Alexander D Cornet

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. doi request reprint Activated protein C attenuates pulmonary coagulopathy in patients with acute respiratory distress syndrome
    A D Cornet
    Department of Intensive Care Medicine, VU University Medical Center Amsterdam, Amsterdam, The Netherlands
    J Thromb Haemost 11:894-901. 2013
  2. doi request reprint Activated protein C in the treatment of acute lung injury and acute respiratory distress syndrome
    Alexander D Cornet
    Department of Intensive Care, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands 31 20 4443933 31 20 4442392
    Expert Opin Drug Discov 4:219-27. 2009
  3. pmc Blood transfusion during cardiac surgery is associated with inflammation and coagulation in the lung: a case control study
    Pieter R Tuinman
    Department of Intensive Care Medicine and Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, Meibergdreef 9, Amsterdam NL 1105 AZ, The Netherlands
    Crit Care 15:R59. 2011
  4. pmc Sildenafil attenuates pulmonary arterial pressure but does not improve oxygenation during ARDS
    Alexander D Cornet
    Department of Intensive Care, VU University Medical Center, De Boelelaan 1117, Amsterdam, The Netherlands
    Intensive Care Med 36:758-64. 2010
  5. pmc Nebulized fibrinolytic agents improve pulmonary fibrinolysis but not inflammation in rat models of direct and indirect acute lung injury
    Jorrit J Hofstra
    Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 8:e55262. 2013
  6. doi request reprint Nebulized anticoagulants limit pulmonary coagulopathy, but not inflammation, in a model of experimental lung injury
    Jorrit J Hofstra
    Laboratory of Experimental Intensive Care and Anesthesiology LEICA, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Aerosol Med Pulm Drug Deliv 23:105-11. 2010
  7. doi request reprint The effect of blood transfusion on pulmonary permeability in cardiac surgery patients: a prospective multicenter cohort study
    Alexander P J Vlaar
    Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Transfusion 52:82-90. 2012
  8. doi request reprint Volume-limited versus pressure-limited hemodynamic management in septic and nonseptic shock
    Ronald J Trof
    Department of Intensive Care, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Crit Care Med 40:1177-85. 2012
  9. pmc Nebulized antithrombin limits bacterial outgrowth and lung injury in Streptococcus pneumoniae pneumonia in rats
    Jorrit J Hofstra
    Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands
    Crit Care 13:R145. 2009

Collaborators

Detail Information

Publications9

  1. doi request reprint Activated protein C attenuates pulmonary coagulopathy in patients with acute respiratory distress syndrome
    A D Cornet
    Department of Intensive Care Medicine, VU University Medical Center Amsterdam, Amsterdam, The Netherlands
    J Thromb Haemost 11:894-901. 2013
    ..We hypothesized that an infusion of recombinant human activated protein C (rh-APC), a natural anticoagulant, would attenuate pulmonary coagulopathy and injury...
  2. doi request reprint Activated protein C in the treatment of acute lung injury and acute respiratory distress syndrome
    Alexander D Cornet
    Department of Intensive Care, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands 31 20 4443933 31 20 4442392
    Expert Opin Drug Discov 4:219-27. 2009
    ..Objective: It discusses the potential role of activated PC in modulating the proinflammatory/procoagulant state for enhancing endothelial barrier function in animal models and human ALI/ARDS...
  3. pmc Blood transfusion during cardiac surgery is associated with inflammation and coagulation in the lung: a case control study
    Pieter R Tuinman
    Department of Intensive Care Medicine and Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, Meibergdreef 9, Amsterdam NL 1105 AZ, The Netherlands
    Crit Care 15:R59. 2011
    ..We hypothesized that blood transfusion is associated with changes in pulmonary and systemic inflammation and coagulation occurring in patients who do not meet the clinical diagnosis of transfusion-related acute lung injury (TRALI)...
  4. pmc Sildenafil attenuates pulmonary arterial pressure but does not improve oxygenation during ARDS
    Alexander D Cornet
    Department of Intensive Care, VU University Medical Center, De Boelelaan 1117, Amsterdam, The Netherlands
    Intensive Care Med 36:758-64. 2010
    ..Administration of sildenafil in ambulatory patients with pulmonary hypertension improves oxygenation and ameliorates pulmonary hypertension. Our aim was to determine whether sildenafil is beneficial for patients with ARDS...
  5. pmc Nebulized fibrinolytic agents improve pulmonary fibrinolysis but not inflammation in rat models of direct and indirect acute lung injury
    Jorrit J Hofstra
    Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 8:e55262. 2013
    ..Nebulized fibrinolytic agents could exert lung-protective effects, via promotion of fibrinolysis as well as anti-inflammation...
  6. doi request reprint Nebulized anticoagulants limit pulmonary coagulopathy, but not inflammation, in a model of experimental lung injury
    Jorrit J Hofstra
    Laboratory of Experimental Intensive Care and Anesthesiology LEICA, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Aerosol Med Pulm Drug Deliv 23:105-11. 2010
    ..Pulmonary coagulopathy may contribute to an adverse outcome in lung injury. We assessed the effects of local anticoagulant therapy on bronchoalveolar and systemic haemostasis in a rat model of endotoxemia-induced lung injury...
  7. doi request reprint The effect of blood transfusion on pulmonary permeability in cardiac surgery patients: a prospective multicenter cohort study
    Alexander P J Vlaar
    Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Transfusion 52:82-90. 2012
    ..Mediators of increased pulmonary vascular leakage after transfusion are unknown. We hypothesized that factors may include antibodies or bioactive lipids, which have been implicated in transfusion-related acute lung injury...
  8. doi request reprint Volume-limited versus pressure-limited hemodynamic management in septic and nonseptic shock
    Ronald J Trof
    Department of Intensive Care, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Crit Care Med 40:1177-85. 2012
    ..To evaluate the effect of hemodynamic management guided by upper limits of cardiac filling volumes or pressures on durations of mechanical ventilation and lengths of stay in critically ill patients with shock...
  9. pmc Nebulized antithrombin limits bacterial outgrowth and lung injury in Streptococcus pneumoniae pneumonia in rats
    Jorrit J Hofstra
    Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands
    Crit Care 13:R145. 2009
    ..We evaluated the effect of nebulized anticoagulants on pulmonary coagulopathy and inflammation in a rat model of Streptococcus pneumoniae pneumonia...