J M Dekker

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. pmc Long-term exposure to traffic-related air pollution and type 2 diabetes prevalence in a cross-sectional screening-study in the Netherlands
    Marieke B A Dijkema
    Department of Environmental Health, Public Health Service Amsterdam, Amsterdam, The Netherlands
    Environ Health 10:76. 2011
  2. pmc Motivational interviewing and problem solving treatment to reduce type 2 diabetes and cardiovascular disease risk in real life: a randomized controlled trial
    Jeroen Lakerveld
    Department of General Practice and the EMGO Institute for Health and Care Research, VU University Medical Center, Van der Boechorststraat 7, Amsterdam, 1081 BT, The Netherlands
    Int J Behav Nutr Phys Act 10:47. 2013
  3. pmc Development of coronary heart disease and ischemic stroke in relation to fasting and 2-hour plasma glucose levels in the normal range
    Feng Ning
    Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland
    Cardiovasc Diabetol 11:76. 2012
  4. pmc The Diabetes Pearl: Diabetes biobanking in The Netherlands
    Esther Van't Riet
    VU University Medical Center, EMGO Institute for Health and Care Research, Amsterdam, The Netherlands
    BMC Public Health 12:949. 2012
  5. pmc Effect of medication review and cognitive behaviour treatment by community pharmacists of patients discharged from the hospital on drug related problems and compliance: design of a randomized controlled trial
    Abeer Ahmad
    Department of Clinical Pharmacology and Pharmacy, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    BMC Public Health 10:133. 2010
  6. pmc The @RISK Study: Risk communication for patients with type 2 diabetes: design of a randomised controlled trial
    Laura M C Welschen
    Department of General Practice, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    BMC Public Health 10:457. 2010
  7. pmc The effectiveness of adding cognitive behavioural therapy aimed at changing lifestyle to managed diabetes care for patients with type 2 diabetes: design of a randomised controlled trial
    Laura M C Welschen
    EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    BMC Public Health 7:74. 2007
  8. pmc Web-based guided insulin self-titration in patients with type 2 diabetes: the Di@log study. Design of a cluster randomised controlled trial [TC1316]
    Mariëlle G A Roek
    The EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    BMC Fam Pract 10:40. 2009
  9. pmc Effects of self-monitoring of glucose in non-insulin treated patients with type 2 diabetes: design of the IN CONTROL-trial
    Uriëll L Malanda
    EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands
    BMC Fam Pract 10:26. 2009
  10. ncbi request reprint [Metabolic syndrome: limited significance for clinical practice]
    J M Dekker
    VU Medisch Centrum, Van der Boechorststraat 7, 0081 BT Amsterdam
    Ned Tijdschr Geneeskd 149:855-8. 2005

Collaborators

Detail Information

Publications154 found, 100 shown here

  1. pmc Long-term exposure to traffic-related air pollution and type 2 diabetes prevalence in a cross-sectional screening-study in the Netherlands
    Marieke B A Dijkema
    Department of Environmental Health, Public Health Service Amsterdam, Amsterdam, The Netherlands
    Environ Health 10:76. 2011
    ..This study examined the relation between long-term exposure to traffic-related air pollution and type 2 diabetes prevalence among 50- to 75-year-old subjects living in Westfriesland, the Netherlands...
  2. pmc Motivational interviewing and problem solving treatment to reduce type 2 diabetes and cardiovascular disease risk in real life: a randomized controlled trial
    Jeroen Lakerveld
    Department of General Practice and the EMGO Institute for Health and Care Research, VU University Medical Center, Van der Boechorststraat 7, Amsterdam, 1081 BT, The Netherlands
    Int J Behav Nutr Phys Act 10:47. 2013
    ..In the Hoorn Prevention Study we aimed to assess the effectiveness of a primary care based lifestyle intervention to reduce the estimated risk of developing T2DM and for CVD mortality, and to motivate changes in lifestyle behaviors...
  3. pmc Development of coronary heart disease and ischemic stroke in relation to fasting and 2-hour plasma glucose levels in the normal range
    Feng Ning
    Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland
    Cardiovasc Diabetol 11:76. 2012
    ..This is further investigated regarding to the first events of coronary heart disease (CHD) and ischemic stroke (IS)...
  4. pmc The Diabetes Pearl: Diabetes biobanking in The Netherlands
    Esther Van't Riet
    VU University Medical Center, EMGO Institute for Health and Care Research, Amsterdam, The Netherlands
    BMC Public Health 12:949. 2012
    ..The aim of the study is to create a research infrastructure that will allow the study of risk factors, including biomarkers and genetic determinants for severe diabetes complications...
  5. pmc Effect of medication review and cognitive behaviour treatment by community pharmacists of patients discharged from the hospital on drug related problems and compliance: design of a randomized controlled trial
    Abeer Ahmad
    Department of Clinical Pharmacology and Pharmacy, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    BMC Public Health 10:133. 2010
    ..The aim of this study is to examine the effect of medication review and cognitive behaviour therapy of discharged patients by community pharmacists to minimize the occurrence of drug related problems...
  6. pmc The @RISK Study: Risk communication for patients with type 2 diabetes: design of a randomised controlled trial
    Laura M C Welschen
    Department of General Practice, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    BMC Public Health 10:457. 2010
    ..The conceptual framework of the intervention is based on the Theory of Planned Behaviour and the Self-regulation Theory...
  7. pmc The effectiveness of adding cognitive behavioural therapy aimed at changing lifestyle to managed diabetes care for patients with type 2 diabetes: design of a randomised controlled trial
    Laura M C Welschen
    EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    BMC Public Health 7:74. 2007
    ..The aim of our study is to investigate if adding a combined behavioural intervention to managed care, is effective in achieving changes in lifestyle and cardiovascular risk profile...
  8. pmc Web-based guided insulin self-titration in patients with type 2 diabetes: the Di@log study. Design of a cluster randomised controlled trial [TC1316]
    Mariëlle G A Roek
    The EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    BMC Fam Pract 10:40. 2009
    ..We developed a web-based self-management programme for insulin titration in T2DM patients. The aim of our study is to investigate if this internet programme helps to improve glycaemic control more effectively than usual care...
  9. pmc Effects of self-monitoring of glucose in non-insulin treated patients with type 2 diabetes: design of the IN CONTROL-trial
    Uriëll L Malanda
    EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands
    BMC Fam Pract 10:26. 2009
    ....
  10. ncbi request reprint [Metabolic syndrome: limited significance for clinical practice]
    J M Dekker
    VU Medisch Centrum, Van der Boechorststraat 7, 0081 BT Amsterdam
    Ned Tijdschr Geneeskd 149:855-8. 2005
    ..Its utility in clinical practice, however, is under debate. Reduction of obesity by life-style changes and treatment of individual risk factors is still the best line of action...
  11. ncbi request reprint Metabolic syndrome and 10-year cardiovascular disease risk in the Hoorn Study
    Jacqueline M Dekker
    The Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Circulation 112:666-73. 2005
    ....
  12. ncbi request reprint Heart rate-corrected QT interval prolongation predicts risk of coronary heart disease in black and white middle-aged men and women: the ARIC study
    Jacqueline M Dekker
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
    J Am Coll Cardiol 43:565-71. 2004
    ....
  13. doi request reprint Prognostic value of adiponectin for cardiovascular disease and mortality
    Jacqueline M Dekker
    EMGO Institute, VU University Medical Center, 1081 BT Amsterdam, The Netherlands
    J Clin Endocrinol Metab 93:1489-96. 2008
    ..Low adiponectin concentrations are associated with the presence of an adverse cardiovascular disease (CVD) risk profile...
  14. ncbi request reprint Cardiovascular autonomic function is associated with (micro-)albuminuria in elderly Caucasian sujects with impaired glucose tolerance or type 2 diabetes: the Hoorn Study
    Y M Smulders
    Department of Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Diabetes Care 23:1369-74. 2000
    ....
  15. ncbi request reprint Leptin and variables of body adiposity, energy balance, and insulin resistance in a population-based study. The Hoorn Study
    J B Ruige
    Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    Diabetes Care 22:1097-104. 1999
    ..We therefore explored, in a large population-based study of 2,484 Caucasian subjects aged 50-74 years, the relationship between leptin and variables of body adiposity, energy balance, and insulin resistance...
  16. ncbi request reprint S-adenosylmethionine and 5-methyltetrahydrofolate are associated with endothelial function after controlling for confounding by homocysteine: the Hoorn Study
    A M W Spijkerman
    Institute for Research in Extramural Medicine, VU VU University Medical Center, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 25:778-84. 2005
    ....
  17. doi request reprint Effects of induced hyperinsulinaemia with and without hyperglycaemia on measures of cardiac vagal control
    M Berkelaar
    Diabetes Center, VU University Medical Center, Amsterdam, The Netherlands
    Diabetologia 56:1436-43. 2013
    ..We also examined whether experimentally induced increases in insulin by beta cell secretagogues, including glucagon-like peptide-1 (GLP-1), will decrease vagal control...
  18. doi request reprint Vitamin D in relation to myocardial structure and function after eight years of follow-up: the Hoorn study
    A J van Ballegooijen
    Department of Health Sciences and the EMGO Institute for Health and Care Research, Faculty of Earth and Life Sciences, VU University Amsterdam, Amsterdam, The Netherlands
    Ann Nutr Metab 60:69-77. 2012
    ..To investigate associations between baseline serum 25-hydroxyvitamin D [25(OH)D] levels and myocardial structure and function after 8 years of follow-up in older Dutch subjects...
  19. ncbi request reprint LDL oxidative modifications in well- or moderately controlled type 2 diabetes
    P G Scheffer
    Metabolic Laboratory, Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
    Diabetes Metab Res Rev 20:298-304. 2004
    ....
  20. ncbi request reprint Postprandial glucose and not triglyceride concentrations are associated with carotid intima media thickness in women with normal glucose metabolism: the Hoorn prandial study
    M Alssema
    EMGO Institute, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Atherosclerosis 196:712-9. 2008
    ..Postprandial glucose levels might be a better indicator of risk than post-OGTT glucose levels or triglyceride levels...
  21. ncbi request reprint Plasma homocysteine and S-adenosylmethionine in erythrocytes as determinants of carotid intima-media thickness: different effects in diabetic and non-diabetic individuals. The Hoorn Study
    A Becker
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, Netherlands
    Atherosclerosis 169:323-30. 2003
    ..We determined whether components of homocysteine metabolism are associated with intima-media thickness in individuals with and without type 2 diabetes...
  22. ncbi request reprint Serum homocysteine levels are associated with the development of (micro)albuminuria: the Hoorn study
    A Jager
    Institute for Research in Extramural Medicine, Vrije Universiteit, Department of Clinical Epidemiology, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 21:74-81. 2001
    ..These data suggest that homocysteine may play a pathophysiological role in the development of (micro)albuminuria...
  23. ncbi request reprint Inflammation and endothelial dysfunction are associated with retinopathy: the Hoorn Study
    M V Van Hecke
    Department of Ophthalmology, VU University Medical Centre, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Diabetologia 48:1300-6. 2005
    ..The aim of this study was to investigate the association of inflammation and endothelial dysfunction with prevalent retinopathy in individuals with and without type 2 diabetes...
  24. ncbi request reprint Homocysteine levels are not associated with cardiovascular autonomic function in elderly Caucasian subjects without or with type 2 diabetes mellitus: the Hoorn Study
    A M E Spoelstra-De Man
    Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    J Intern Med 258:536-43. 2005
    ..The objective of our study was to determine whether hyperhomocysteinaemia is associated with impaired cardiovascular autonomic function in an age-, sex-, and glucose tolerance-stratified sample of an elderly Caucasian population...
  25. ncbi request reprint Dietary polyunsaturated fat intake is associated with low-density lipoprotein size, but not with susceptibility to oxidation in subjects with impaired glucose metabolism and type II diabetes: the Hoorn study
    G Bos
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Clin Nutr 61:205-11. 2007
    ..However, PUFA may increase the susceptibility of LDL to undergo oxidative modifications. The aim of this study was to analyze the association of habitual dietary fat intake with LDL size and oxidizability...
  26. ncbi request reprint Deteriorating glucose tolerance status is associated with left ventricular dysfunction--the Hoorn Study
    R M A Henry
    Institute for Research in Extramural Medicine, VU University Medical Centre, Amsterdam, The Netherlands
    Neth J Med 66:110-7. 2008
    ..We investigated, in a population-based cohort (n=746), the association between glucose tolerance status and SDF and DDF ...
  27. ncbi request reprint The 1997 American Diabetes Association criteria versus the 1985 World Health Organization criteria for the diagnosis of abnormal glucose tolerance: poor agreement in the Hoorn Study
    F de Vegt
    Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    Diabetes Care 21:1686-90. 1998
    ..We compared the 1997 ADA criteria with the 1985 World Health Organization (WHO) criteria with respect to the prevalence of diabetes and the cardiovascular risk profile in the population of the Hoorn Study..
  28. ncbi request reprint [Finnish questionnaire reasonably good predictor of the incidence of diabetes in The Netherlands]
    M Alssema
    VU Medisch Centrum, afd Epidemiologie en Biostatistiek, EMGO Instituut, Van der Boechorststraat 7, 1081 BT Amsterdam
    Ned Tijdschr Geneeskd 152:2418-24. 2008
    ..To establish whether the Finnish diabetes risk score for predicting the incidence of diabetes (FINDRISK) is also valid in the Netherlands, and to choose cut-off points suitable for the Dutch situation...
  29. ncbi request reprint Neuropeptide Y polymorphism significantly magnifies diabetes and cardiovascular disease risk in obesity: the Hoorn Study
    U Jaakkola
    EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Clin Nutr 63:150-2. 2009
    ..58; 95% CI 2.87-20.03, P<0.001) in the obese but not in the nonobese subjects. The results indicate that obesity may be a pivotal factor in multiplying the disease risk associated with the Leu7Pro polymorphism in preproNPY...
  30. ncbi request reprint Hyperhomocysteinemia increases risk of death, especially in type 2 diabetes : 5-year follow-up of the Hoorn Study
    E K Hoogeveen
    Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    Circulation 101:1506-11. 2000
    ..We therefore prospectively investigated the combined effect of hyperhomocysteinemia and type 2 diabetes on mortality...
  31. ncbi request reprint Prognostic implications of retinopathy and a high plasma von Willebrand factor concentration in type 2 diabetic subjects with microalbuminuria
    A Jager
    Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    Nephrol Dial Transplant 16:529-36. 2001
    ....
  32. ncbi request reprint Relation of impaired fasting and postload glucose with incident type 2 diabetes in a Dutch population: The Hoorn Study
    F de Vegt
    Institute for Research in Extramural Medicine, Vrije Universiteit, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    JAMA 285:2109-13. 2001
    ..002). CONCLUSION: In this study, the cumulative incidence of diabetes was strongly related to both IFG and IGT at baseline and, in particular, to the combined presence of IFG and IGT...
  33. ncbi request reprint Prevalence of macrovascular disease amongst type 2 diabetic patients detected by targeted screening and patients newly diagnosed in general practice: the Hoorn Screening Study
    A M W Spijkerman
    Institutes for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    J Intern Med 256:429-36. 2004
    ..The aim was to investigate whether diabetic patients identified by a targeted screening procedure differ from newly diagnosed diabetic patients in general practice with regard to the prevalence of macrovascular complications...
  34. doi request reprint Fasting proinsulin levels are significantly associated with 20 year cancer mortality rates. The Hoorn Study
    I Walraven
    EMGO Institute for Health and Care Research, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Diabetologia 56:1148-54. 2013
    ..Proinsulin is possibly associated with cancer through activation of insulin receptor isoform A. We sought to investigate the associations between proinsulin and 20 year cancer mortality rates...
  35. doi request reprint Absence of an acute insulin response predicts onset of type 2 diabetes in a Caucasian population with impaired glucose tolerance
    G Nijpels
    Department of General Practice, Vrije Universiteit Medical Center, Van der Boechorststraat 7, Amsterdam
    J Clin Endocrinol Metab 93:2633-8. 2008
    ..However, few studies have used criterion standard measures to asses the predictive value of impaired insulin secretion and insulin resistance for the conversion to T2DM in a Caucasian IGT population...
  36. ncbi request reprint Elevated cholesteryl ester transfer protein concentration is associated with an increased risk for cardiovascular disease in women, but not in men, with Type 2 diabetes: the Hoorn Study
    M Alssema
    EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    Diabet Med 24:117-23. 2007
    ....
  37. ncbi request reprint [Estimate of the number of new patients with type 2 diabetes mellitus in the Netherlands: at least 65,000 per year in the age group of 50 years and above]
    J M Dekker
    VU Medisch Centrum, Instituut voor Extramuraal Geneeskundig Onderzoek, Van der Boechorststraat 7, 1081 BT Amsterdam
    Ned Tijdschr Geneeskd 147:1419-23. 2003
    ..To estimate the incidence of type-2 diabetes mellitus in the Netherlands, using figures which were observed in a population-based cohort study of diabetes, the Hoorn Study...
  38. ncbi request reprint Meal composition affects insulin secretion in women with type 2 diabetes: a comparison with healthy controls. The Hoorn prandial study
    M Alssema
    EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Clin Nutr 63:398-404. 2009
    ....
  39. ncbi request reprint Hyperhomocysteinaemia is not associated with isolated crural arterial occlusive disease: The Hoorn Study
    E K Hoogeveen
    Institute for Research in Extramural Medicine, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    J Intern Med 247:442-8. 2000
    ..The aim of the study was to investigate whether the strength of the association between hyperhomocysteinaemia and peripheral arterial disease differs according to the localization of the anatomical obstruction...
  40. ncbi request reprint Hyperhomocysteinaemia is not related to risk of distal somatic polyneuropathy: the Hoorn Study
    E K Hoogeveen
    Institute for Resaerch in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    J Intern Med 246:561-6. 1999
    ..Both metabolic and vascular abnormalities may contribute to the development of impaired nerve function. We therefore assessed the association between hyperhomocysteinaemia, a risk factor for cardiovascular disease, and polyneuropathy...
  41. ncbi request reprint Impact of diabetes duration and cardiovascular risk factors on mortality in type 2 diabetes: the Hoorn Study
    A M W Spijkerman
    Institute for Research in Extramural Medicine, VU University Medical Centre, Amsterdam, The Netherlands
    Eur J Clin Invest 32:924-30. 2002
    ..We studied mortality in relation to diabetes duration, and the contribution of other cardiovascular risk factors to the elevated risk...
  42. ncbi request reprint Hyperhomocysteinemia is associated with the presence of retinopathy in type 2 diabetes mellitus: the Hoorn study
    E K Hoogeveen
    Institute for Research in Extramural Medicine, Vrije Universiteit, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Arch Intern Med 160:2984-90. 2000
    ..Retinopathy is the leading cause of blindness among patients with type 2 diabetes mellitus (DM). Hyperhomocysteinemia is a recently recognized risk factor for cardiovascular disease, independent of established risk factors...
  43. ncbi request reprint Coffee consumption and incidence of impaired fasting glucose, impaired glucose tolerance, and type 2 diabetes: the Hoorn Study
    R M van Dam
    Department of Nutrition and Health, Faculty of Earth and Life Sciences, Vrije University Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands
    Diabetologia 47:2152-9. 2004
    ..Coffee contains several substances that may affect glucose metabolism. The aim of this study was to evaluate the relationship between habitual coffee consumption and the incidence of IFG, IGT and type 2 diabetes...
  44. ncbi request reprint Vitamin D status and parathyroid hormone levels in relation to blood pressure: a population-based study in older men and women
    M B Snijder
    Institute of Health Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
    J Intern Med 261:558-65. 2007
    ..Effects of poor vitamin D status on blood pressure may be mediated by elevated parathyroid hormone (PTH) levels...
  45. ncbi request reprint Health-related quality of life in the first year following diagnosis of Type 2 diabetes: newly diagnosed patients in general practice compared with screening-detected patients. The Hoorn Screening Study
    M C Adriaanse
    Institute for Research in Extramural Medicine EMGO Institute, VU University Medical Centre, Amsterdam, The Netherlands
    Diabet Med 21:1075-81. 2004
    ..To determine health-related quality of life (HRQoL) in the first year following diagnosis of Type 2 diabetes among newly diagnosed patients in general practice compared with patients detected by targeted population screening...
  46. ncbi request reprint Brachial artery pulse pressure and common carotid artery diameter: mutually independent associations with mortality in subjects with a recent history of impaired glucose tolerance
    R A van Dijk
    Institute for Cardiovascular Research Vrije Universiteit and Department of Internal Medicine, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Eur J Clin Invest 31:756-63. 2001
    ....
  47. ncbi request reprint Alanine aminotransferase and the 6-year risk of the metabolic syndrome in Caucasian men and women: the Hoorn Study
    R K Schindhelm
    Department of Endocrinology Diabetes Centre, VU University Medical Centre, Amsterdam, The Netherlands
    Diabet Med 24:430-5. 2007
    ..To study the association between alanine aminotransferase (ALT) and the 6-year risk of the metabolic syndrome in a population-based study in Caucasian men and women...
  48. ncbi request reprint A combination of high concentrations of serum triglyceride and non-high-density-lipoprotein-cholesterol is a risk factor for cardiovascular disease in subjects with abnormal glucose metabolism--The Hoorn Study
    G Bos
    Institute for Research in Extramural Medicine, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Diabetologia 46:910-6. 2003
    ..The aim of this study was to investigate the association of triglyceride and non-HDL-cholesterol concentrations with cardiovascular disease in subjects with normal and abnormal glucose metabolism...
  49. doi request reprint Hyperglycemia and oxidative stress strengthen the association between myeloperoxidase and blood pressure
    Leonard P van der Zwan
    Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
    Hypertension 55:1366-72. 2010
    ..These observations, together with emerging evidence that myeloperoxidase-derived oxidants contribute to the initiation and propagation of cardiovascular disease, identify myeloperoxidase as a promising target for drug development...
  50. doi request reprint A prospective study of dairy consumption in relation to changes in metabolic risk factors: the Hoorn Study
    Marieke B Snijder
    Institute of Health Sciences, Faculty of Earth and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
    Obesity (Silver Spring) 16:706-9. 2008
    ..The aim of our study was to investigate the prospective association between dairy consumption and changes in weight and metabolic disturbances...
  51. ncbi request reprint Hyperhomocysteinaemia is associated with coronary events in type 2 diabetes
    A Becker
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    J Intern Med 253:293-300. 2003
    ..However, it is not known whether homocysteine increases risk of coronary events in type 2 diabetes. Therefore, we examined the combined effect of homocysteine and type 2 diabetes on risk of fatal and nonfatal coronary events...
  52. pmc The heritability of beta cell function parameters in a mixed meal test design
    A M C Simonis-Bik
    Diabetes Center, VU University Medical Center, ZH 4A62, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Diabetologia 54:1043-51. 2011
    ..We estimated the heritability of individual differences in beta cell function after a mixed meal test designed to assess a wide range of classical and model-derived beta cell function parameters...
  53. ncbi request reprint Low subcutaneous thigh fat is a risk factor for unfavourable glucose and lipid levels, independently of high abdominal fat. The Health ABC Study
    M B Snijder
    Institute for Research in Extramural Medicine, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Diabetologia 48:301-8. 2005
    ..Our secondary aim was to investigate which body composition characteristics (lean tissue, fat tissue) are reflected by anthropometric measures (waist and thigh circumference)...
  54. doi request reprint Relationship of adiposity with arterial stiffness as mediated by adiponectin in older men and women: the Hoorn Study
    M B Snijder
    Department of Health Sciences, VU University Amsterdam, Amsterdam, The Netherlands
    Eur J Endocrinol 160:387-95. 2009
    ..To investigate whether adiponectin is associated with arterial stiffness, and whether adiponectin explains the association between body composition and arterial stiffness...
  55. ncbi request reprint Associations between depressive symptoms and insulin resistance: the Hoorn Study
    M C Adriaanse
    Faculty of Earth and Life Sciences, Institute of Health Sciences, Vrije University Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands
    Diabetologia 49:2874-7. 2006
    ..The aim of this study was to determine whether the association between symptoms of depression and insulin resistance varies across glucose tolerance status and between men and women...
  56. ncbi request reprint Baroreflex sensitivity in the elderly: influence of age, breathing and spectral methods
    J Gerritsen
    Department of Clinical Physics and Informatics, Vrije Universiteit, Amsterdam, The Netherlands
    Clin Sci (Lond) 99:371-81. 2000
    ..In conclusion, this study shows age, breathing mode, frequency and coherence threshold to affect measures of BRS. Therefore these factors should be considered in clinical studies; appropriate reference values are given...
  57. ncbi request reprint No substantial psychological impact of the diagnosis of Type 2 diabetes following targeted population screening: The Hoorn Screening Study
    M C Adriaanse
    Institute for Research in Extramural Medicine EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    Diabet Med 21:992-8. 2004
    ..To examine the impact of the diagnosis of Type 2 diabetes on psychological well-being and perceived health status in subjects who participated in a targeted population-screening programme...
  58. doi request reprint Rheumatoid arthritis versus diabetes as a risk factor for cardiovascular disease: a cross-sectional study, the CARRE Investigation
    V P van Halm
    Department of Rheumatology, VU University Medical Center, Amsterdam 1007 MB, The Netherlands
    Ann Rheum Dis 68:1395-400. 2009
    ..A study was undertaken to investigate the associations between RA and type 2 diabetes (DM2), a well-established cardiovascular risk factor, on the one hand, and cardiovascular disease (CVD) on the other...
  59. doi request reprint Fasting insulin has a stronger association with an adverse cardiometabolic risk profile than insulin resistance: the RISC study
    Susanne R de Rooij
    Department of Clinical Epidemiology and Biostatistics, Institute for Research in Extramural Medicine, VU University Medical Center, 1081 BT, Amsterdam, The Netherlands
    Eur J Endocrinol 161:223-30. 2009
    ..Fasting insulin concentrations are often used as a surrogate measure of insulin resistance. We investigated the relative contributions of fasting insulin and insulin resistance to cardiometabolic risk and preclinical atherosclerosis...
  60. ncbi request reprint Associations of hip and thigh circumferences independent of waist circumference with the incidence of type 2 diabetes: the Hoorn Study
    Marieke B Snijder
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, Netherlands
    Am J Clin Nutr 77:1192-7. 2003
    ..However, smaller hip or thigh circumference may also explain the predictive value of the WHR or WTR for type 2 diabetes...
  61. ncbi request reprint Larger thigh and hip circumferences are associated with better glucose tolerance: the Hoorn study
    Marieke B Snijder
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Obes Res 11:104-11. 2003
    ..Muscle mass might be better reflected by thigh circumference. The aim of this study was to investigate the contributions of thigh and hip circumferences, independent of waist circumference, to measures of glucose metabolism...
  62. ncbi request reprint Fasting and postprandial glycoxidative and lipoxidative stress are increased in women with type 2 diabetes
    Roger K Schindhelm
    Department of Endocrinology, Vrije University Medical Center, Amsterdam, The Netherlands
    Diabetes Care 30:1789-94. 2007
    ....
  63. ncbi request reprint Diabetic patients detected by population-based stepwise screening already have a diabetic cardiovascular risk profile
    Annemieke M W Spijkerman
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Diabetes Care 25:1784-9. 2002
    ..To describe a population-based two-step screening procedure for type 2 diabetes and to study the cardiovascular risk profile of the patients identified by the screening...
  64. ncbi request reprint Microvascular complications at time of diagnosis of type 2 diabetes are similar among diabetic patients detected by targeted screening and patients newly diagnosed in general practice: the hoorn screening study
    Annemieke M W Spijkerman
    Institute for Research in Extramural Medicine, Vrije University Medical Center, Amsterdam, The Netherlands
    Diabetes Care 26:2604-8. 2003
    ..To investigate whether screening-detected diabetic patients differ from diabetic patients newly diagnosed in general practice with regard to the presence of microvascular complications...
  65. doi request reprint Glucocorticoid receptor gene polymorphisms are associated with reduced first-phase glucose-stimulated insulin secretion and disposition index in women, but not in men
    D H van Raalte
    Diabetes Center, Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Diabet Med 29:e211-6. 2012
    ..We assessed whether polymorphisms in the glucocorticoid receptor gene NR3C1 associate with measures of β-cell function and insulin sensitivity derived from hyperglycaemic clamps in subjects with normal or impaired glucose tolerance...
  66. ncbi request reprint [Estimating the individual risk of diabetes: not on the grounds of overweight only]
    E van 't Riet
    VU Medisch Centrum, EMGO Instituut, Van der Boechorststraat 7, kamer D 528, io8x BT Amsterdam
    Ned Tijdschr Geneeskd 152:2385-8. 2008
    ....
  67. ncbi request reprint Screening for Type 2 diabetes: an exploration of subjects' perceptions regarding diagnosis and procedure
    M C Adriaanse
    Institute for Research in Extramural Medicine EMGO Institute, Amsterdam, The Netherlands
    Diabet Med 19:406-11. 2002
    ..To explore the psychological impact of a stepwise population-screening project for Type 2 diabetes...
  68. doi request reprint Genetic influences on the insulin response of the beta cell to different secretagogues
    A M C Simonis-Bik
    Diabetes Centre, VU University Medical Centre, ZH 4A62, PO Box 7057, 1007, Amsterdam, The Netherlands
    Diabetologia 52:2570-7. 2009
    ..The aim of the present study was to estimate the heritability of the beta cell insulin response to glucose and to glucose combined with glucagon-like peptide-1 (GLP-1) or with GLP-1 plus arginine...
  69. doi request reprint Body composition, insulin sensitivity, and cardiovascular disease profile in healthy Europeans
    Wiebe Boorsma
    EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    Obesity (Silver Spring) 16:2696-701. 2008
    ..To assess whether insulin sensitivity can explain the associations of leg-fat mass (LFM) and trunk-fat mass (TFM) with the cardiovascular disease (CVD) risk profile in healthy European men and women...
  70. ncbi request reprint Carotid arterial remodeling: a maladaptive phenomenon in type 2 diabetes but not in impaired glucose metabolism: the Hoorn study
    Ronald M A Henry
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Stroke 35:671-6. 2004
    ..Arterial remodeling has not been studied in relation to glucose tolerance...
  71. ncbi request reprint Trunk fat and leg fat have independent and opposite associations with fasting and postload glucose levels: the Hoorn study
    Marieke B Snijder
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Diabetes Care 27:372-7. 2004
    ..The main goal was to determine which tissue in the trunk and legs, fat or lean tissue, is associated with measures of glucose metabolism...
  72. ncbi request reprint Sagittal abdominal diameter: no advantage compared with other anthropometric measures as a correlate of components of the metabolic syndrome in elderly from the Hoorn Study
    Janine Mukuddem-Petersen
    Institute of Health Sciences, Faculty of Earth and Life Sciences, Vrije University Amsterdam, Amsterdam, The Netherlands
    Am J Clin Nutr 84:995-1002. 2006
    ..The sagittal abdominal diameter has been proposed as a useful measure by which to estimate abdominal obesity and as being more strongly related to components of the metabolic syndrome than are other anthropometric measures...
  73. ncbi request reprint S-adenosylhomocysteine and the ratio of S-adenosylmethionine to S-adenosylhomocysteine are not related to folate, cobalamin and vitamin B6 concentrations
    A Becker
    Department of Internal Medicine, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Eur J Clin Invest 33:17-25. 2003
    ..Therefore, it is relevant to know how these moieties are interrelated, and whether, as is the case for homocysteine, they are influenced by blood levels of folate, cobalamin or vitamin B6...
  74. ncbi request reprint [From the Cochrane Library and Diabetes Care: self-monitoring of blood glucose probably an effective way to improve glycaemic control in patients with type 2 diabetes not taking insulin]
    L M C Welschen
    VU Medisch Centrum, Instituut voor Extramuraal Geneeskundig Onderzoek EMGO, Van der Boechorststraat 7, 1081 BT Amsterdam
    Ned Tijdschr Geneeskd 150:1826-9. 2006
    ..There was scant data on patient-related outcomes, such as quality of life, well being and satisfaction. Therefore, more large long-term studies of high quality are needed...
  75. ncbi request reprint Fat food for a bad mood. Could we treat and prevent depression in Type 2 diabetes by means of omega-3 polyunsaturated fatty acids? A review of the evidence
    F Pouwer
    Vrije Universiteit Medical Centre, Department of Medical Psychology, EMGO Institute, Amsterdam, The Netherlands
    Diabet Med 22:1465-75. 2005
    ..The aim of the present paper was to review whether polyunsaturated fatty acids (PUFA) of the omega-3 family could be used for the prevention and treatment of depression in Type 2 diabetes...
  76. ncbi request reprint Impaired autonomic function is associated with increased mortality, especially in subjects with diabetes, hypertension, or a history of cardiovascular disease: the Hoorn Study
    J Gerritsen
    Department of Clinical Physics and Informatics, Vrije Universiteit, Amsterdam, The Netherlands
    Diabetes Care 24:1793-8. 2001
    ..Moreover, the results of the present study suggest that cardiac autonomic dysfunction in patients already at risk (diabetes, hypertension, or history of cardiovascular disease) may be especially hazardous...
  77. ncbi request reprint Moderate alcohol consumption is associated with lower risk for incident diabetes and mortality: the Hoorn Study
    Femmie de Vegt
    Institute for Research in Extramural Medicine EMGO, Vrije Universiteit Medical Centre, Van der Boechorststraat 7, Amsterdam, The Netherlands
    Diabetes Res Clin Pract 57:53-60. 2002
    ..Adjustment for classical cardiovascular risk factors and other lifestyle variables did not materially affect the estimates. In conclusion, moderate alcohol consumption was associated with a lower risk for mortality and diabetes...
  78. doi request reprint Experience of hypoglycaemia is associated with changes in beliefs about diabetes in patients with type 2 diabetes
    U L Malanda
    Department of General Practice, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    Diabet Med 28:1395-400. 2011
    ..The aim of this study was to explore associations between experience of hypoglycaemia and changes in diabetes beliefs and self-reported health status in patients with non-insulin-treated Type 2 diabetes using a blood glucose meter...
  79. ncbi request reprint Rates and risks for co-morbid depression in patients with Type 2 diabetes mellitus: results from a community-based study
    F Pouwer
    Diabetes Research Group, Department of Medical Psychology, Institute for Research in Extramural Medicine EMGO, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Diabetologia 46:892-8. 2003
    ..We studied the prevalence and risk factors of co-morbid depression in a community-based sample of older adults, comparing Type 2 diabetic patients with healthy control subjects...
  80. ncbi request reprint Associations of LDL size with in vitro oxidizability and plasma levels of in vivo oxidized LDL in Type 2 diabetic patients
    P G Scheffer
    Metabolic Laboratory, Department of Clinical Chemistry, VU University Medical Centre, Amsterdam, The Netherlands
    Diabet Med 20:563-7. 2003
    ..The aim of this study was to investigate the relationship of in vitro LDL oxidizability and circulating in vivo oxidized LDL with LDL particle size in Type 2 diabetic patients and healthy control subjects...
  81. ncbi request reprint Insulin and risk of cardiovascular disease: a meta-analysis
    J B Ruige
    Institute for Research in Extramural Medicine and Endocrinology, Department of Epidemiology and Biostatistics, Vrije Universiteit, Amsterdam, The Netherlands
    Circulation 97:996-1001. 1998
    ..Our purposes were to estimate the strength of the longitudinal relationship between hyperinsulinemia and cardiovascular diseases (CVD) from the available literature and to identify study characteristics that modify this relationship...
  82. doi request reprint Comparison of two consecutive fat-rich and carbohydrate-rich meals on postprandial myeloperoxidase response in women with and without type 2 diabetes mellitus
    Roger K Schindhelm
    Department of Endocrinology Diabetes Center, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Metabolism 57:262-7. 2008
    ..Our findings provide no support to our initial hypothesis that meal-induced release of MPO might be a mechanism that contributes to CVD risk...
  83. ncbi request reprint Diabetes, pulse pressure and cardiovascular mortality: the Hoorn Study
    Miranda T Schram
    Institute for Cardiovascular Research and Department of Internal Medicine, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    J Hypertens 20:1743-51. 2002
    ..Second, we determined the relationship between pulse pressure and its main determinant (i.e. age), and the influence of diabetes and mean arterial pressure on this relationship...
  84. ncbi request reprint Arterial stiffness increases with deteriorating glucose tolerance status: the Hoorn Study
    Ronald M A Henry
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Circulation 107:2089-95. 2003
    ..In nondiabetic individuals, increased arterial stiffness is an important cause of cardiovascular disease. Associations between DM-2 and IGM and arterial stiffness have not been systematically investigated...
  85. ncbi request reprint [Insulin resistance and diabetes type 2 in overweight children]
    C M Renders
    afd Sociale Geneeskunde, Instituut voor Extramuraal Geneeskundig Onderzoek, VU Medisch Centrum, Van der Boechorststraat 7, 1081 BT Amsterdam
    Ned Tijdschr Geneeskd 147:2060-3. 2003
    ..Early detection is very useful in obese children with two additional risk factors: diabetes type 2 in first- and second-degree relatives, members of certain ethnic groups or indications of insulin resistance...
  86. doi request reprint Evaluation of the one-minute exercise test to detect peripheral arterial disease
    E K Hoogeveen
    Vrije Universiteit University Medical Center, Amsterdam, and Jeroen Bosch Hospital, Den Bosch, The Netherlands
    Eur J Clin Invest 38:290-5. 2008
    ..We also investigated whether the combination of the ABPI at rest and the one-minute exercise test could replace DFV scanning...
  87. ncbi request reprint Diabetes-related symptoms and negative mood in participants of a targeted population-screening program for type 2 diabetes: The Hoorn Screening Study
    Marcel C Adriaanse
    Institute for Research in Extramural Medicine, VU University Medical Centre, Amsterdam, The Netherlands
    Qual Life Res 14:1501-9. 2005
    ..those who did not...
  88. ncbi request reprint [Self-monitoring by patients with type-2 diabetes mellitus one year after initiation: user errors in a quarter of cases]
    G Nijpels
    VU Medisch Centrum, Van der Boechorststraat 7, 1081 BT Amsterdam
    Ned Tijdschr Geneeskd 147:1068-70. 2003
    ..To inventory the errors made during self-monitoring of blood-glucose values by diabetes patients...
  89. ncbi request reprint Meta-analysis of the relationship between alcohol consumption and coronary heart disease and mortality in type 2 diabetic patients
    L L J Koppes
    EMGO Institute, VU University Medical Center, Van der Boechorststraat 7, 1081, BT, Amsterdam, The Netherlands
    Diabetologia 49:648-52. 2006
    ..Meta-analyses could only be performed for total mortality, mortality from CHD, and CHD incidence, because the availability of articles on other complications was too limited...
  90. ncbi request reprint Perceived risk for Type 2 diabetes in participants in a stepwise population-screening programme
    M C Adriaanse
    Institute for Research in Extramural Medicine EMGO Institute, VU University Medical Centre, Amsterdam, The Netherlands
    Diabet Med 20:210-5. 2003
    ..To determine the risk perception of Type 2 diabetes in participants in a stepwise population-screening programme...
  91. ncbi request reprint The prediction of visceral fat by dual-energy X-ray absorptiometry in the elderly: a comparison with computed tomography and anthropometry
    M B Snijder
    Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    Int J Obes Relat Metab Disord 26:984-93. 2002
    ..The aim of the present study is to investigate whether the dual-energy X-ray absorptiometry (DXA) method, possibly combined with anthropometry, offers a good alternative to CT for the prediction of visceral fat in the elderly...
  92. doi request reprint A study of the effects of acarbose on glucose metabolism in patients predisposed to developing diabetes: the Dutch acarbose intervention study in persons with impaired glucose tolerance (DAISI)
    G Nijpels
    Department of General Practice, VU University Medical Centre, Amsterdam, Netherlands
    Diabetes Metab Res Rev 24:611-6. 2008
    ..Our study's main objective was to investigate the effect of acarbose in IGT-persons on their 2-h plasma glucose level and beta-cell function...
  93. doi request reprint The Evaluation of Screening and Early Detection Strategies for Type 2 Diabetes and Impaired Glucose Tolerance (DETECT-2) update of the Finnish diabetes risk score for prediction of incident type 2 diabetes
    M Alssema
    Department of Epidemiology and Biostatistics and the EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    Diabetologia 54:1004-12. 2011
    ..We updated the risk questionnaire by using clinically diagnosed and screen-detected type 2 diabetes instead of drug-treated diabetes as an endpoint and by considering additional predictors...
  94. ncbi request reprint The relationship of lipoprotein lipase activity and LDL size is dependent on glucose metabolism in an elderly population: the Hoorn Study
    Griët Bos
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Diabetes Care 27:796-8. 2004
  95. pmc Relationship between A1C and glucose levels in the general Dutch population: the new Hoorn study
    Esther van 't Riet
    EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    Diabetes Care 33:61-6. 2010
    ..To investigate the relationship among A1C, fasting plasma glucose (FPG), and 2-h postload plasma glucose in the Dutch general population and to evaluate the results of using A1C for screening and diagnosis of diabetes...
  96. doi request reprint Slightly elevated B-type natriuretic peptide levels in a non-heart failure range indicate a worse left ventricular diastolic function in individuals with, as compared with individuals without, type 2 diabetes: the Hoorn Study
    Katja van den Hurk
    Department of Epidemiology and Biostatistics and the EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Heart Fail 12:958-65. 2010
    ..We therefore aimed to explore (i) the association of BNP levels in a non-HF range with structural and functional markers of LV function, and (ii) possible effect modification by glucose tolerance categories...
  97. doi request reprint Hepatic fat is not associated with beta-cell function or postprandial free fatty acid response
    Josina M Rijkelijkhuizen
    EMGO Institute, VU University Medical Center, 1081 BT Amsterdam, The Netherlands
    Metabolism 58:196-203. 2009
    ..We conclude that fat accumulation in the liver is tightly linked to insulin sensitivity but not to beta-cell function. Furthermore, liver fat is associated with circulating TG levels, but not with FFA concentrations...
  98. ncbi request reprint Type 2 diabetes is associated with impaired endothelium-dependent, flow-mediated dilation, but impaired glucose metabolism is not; The Hoorn Study
    Ronald M A Henry
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Atherosclerosis 174:49-56. 2004
    ..It is controversial whether or not FMD is impaired in DM2 and IGM. We investigated this issue in a population-based setting...
  99. ncbi request reprint Steroids in adult men with type 1 diabetes: a tendency to hypogonadism
    Eveline W C M van Dam
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Diabetes Care 26:1812-8. 2003
    ..To compare steroids and their associations in men with type 1 diabetes and healthy control subjects...
  100. doi request reprint Increased plasma apolipoprotein C-III concentration independently predicts cardiovascular mortality: the Hoorn Study
    Peter G Scheffer
    Metabolic Laboratory, Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
    Clin Chem 54:1325-30. 2008
    ..The aim of this study was to investigate the prognostic value of plasma apoC-III concentrations for cardiovascular mortality...
  101. doi request reprint Classical and model-based estimates of beta-cell function during a mixed meal vs. an OGTT in a population-based cohort
    Josina M Rijkelijkhuizen
    EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    Diabetes Res Clin Pract 83:280-8. 2009
    ..The higher response was mostly explained by higher beta-cell sensitivity during the meal...