-9. 2008
    ..Commonly measured clinical and biochemical parameters can only partly explain postprandial glucose and triglyceride excursions...
  24. doi request reprint Islet-cell dysfunction induced by glucocorticoid treatment: potential role for altered sympathovagal balance?
    Daniel H van Raalte
    Diabetes Center, Department of Internal Medicine, VU University Medical Center, Amsterdam, De Boelelaan 1117, 1007MB, PO Box 7057, Amsterdam, The Netherlands
    Metabolism 62:568-77. 2013
    ..Glucocorticoids impair glucose tolerance by inducing insulin resistance. We investigated the dose-dependent effects of glucocorticoid treatment on islet-cell function in healthy males and studied the role of the autonomic nervous system...
  25. doi request reprint The ageing male heart: myocardial triglyceride content as independent predictor of diastolic function
    Rutger W van der Meer
    Department of Radiology C2 S, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur Heart J 29:1516-22. 2008
    ..Therefore, the purpose of our study was to evaluate the effects of ageing on myocardial TG content, and to determine the association between myocardial TG content and heart function...
  26. doi request reprint Effects of hepatic triglyceride content on myocardial metabolism in type 2 diabetes
    Luuk J Rijzewijk
    Diabetes Center, Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Am Coll Cardiol 56:225-33. 2010
    ..The purpose of this study was to investigate the relationship between hepatic triglyceride content and both myocardial function and metabolism in type 2 diabetes mellitus (T2DM)...
  27. doi request reprint Fasting cholesteryl ester transfer protein concentration is independently associated with the postprandial decrease in high-density lipoprotein cholesterol concentration after fat-rich meals: the Hoorn prandial study
    Marjan Alssema
    EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    Metabolism 59:854-60. 2010
    ..This effect is independent from the postprandial increase in triglycerides...
  28. doi request reprint Altered myocardial substrate metabolism and decreased diastolic function in nonischemic human diabetic cardiomyopathy: studies with cardiac positron emission tomography and magnetic resonance imaging
    Luuk J Rijzewijk
    Diabetes Center, VU University Medical Center, Amsterdam, The Netherlands
    J Am Coll Cardiol 54:1524-32. 2009
    ....
  29. doi request reprint Findings from left ventricular strain and strain rate imaging in asymptomatic patients with type 2 diabetes mellitus
    Arnold C T Ng
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Cardiol 104:1398-401. 2009
    ..001). In conclusion, the LV longitudinal systolic and diastolic function were impaired, but the circumferential and radial functions were preserved in patients with uncomplicated type 2 diabetes mellitus...
  30. pmc Pioglitazone decreases plasma cholesteryl ester transfer protein mass, associated with a decrease in hepatic triglyceride content, in patients with type 2 diabetes
    Jacqueline T Jonker
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Diabetes Care 33:1625-8. 2010
    ..Therefore, the aim of the present study was to assess the effects of pioglitazone on CETP mass in patients with type 2 diabetes...
  31. doi request reprint Effects of short-term high-fat, high-energy diet on hepatic and myocardial triglyceride content in healthy men
    Rutger W van der Meer
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Endocrinol Metab 93:2702-8. 2008
    ..An association has been suggested between elevated plasma nonesterified fatty acid (NEFA) levels, myocardial triglyceride (TG) accumulation, and myocardial function...
  32. pmc Cardiometabolic risk variables in overweight and obese children: a worldwide comparison
    Mariska van Vliet
    Department of Pediatrics, Slotervaart Hospital, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands
    Cardiovasc Diabetol 10:106. 2011
    ..The results of our review present a fair estimation of the true differences between cardiometabolic risk profiles among pediatric cohorts worldwide, based on available literature...
  33. doi request reprint Comparison of two consecutive fat-rich and carbohydrate-rich meals on postprandial myeloperoxidase response in women with and without type 2 diabetes mellitus
    Roger K Schindhelm
    Department of Endocrinology Diabetes Center, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Metabolism 57:262-7. 2008
    ..Our findings provide no support to our initial hypothesis that meal-induced release of MPO might be a mechanism that contributes to CVD risk...
  34. pmc Effects of exenatide on measures of β-cell function after 3 years in metformin-treated patients with type 2 diabetes
    Mathijs C Bunck
    Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Diabetes Care 34:2041-7. 2011
    ..These effects were not sustained after a 4-week off-drug period. This article reports the results after additional 2 years of exposure...
  35. doi request reprint Postprandial lipid and apolipoprotein responses following three consecutive meals associate with liver fat content in type 2 diabetes and the metabolic syndrome
    Maarten E Tushuizen
    Department of Endocrinology Diabetes Center, VU University Medical Center, Amsterdam, The Netherlands
    Atherosclerosis 211:308-14. 2010
    ....
  36. pmc Glucagon-like peptide-1 receptor agonist treatment prevents glucocorticoid-induced glucose intolerance and islet-cell dysfunction in humans
    Daniel H van Raalte
    Diabetes Center, Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Diabetes Care 34:412-7. 2011
    ..This study assessed whether treatment with the glucagon-like peptide receptor agonist (GLP-1 RA) exenatide (EXE) could prevent GC-induced glucose intolerance...
  37. ncbi request reprint Fasting and postprandial glycoxidative and lipoxidative stress are increased in women with type 2 diabetes
    Roger K Schindhelm
    Department of Endocrinology, Vrije University Medical Center, Amsterdam, The Netherlands
    Diabetes Care 30:1789-94. 2007
    ....
  38. pmc Overweight children with type 1 diabetes have a more favourable lipid profile than overweight non-diabetic children
    Mariska van Vliet
    Department of Pediatrics, Slotervaart Hospital, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands
    Eur J Pediatr 171:493-8. 2012
    ..Still, paediatricians should give extra attention to cardiometabolic risk factors within this vulnerable group, taking into account the already high cardiometabolic risk...
  39. pmc Exenatide affects circulating cardiovascular risk biomarkers independently of changes in body composition
    Mathijs C Bunck
    Department of Internal Medicine, Section of Endocrinology, Diabetes Center, VU University Medical Center, Amsterdam, The Netherlands
    Diabetes Care 33:1734-7. 2010
    ..To study the effect of exenatide on body composition and circulating cardiovascular risk biomarkers...
  40. doi request reprint Increased plasma apolipoprotein C-III concentration independently predicts cardiovascular mortality: the Hoorn Study
    Peter G Scheffer
    Metabolic Laboratory, Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
    Clin Chem 54:1325-30. 2008
    ..The aim of this study was to investigate the prognostic value of plasma apoC-III concentrations for cardiovascular mortality...
  41. doi request reprint Carotid atherosclerosis in depression and anxiety: associations for age of depression onset
    Adrie Seldenrijk
    EMGO Institute for Health and Care Research, Amsterdam, The Netherlands
    World J Biol Psychiatry 12:549-58. 2011
    ..Our aims were to examine the presence of subclinical atherosclerosis in subjects with depressive or anxiety disorder, also taking into account disorder characteristics (subtype, severity, duration, age of onset, medication)...
  42. pmc Association of plasma osteoprotegerin and adiponectin with arterial function, cardiac function and metabolism in asymptomatic type 2 diabetic men
    Weena J Y Chen
    Diabetes Center Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Cardiovasc Diabetol 10:67. 2011
    ..We assessed the relationship of plasma OPG and ADPN and arterial function, cardiac function and myocardial glucose metabolism in T2DM...
  43. ncbi request reprint Pancreatic fat content and beta-cell function in men with and without type 2 diabetes
    Maarten E Tushuizen
    Department of Endocrinology Diabetes Center, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Diabetes Care 30:2916-21. 2007
    ..Experimental data indicate that fatty infiltration of pancreatic islets may also contribute to beta-cell dysfunction, but whether this occurs in humans in vivo is unknown...
  44. pmc Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function
    Annemarie M Simonis-Bik
    Diabetes Center, VU University Medical Center, Amsterdam, The Netherlands
    Diabetes 59:293-301. 2010
    ..In this study we used hyperglycemic clamps with three different stimuli to test associations between these novel loci and various measures of beta-cell function...
  45. pmc Differential impact of impaired fasting glucose versus impaired glucose tolerance on cardiometabolic risk factors in multi-ethnic overweight/obese children
    Mariska van Vliet
    Department of Paediatrics, Slotervaart Hospital, Amsterdam, The Netherlands
    Eur J Pediatr 170:589-97. 2011
    ..In conclusion, in a Dutch multi-ethnic cohort of overweight/obese children, a high prevalence of IFG was found against a low prevalence of IGT, which differed in their associations with cardiometabolic risk factors...
  46. ncbi request reprint Elevated endothelial microparticles following consecutive meals are associated with vascular endothelial dysfunction in type 2 diabetes
    Maarten E Tushuizen
    Department of Endocrinology Diabetes Center, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Diabetes Care 30:728-30. 2007
  47. doi request reprint Limited value of routine microalbuminuria assessment in multi-ethnic obese children
    Nalini N E Radhakishun
    Department of Pediatrics, Slotervaart Hospital, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands
    Pediatr Nephrol 28:1145-9. 2013
    ..To determine the prevalence of microalbuminuria and its association with cardiometabolic risk factors in a multi-ethnic cohort of overweight and obese children...
  48. pmc Ethnic differences in cardiometabolic risk profile in an overweight/obese paediatric cohort in the Netherlands: a cross-sectional study
    Mariska van Vliet
    Department of Paediatrics, Slotervaart Hospital, Amsterdam, The Netherlands
    Cardiovasc Diabetol 8:2. 2009
    ..Differences in prevalence of cardiometabolic risk factors between different ethnic groups are largely unknown. We determined the variation in cardiometabolic risk profile according to ethnicity in a cohort overweight/obese Dutch children...
  49. ncbi request reprint Alanine aminotransferase as a marker of non-alcoholic fatty liver disease in relation to type 2 diabetes mellitus and cardiovascular disease
    Roger K Schindhelm
    Department of Endocrinology Diabetes Centre, VU University Medical Centre, 1007 MB Amsterdam, The Netherlands
    Diabetes Metab Res Rev 22:437-43. 2006
    ..In addition, treatment strategies to ameliorate NAFLD and the associated risks are discussed...
  50. ncbi request reprint Short-term caloric restriction induces accumulation of myocardial triglycerides and decreases left ventricular diastolic function in healthy subjects
    Rutger W van der Meer
    Department of Radiology, C2S, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, Netherlands
    Diabetes 56:2849-53. 2007
    ..Because a very low-calorie diet (VLCD) also increases plasma NEFA levels, we studied the effect of a VLCD on myocardial triglyceride content and cardiac function in healthy subjects...
  51. pmc One-year treatment with exenatide improves beta-cell function, compared with insulin glargine, in metformin-treated type 2 diabetic patients: a randomized, controlled trial
    Mathijs C Bunck
    Department of Endocrinology, Diabetes Center, VU University Medical Center, Amsterdam, The Netherlands
    Diabetes Care 32:762-8. 2009
    ..We investigated the effects of 52 weeks of treatment with exenatide or insulin glargine followed by an off-drug period on hyperglycemic clamp-derived measures of beta-cell function, glycemic control, and body weight...
  52. ncbi request reprint Palmitate and oleate have distinct effects on the inflammatory phenotype of human endothelial cells
    Jolita Ciapaite
    Department of Molecular Cell Physiology, Institute for Molecular Cell Biology, VU University, Amsterdam, The Netherlands
    Biochim Biophys Acta 1771:147-54. 2007
    ..Our results indicate that the effects depend on the fatty acid type and may be related to accumulation of LCAC...
  53. doi request reprint Sensitivity to depression or anxiety and subclinical cardiovascular disease
    Adrie Seldenrijk
    EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    J Affect Disord 146:126-31. 2013
    ..Our aim is to examine sensitivity to depression or anxiety in association with indicators of subclinical CVD...
  54. doi request reprint Effects of vildagliptin on postprandial markers of bone resorption and calcium homeostasis in recently diagnosed, well-controlled type 2 diabetes patients
    Mathijs C Bunck
    Diabetes Center, Department of Internal Medicine, Section of Endocrinology, VU University Medical Center, Amsterdam, The Netherlands
    J Diabetes 4:181-5. 2012
    ..Endogenous incretins have been shown to be important regulators of bone turnover. The aim of the present study was to assess whether a dipeptidylpeptidase (DPP)-4 inhibitor affects markers of bone resorption and calcium homeostasis...
  55. doi request reprint Acute and 2-week exposure to prednisolone impair different aspects of beta-cell function in healthy men
    Daniel H van Raalte
    Endocrinology Section, Department of Internal Medicine, Diabetes Centre, VU University Medical Centre, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Eur J Endocrinol 162:729-35. 2010
    ..In contrast to the well known GC-induced insulin resistance, the effects of GCs on beta-cell function are less well established. We assessed the acute and short-term effects of prednisolone treatment on beta-cell function in healthy men...
  56. ncbi request reprint Alanine aminotransferase predicts coronary heart disease events: a 10-year follow-up of the Hoorn Study
    Roger K Schindhelm
    Department of Endocrinology, VU University Medical Centre, Amsterdam, The Netherlands
    Atherosclerosis 191:391-6. 2007
    ..Further studies should confirm these findings and elucidate the pathophysiological mechanisms...
  57. pmc Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps
    Leen M 't Hart
    Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Diabetes 59:287-92. 2010
    ..In this study, we have investigated the combined effects of eight known beta-cell loci on insulin secretion stimulated by three different secretagogues during hyperglycemic clamps...
  58. ncbi request reprint Metabolic imaging of myocardial triglyceride content: reproducibility of 1H MR spectroscopy with respiratory navigator gating in volunteers
    Rutger W van der Meer
    Department of Radiology, Leiden University Medical Center, Albinusdreef 2, C2 S, 2333 ZA Leiden, The Netherlands
    Radiology 245:251-7. 2007
    ..32 to 0.81. Therefore, the authors believe that respiratory motion correction is essential for reproducible assessment of myocardial triglycerides...
  59. doi request reprint Overweight is highly prevalent in children with type 1 diabetes and associates with cardiometabolic risk
    Mariska van Vliet
    Department of Pediatrics, Slotervaart Hospital, Amsterdam, The Netherlands
    J Pediatr 156:923-9. 2010
    ..To determine the prevalence of traditional cardiometabolic risk factors and to assess the effect of overweight/obesity on the occurrence of these risk factors in a cohort of children with type 1 diabetes mellitus (T1DM)...
  60. doi request reprint Effects of sex steroids on the neurotransmitter-specific aromatic amino acids phenylalanine, tyrosine, and tryptophan in transsexual subjects
    Erik J Giltay
    Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
    Neuroendocrinology 88:103-10. 2008
    ..The aim of this study was to assess whether sex steroids affect plasma levels of these aromatic amino acids...
  61. ncbi request reprint Functioning of oxidative phosphorylation in liver mitochondria of high-fat diet fed rats
    Jolita Ciapaite
    Department of Molecular Cell Physiology, Institute for Molecular Cell Biology, Faculty of Earth and Life Sciences, VU University, Amsterdam, The Netherlands
    Biochim Biophys Acta 1772:307-16. 2007
    ..Furthermore, ANT retains control of fluxes and intermediates, making inhibition of this enzyme a more probable link between obesity and type 2 diabetes...
  62. doi request reprint Slightly elevated B-type natriuretic peptide levels in a non-heart failure range indicate a worse left ventricular diastolic function in individuals with, as compared with individuals without, type 2 diabetes: the Hoorn Study
    Katja van den Hurk
    Department of Epidemiology and Biostatistics and the EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Heart Fail 12:958-65. 2010
    ..We therefore aimed to explore (i) the association of BNP levels in a non-HF range with structural and functional markers of LV function, and (ii) possible effect modification by glucose tolerance categories...
  63. doi request reprint Depression, anxiety, and arterial stiffness
    Adrie Seldenrijk
    EMGO Institute for Health and Care Research, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Biol Psychiatry 69:795-803. 2011
    ..The current study aimed to examine whether subjects with a diagnosis of depressive or anxiety disorder showed increased stiffness and to explore associations between various psychiatric characteristics and arterial stiffness...
  64. doi request reprint Pancreatic steatosis in humans: cause or marker of lipotoxicity?
    Daniel H van Raalte
    Diabetes Centre, Department of Internal Medicine, VU University Medical Centre, Amsterdam, The Netherlands
    Curr Opin Clin Nutr Metab Care 13:478-85. 2010
    ..The purpose of this review is to describe the mechanisms underlying lipotoxicity in vitro, to discuss the evidence for lipotoxicity in vivo and to address whether pancreatic lipid accumulation interferes with insulin secretion in humans...
  65. doi request reprint Prednisolone-induced beta cell dysfunction is associated with impaired endoplasmic reticulum homeostasis in INS-1E cells
    Margot M L Linssen
    Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Cell Signal 23:1708-15. 2011
    ..Taken together, our data suggest that the inhibition of insulin biosynthesis by PRED in the insulin-secreting INS-1E cells results, at least in part, from a GR-mediated impairment in ER homeostasis which may lead to apoptotic cell death...
  66. pmc Right ventricular involvement in diabetic cardiomyopathy
    Ralph L Widya
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    Diabetes Care 36:457-62. 2013
    ..To compare magnetic resonance imaging-derived right ventricular (RV) dimensions and function between men with type 2 diabetes and healthy subjects, and to relate these parameters to left ventricular (LV) dimensions and function...
  67. pmc Parametric imaging of myocardial viability using ¹⁵O-labelled water and PET/CT: comparison with late gadolinium-enhanced CMR
    Stefan de Haan
    Department of Cardiology, VU University Medical Center, De Boelelaan 1118, 1081 HV, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 39:1240-5. 2012
    ..Recent technological advances have made it possible to generate parametric PTI images from a single [(15)O]H(2)O PET/CT scan. The purpose of this study was to validate these parametric PTI images...
  68. doi request reprint Postprandial changes in the phospholipid composition of circulating microparticles are not associated with coagulation activation
    Maarten E Tushuizen
    Department of Internal Medicine, Diabetes Center, VU University Medical Center, Amsterdam, The Netherlands
    Thromb Res 130:115-21. 2012
    ..Our objective was to investigate whether postprandial metabolic responses affect the phospholipid composition of MP, and whether such changes are associated with coagulation activation...
  69. doi request reprint Metabolic effects of high-dose prednisolone treatment in early rheumatoid arthritis: balance between diabetogenic effects and inflammation reduction
    Debby den Uyl
    VU University Medical Center, Amsterdam, The Netherlands
    Arthritis Rheum 64:639-46. 2012
    ..To investigate the dose-related effects of glucocorticoid treatment on glucose tolerance, beta cell function, and insulin sensitivity in patients with early active rheumatoid arthritis (RA)...
  70. doi request reprint Valsartan-induced improvement in insulin sensitivity is not paralleled by changes in microvascular function in individuals with impaired glucose metabolism
    Nynke J van der Zijl
    Diabetes Centre, Department of Internal Medicine, VU University Medical Centre, Amsterdam, The Netherlands
    J Hypertens 29:1955-62. 2011
    ....
  71. doi request reprint Myocardial steatosis and biventricular strain and strain rate imaging in patients with type 2 diabetes mellitus
    Arnold C T Ng
    Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Circulation 122:2538-44. 2010
    ..Magnetic resonance spectroscopy can quantify myocardial triglyceride content in type 2 diabetic patients. Its relation to alterations in left (LV) and right (RV) ventricular myocardial functions is unknown...
  72. ncbi request reprint Incretin mimetics as a novel therapeutic option for hepatic steatosis
    Maarten E Tushuizen
    Department of Endocrinology Diabetes Centre, VU University Medical Centre, Amsterdam, The Netherlands
    Liver Int 26:1015-7. 2006
    ..We had the opportunity to study the effect of additional exenatide administration on liver fat content in a patient with type 2 diabetes...
  73. ncbi request reprint Nonalcoholic fatty liver disease and cardiovascular disease risk
    Roger K Schindhelm
    Department of Endocrinology Diabetes Center, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Curr Diab Rep 7:181-7. 2007
    ..Long-term outcome studies need to establish whether treatment of NAFLD (and in particular which therapy) will affect the long-term outcome...
  74. doi request reprint Stroke volume measurements with first-pass dynamic positron emission tomography: comparison with cardiovascular magnetic resonance
    Paul Knaapen
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Cardiol 15:218-24. 2008
    ..The aim of this study was to compare first-pass derived SV with cardiovascular magnetic resonance imaging (CMR)-obtained values in a larger population of subjects...
  75. ncbi request reprint Simvastatin-induced endothelial cell detachment and microparticle release are prenylation dependent
    Michaela Diamant
    Department of Endocrinology Diabetes Center, VU University Medical Center, Amsterdam, The Netherlands
    Thromb Haemost 100:489-97. 2008
    ..We hypothesize that by facilitating detachment and EMP release, statins improve the overall condition of the remaining vascular endothelium...
  76. ncbi request reprint Magnetic resonance assessment of aortic pulse wave velocity, aortic distensibility, and cardiac function in uncomplicated type 2 diabetes mellitus
    Rutger W van der Meer
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    J Cardiovasc Magn Reson 9:645-51. 2007
    ..Furthermore, CMR is a reliable method for assessing left ventricular (LV) function. The purpose of this study was to assess LV function, PWV, and aortic distensibility in patients with DM2 using MR...
  77. doi request reprint Urinary matrix metalloproteinase-8 and -9 activities in type 2 diabetic subjects: A marker of incipient diabetic nephropathy?
    Nynke J van der Zijl
    Department of Endocrinology Diabetes Center, VU University Medical Center, Amsterdam, The Netherlands
    Clin Biochem 43:635-9. 2010
    ..05). In summary, MMP-8 and -9 are highest in T2DM UA patients. MMP-9, showed the strongest associations with clinical parameters related to DN...
  78. doi request reprint Does glucagon-like peptide-1 receptor agonist therapy add value in the treatment of type 2 diabetes? Focus on exenatide
    Renate E van Genugten
    Diabetes Centre, Department of Internal Medicine, VU University Medical Centre, Amsterdam, The Netherlands
    Diabetes Res Clin Pract 86:S26-34. 2009
    ..Long-term prospective studies in high-risk populations should address the potentially disease modifying effect of exenatide and its effect on CVD risk, in addition to its safety and tolerability...
  79. ncbi request reprint The relationship of lipoprotein lipase activity and LDL size is dependent on glucose metabolism in an elderly population: the Hoorn Study
    Griët Bos
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Diabetes Care 27:796-8. 2004
  80. ncbi request reprint Diastolic stiffness of the failing diabetic heart: importance of fibrosis, advanced glycation end products, and myocyte resting tension
    Loek van Heerebeek
    Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Circulation 117:43-51. 2008
    ..The contribution to diastolic stiffness of fibrosis, AGEs, and cardiomyocyte resting tension was assessed in diabetic heart failure patients with normal or reduced LVEF...
  81. ncbi request reprint Effects of low-iodide diet on postsurgical radioiodide ablation therapy in patients with differentiated thyroid carcinoma
    Maurice J H M Pluijmen
    Departments of Endocrinology and Metabolism and Nuclear Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Clin Endocrinol (Oxf) 58:428-35. 2003
    ..The efficacy of an LID on thyroid remnant ablation, however, has never been demonstrated convincingly...
  82. doi request reprint The heritability of HbA1c and fasting blood glucose in different measurement settings
    Annemarie M C Simonis-Bik
    Diabetes Centre, VU University Medical Centre, 1081 HV Amsterdam, The Netherlands
    Twin Res Hum Genet 11:597-602. 2008
    ..As a consequence these two glycemic parameters can not be used interchangeably in diagnostic procedures or in studies attempting to find genes for diabetes. Both contribute unique (genetic) information...
  83. pmc Functional brain connectivity and neurocognitive functioning in patients with long-standing type 1 diabetes with and without microvascular complications: a magnetoencephalography study
    Eelco van Duinkerken
    Department of Medical Psychology and Endocrinology, VU University Medical Center, Amsterdam, The Netherlands
    Diabetes 58:2335-43. 2009
    ..This study addresses functional connectivity and cognition in type 1 diabetic patients with and without proliferative retinopathy, relative to healthy control subjects, using magnetoencephalography...
  84. pmc Valsartan improves {beta}-cell function and insulin sensitivity in subjects with impaired glucose metabolism: a randomized controlled trial
    Nynke J van der Zijl
    Diabetes Center, Department of Internal Medicine, Vrije University Medical Center, Amsterdam, The Netherlands
    Diabetes Care 34:845-51. 2011
    ..We investigated whether improvements in β-cell function and/or insulin sensitivity underlie these preventive effects of the ARB valsartan in the onset of type 2 diabetes...
  85. doi request reprint The association of elevated alanine aminotransferase and the metabolic syndrome in an overweight and obese pediatric population of multi-ethnic origin
    Mariska van Vliet
    Department of Pediatrics, Slotervaart Hospital, Louwesweg 6, 1066 EC Amsterdam, The Netherlands
    Eur J Pediatr 168:585-91. 2009
    ..In conclusion, elevated ALT levels were highly prevalent and associated with the metabolic syndrome, insulin resistance, high triglycerides, and low HDL-cholesterol in an obese multiethnic pediatric population...
  86. pmc Postprandial dysmetabolism and cardiovascular disease in type 2 diabetes
    M E Tushuizen
    Department of Endocrinology Diabetes Centre, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Postgrad Med J 81:1-6. 2005
    ..Finally, some possible therapeutic options and recommendations for future research are discussed...
  87. pmc The heritability of beta cell function parameters in a mixed meal test design
    A M C Simonis-Bik
    Diabetes Center, VU University Medical Center, ZH 4A62, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Diabetologia 54:1043-51. 2011
    ..We estimated the heritability of individual differences in beta cell function after a mixed meal test designed to assess a wide range of classical and model-derived beta cell function parameters...
  88. ncbi request reprint Elevated cholesteryl ester transfer protein concentration is associated with an increased risk for cardiovascular disease in women, but not in men, with Type 2 diabetes: the Hoorn Study
    M Alssema
    EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    Diabet Med 24:117-23. 2007
    ....
  89. pmc Management of hyperglycaemia in type 2 diabetes: the end of recurrent failure?
    R J Heine
    Diabetes Centre, Department of Endocrinology, VU University Medical Centre, Amsterdam, De Boelelaan 1117, Netherlands
    BMJ 333:1200-4. 2006
  90. ncbi request reprint [Metabolic syndrome: limited significance for clinical practice]
    J M Dekker
    VU Medisch Centrum, Van der Boechorststraat 7, 0081 BT Amsterdam
    Ned Tijdschr Geneeskd 149:855-8. 2005
    ..Its utility in clinical practice, however, is under debate. Reduction of obesity by life-style changes and treatment of individual risk factors is still the best line of action...
  91. ncbi request reprint Liver alanine aminotransferase, insulin resistance and endothelial dysfunction in normotriglyceridaemic subjects with type 2 diabetes mellitus
    R K Schindhelm
    Diabetes Centre Department of Endocrinology, VU University Medical Centre, Amsterdam, The Netherlands
    Eur J Clin Invest 35:369-74. 2005
    ..Alanine aminotransferase predicts the development of type 2 diabetes (DM2) in subjects with the metabolic syndrome. However, the role of elevated ALT levels in subjects with overt DM2 has yet not been explored...
  92. ncbi request reprint [Diabetes mellitus: simple classification and corresponding treatment]
    S Simsek
    VU Medisch Centrum, afd Endocrinologie Diabetescentrum, Postbus 7057, I007 MB Amsterdam
    Ned Tijdschr Geneeskd 150:1007-12. 2006
    ..In practice, the proposed flow chart can readily be applied for the classification and treatment of patients with hyperglycaemia...
  93. ncbi request reprint Alanine aminotransferase and the 6-year risk of the metabolic syndrome in Caucasian men and women: the Hoorn Study
    R K Schindhelm
    Department of Endocrinology Diabetes Centre, VU University Medical Centre, Amsterdam, The Netherlands
    Diabet Med 24:430-5. 2007
    ..To study the association between alanine aminotransferase (ALT) and the 6-year risk of the metabolic syndrome in a population-based study in Caucasian men and women...
  94. doi request reprint Ectopic fat storage in the pancreas, liver, and abdominal fat depots: impact on β-cell function in individuals with impaired glucose metabolism
    N J van der Zijl
    Diabetes Center Department of Internal Medicine, Vrije Universiteit University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    J Clin Endocrinol Metab 96:459-67. 2011
    ..Pancreatic fat content (PFC) may have deleterious effects on β-cell function...
  95. doi request reprint Genetic influences on the insulin response of the beta cell to different secretagogues
    A M C Simonis-Bik
    Diabetes Centre, VU University Medical Centre, ZH 4A62, PO Box 7057, 1007, Amsterdam, The Netherlands
    Diabetologia 52:2570-7. 2009
    ..The aim of the present study was to estimate the heritability of the beta cell insulin response to glucose and to glucose combined with glucagon-like peptide-1 (GLP-1) or with GLP-1 plus arginine...
  96. ncbi request reprint Postprandial glucose and not triglyceride concentrations are associated with carotid intima media thickness in women with normal glucose metabolism: the Hoorn prandial study
    M Alssema
    EMGO Institute, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Atherosclerosis 196:712-9. 2008
    ..Postprandial glucose levels might be a better indicator of risk than post-OGTT glucose levels or triglyceride levels...
  97. doi request reprint Novel insights into glucocorticoid-mediated diabetogenic effects: towards expansion of therapeutic options?
    D H van Raalte
    VU University Medical Centre, Amsterdam, The Netherlands
    Eur J Clin Invest 39:81-93. 2009
    ..In particular, recent progress in research into the role of GCs in the pathogenesis of insulin resistance and beta-cell dysfunction will be discussed...
  98. ncbi request reprint A combination of high concentrations of serum triglyceride and non-high-density-lipoprotein-cholesterol is a risk factor for cardiovascular disease in subjects with abnormal glucose metabolism--The Hoorn Study
    G Bos
    Institute for Research in Extramural Medicine, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Diabetologia 46:910-6. 2003
    ..The aim of this study was to investigate the association of triglyceride and non-HDL-cholesterol concentrations with cardiovascular disease in subjects with normal and abnormal glucose metabolism...
  99. ncbi request reprint Prevalence of and risk factors for the metabolic syndrome in women with systemic lupus erythematosus
    I E M Bultink
    Department of Rheumatology, VU University Medical Center, Slotervaart Hospital and Jan van Breemen Institute, Amsterdam, The Netherlands
    Clin Exp Rheumatol 26:32-8. 2008
    ..To examine the prevalence of the metabolic syndrome and the relationship between metabolic syndrome score (MetS score) and disease characteristics and cardiovascular events (CVEs) in women with SLE...
  100. ncbi request reprint LDL oxidative modifications in well- or moderately controlled type 2 diabetes
    P G Scheffer
    Metabolic Laboratory, Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
    Diabetes Metab Res Rev 20:298-304. 2004
    ....
  101. ncbi request reprint Two consecutive high-fat meals affect endothelial-dependent vasodilation, oxidative stress and cellular microparticles in healthy men
    M E Tushuizen
    Department of Endocrinology Diabetes Center, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    J Thromb Haemost 4:1003-10. 2006
    ..A large body of evidence has accumulated indicating a relation between postprandial hyperglycemia and hypertriglyceridemia, and the risk of cardiovascular disease...