B J M Braakhuis

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Treatment choice for locally advanced head and neck cancers on the basis of risk factors: biological risk factors
    B J M Braakhuis
    Department of Otolaryngology Head Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Ann Oncol 23:x173-7. 2012
  2. pmc Genomic profiling identifies common HPV-associated chromosomal alterations in squamous cell carcinomas of cervix and head and neck
    Saskia M Wilting
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    BMC Med Genomics 2:32. 2009
  3. ncbi request reprint Second field tumors: a new opportunity for cancer prevention?
    Boudewijn J M Braakhuis
    Department of Otolaryngology Head and Neck Surgery, Room 1D 116, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Oncologist 10:493-500. 2005
  4. ncbi request reprint Genetic patterns in head and neck cancers that contain or lack transcriptionally active human papillomavirus
    Boudewijn J M Braakhuis
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    J Natl Cancer Inst 96:998-1006. 2004
  5. ncbi request reprint Using tissue adjacent to carcinoma as a normal control: an obvious but questionable practice
    Boudewijn J M Braakhuis
    Department of Otolaryngology Head and Neck Surgery, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    J Pathol 203:620-1. 2004
  6. pmc Expression profiling and prediction of distant metastases in head and neck squamous cell carcinoma
    B J M Braakhuis
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Pathol 59:1254-60. 2006
  7. ncbi request reprint Expanding fields of genetically altered cells in head and neck squamous carcinogenesis
    Boudewijn J M Braakhuis
    Section Tumorbiology, Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Semin Cancer Biol 15:113-20. 2005
  8. ncbi request reprint A genetic explanation of Slaughter's concept of field cancerization: evidence and clinical implications
    Boudewijn J M Braakhuis
    Department of Otolaryngology Head and Neck Surgery, Section Tumor Biology, Vrije Universiteit Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Cancer Res 63:1727-30. 2003
  9. doi request reprint Oral and oropharyngeal cancer in The Netherlands between 1989 and 2006: Increasing incidence, but not in young adults
    Boudewijn J M Braakhuis
    Department of Otolaryngology Head Neck Surgery, VU University Medical Center, MB Amsterdam, The Netherlands
    Oral Oncol 45:e85-9. 2009
  10. doi request reprint Human papilloma virus in head and neck cancer: the need for a standardised assay to assess the full clinical importance
    Boudewijn J M Braakhuis
    Section Tumor Biology, Department of Otolaryngology Head Neck Surgery, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Cancer 45:2935-9. 2009

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Treatment choice for locally advanced head and neck cancers on the basis of risk factors: biological risk factors
    B J M Braakhuis
    Department of Otolaryngology Head Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Ann Oncol 23:x173-7. 2012
    ..Also, the implementation of more targeting therapies based on the characteristics of the discovered markers should lead to better survival rates...
  2. pmc Genomic profiling identifies common HPV-associated chromosomal alterations in squamous cell carcinomas of cervix and head and neck
    Saskia M Wilting
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    BMC Med Genomics 2:32. 2009
    ..The existence of hrHPV-specific alterations in SCCs of different anatomical origin, suggests that these alterations are crucial for hrHPV-mediated carcinogenesis...
  3. ncbi request reprint Second field tumors: a new opportunity for cancer prevention?
    Boudewijn J M Braakhuis
    Department of Otolaryngology Head and Neck Surgery, Room 1D 116, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Oncologist 10:493-500. 2005
    ..It is important to note that SFTs also may occur after treatment of various other cancers, including those of the bladder, skin, esophagus, lung, cervix, breast, and colon...
  4. ncbi request reprint Genetic patterns in head and neck cancers that contain or lack transcriptionally active human papillomavirus
    Boudewijn J M Braakhuis
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    J Natl Cancer Inst 96:998-1006. 2004
    ..We tested the hypothesis that HPV-associated HNSCCs display a pattern of genetic alterations different from those of HNSCCs without HPV DNA...
  5. ncbi request reprint Using tissue adjacent to carcinoma as a normal control: an obvious but questionable practice
    Boudewijn J M Braakhuis
    Department of Otolaryngology Head and Neck Surgery, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    J Pathol 203:620-1. 2004
    ..This indicates that adjacent epithelium must be checked for genetic abnormalities before it is considered normal and used as a control for comparison with carcinoma...
  6. pmc Expression profiling and prediction of distant metastases in head and neck squamous cell carcinoma
    B J M Braakhuis
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Pathol 59:1254-60. 2006
    ..Regarding head and neck squamous cell carcinoma (HNSCC), the only known risk factor is the presence of > or =3 tumour-positive lymph nodes...
  7. ncbi request reprint Expanding fields of genetically altered cells in head and neck squamous carcinogenesis
    Boudewijn J M Braakhuis
    Section Tumorbiology, Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Semin Cancer Biol 15:113-20. 2005
    ..These fields can be large (over 7 cm diameter) and are often not visible for the surgeon explaining that they may remain after resection of the primary tumor. When not removed, a field is an important risk factor for secondary cancer...
  8. ncbi request reprint A genetic explanation of Slaughter's concept of field cancerization: evidence and clinical implications
    Boudewijn J M Braakhuis
    Department of Otolaryngology Head and Neck Surgery, Section Tumor Biology, Vrije Universiteit Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Cancer Res 63:1727-30. 2003
    ..Diagnosis and treatment of epithelial cancers should not only be focused on the tumor but also on the field from which it developed...
  9. doi request reprint Oral and oropharyngeal cancer in The Netherlands between 1989 and 2006: Increasing incidence, but not in young adults
    Boudewijn J M Braakhuis
    Department of Otolaryngology Head Neck Surgery, VU University Medical Center, MB Amsterdam, The Netherlands
    Oral Oncol 45:e85-9. 2009
    ..The reason for the decreasing annual incidence rate at all sites observed for Dutch young adults remains to be explained...
  10. doi request reprint Human papilloma virus in head and neck cancer: the need for a standardised assay to assess the full clinical importance
    Boudewijn J M Braakhuis
    Section Tumor Biology, Department of Otolaryngology Head Neck Surgery, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Cancer 45:2935-9. 2009
    ....
  11. doi request reprint Gene expression profiling in head and neck squamous cell carcinoma
    Boudewijn J M Braakhuis
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Curr Opin Otolaryngol Head Neck Surg 18:67-71. 2010
    ..Micro-array expression profiling has been proposed to have predictive and prognostic value for patients with head and neck squamous cell carcinoma. A critical update of recent publications on this topic is presented...
  12. doi request reprint Molecular analysis of surgical margins in head and neck cancer: more than a marginal issue
    Boudewijn J M Braakhuis
    Department of Otolaryngology Head Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Oral Oncol 46:485-91. 2010
    ..For this latter entity, there is no intervention available at present, except for a more intensive surveillance...
  13. ncbi request reprint Genome-wide DNA copy number alterations in head and neck squamous cell carcinomas with or without oncogene-expressing human papillomavirus
    S J Smeets
    Department of Otolaryngology Head Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Oncogene 25:2558-64. 2006
    ..A number of genetic changes are shared in both tumor groups and can be considered crucial in the later stages of HNSCC progression...
  14. pmc Integrated genomic and transcriptional profiling identifies chromosomal loci with altered gene expression in cervical cancer
    Saskia M Wilting
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Genes Chromosomes Cancer 47:890-905. 2008
    ..In conclusion, integrated chromosomal and transcriptional profiling identified chromosomal hotspots at 1q, 3q, 11q, and 20q with altered gene expression within large commonly altered chromosomal regions in cervical cancer...
  15. ncbi request reprint Microarray analysis of bleomycin-exposed lymphoblastoid cells for identifying cancer susceptibility genes
    Jacqueline Cloos
    Section Tumor Biology, Department of Otolaryngology Head Neck Surgery, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Mol Cancer Res 4:71-7. 2006
    ..g., BUB1 and DUSP4). This difference in expression profiles between mutagen-sensitive and mutagen-insensitive individuals justifies further studies aimed at elucidating the genes responsible for the development of sporadic cancers...
  16. ncbi request reprint A noninvasive genetic screening test to detect oral preneoplastic lesions
    Jantine F Bremmer
    Department of Oromaxillofacial Surgery and Oral Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Lab Invest 85:1481-8. 2005
    ....
  17. ncbi request reprint Discordance of genetic alterations between primary head and neck tumors and corresponding metastases associated with mutational status of the TP53 gene
    Maarten P Tabor
    Department of Otolaryngology Head and Neck Surgery, Vrije Universiteit Medical Center, Amsterdam, Netherlands
    Genes Chromosomes Cancer 33:168-77. 2002
    ..008 and P = 0.029; two-sided Fisher exact test). This finding suggests that TP53-mutated tumors need fewer additional genetic alterations to develop metastases compared with TP53 wild-type primary tumors...
  18. doi request reprint The molecular biology of head and neck cancer
    C Rene Leemans
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Nat Rev Cancer 11:9-22. 2011
    ....
  19. ncbi request reprint A genetic progression model of oral cancer: current evidence and clinical implications
    Boudewijn J M Braakhuis
    Section Tumorbiology, Department Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    J Oral Pathol Med 33:317-22. 2004
    ..An important clinical implication of this model is that fields often remain after surgery of the primary tumor and may lead to new cancers, presently designated by clinicians as second primary tumors or local recurrences...
  20. ncbi request reprint Genetically altered fields as origin of locally recurrent head and neck cancer: a retrospective study
    Maarten P Tabor
    Departments of Otolaryngology Head Neck Surgery and Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Clin Cancer Res 10:3607-13. 2004
    ..outgrowth of a relatively small number of tumor cells that have not been detected by the pathologist or (b). a precursor lesion in which additional genetic alterations have led again to invasive cancer...
  21. ncbi request reprint TSLC1 gene silencing in cervical cancer cell lines and cervical neoplasia
    Renske D M Steenbergen
    Department of Pathology, Unit of Molecular Pathology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Natl Cancer Inst 96:294-305. 2004
    ..We assessed the role of the gene encoding the adhesion molecule tumor suppressor in lung cancer 1 (TSLC1) in this progression...
  22. ncbi request reprint A novel algorithm for reliable detection of human papillomavirus in paraffin embedded head and neck cancer specimen
    Serge J Smeets
    Department of Otolaryngology Head Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Int J Cancer 121:2465-72. 2007
    ....
  23. ncbi request reprint Comparative molecular and histological grading of epithelial dysplasia of the oral cavity and the oropharynx
    Maarten P Tabor
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    J Pathol 199:354-60. 2003
    ..Assessment of proliferation with Ki-67 is a better surrogate for LOH than histological grading...
  24. pmc Multiple head and neck tumors frequently originate from a single preneoplastic lesion
    Maarten P Tabor
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Am J Pathol 161:1051-60. 2002
    ....
  25. doi request reprint Screening for oral precancer with noninvasive genetic cytology
    Jantine F Bremmer
    Department of Oral and Maxillofacial Surgery and Oral Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Cancer Prev Res (Phila) 2:128-33. 2009
    ..This assay could therefore contribute to the secondary prevention of oral squamous cell carcinoma. The assay also shows promise for the detection of precancerous changes that are not macroscopically visible...
  26. ncbi request reprint Head and neck cancer: molecular carcinogenesis
    B J M Braakhuis
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Ann Oncol 16:ii249-50. 2005
  27. ncbi request reprint Nonmalignant oral keratinocytes from patients with head and neck squamous cell carcinoma show enhanced metabolism of retinoic acid
    Ingeborg Klaassen
    Section of Tumor Biology, Department of Otolaryngology Head and Neck Surgery, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Oncology 63:56-63. 2002
    ..We aimed to establish whether this altered retinoid metabolism is an intrinsic characteristic of HNSCC patients...
  28. doi request reprint Comparative evaluation of genetic assays to identify oral pre-cancerous fields
    Jantine F Bremmer
    Department of Oromaxillofacial Surgery and Oral Pathology, VU University Medical Center, Amsterdam, The Netherlands
    J Oral Pathol Med 37:599-606. 2008
    ..The test characteristics of three genetic assays that were developed to detect pre-cancerous fields were investigated and compared to histology...
  29. doi request reprint Molecular detection of minimal residual cancer in surgical margins of head and neck cancer patients
    A Peggy Graveland
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Cell Oncol 31:317-28. 2009
    ..001). This study shows a novel approach for molecular analysis of deep surgical margins in head and neck cancer surgery. The preliminary data of this approach for detection of MRC in deep margins of HNSCC patients are promising...
  30. doi request reprint Effector memory T-cell frequencies in relation to tumour stage, location and HPV status in HNSCC patients
    A W Turksma
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Oral Dis 19:577-84. 2013
    ..The immune system plays an important role in tumour immune surveillance. Head and neck squamous cell carcinoma patients are often immune compromised...
  31. ncbi request reprint Anticancer activity and mechanism of action of retinoids in oral and pharyngeal cancer
    Ingeborg Klaassen
    Section Tumor Biology, Department of Otolaryngology Head and Neck Surgery, Vrije Universiteit Medical Center, PO Box 7057, The, Amsterdam, Netherlands
    Oral Oncol 38:532-42. 2002
    ..This review gives an update on the role of retinoids in oral and oropharyngeal cancer and their precursor lesions. The focus will be on the anticancer activity, the mechanism of action and future directions...
  32. ncbi request reprint Second primary tumors and field cancerization in oral and oropharyngeal cancer: molecular techniques provide new insights and definitions
    Boudewijn J M Braakhuis
    Department of Otolaryngology Head and Neck Surgery, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Head Neck 24:198-206. 2002
    ..Considering the etiologic differences of these lesions, we believe that an accurate molecular definition is essential to make headway with the clinical management of oral and oropharyngeal cancer...
  33. ncbi request reprint Pretreatment deoxycytidine kinase levels predict in vivo gemcitabine sensitivity
    Judith R Kroep
    Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Mol Cancer Ther 1:371-6. 2002
    ..In conclusion, the clear correlation between dCK levels and gemcitabine sensitivity in various murine tumors and human tumor xenografts may be a prognostic parameter when considering gemcitabine therapy...
  34. doi request reprint Genetic classification of oral and oropharyngeal carcinomas identifies subgroups with a different prognosis
    Serge J Smeets
    Section Tumor Biology, Department of Otolaryngology Head Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Cell Oncol 31:291-300. 2009
    ..In conclusion, the discovery of these new classes of oral and oropharyngeal cancer with unique genetic and clinical characteristics has important consequences for future basic and clinical studies...
  35. ncbi request reprint Correspondence re: M. P. Rosin et al., 3p14 and 9p21 Loss is a simple tool for predicting second oral malignancy at previously treated oral cancer sites. Cancer Res., 62: 6447-6450, 2002
    Boudewijn J M Braakhuis
    Cancer Res 63:5167-8; author reply 5168-9. 2003