Alexander D Cornet

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. doi request reprint Activated protein C attenuates pulmonary coagulopathy in patients with acute respiratory distress syndrome
    A D Cornet
    Department of Intensive Care Medicine, VU University Medical Center Amsterdam, Amsterdam, The Netherlands
    J Thromb Haemost 11:894-901. 2013
  2. doi request reprint Activated protein C in the treatment of acute lung injury and acute respiratory distress syndrome
    Alexander D Cornet
    Department of Intensive Care, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands 31 20 4443933 31 20 4442392
    Expert Opin Drug Discov 4:219-27. 2009
  3. pmc Blood transfusion during cardiac surgery is associated with inflammation and coagulation in the lung: a case control study
    Pieter R Tuinman
    Department of Intensive Care Medicine and Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, Meibergdreef 9, Amsterdam NL 1105 AZ, The Netherlands
    Crit Care 15:R59. 2011
  4. pmc Sildenafil attenuates pulmonary arterial pressure but does not improve oxygenation during ARDS
    Alexander D Cornet
    Department of Intensive Care, VU University Medical Center, De Boelelaan 1117, Amsterdam, The Netherlands
    Intensive Care Med 36:758-64. 2010
  5. pmc Nebulized fibrinolytic agents improve pulmonary fibrinolysis but not inflammation in rat models of direct and indirect acute lung injury
    Jorrit J Hofstra
    Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 8:e55262. 2013
  6. doi request reprint Nebulized anticoagulants limit pulmonary coagulopathy, but not inflammation, in a model of experimental lung injury
    Jorrit J Hofstra
    Laboratory of Experimental Intensive Care and Anesthesiology LEICA, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Aerosol Med Pulm Drug Deliv 23:105-11. 2010
  7. pmc Recombinant human activated protein C in the treatment of acute respiratory distress syndrome: a randomized clinical trial
    Alexander D Cornet
    Department of Intensive Care, VU University Medical Center, Amsterdam, The Netherlands Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands Institute for Cardiovascular Research ICaR VU, VU University Medical Center, Amsterdam, The Netherlands
    PLoS ONE 9:e90983. 2014
  8. doi request reprint The effect of blood transfusion on pulmonary permeability in cardiac surgery patients: a prospective multicenter cohort study
    Alexander P J Vlaar
    Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Transfusion 52:82-90. 2012
  9. doi request reprint Volume-limited versus pressure-limited hemodynamic management in septic and nonseptic shock
    Ronald J Trof
    Department of Intensive Care, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Crit Care Med 40:1177-85. 2012
  10. pmc Nebulized antithrombin limits bacterial outgrowth and lung injury in Streptococcus pneumoniae pneumonia in rats
    Jorrit J Hofstra
    Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands
    Crit Care 13:R145. 2009

Detail Information

Publications14

  1. doi request reprint Activated protein C attenuates pulmonary coagulopathy in patients with acute respiratory distress syndrome
    A D Cornet
    Department of Intensive Care Medicine, VU University Medical Center Amsterdam, Amsterdam, The Netherlands
    J Thromb Haemost 11:894-901. 2013
    ..We hypothesized that an infusion of recombinant human activated protein C (rh-APC), a natural anticoagulant, would attenuate pulmonary coagulopathy and injury...
  2. doi request reprint Activated protein C in the treatment of acute lung injury and acute respiratory distress syndrome
    Alexander D Cornet
    Department of Intensive Care, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands 31 20 4443933 31 20 4442392
    Expert Opin Drug Discov 4:219-27. 2009
    ..Objective: It discusses the potential role of activated PC in modulating the proinflammatory/procoagulant state for enhancing endothelial barrier function in animal models and human ALI/ARDS...
  3. pmc Blood transfusion during cardiac surgery is associated with inflammation and coagulation in the lung: a case control study
    Pieter R Tuinman
    Department of Intensive Care Medicine and Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, Meibergdreef 9, Amsterdam NL 1105 AZ, The Netherlands
    Crit Care 15:R59. 2011
    ..We hypothesized that blood transfusion is associated with changes in pulmonary and systemic inflammation and coagulation occurring in patients who do not meet the clinical diagnosis of transfusion-related acute lung injury (TRALI)...
  4. pmc Sildenafil attenuates pulmonary arterial pressure but does not improve oxygenation during ARDS
    Alexander D Cornet
    Department of Intensive Care, VU University Medical Center, De Boelelaan 1117, Amsterdam, The Netherlands
    Intensive Care Med 36:758-64. 2010
    ..Administration of sildenafil in ambulatory patients with pulmonary hypertension improves oxygenation and ameliorates pulmonary hypertension. Our aim was to determine whether sildenafil is beneficial for patients with ARDS...
  5. pmc Nebulized fibrinolytic agents improve pulmonary fibrinolysis but not inflammation in rat models of direct and indirect acute lung injury
    Jorrit J Hofstra
    Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 8:e55262. 2013
    ..Nebulized fibrinolytic agents could exert lung-protective effects, via promotion of fibrinolysis as well as anti-inflammation...
  6. doi request reprint Nebulized anticoagulants limit pulmonary coagulopathy, but not inflammation, in a model of experimental lung injury
    Jorrit J Hofstra
    Laboratory of Experimental Intensive Care and Anesthesiology LEICA, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Aerosol Med Pulm Drug Deliv 23:105-11. 2010
    ..Pulmonary coagulopathy may contribute to an adverse outcome in lung injury. We assessed the effects of local anticoagulant therapy on bronchoalveolar and systemic haemostasis in a rat model of endotoxemia-induced lung injury...
  7. pmc Recombinant human activated protein C in the treatment of acute respiratory distress syndrome: a randomized clinical trial
    Alexander D Cornet
    Department of Intensive Care, VU University Medical Center, Amsterdam, The Netherlands Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands Institute for Cardiovascular Research ICaR VU, VU University Medical Center, Amsterdam, The Netherlands
    PLoS ONE 9:e90983. 2014
    ..Recombinant human activated protein C (rh-APC) may inhibit this process and thereby improve patient outcome...
  8. doi request reprint The effect of blood transfusion on pulmonary permeability in cardiac surgery patients: a prospective multicenter cohort study
    Alexander P J Vlaar
    Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Transfusion 52:82-90. 2012
    ..Mediators of increased pulmonary vascular leakage after transfusion are unknown. We hypothesized that factors may include antibodies or bioactive lipids, which have been implicated in transfusion-related acute lung injury...
  9. doi request reprint Volume-limited versus pressure-limited hemodynamic management in septic and nonseptic shock
    Ronald J Trof
    Department of Intensive Care, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Crit Care Med 40:1177-85. 2012
    ..To evaluate the effect of hemodynamic management guided by upper limits of cardiac filling volumes or pressures on durations of mechanical ventilation and lengths of stay in critically ill patients with shock...
  10. pmc Nebulized antithrombin limits bacterial outgrowth and lung injury in Streptococcus pneumoniae pneumonia in rats
    Jorrit J Hofstra
    Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands
    Crit Care 13:R145. 2009
    ..We evaluated the effect of nebulized anticoagulants on pulmonary coagulopathy and inflammation in a rat model of Streptococcus pneumoniae pneumonia...
  11. ncbi request reprint The role of heparin and allied compounds in the treatment of sepsis
    Alexander D Cornet
    Department of Intensive Care, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Thromb Haemost 98:579-86. 2007
    ..Therefore, a prospective randomized clinical trial is called upon to study effects in human sepsis...
  12. ncbi request reprint Hepatosplanchnic ischemia/reperfusion is a major determinant of lung vascular injury after aortic surgery
    Alexander D Cornet
    Department of Intensive Care, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
    J Surg Res 157:48-54. 2009
    ..To study risk factors, including the level of cross-clamping and ischemia/reperfusion, for lung vascular injury after aortic surgery...
  13. ncbi request reprint Coronary stent occlusion after platelet transfusion: a case series
    Alexander D Cornet
    Department of Intensive Care, V U Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    J Invasive Cardiol 19:E297-9. 2007
    ..Our observations emphasize the risks involved in platelet transfusion, and support withholding such therapy, unless vitally indicated, in patients who have undergone recent bare-metal coronary artery stent implantation...