Marco Colonna

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint On the origins of adaptive immunity: innate immune receptors join the tale
    Timo K van den Berg
    Department of Molecular Cell Biology, VU Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Trends Immunol 25:11-6. 2004
  2. ncbi request reprint A nomenclature for signal regulatory protein family members
    Timo K van den Berg
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    J Immunol 175:7788-9. 2005
  3. ncbi request reprint LacdiNAc-glycans constitute a parasite pattern for galectin-3-mediated immune recognition
    Timo K van den Berg
    Department of Molecular Cell Biology and Immunology, Vrige University University Medical Center, Amsterdam, The Netherlands
    J Immunol 173:1902-7. 2004
  4. ncbi request reprint A function for the macrophage F4/80 molecule in tolerance induction
    Timo K van den Berg
    Department of Molecular Cell Biology and Immunology, Vrije University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Trends Immunol 26:506-9. 2005
  5. ncbi request reprint Cutting edge: expression patterns of surface and soluble triggering receptor expressed on myeloid cells-1 in human endotoxemia
    Sylvia Knapp
    Laboratory of Experimental Internal Medicine, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 173:7131-4. 2004
  6. ncbi request reprint A cell-surface molecule selectively expressed on murine natural interferon-producing cells that blocks secretion of interferon-alpha
    Amanda Blasius
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, Box 8118, St Louis, MO 63110, USA
    Blood 103:4201-6. 2004
  7. ncbi request reprint Crystal structure of the human natural killer (NK) cell activating receptor NKp46 reveals structural relationship to other leukocyte receptor complex immunoreceptors
    Christine E Foster
    Structural Immunology Section, Laboratory of Immunogenetics, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA
    J Biol Chem 278:46081-6. 2003
  8. ncbi request reprint The TREM receptor family and signal integration
    Julia Klesney-Tait
    Washington University School of Medicine, Department of Pathology and Immunology, Saint Louis, Missouri 63110, USA
    Nat Immunol 7:1266-73. 2006
  9. ncbi request reprint Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation
    Laura Piccio
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    Blood 105:2421-7. 2005
  10. ncbi request reprint Recombinant HLA-G5 and -G6 drive U937 myelomonocytic cell production of TGF-beta1
    Ramsey H McIntire
    Departments of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Leukoc Biol 76:1220-8. 2004

Collaborators

Detail Information

Publications62

  1. ncbi request reprint On the origins of adaptive immunity: innate immune receptors join the tale
    Timo K van den Berg
    Department of Molecular Cell Biology, VU Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Trends Immunol 25:11-6. 2004
    ..We propose the existence of an evolutionary and functional link between innate and adaptive immune receptors that sheds light on the nature of the antigen receptor predecessor(s)...
  2. ncbi request reprint A nomenclature for signal regulatory protein family members
    Timo K van den Berg
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    J Immunol 175:7788-9. 2005
  3. ncbi request reprint LacdiNAc-glycans constitute a parasite pattern for galectin-3-mediated immune recognition
    Timo K van den Berg
    Department of Molecular Cell Biology and Immunology, Vrige University University Medical Center, Amsterdam, The Netherlands
    J Immunol 173:1902-7. 2004
    ..These findings provide evidence that LDN-glycans constitute a parasite pattern for galectin-3-mediated immune recognition...
  4. ncbi request reprint A function for the macrophage F4/80 molecule in tolerance induction
    Timo K van den Berg
    Department of Molecular Cell Biology and Immunology, Vrije University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Trends Immunol 26:506-9. 2005
    ..This study appears to provide clear evidence for a role of the F4/80 molecule in the immune system, however, what does it really tell us about the activities of the F4/80 molecule?..
  5. ncbi request reprint Cutting edge: expression patterns of surface and soluble triggering receptor expressed on myeloid cells-1 in human endotoxemia
    Sylvia Knapp
    Laboratory of Experimental Internal Medicine, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 173:7131-4. 2004
    ..Inhibitor studies disclosed a PI3K-dependent pathway in LPS-induced up-regulation of TREM-1 on monocytes, whereas MAPK played a limited role...
  6. ncbi request reprint A cell-surface molecule selectively expressed on murine natural interferon-producing cells that blocks secretion of interferon-alpha
    Amanda Blasius
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, Box 8118, St Louis, MO 63110, USA
    Blood 103:4201-6. 2004
    ..Thus, the antibody identifies an IPC-specific surface molecule that, when engaged, inhibits IFN-alpha secretion...
  7. ncbi request reprint Crystal structure of the human natural killer (NK) cell activating receptor NKp46 reveals structural relationship to other leukocyte receptor complex immunoreceptors
    Christine E Foster
    Structural Immunology Section, Laboratory of Immunogenetics, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA
    J Biol Chem 278:46081-6. 2003
    ..The structural similarity of NKp46 to inhibitory KIR receptors may have implications for how NK cells balance activating and inhibitory signals...
  8. ncbi request reprint The TREM receptor family and signal integration
    Julia Klesney-Tait
    Washington University School of Medicine, Department of Pathology and Immunology, Saint Louis, Missouri 63110, USA
    Nat Immunol 7:1266-73. 2006
    ..Here we discuss the state of the field, putative ligands of TREM proteins and the challenges that remain in understanding TREM biology...
  9. ncbi request reprint Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation
    Laura Piccio
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    Blood 105:2421-7. 2005
    ..Consequently, engagement of SIRPbeta2 on T cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation...
  10. ncbi request reprint Recombinant HLA-G5 and -G6 drive U937 myelomonocytic cell production of TGF-beta1
    Ramsey H McIntire
    Departments of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Leukoc Biol 76:1220-8. 2004
    ..Collectively, the results are consistent with the postulate that environmental programming of decidual macrophages may be dictated in part by their proximity to soluble HLA-G-producing fetal cytotrophoblast cells...
  11. pmc Alerting dendritic cells to pathogens: the importance of Toll-like receptor signaling of stromal cells
    Marco Colonna
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 101:16083-4. 2004
  12. ncbi request reprint Dendritic cells respond to influenza virus through TLR7- and PKR-independent pathways
    Winfried Barchet
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Eur J Immunol 35:236-42. 2005
    ..We conclude that DC and IPC are hard-wired to secrete IFN-alpha via different pathways, reflecting their complementary but distinct roles in anti-viral immunity...
  13. ncbi request reprint Macrophages expressing triggering receptor expressed on myeloid cells-1 are underrepresented in the human intestine
    Mirjam Schenk
    Division of Immunopathology, Institute of Pathology, University of Bern, Murtenstrasse 31, CH 3010 Bern, Switzerland
    J Immunol 174:517-24. 2005
    ..The absence of TREM-1 expression on lamina propria macrophages is likely to prevent excessive inflammatory reactions, and thus, excessive tissue damage in the intestine...
  14. ncbi request reprint Crystal structure of the human myeloid cell activating receptor TREM-1
    Sergei Radaev
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA
    Structure 11:1527-35. 2003
    ..As a result, the dimeric TREM-1 most likely contains two distinct ligand binding sites...
  15. ncbi request reprint Uncovering the TREM-1-TLR connection
    Julia Klesney-Tait
    University of Iowa Hospitals and Clinics, Pulmonary, Occupational Medicine, and Critical Care, Iowa City, IA 52242 1081, USA
    Am J Physiol Lung Cell Mol Physiol 293:L1374-6. 2007
  16. pmc Phosphatidylinositol 3-kinase activation is required to form the NKG2D immunological synapse
    Emanuele Giurisato
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cell Biol 27:8583-99. 2007
    ..These results provide new insights into the mechanism of immunological synapse formation and also demonstrate how multiple mechanisms can be used to recruit the same signaling proteins to the plasma membrane...
  17. ncbi request reprint 2B4 (CD244) is expressed and functional on human eosinophils
    Ariel Munitz
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel
    J Immunol 174:110-8. 2005
    ..Furthermore, we showed that eosinophils express slam-associated protein. The demonstration that human eosinophils express a functional 2B4 receptor indicates a broader role for these cells in health and disease...
  18. ncbi request reprint Blockade of TREM-2 exacerbates experimental autoimmune encephalomyelitis
    Laura Piccio
    Bioxell SpA, Milan, Italy
    Eur J Immunol 37:1290-301. 2007
    ..These results demonstrate a critical role for TREM-2 during inflammatory responses in the CNS...
  19. ncbi request reprint Running to stand still: BCR-like signaling suppresses type I IFN responses in pDC
    Melissa K Swiecki
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis MO 63110, USA
    Eur J Immunol 37:3327-9. 2007
    ..In this issue of the European Journal of Immunology, evidence for a B cell receptor (BCR)-like signaling cascade in pDC that suppresses type I IFN production is provided...
  20. ncbi request reprint Cutting edge: TREM-2 attenuates macrophage activation
    Isaiah R Turnbull
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 177:3520-4. 2006
    ..Taken together, these data show that TREM-2 is expressed on newly differentiated and alternatively activated macrophages and functions to restrain macrophage activation...
  21. ncbi request reprint TREM-1 (triggering receptor expressed on myeloid cells): a new player in acute inflammatory responses
    Marco Colonna
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Infect Dis 187:S397-401. 2003
    ..Whatever the ligands, targeted activation or blockade of TREM-1 and its ligands may help maximize the efficacy of existing treatments for sepsis...
  22. pmc Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G
    Mitsunori Shiroishi
    Division of Structural Biology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Proc Natl Acad Sci U S A 100:8856-61. 2003
    ....
  23. pmc Siglec-H is an IPC-specific receptor that modulates type I IFN secretion through DAP12
    Amanda L Blasius
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Blood 107:2474-6. 2006
    ..Moreover, it supports a model in which engagement of DNAX-activation protein 12 (DAP12)-associated receptors with antibodies or low avidity endogenous ligands interferes with TLR-mediated cellular activation...
  24. doi request reprint N-linked glycosylation selectively regulates the generic folding of HLA-Cw1
    Aline Martayan
    Laboratory of Immunology, Regina Elena National Cancer Research Institute, Centro della Ricerca Sperimentale, Via delle Messi d Oro 156, 00158 Rome, Italy
    J Biol Chem 283:16469-76. 2008
    ..g. primary quality control is suggested to supervise a crucial, generic folding step preliminary to the acquisition of peptide receptivity...
  25. ncbi request reprint Fine-tuning NK cell responses: it's a family affair
    Marco Colonna
    Nat Immunol 6:961-2. 2005
  26. ncbi request reprint Costimulation through NKG2D enhances murine CD8+ CTL function: similarities and differences between NKG2D and CD28 costimulation
    Mary A Markiewicz
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 175:2825-33. 2005
    ..Understanding the outcomes of these differences may allow for a better understanding of T cell costimulation in general...
  27. ncbi request reprint The enigmatic function of TREM-2 in osteoclastogenesis
    Marco Colonna
    Washington University School of Medicine, St Louis, Department of Pathology and Immunology, MO, USA
    Adv Exp Med Biol 602:97-105. 2007
    ....
  28. ncbi request reprint Plasmacytoid dendritic cells: in search of their niche in immune responses
    Winfried Barchet
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunol Res 32:75-83. 2005
    ..This review highlights aspects in which pDCs are unique in comparison to other antigen-presenting cells in regulating innate and adaptive immune responses...
  29. ncbi request reprint The role of NK cell recognition of nectin and nectin-like proteins in tumor immunosurveillance
    Anja Fuchs
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    Semin Cancer Biol 16:359-66. 2006
    ..We here review current knowledge on these receptors, CD226, CD96 and CRTAM, and their role in tumor immunosurveillance...
  30. ncbi request reprint The cytotoxicity receptor CRACC (CS-1) recruits EAT-2 and activates the PI3K and phospholipase Cgamma signaling pathways in human NK cells
    Ilaria Tassi
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 175:7996-8002. 2005
    ..These results outline a new signaling pathway that triggers CRACC-mediated cytotoxicity and modulates 2B4-mediated activation...
  31. ncbi request reprint Nonleukoreduced red blood cell transfusion induces a sustained inhibition of neutrophil chemotaxis by stimulating in vivo production of transforming growth factor-beta1 by neutrophils: role of the immunoglobulinlike transcript 1, sFasL, and sHLA-I
    Luciano Ottonello
    Divisions of Internal Medicine and Clinical Immunology, Department of Internal Medicine, University of Genoa Medical School, Viale Benedetto XV 6, I 16132 Genoa, Italy
    Transfusion 47:1395-404. 2007
    ..Such inhibitory activity is due to transforming growth factor (TGF)-beta1 contained in the supernatants that desensitize neutrophils to subsequent chemotaxic stimulation...
  32. ncbi request reprint Dendritic cells at the host-pathogen interface
    Marco Colonna
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Immunol 7:117-20. 2006
    ..How DCs integrate information from pathogens, tissues, and innate leukocytes for the induction of immune responses was presented at the second International Conference on Dendritic Cells at the Host-Pathogen Interface...
  33. pmc CpG-induced tyrosine phosphorylation occurs via a TLR9-independent mechanism and is required for cytokine secretion
    Miguel A Sanjuan
    Johnson and Johnson Pharmaceutical Research and Development, L L C, San Diego, CA 92121, USA
    J Cell Biol 172:1057-68. 2006
    ..The Src family pathway intersects the TLR9-MyD88 pathway by promoting the tyrosine phosphorylation of TLR9 and the recruitment of Syk to this receptor...
  34. ncbi request reprint New nomenclature for Fc receptor-like molecules
    Lois J Maltais
    Nat Immunol 7:431-2. 2006
  35. ncbi request reprint Bone marrow stromal cell antigen 2 is a specific marker of type I IFN-producing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulation
    Amanda L Blasius
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 177:3260-5. 2006
    ..Finally, we show that BST2 resides within an intracellular compartment corresponding to the Golgi apparatus, and may be involved in trafficking secreted cytokines in IPC...
  36. pmc Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus
    Leonid Gitlin
    Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Campus Box 8118, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 103:8459-64. 2006
    ..Moreover, mda-5-/- mice exhibited a selectively impaired antiviral response to encephalomyocarditis picornavirus, indicating functional specialization of mda-5 in vivo...
  37. ncbi request reprint Vav1 controls DAP10-mediated natural cytotoxicity by regulating actin and microtubule dynamics
    Daniel B Graham
    Department of Pathology and Immunology, Washington University School of Medicine and Siteman Cancer Center, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Immunol 177:2349-55. 2006
    ..Based on these findings, we propose a novel model of ITAM-independent signaling by Vav downstream of DAP10 in NK cells...
  38. pmc NKG2D-independent suppression of T cell proliferation by H60 and MICA
    Anja K Kriegeskorte
    Institute for Medical Microbiology, Immunology, and Hygiene, Technical University Munich, 81675 Munich, Germany
    Proc Natl Acad Sci U S A 102:11805-10. 2005
    ....
  39. pmc Differential requirements for Vav proteins in DAP10- and ITAM-mediated NK cell cytotoxicity
    Marina Cella
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    J Exp Med 200:817-23. 2004
    ..Our results provide evidence that these three Vav proteins function specifically in distinct pathways that trigger NK cell cytotoxicity...
  40. pmc DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis
    Isaiah R Turnbull
    Department of Pathology and Immunology, Department of Surgery, Washington University School of Medicine, St Louis, MO 63110
    J Exp Med 202:363-9. 2005
    ..These data demonstrate that, during sepsis, DAP12 signaling augments the response to microbial products, amplifying inflammation and contributing to mortality...
  41. pmc Impaired differentiation of osteoclasts in TREM-2-deficient individuals
    Marina Cella
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Exp Med 198:645-51. 2003
    ..These results demonstrate a critical role for TREM-2 in the differentiation of mononuclear myeloid precursors into functional multinucleated OCs...
  42. ncbi request reprint TREMs in the immune system and beyond
    Marco Colonna
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Rev Immunol 3:445-53. 2003
    ..Remarkably, TREM2 deficiency leads to a severe disease that is characterized by bone cysts and demyelination of the central nervous system, which results in dementia, implying that the function of TREM2 extends beyond the immune system...
  43. ncbi request reprint Inhibitory receptors: friend or foe?
    Marco Colonna
    Washington University School of Medicine, St Louis, MO 63110, USA
    Lancet 361:1067-8. 2003
  44. ncbi request reprint A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune response
    Joshua R Bleharski
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 170:3812-8. 2003
    ..Our data suggest that activation of TREM-1 on monocytes participates during the early-induced and adaptive immune responses involved in host defense against microbial challenges...
  45. ncbi request reprint Monoclonal T-cell expansions in asymptomatic individuals and in patients with large granular leukemia consist of cytotoxic effector T cells expressing the activating CD94:NKG2C/E and NKD2D killer cell receptors
    Valerie Bigouret
    Division of Immunology and Allergology, University Hospital, Geneva, Switzerland
    Blood 101:3198-204. 2003
    ....
  46. ncbi request reprint CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity
    Todd A Fehniger
    Department of Internal Medicine, Division of Hematology Oncology, The Ohio State University, Columbus, OH 43210, USA
    Blood 101:3052-7. 2003
    ..These data show a dynamic interaction between innate and adaptive human lymphocytes and emphasize the importance of studying interactions between immune components to understand the immune response as a whole...
  47. ncbi request reprint Making sense of the diverse ligand recognition by NKG2D
    Sergei Radaev
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 169:6279-85. 2002
    ....
  48. ncbi request reprint NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation
    Susan Gilfillan
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    Nat Immunol 3:1150-5. 2002
    ..Thus, NKG2D is a versatile receptor that, depending on the availability of adapter partners, mediates costimulation in T cells and/or activation in NK cells...
  49. pmc Capture and transfer of simian immunodeficiency virus by macaque dendritic cells is enhanced by DC-SIGN
    Monica T Yu Kimata
    Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, Texas 78227, USA
    J Virol 76:11827-36. 2002
    ..Thus, SIVmne infection of pig-tailed macaques may provide an opportunity to investigate the significance of DC-SIGN in primate lentiviral infections...
  50. pmc An unusual Fc receptor-related protein expressed in human centroblasts
    Fabio Facchetti
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 99:3776-81. 2002
    ..Remarkably, FREB is expressed in a subset of diffuse large B cell lymphomas, providing a unique marker for the characterization of this B cell malignancy...
  51. ncbi request reprint Use of genetic profiling in leprosy to discriminate clinical forms of the disease
    Joshua R Bleharski
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at University of California Los Angeles UCLA, Los Angeles, CA 90095, USA
    Science 301:1527-30. 2003
    ..Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens...
  52. ncbi request reprint Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9
    Anne Krug
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Blood 103:1433-7. 2004
    ....
  53. ncbi request reprint Phospholipase C-gamma 2 is a critical signaling mediator for murine NK cell activating receptors
    Ilaria Tassi
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Immunol 175:749-54. 2005
    ..These results demonstrate that PLCgamma2 is crucial for development of the NK cell receptor repertoire and signaling of activating NK cell receptors, mediating optimal NK cell function in vivo...
  54. ncbi request reprint Altered NKG2D function in NK cells induced by chronic exposure to NKG2D ligand-expressing tumor cells
    Jerome D Coudert
    Ludwig Institute for Cancer Research, Lausanne Branch, Ch des Boveresses 155, 1066 Epalinges, Switzerland
    Blood 106:1711-7. 2005
    ..Thus, the chronic exposure to tumor cells expressing NKG2D ligand alters NKG2D signaling and may facilitate the evasion of tumor cells from NK cell reactions...
  55. ncbi request reprint The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM
    Kent S Boles
    Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    Blood 106:779-86. 2005
    ..Furthermore, they reveal Necl-2 as one of the molecular targets that allows the immunosurveillance network to distinguish tumor cells from normal cells...
  56. ncbi request reprint The structure of DC-SIGNR with a portion of its repeat domain lends insights to modeling of the receptor tetramer
    Greg A Snyder
    Laboratory of Immunogenetics, Structural Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook II, 12441 Parklawn Drive, Rockville, MD 20852, USA
    J Mol Biol 347:979-89. 2005
    ....
  57. pmc DAP12 signaling: from immune cells to bone modeling and brain myelination
    Marco Colonna
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 111:313-4. 2003
  58. ncbi request reprint Distribution and signaling of TREM2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia
    Giuseppina Sessa
    Department of Neuroscience, DIBIT, Vita Salute San Raffaele University and San Raffaele Institute, Via Olgettina 58, 20132 Milan, Italy
    Eur J Neurosci 20:2617-28. 2004
    ....
  59. ncbi request reprint TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function
    Anne Krug
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunity 21:107-19. 2004
    ..We conclude that the TLR9/MyD88 pathway mediates antiviral cytokine responses by IPC, DC, and possibly other cell types, which are coordinated to promote effective NK cell function and MCMV clearance...
  60. ncbi request reprint IL-4 confers NK stimulatory capacity to murine dendritic cells: a signaling pathway involving KARAP/DAP12-triggering receptor expressed on myeloid cell 2 molecules
    Magali Terme
    ERM0208 Institut National de la Sante et de la Recherche Medicale, Department of Clinical Biology, Institut Gustave Roussy, Villejuif, France
    J Immunol 172:5957-66. 2004
    ..These data outline a novel role for Th2 cytokines in the regulation of innate immune responses through triggering receptors expressed on myeloid cells...
  61. pmc Viral immunosuppression: disabling the guards
    Marco Colonna
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 113:660-2. 2004
    ..The discovery of these immunosuppressive mechanisms provides new perspectives for the therapy of chronic infections associated with immunosuppression...
  62. ncbi request reprint Interferon-producing cells: on the front line in immune responses against pathogens
    Marco Colonna
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8118, St Louis, MO 63110, USA
    Curr Opin Immunol 14:373-9. 2002
    ..These breakthroughs have brought IPC to the attention of immunologists for their role in innate immunity and in shaping T cell responses. Here we review recent progress and outstanding questions in the field...