Philip C De Witt Hamer

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. doi Impact of intraoperative stimulation brain mapping on glioma surgery outcome: a meta-analysis
    Philip C De Witt Hamer
    Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Oncol 30:2559-65. 2012
  2. pmc Early postoperative MRI overestimates residual tumour after resection of gliomas with no or minimal enhancement
    Sinan M K Belhawi
    Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Eur Radiol 21:1526-34. 2011
  3. doi WEE1 kinase targeting combined with DNA-damaging cancer therapy catalyzes mitotic catastrophe
    Philip C De Witt Hamer
    Department of Neurosurgery, VU University Medical Center, Amsterdam, The Netherlands
    Clin Cancer Res 17:4200-7. 2011
  4. pmc Small molecule kinase inhibitors in glioblastoma: a systematic review of clinical studies
    Philip C De Witt Hamer
    Neurosurgical Center Amsterdam, VU University Medical Center, De Boelelaan 1117, Amsterdam, The Netherlands
    Neuro Oncol 12:304-16. 2010
  5. pmc Resection probability maps for quality assessment of glioma surgery without brain location bias
    Philip C De Witt Hamer
    Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    PLoS ONE 8:e73353. 2013
  6. pmc In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma
    Shahryar E Mir
    Neuro oncology Research Group, Departments of Neurosurgery and Pediatric Oncology Hematology, VU University Medical Center, 1081 HV, Amsterdam, The Netherlands
    Cancer Cell 18:244-57. 2010
  7. doi Epilepsy surgery outcome and functional network alterations in longitudinal MEG: a minimum spanning tree analysis
    Edwin van Dellen
    Department of Neurology, Cancer Center Amsterdam, VU University Medical Center, De Boelaan 1117, P O Box 7057, 1007 MB Amsterdam, The Netherlands Department of Clinical Neurophysiology and MEG Center, Neuroscience Campus Amsterdam, VU University Medical Center, De Boelelaan 1118, P O Box 7057, Amsterdam, The Netherlands Electronic address
    Neuroimage 86:354-63. 2014
  8. doi WEE1 inhibition and genomic instability in cancer
    Lianne E M Vriend
    Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands Neuro Oncology Research Group, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Biochim Biophys Acta 1836:227-35. 2013
  9. pmc MEG network differences between low- and high-grade glioma related to epilepsy and cognition
    Edwin van Dellen
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    PLoS ONE 7:e50122. 2012
  10. doi Is the human left middle longitudinal fascicle essential for language? A brain electrostimulation study
    Philip C De Witt Hamer
    Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Hum Brain Mapp 32:962-73. 2011

Collaborators

Detail Information

Publications15

  1. doi Impact of intraoperative stimulation brain mapping on glioma surgery outcome: a meta-analysis
    Philip C De Witt Hamer
    Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Oncol 30:2559-65. 2012
    ..The usefulness of intraoperative stimulation mapping (ISM) has not been addressed in randomized trials. This study addresses glioma surgery outcome on the basis of a meta-analysis of observational studies...
  2. pmc Early postoperative MRI overestimates residual tumour after resection of gliomas with no or minimal enhancement
    Sinan M K Belhawi
    Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Eur Radiol 21:1526-34. 2011
    ..Standards for residual tumour measurement after resection of gliomas with no or minimal enhancement have not yet been established. In this study residual volumes on early and late postoperative T2-/FLAIR-weighted MRI are compared...
  3. doi WEE1 kinase targeting combined with DNA-damaging cancer therapy catalyzes mitotic catastrophe
    Philip C De Witt Hamer
    Department of Neurosurgery, VU University Medical Center, Amsterdam, The Netherlands
    Clin Cancer Res 17:4200-7. 2011
    ..The combination of DNA-damaging cancer therapy with WEE1 inhibition seems to be a rational approach to push cancer cells in mitotic catastrophe. Its safety and efficacy are being evaluated in clinical studies...
  4. pmc Small molecule kinase inhibitors in glioblastoma: a systematic review of clinical studies
    Philip C De Witt Hamer
    Neurosurgical Center Amsterdam, VU University Medical Center, De Boelelaan 1117, Amsterdam, The Netherlands
    Neuro Oncol 12:304-16. 2010
    ....
  5. pmc Resection probability maps for quality assessment of glioma surgery without brain location bias
    Philip C De Witt Hamer
    Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    PLoS ONE 8:e73353. 2013
    ..In this study, glioma resection results are quantified and compared using a novel approach, so-called resection probability maps (RPM), exemplified by a surgical team comparison, here with long and short experience in mapping...
  6. pmc In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma
    Shahryar E Mir
    Neuro oncology Research Group, Departments of Neurosurgery and Pediatric Oncology Hematology, VU University Medical Center, 1081 HV, Amsterdam, The Netherlands
    Cancer Cell 18:244-57. 2010
    ..Our results suggest that inhibition of WEE1 kinase holds potential as a therapeutic approach in treatment of glioblastoma...
  7. doi Epilepsy surgery outcome and functional network alterations in longitudinal MEG: a minimum spanning tree analysis
    Edwin van Dellen
    Department of Neurology, Cancer Center Amsterdam, VU University Medical Center, De Boelaan 1117, P O Box 7057, 1007 MB Amsterdam, The Netherlands Department of Clinical Neurophysiology and MEG Center, Neuroscience Campus Amsterdam, VU University Medical Center, De Boelelaan 1118, P O Box 7057, Amsterdam, The Netherlands Electronic address
    Neuroimage 86:354-63. 2014
    ..Our results increase insight into functional network changes in successful epilepsy surgery and might eventually be utilized for optimization of neurosurgical approaches. ..
  8. doi WEE1 inhibition and genomic instability in cancer
    Lianne E M Vriend
    Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands Neuro Oncology Research Group, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Biochim Biophys Acta 1836:227-35. 2013
    ..Therefore, chromosomal instability may need to be taken into account when determining the most effective strategy for the use of WEE1 inhibitors in cancer therapy. ..
  9. pmc MEG network differences between low- and high-grade glioma related to epilepsy and cognition
    Edwin van Dellen
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    PLoS ONE 7:e50122. 2012
    ..Finally, we related network characteristics to seizure frequency and cognitive performance within patient groups...
  10. doi Is the human left middle longitudinal fascicle essential for language? A brain electrostimulation study
    Philip C De Witt Hamer
    Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Hum Brain Mapp 32:962-73. 2011
    ..Postoperatively, no new permanent language deficits are detected by systematic language examination. Therefore, we suggest that the middle longitudinal fascicle may participate but is not essential for language processing...
  11. doi Organotypic glioma spheroids for screening of experimental therapies: how many spheroids and sections are required?
    Philip C De Witt Hamer
    Department of Neurosurgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Cytometry A 75:528-34. 2009
    ..It is the model of choice for low-throughput screening, because this model is far more representative for the parental tumor than any other more efficient glioma model...
  12. ncbi Current perspectives on antiangiogenesis strategies in the treatment of malignant gliomas
    Marnix Jansen
    Department of Pathology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Brain Res Brain Res Rev 45:143-63. 2004
    ..Future research on endothelial markers expressed on tumor-associated vasculature as well as endothelial responses to cytotoxic treatment will provide new avenues for molecularly targeted therapy in malignant gliomas...
  13. pmc Cognition and resective surgery for diffuse infiltrative glioma: an overview
    Martin Klein
    Department of Medical Psychology, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    J Neurooncol 108:309-18. 2012
    ..The purpose of this paper is to provide an overview of cognition in patients with diffuse infiltrative gliomas and the impact of resective surgery as well as other tumor and treatment-related factors...
  14. pmc Differential activity of NADPH-producing dehydrogenases renders rodents unsuitable models to study IDH1R132 mutation effects in human glioblastoma
    Nadia A Atai
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Histochem Cytochem 59:489-503. 2011
    ..It is concluded that rodents are a poor model to study consequences of the IDH1(R132) mutation in glioblastoma...
  15. ncbi Can you trust your cryostat? Reproducibility of cryostat section thickness
    Philip C De Witt Hamer
    Department of Neurosurgery, Academic Medical Center, University of Amsterdam, The Netherlands
    Microsc Res Tech 69:835-8. 2006
    ..7% for motorized sectioning and 3.3% for manual sectioning. In conclusion, section thickness is similarly reproducible after manual sectioning compared with motorized sectioning, if not better...