Research Topics
Genomes and Genes | Marco ColonnaSummaryAffiliation: VU University Medical Center Country: The Netherlands Publications
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Publications
On the origins of adaptive immunity: innate immune receptors join the taleTimo K van den Berg
Department of Molecular Cell Biology, VU Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
Trends Immunol 25:11-6. 2004..We propose the existence of an evolutionary and functional link between innate and adaptive immune receptors that sheds light on the nature of the antigen receptor predecessor(s)...- A nomenclature for signal regulatory protein family membersTimo K van den Berg
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
J Immunol 175:7788-9. 2005 - LacdiNAc-glycans constitute a parasite pattern for galectin-3-mediated immune recognitionTimo K van den Berg
Department of Molecular Cell Biology and Immunology, Vrige University University Medical Center, Amsterdam, The Netherlands
J Immunol 173:1902-7. 2004..These findings provide evidence that LDN-glycans constitute a parasite pattern for galectin-3-mediated immune recognition... - A function for the macrophage F4/80 molecule in tolerance inductionTimo K van den Berg
Department of Molecular Cell Biology and Immunology, Vrije University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
Trends Immunol 26:506-9. 2005..This study appears to provide clear evidence for a role of the F4/80 molecule in the immune system, however, what does it really tell us about the activities of the F4/80 molecule?.. - Cutting edge: expression patterns of surface and soluble triggering receptor expressed on myeloid cells-1 in human endotoxemiaSylvia Knapp
Laboratory of Experimental Internal Medicine, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Immunol 173:7131-4. 2004..Inhibitor studies disclosed a PI3K-dependent pathway in LPS-induced up-regulation of TREM-1 on monocytes, whereas MAPK played a limited role... - A cell-surface molecule selectively expressed on murine natural interferon-producing cells that blocks secretion of interferon-alphaAmanda Blasius
Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, Box 8118, St Louis, MO 63110, USA
Blood 103:4201-6. 2004..Thus, the antibody identifies an IPC-specific surface molecule that, when engaged, inhibits IFN-alpha secretion... - Crystal structure of the human natural killer (NK) cell activating receptor NKp46 reveals structural relationship to other leukocyte receptor complex immunoreceptorsChristine E Foster
Structural Immunology Section, Laboratory of Immunogenetics, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA
J Biol Chem 278:46081-6. 2003..The structural similarity of NKp46 to inhibitory KIR receptors may have implications for how NK cells balance activating and inhibitory signals... - The TREM receptor family and signal integrationJulia Klesney-Tait
Washington University School of Medicine, Department of Pathology and Immunology, Saint Louis, Missouri 63110, USA
Nat Immunol 7:1266-73. 2006..Here we discuss the state of the field, putative ligands of TREM proteins and the challenges that remain in understanding TREM biology... - Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferationLaura Piccio
Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
Blood 105:2421-7. 2005..Consequently, engagement of SIRPbeta2 on T cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation... - Recombinant HLA-G5 and -G6 drive U937 myelomonocytic cell production of TGF-beta1Ramsey H McIntire
Departments of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
J Leukoc Biol 76:1220-8. 2004..Collectively, the results are consistent with the postulate that environmental programming of decidual macrophages may be dictated in part by their proximity to soluble HLA-G-producing fetal cytotrophoblast cells... 
Alerting dendritic cells to pathogens: the importance of Toll-like receptor signaling of stromal cellsMarco Colonna
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
Proc Natl Acad Sci U S A 101:16083-4. 2004- Dendritic cells respond to influenza virus through TLR7- and PKR-independent pathwaysWinfried Barchet
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Eur J Immunol 35:236-42. 2005..We conclude that DC and IPC are hard-wired to secrete IFN-alpha via different pathways, reflecting their complementary but distinct roles in anti-viral immunity... - Macrophages expressing triggering receptor expressed on myeloid cells-1 are underrepresented in the human intestineMirjam Schenk
Division of Immunopathology, Institute of Pathology, University of Bern, Murtenstrasse 31, CH-3010 Bern, Switzerland
J Immunol 174:517-24. 2005..The absence of TREM-1 expression on lamina propria macrophages is likely to prevent excessive inflammatory reactions, and thus, excessive tissue damage in the intestine... - Crystal structure of the human myeloid cell activating receptor TREM-1Sergei Radaev
Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA
Structure 11:1527-35. 2003..As a result, the dimeric TREM-1 most likely contains two distinct ligand binding sites... - Uncovering the TREM-1-TLR connectionJulia Klesney-Tait
University of Iowa Hospitals and Clinics, Pulmonary, Occupational Medicine, and Critical Care, Iowa City, IA 52242-1081, USA
Am J Physiol Lung Cell Mol Physiol 293:L1374-6. 2007 - Phosphatidylinositol 3-kinase activation is required to form the NKG2D immunological synapseEmanuele Giurisato
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
Mol Cell Biol 27:8583-99. 2007..These results provide new insights into the mechanism of immunological synapse formation and also demonstrate how multiple mechanisms can be used to recruit the same signaling proteins to the plasma membrane... - 2B4 (CD244) is expressed and functional on human eosinophilsAriel Munitz
Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel
J Immunol 174:110-8. 2005..Furthermore, we showed that eosinophils express slam-associated protein. The demonstration that human eosinophils express a functional 2B4 receptor indicates a broader role for these cells in health and disease... - Blockade of TREM-2 exacerbates experimental autoimmune encephalomyelitisLaura Piccio
Bioxell SpA, Milan, Italy
Eur J Immunol 37:1290-301. 2007..These results demonstrate a critical role for TREM-2 during inflammatory responses in the CNS... - Running to stand still: BCR-like signaling suppresses type I IFN responses in pDCMelissa K Swiecki
Department of Pathology and Immunology, Washington University School of Medicine, St Louis MO 63110, USA
Eur J Immunol 37:3327-9. 2007..In this issue of the European Journal of Immunology, evidence for a B cell receptor (BCR)-like signaling cascade in pDC that suppresses type I IFN production is provided... - Cutting edge: TREM-2 attenuates macrophage activationIsaiah R Turnbull
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
J Immunol 177:3520-4. 2006..Taken together, these data show that TREM-2 is expressed on newly differentiated and alternatively activated macrophages and functions to restrain macrophage activation... - TREM-1 (triggering receptor expressed on myeloid cells): a new player in acute inflammatory responsesMarco Colonna
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Infect Dis 187:S397-401. 2003..Whatever the ligands, targeted activation or blockade of TREM-1 and its ligands may help maximize the efficacy of existing treatments for sepsis... - Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-GMitsunori Shiroishi
Division of Structural Biology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Proc Natl Acad Sci U S A 100:8856-61. 2003.... - Siglec-H is an IPC-specific receptor that modulates type I IFN secretion through DAP12Amanda L Blasius
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
Blood 107:2474-6. 2006..Moreover, it supports a model in which engagement of DNAX-activation protein 12 (DAP12)-associated receptors with antibodies or low avidity endogenous ligands interferes with TLR-mediated cellular activation... 
N-linked glycosylation selectively regulates the generic folding of HLA-Cw1Aline Martayan
Laboratory of Immunology, Regina Elena National Cancer Research Institute, Centro della Ricerca Sperimentale, Via delle Messi d Oro 156, 00158 Rome, Italy
J Biol Chem 283:16469-76. 2008..g. primary quality control is suggested to supervise a crucial, generic folding step preliminary to the acquisition of peptide receptivity...- Fine-tuning NK cell responses: it's a family affairMarco Colonna
Nat Immunol 6:961-2. 2005 - Costimulation through NKG2D enhances murine CD8+ CTL function: similarities and differences between NKG2D and CD28 costimulationMary A Markiewicz
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
J Immunol 175:2825-33. 2005..Understanding the outcomes of these differences may allow for a better understanding of T cell costimulation in general... - The enigmatic function of TREM-2 in osteoclastogenesisMarco Colonna
Washington University School of Medicine, St Louis, Department of Pathology and Immunology, MO, USA
Adv Exp Med Biol 602:97-105. 2007.... - Plasmacytoid dendritic cells: in search of their niche in immune responsesWinfried Barchet
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
Immunol Res 32:75-83. 2005..This review highlights aspects in which pDCs are unique in comparison to other antigen-presenting cells in regulating innate and adaptive immune responses... - The role of NK cell recognition of nectin and nectin-like proteins in tumor immunosurveillanceAnja Fuchs
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
Semin Cancer Biol 16:359-66. 2006..We here review current knowledge on these receptors, CD226, CD96 and CRTAM, and their role in tumor immunosurveillance... - The cytotoxicity receptor CRACC (CS-1) recruits EAT-2 and activates the PI3K and phospholipase Cgamma signaling pathways in human NK cellsIlaria Tassi
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
J Immunol 175:7996-8002. 2005..These results outline a new signaling pathway that triggers CRACC-mediated cytotoxicity and modulates 2B4-mediated activation... - Nonleukoreduced red blood cell transfusion induces a sustained inhibition of neutrophil chemotaxis by stimulating in vivo production of transforming growth factor-beta1 by neutrophils: role of the immunoglobulinlike transcript 1, sFasL, and sHLA-ILuciano Ottonello
Divisions of Internal Medicine and Clinical Immunology, Department of Internal Medicine, University of Genoa Medical School, Viale Benedetto XV 6, I 16132 Genoa, Italy
Transfusion 47:1395-404. 2007..Such inhibitory activity is due to transforming growth factor (TGF)-beta1 contained in the supernatants that desensitize neutrophils to subsequent chemotaxic stimulation... - Dendritic cells at the host-pathogen interfaceMarco Colonna
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
Nat Immunol 7:117-20. 2006..How DCs integrate information from pathogens, tissues, and innate leukocytes for the induction of immune responses was presented at the second International Conference on Dendritic Cells at the Host-Pathogen Interface... - CpG-induced tyrosine phosphorylation occurs via a TLR9-independent mechanism and is required for cytokine secretionMiguel A Sanjuan
Johnson and Johnson Pharmaceutical Research and Development, L.L.C, San Diego, CA 92121, USA
J Cell Biol 172:1057-68. 2006..The Src family pathway intersects the TLR9-MyD88 pathway by promoting the tyrosine phosphorylation of TLR9 and the recruitment of Syk to this receptor... - New nomenclature for Fc receptor-like moleculesLois J Maltais
Nat Immunol 7:431-2. 2006 - Bone marrow stromal cell antigen 2 is a specific marker of type I IFN-producing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulationAmanda L Blasius
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
J Immunol 177:3260-5. 2006..Finally, we show that BST2 resides within an intracellular compartment corresponding to the Golgi apparatus, and may be involved in trafficking secreted cytokines in IPC... - Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirusLeonid Gitlin
Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Campus Box 8118, 660 South Euclid Avenue, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 103:8459-64. 2006..Moreover, mda-5-/- mice exhibited a selectively impaired antiviral response to encephalomyocarditis picornavirus, indicating functional specialization of mda-5 in vivo... - Vav1 controls DAP10-mediated natural cytotoxicity by regulating actin and microtubule dynamicsDaniel B Graham
Department of Pathology and Immunology, Washington University School of Medicine and Siteman Cancer Center, 660 South Euclid Avenue, St Louis, MO 63110, USA
J Immunol 177:2349-55. 2006..Based on these findings, we propose a novel model of ITAM-independent signaling by Vav downstream of DAP10 in NK cells... - NKG2D-independent suppression of T cell proliferation by H60 and MICAAnja K Kriegeskorte
Institute for Medical Microbiology, Immunology, and Hygiene, Technical University Munich, 81675 Munich, Germany
Proc Natl Acad Sci U S A 102:11805-10. 2005.... - Differential requirements for Vav proteins in DAP10- and ITAM-mediated NK cell cytotoxicityMarina Cella
Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
J Exp Med 200:817-23. 2004..Our results provide evidence that these three Vav proteins function specifically in distinct pathways that trigger NK cell cytotoxicity... - DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitisIsaiah R Turnbull
Department of Pathology and Immunology, Department of Surgery, Washington University School of Medicine, St Louis, MO 63110
J Exp Med 202:363-9. 2005..These data demonstrate that, during sepsis, DAP12 signaling augments the response to microbial products, amplifying inflammation and contributing to mortality... - Impaired differentiation of osteoclasts in TREM-2-deficient individualsMarina Cella
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
J Exp Med 198:645-51. 2003..These results demonstrate a critical role for TREM-2 in the differentiation of mononuclear myeloid precursors into functional multinucleated OCs... - TREMs in the immune system and beyondMarco Colonna
Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
Nat Rev Immunol 3:445-53. 2003..Remarkably, TREM2 deficiency leads to a severe disease that is characterized by bone cysts and demyelination of the central nervous system, which results in dementia, implying that the function of TREM2 extends beyond the immune system... - Inhibitory receptors: friend or foe?Marco Colonna
Washington University School of Medicine, St Louis, MO 63110, USA
Lancet 361:1067-8. 2003 - A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune responseJoshua R Bleharski
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
J Immunol 170:3812-8. 2003..Our data suggest that activation of TREM-1 on monocytes participates during the early-induced and adaptive immune responses involved in host defense against microbial challenges... - Monoclonal T-cell expansions in asymptomatic individuals and in patients with large granular leukemia consist of cytotoxic effector T cells expressing the activating CD94:NKG2C/E and NKD2D killer cell receptorsValerie Bigouret
Division of Immunology and Allergology, University Hospital, Geneva, Switzerland
Blood 101:3198-204. 2003.... - CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunityTodd A Fehniger
Department of Internal Medicine, Division of Hematology Oncology, The Ohio State University, Columbus, OH 43210, USA
Blood 101:3052-7. 2003..These data show a dynamic interaction between innate and adaptive human lymphocytes and emphasize the importance of studying interactions between immune components to understand the immune response as a whole... - Making sense of the diverse ligand recognition by NKG2DSergei Radaev
Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
J Immunol 169:6279-85. 2002.... - NKG2D recruits two distinct adapters to trigger NK cell activation and costimulationSusan Gilfillan
Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
Nat Immunol 3:1150-5. 2002..Thus, NKG2D is a versatile receptor that, depending on the availability of adapter partners, mediates costimulation in T cells and/or activation in NK cells... - Capture and transfer of simian immunodeficiency virus by macaque dendritic cells is enhanced by DC-SIGNMonica T Yu Kimata
Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, Texas 78227, USA
J Virol 76:11827-36. 2002..Thus, SIVmne infection of pig-tailed macaques may provide an opportunity to investigate the significance of DC-SIGN in primate lentiviral infections... - An unusual Fc receptor-related protein expressed in human centroblastsFabio Facchetti
Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 99:3776-81. 2002..Remarkably, FREB is expressed in a subset of diffuse large B cell lymphomas, providing a unique marker for the characterization of this B cell malignancy... - Use of genetic profiling in leprosy to discriminate clinical forms of the diseaseJoshua R Bleharski
Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at University of California Los Angeles (UCLA, Los Angeles, CA 90095, USA
Science 301:1527-30. 2003..Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens... - Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9Anne Krug
Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
Blood 103:1433-7. 2004.... - Phospholipase C-gamma 2 is a critical signaling mediator for murine NK cell activating receptorsIlaria Tassi
Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
J Immunol 175:749-54. 2005..These results demonstrate that PLCgamma2 is crucial for development of the NK cell receptor repertoire and signaling of activating NK cell receptors, mediating optimal NK cell function in vivo... - Altered NKG2D function in NK cells induced by chronic exposure to NKG2D ligand-expressing tumor cellsJerome D Coudert
Ludwig Institute for Cancer Research, Lausanne Branch, Ch des Boveresses 155, 1066 Epalinges, Switzerland
Blood 106:1711-7. 2005..Thus, the chronic exposure to tumor cells expressing NKG2D ligand alters NKG2D signaling and may facilitate the evasion of tumor cells from NK cell reactions... - The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAMKent S Boles
Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
Blood 106:779-86. 2005..Furthermore, they reveal Necl-2 as one of the molecular targets that allows the immunosurveillance network to distinguish tumor cells from normal cells... - The structure of DC-SIGNR with a portion of its repeat domain lends insights to modeling of the receptor tetramerGreg A Snyder
Laboratory of Immunogenetics, Structural Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook II, 12441 Parklawn Drive, Rockville, MD 20852, USA
J Mol Biol 347:979-89. 2005.... - DAP12 signaling: from immune cells to bone modeling and brain myelinationMarco Colonna
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
J Clin Invest 111:313-4. 2003 - Distribution and signaling of TREM2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementiaGiuseppina Sessa
Department of Neuroscience, DIBIT, Vita-Salute San Raffaele University and San Raffaele Institute, Via Olgettina 58, 20132 Milan, Italy
Eur J Neurosci 20:2617-28. 2004.... - TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell functionAnne Krug
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
Immunity 21:107-19. 2004..We conclude that the TLR9/MyD88 pathway mediates antiviral cytokine responses by IPC, DC, and possibly other cell types, which are coordinated to promote effective NK cell function and MCMV clearance... - IL-4 confers NK stimulatory capacity to murine dendritic cells: a signaling pathway involving KARAP/DAP12-triggering receptor expressed on myeloid cell 2 moleculesMagali Terme
ERM0208 Institut National de la Sante et de la Recherche Medicale, Department of Clinical Biology, Institut Gustave Roussy, Villejuif, France
J Immunol 172:5957-66. 2004..These data outline a novel role for Th2 cytokines in the regulation of innate immune responses through triggering receptors expressed on myeloid cells... - Viral immunosuppression: disabling the guardsMarco Colonna
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Clin Invest 113:660-2. 2004..The discovery of these immunosuppressive mechanisms provides new perspectives for the therapy of chronic infections associated with immunosuppression... - Interferon-producing cells: on the front line in immune responses against pathogensMarco Colonna
Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8118, St Louis, MO 63110, USA
Curr Opin Immunol 14:373-9. 2002..These breakthroughs have brought IPC to the attention of immunologists for their role in innate immunity and in shaping T cell responses. Here we review recent progress and outstanding questions in the field...