Maarten Boers

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Progress toward the development of a new definition of remission in rheumatoid arthritis
    Maarten Boers
    Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands
    Bull NYU Hosp Jt Dis 68:140-2. 2010
  2. ncbi request reprint The COBRA trial 20 years later
    M Boers
    Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands
    Clin Exp Rheumatol 29:S46-51. 2011
  3. doi request reprint Meta-analysis suggests that intensive non-biological combination therapy with step-down prednisolone (COBRA strategy) may also 'disconnect' disease activity and damage in rheumatoid arthritis
    Maarten Boers
    Department of Epidemiology and Biostatistics, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Ann Rheum Dis 72:406-9. 2013
  4. doi request reprint The time has come to limit the placebo period in rheumatoid arthritis trials to 3 months: a systematic comparison of 3- and 6-month response rates in trials of biological agents
    M Boers
    Department of Epidemiology and Biostatistics, VU University Medical Centre, PK 6Z 165, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Ann Rheum Dis 69:186-92. 2010
  5. doi request reprint A first step to assess harm and benefit in clinical trials in one scale
    Maarten Boers
    Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Epidemiol 63:627-32. 2010
  6. doi request reprint A new graph and scoring system simplified analysis of changing states: disease remissions in a rheumatoid arthritis clinical trial
    Maarten Boers
    Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Epidemiol 63:633-7. 2010
  7. doi request reprint A new design for registration trials in rheumatoid arthritis allowing secondary head-to-head comparisons with standard of care treatment including biologicals
    Maarten Boers
    Department of Epidemiology and Biostatistics, VU University Medical Center, PK 6Z 165, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Ann Rheum Dis 69:4-6. 2010
  8. doi request reprint American College of Rheumatology/European League against Rheumatism provisional definition of remission in rheumatoid arthritis for clinical trials
    David T Felson
    Correspondence to Maarten Boers, Department of Epidemiology and Biostatistics, VU University Medical Center, PK 6Z 165, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Ann Rheum Dis 70:404-13. 2011
  9. doi request reprint Helicobacter pylori eradication in patients on long-term treatment with NSAIDs reduces the severity of gastritis: a randomized controlled trial
    Helena T J I de Leest
    Department of Rheumatology, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Gastroenterol 43:140-6. 2009
  10. pmc Why are Dutch rheumatologists reluctant to use the COBRA treatment strategy in early rheumatoid arthritis?
    Lilian H D van Tuyl
    Department of Clinical Epidemiology and Biostatistics, VU University Medical Center, PO Box 7057, 1053 MB Amsterdam, The Netherlands
    Ann Rheum Dis 66:974-6. 2007

Detail Information

Publications82

  1. ncbi request reprint Progress toward the development of a new definition of remission in rheumatoid arthritis
    Maarten Boers
    Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands
    Bull NYU Hosp Jt Dis 68:140-2. 2010
    ..This article summarizes the development process to date. The new definition is expected to be launched in 2010...
  2. ncbi request reprint The COBRA trial 20 years later
    M Boers
    Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands
    Clin Exp Rheumatol 29:S46-51. 2011
    ..Subsequent studies have shown COBRA is feasible in practice, acceptable to patients, and has efficacy similar to the combination of TNF inhibition and high-dose methotrexate, at a fraction of the cost...
  3. doi request reprint Meta-analysis suggests that intensive non-biological combination therapy with step-down prednisolone (COBRA strategy) may also 'disconnect' disease activity and damage in rheumatoid arthritis
    Maarten Boers
    Department of Epidemiology and Biostatistics, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Ann Rheum Dis 72:406-9. 2013
    ..We investigated whether COBRA treatment can also 'disconnect' disease activity and damage...
  4. doi request reprint The time has come to limit the placebo period in rheumatoid arthritis trials to 3 months: a systematic comparison of 3- and 6-month response rates in trials of biological agents
    M Boers
    Department of Epidemiology and Biostatistics, VU University Medical Centre, PK 6Z 165, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Ann Rheum Dis 69:186-92. 2010
    ..A minimum duration of 6 months is required despite serious methodological and ethical shortcomings...
  5. doi request reprint A first step to assess harm and benefit in clinical trials in one scale
    Maarten Boers
    Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Epidemiol 63:627-32. 2010
    ..Several systems have been developed for assessment, but few attempt to incorporate both benefit and risk in the same metric while retaining enough simplicity to aid patients and clinicians in their decision making...
  6. doi request reprint A new graph and scoring system simplified analysis of changing states: disease remissions in a rheumatoid arthritis clinical trial
    Maarten Boers
    Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Epidemiol 63:633-7. 2010
    ..However, this approach is complex and not intuitive to clinicians. In this paper we propose a simple scoring system and a graph that can enhance the information about the remission experience in a trial or cohort study...
  7. doi request reprint A new design for registration trials in rheumatoid arthritis allowing secondary head-to-head comparisons with standard of care treatment including biologicals
    Maarten Boers
    Department of Epidemiology and Biostatistics, VU University Medical Center, PK 6Z 165, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Ann Rheum Dis 69:4-6. 2010
    ..Widespread adoption of the design will greatly help to determine the place of a new product in the spectrum of treatment possibilities of rheumatoid arthritis...
  8. doi request reprint American College of Rheumatology/European League against Rheumatism provisional definition of remission in rheumatoid arthritis for clinical trials
    David T Felson
    Correspondence to Maarten Boers, Department of Epidemiology and Biostatistics, VU University Medical Center, PK 6Z 165, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Ann Rheum Dis 70:404-13. 2011
    ..This work was undertaken to develop such a definition...
  9. doi request reprint Helicobacter pylori eradication in patients on long-term treatment with NSAIDs reduces the severity of gastritis: a randomized controlled trial
    Helena T J I de Leest
    Department of Rheumatology, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Gastroenterol 43:140-6. 2009
    ....
  10. pmc Why are Dutch rheumatologists reluctant to use the COBRA treatment strategy in early rheumatoid arthritis?
    Lilian H D van Tuyl
    Department of Clinical Epidemiology and Biostatistics, VU University Medical Center, PO Box 7057, 1053 MB Amsterdam, The Netherlands
    Ann Rheum Dis 66:974-6. 2007
    ..In addition, 5 years of follow-up proved that COBRA therapy results in sustained reduction of the rate of radiological progression. Despite this evidence, Dutch rheumatologists seem reluctant to prescribe COBRA therapy...
  11. doi request reprint Relapse-remission and remission-relapse switches in rheumatoid arthritis patients were modeled by random effects
    Johannes Berkhof
    Department of Clinical Epidemiology and Biostatistics, VU University Medical Centre, Amsterdam, The Netherlands
    J Clin Epidemiol 62:1085-94. 2009
    ..To compare statistical models for the analysis of two-state disease processes...
  12. doi request reprint Facilitating the use of COBRA combination therapy in early rheumatoid arthritis: a pilot implementation study
    Lilian H D van Tuyl
    Department of Rheumatology, EMGO Institute, and the Department of Epidemiology and Biostatistics, VU University Medical Center, 1081 HV Amsterdam, The Netherlands
    J Rheumatol 36:1380-6. 2009
    ....
  13. ncbi request reprint Indirect and total costs of early rheumatoid arthritis: a randomized comparison of combined step-down prednisolone, methotrexate, and sulfasalazine with sulfasalazine alone
    Ingeborg Korthals-de Bos
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    J Rheumatol 31:1709-16. 2004
    ..Analyses of the efficacy and direct costs of the treatments have already been reported...
  14. doi request reprint Remission in early rheumatoid arthritis defined by 28 joint counts: limited consequences of residual disease activity in the forefeet on outcome
    Lilian H D van Tuyl
    VU University Medical Centre, Department of Rheumatology, ZH 3A 56, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Ann Rheum Dis 71:33-7. 2012
    ..A study was undertaken to study the consequences of remission misclassification due to residual disease activity in the feet on physical function and joint damage in the subsequent year in an observational early disease cohort...
  15. doi request reprint Baseline RANKL:OPG ratio and markers of bone and cartilage degradation predict annual radiological progression over 11 years in rheumatoid arthritis
    Lilian H D van Tuyl
    VU University Medical Center, Department of Rheumatology, De Boelelaan 1117, Amsterdam, The Netherlands
    Ann Rheum Dis 69:1623-8. 2010
    ....
  16. pmc Evidence for predictive validity of remission on long-term outcome in rheumatoid arthritis: a systematic review
    Lilian H D van Tuyl
    Department of Rheumatology, VU University Medical Center, Amsterdam, The Netherlands
    Arthritis Care Res (Hoboken) 62:108-17. 2010
    ..As part of an undertaking to redefine remission, the current review describes the relationship between remission and long-term structural outcome...
  17. doi request reprint Survival, comorbidities and joint damage 11 years after the COBRA combination therapy trial in early rheumatoid arthritis
    Lilian H D van Tuyl
    VU University Medical Center, Department of Rheumatology, ZH 3A 56, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Ann Rheum Dis 69:807-12. 2010
    ..This study evaluates survival, comorbidities and joint damage in the original COBRA trial cohort...
  18. ncbi request reprint [Rheumatoid arthritis: an equally strong risk factor for cardiovascular disease as diabetes mellitus]
    Mike J L Peters
    Vrije Universiteit Medisch Centrum, afd Reumatologie, Amsterdam, The Netherlands
    Ned Tijdschr Geneeskd 154:A1469. 2010
    ..16 (95% CI: 1.28-3.63) and 2.04 (95% CI: 1.12-3.67) respectively. CONCLUSION: RA is associated with an increased risk of CVD and this risk is similar to that associated with DM2...
  19. pmc Aggressive therapy in patients with early arthritis results in similar outcome compared with conventional care: the STREAM randomized trial
    Izhar C van Eijk
    Jan van Breemen Research Institute Reade, Dr Jan van Breemenstraat 2, 1056 AB, Amsterdam, The Netherlands
    Rheumatology (Oxford) 51:686-94. 2012
    ..To compare the effects of aggressive tight control therapy and conventional care on radiographic progression and disease activity in patients with early mild inflammatory arthritis...
  20. ncbi request reprint Development of a standardized method of assessment of radiographs and radiographic change in juvenile idiopathic arthritis: introduction of the Dijkstra composite score
    Marion A J van Rossum
    Emma Children s Hospital AMC, Pediatric Rheumatology, Amsterdam, The Netherlands
    Arthritis Rheum 52:2865-72. 2005
    ..To evaluate the sensitivity to change of a newly developed radiologic assessment tool, the Dijkstra score, and to develop a numeric composite score and progressor classification scheme to apply in juvenile idiopathic arthritis (JIA) trials...
  21. ncbi request reprint Glucocorticoids in rheumatoid arthritis: a senescent research agenda on the brink of rejuvenation?
    Maarten Boers
    Department of Clinical Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands
    Best Pract Res Clin Rheumatol 18:21-9. 2004
    ..This chapter focuses on the research agenda in urgent need of execution: to define conclusively the benefit/harm trade-offs and pin down the place of these agents in the treatment cascade...
  22. ncbi request reprint American College of Rheumatology criteria for improvement in rheumatoid arthritis should only be calculated from scores that decrease on improvement
    M Boers
    Department of Clinical Epidemiology and Biostatistics, Free University Hospital, Amsterdam, The Netherlands
    Arthritis Rheum 44:1052-5. 2001
    ..g., 50%, 70%). CONCLUSION: We recommend that percentage improvement in RA be calculated only on scores that decrease on improvement. When necessary, raw data should be recoded before the ACR improvement criteria are applied...
  23. doi request reprint Patient perspective on remission in rheumatoid arthritis
    Lilian H D van Tuyl
    VU University Medical Center, Amsterdam, The Netherlands
    J Rheumatol 38:1735-8. 2011
    ....
  24. ncbi request reprint A randomized trial of PET scanning to improve diagnostic yield of direct laryngoscopy in patients with suspicion of recurrent laryngeal carcinoma after radiotherapy
    Remco de Bree
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Contemp Clin Trials 28:705-12. 2007
    ..Resectability of recurrent tumor and tumor negative surgical margins after total laryngectomy will be used as proxy endpoints. The trial will also compare quality of life and direct medical costs between both arms...
  25. pmc Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews
    Beverley J Shea
    EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    BMC Med Res Methodol 7:10. 2007
    ..Our objective was to develop an instrument to assess the methodological quality of systematic reviews, building upon previous tools, empirical evidence and expert consensus...
  26. ncbi request reprint Traditional versus up-front [18F] fluorodeoxyglucose-positron emission tomography staging of non-small-cell lung cancer: a Dutch cooperative randomized study
    Gerarda J M Herder
    Department of Pulmonology, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Oncol 24:1800-6. 2006
    ..We investigated whether application of positron emission tomography (PET) immediately after first presentation might simplify staging while maintaining accuracy, as compared with traditional strategy in routine clinical setting...
  27. doi request reprint Does rheumatoid arthritis equal diabetes mellitus as an independent risk factor for cardiovascular disease? A prospective study
    Mike J L Peters
    VU Medical Center, Amsterdam, The Netherlands
    Arthritis Rheum 61:1571-9. 2009
    ..We prospectively assessed the incidence of CVD in patients with RA compared with patients with type 2 diabetes mellitus (DM) and the general population...
  28. pmc Defining remission in rheumatoid arthritis: results of an initial American College of Rheumatology/European League Against Rheumatism consensus conference
    Lilian H D van Tuyl
    VU University Medical Center, Amsterdam, The Netherlands
    Arthritis Rheum 61:704-10. 2009
    ..The need for a uniform definition of remission is vital for research findings to be correctly interpreted...
  29. doi request reprint Chronological reading of radiographs in rheumatoid arthritis increases efficiency and does not lead to bias
    Lilian H D van Tuyl
    Department of Rheumatology, VU University Medical Center, Amsterdam, The Netherlands
    Ann Rheum Dis 73:391-5. 2014
    ..To evaluate the difference between chronological and random sequence reading in a series of radiographs with 11 years' follow-up. In addition, the influence of the starting point and length of series was evaluated...
  30. pmc The interferon type I signature towards prediction of non-response to rituximab in rheumatoid arthritis patients
    Hennie G Raterman
    Department of Rheumatology, VU University Medical Center, De Boelelaan 1117, Amsterdam, 1081HV, The Netherlands
    Arthritis Res Ther 14:R95. 2012
    ..However, approximately 40% to 50% of rituximab (RTX) treated RA patients have a poor response. We investigated whether baseline gene expression levels can discriminate between clinical non-responders and responders to RTX...
  31. doi request reprint Comparison of long-term clinical outcome with etanercept treatment and adalimumab treatment of rheumatoid arthritis with respect to immunogenicity
    Charlotte L Krieckaert
    Jan van Breemen Research Institute Reade, Amsterdam, The Netherlands
    Arthritis Rheum 64:3850-5. 2012
    ....
  32. ncbi request reprint Add-on or step-up trials for new drug development in rheumatoid arthritis: a new standard?
    Maarten Boers
    Department of Clinical Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands
    Arthritis Rheum 48:1481-3. 2003
  33. ncbi request reprint Practice, efficacy, and costs of thyroid nodule evaluation: a retrospective study in a Dutch university hospital
    Lotty Hooft
    Department of Clinical Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands
    Thyroid 14:287-93. 2004
    ..Thyroid scintigraphy proved most productive in the inadequate FNA category. Improvement of the diagnostic process using immunohistochemistry and/or imaging is needed from the patient's and society's perspective...
  34. ncbi request reprint Direct medical costs of traumatic thoracolumbar spine fractures
    Nicole van der Roer
    Department of Clinical Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands
    Acta Orthop 76:662-6. 2005
    ..The costs and cost-effectiveness of treatment of thoracolumbar fractures are poorly known...
  35. ncbi request reprint Eradication of Helicobacter pylori does not reduce the incidence of gastroduodenal ulcers in patients on long-term NSAID treatment: double-blind, randomized, placebo-controlled trial
    Helena T J I de Leest
    Department of Rheumatology, VU University Medical Center, Amsterdam, The Netherlands
    Helicobacter 12:477-85. 2007
    ..Helicobacter pylori and nonsteroidal antiinflammatory drugs (NSAIDs) are the major causes of gastroduodenal ulcers. Studies on the benefit of eradication of H. pylori in NSAID users yielded conflicting results...
  36. ncbi request reprint Progression of radiologic damage in patients with rheumatoid arthritis in clinical remission
    Esmeralda T H Molenaar
    VU University Medical Center, Amsterdam, The Netherlands
    Arthritis Rheum 50:36-42. 2004
    ..To assess whether radiologic progression occurs during clinical remission in patients with rheumatoid arthritis (RA)...
  37. ncbi request reprint Seminal pharmaceutical trials: maintaining masking in analysis
    Maarten Boers
    Department of Clinical Epidemiology and Biostatistics, VU University Medical Centre, 1007 MB Amsterdam, Netherlands
    Lancet 360:100-1. 2002
  38. ncbi request reprint Decreasing incidence of symptomatic gastrointestinal ulcers and ulcer complications in patients with rheumatoid arthritis
    K S S Steen
    Department of Rheumatology, VU University Medical Center, Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Ann Rheum Dis 67:256-9. 2008
    ..Over the same time period, a decline of GI events over the last decade was reported for US patients...
  39. doi request reprint Discordant perspectives of rheumatologists and patients on COBRA combination therapy in rheumatoid arthritis
    L H D van Tuyl
    Department of Clinical Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands
    Rheumatology (Oxford) 47:1571-6. 2008
    ..The present qualitative study was carried out to further explore the reservation of Dutch rheumatologists towards prescribing COBRA therapy and include patients' view on (components of) COBRA therapy...
  40. ncbi request reprint [The predictive value of autoantibodies in disseminating lupus erythematosus and rheumatoid arthritis]
    B A C Dijkmans
    VU Medisch Centrum, afd Reumatologie, Postbus 7057, 1007 MB Amsterdam
    Ned Tijdschr Geneeskd 149:688-93. 2005
    ....
  41. ncbi request reprint Reproducibility and clinical value of 18F-fluorodeoxyglucose positron emission tomography in recurrent melanoma
    G S Mijnhout
    Department of Nuclear Medicine, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Nucl Med Commun 23:475-81. 2002
    ..Together with the excellent observer reliability, these results justify further studies to determine the optimal place of PET in routine diagnostic algorithms in recurrent melanoma...
  42. ncbi request reprint Inflammation and damage in an individual joint predict further damage in that joint in patients with early rheumatoid arthritis
    M Boers
    Department of Clinical Epidemiology and Biostatistics, Free University Medical Center, Amsterdam, The Netherlands
    Arthritis Rheum 44:2242-6. 2001
    ..In the context of a trial in early RA, we studied the relationship between clinical signs in individual joints and their propensity to develop progressive damage...
  43. doi request reprint Dutch National Registry of GH Treatment in Adults: patient characteristics and diagnostic test procedures
    I C van Nieuwpoort
    Section Endocrinology, Department of Internal Medicine, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Eur J Endocrinol 164:491-7. 2011
    ..The main goals were to gain more insight into long-term efficacy, safety, and costs of GH therapy (GHT) in adult GH-deficient (GHD) patients in The Netherlands...
  44. ncbi request reprint Fluorine-18 fluorodeoxyglucose positron emission tomography (PET) to detect vital retinoblastoma in the eye: preliminary experience
    A C Moll
    Department of Ophthalmology, VU University Medical Center, Amsterdam, The Netherlands
    Ophthalmic Genet 25:31-5. 2004
    ..To report our first experience with FDG-PET in the detection of vital retinoblastoma...
  45. doi request reprint Tight control and intensified COBRA combination treatment in early rheumatoid arthritis: 90% remission in a pilot trial
    L H D van Tuyl
    Department of Clinical Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands
    Ann Rheum Dis 67:1574-7. 2008
    ..To investigate the efficacy and feasibility of an intensive combination treatment in early rheumatoid arthritis (RA) combined with monitoring both disease activity and cartilage degradation...
  46. doi request reprint A simple model that suggests possible cost savings when modified-release prednisone 5 mg/day is added to current treatment in patients with active rheumatoid arthritis
    Maarten Boers
    Department of Epidemiology and Biostatistics, VU University Medical Center, PK 6Z 165, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Rheumatology (Oxford) 52:1435-7. 2013
    ..The effects of a 12-week treatment with modified-release prednisone (MR-pred) on the costs of drug treatment of RA were modelled...
  47. doi request reprint Repeatability of 18F-FDG uptake measurements in tumors: a metaanalysis
    Adrianus J de Langen
    Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Med 53:701-8. 2012
    ..Therefore, we determined the repeatability of different standardized uptake value (SUV) measurements using the available data...
  48. ncbi request reprint Deriving an operational definition of low disease activity state in rheumatoid arthritis
    Maarten Boers
    VU University Medical Centre, Amsterdam, The Netherlands
    J Rheumatol 30:1112-4. 2003
    ..Once a few candidate definitions have been selected, their usefulness and prognostic validity can be tested in longitudinal datasets...
  49. ncbi request reprint Posttraumatic stress in aging World War II survivors after a fireworks disaster: a controlled prospective study
    Inge Bramsen
    VU University Medical Center, Amsterdam, The Netherlands
    J Trauma Stress 19:291-300. 2006
    ..This unique controlled observation suggests that disasters do increase the levels of posttraumatic stress, and that reactivation of previous traumatic events generally occurs. However, the vulnerability hypothesis was not supported...
  50. doi request reprint Delphi process yielded consensus on terminology and research agenda for therapeutic footwear for neuropathic foot
    Rutger Dahmen
    Jan van Breemen Institute, Amsterdam, The Netherlands
    J Clin Epidemiol 61:819-26. 2008
    ..To investigate areas of consensus and disagreement among Dutch physiatrists concerning prescription of therapeutic footwear for the neuropathic foot and to develop a research agenda...
  51. pmc Minimally important change determined by a visual method integrating an anchor-based and a distribution-based approach
    Henrica C W de Vet
    EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    Qual Life Res 16:131-42. 2007
    ..Minimally important changes (MIC) in scores help interpret results from health status instruments. Various distribution-based and anchor-based approaches have been proposed to assess MIC...
  52. ncbi request reprint Null bar and null zone are better than the error bar to compare group means in graphs
    Maarten Boers
    Department of Clinical Epidemiology and Biostatistics, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    J Clin Epidemiol 57:712-5. 2004
    ..Conventional graphs often include error bars around the group means. Regardless of what these bars depict, they are uninformative as to whether a difference between the groups is statistically significant...
  53. doi request reprint Measurement of stiffness in patients with rheumatoid arthritis in low disease activity or remission: a systematic review
    Lilian H D van Tuyl
    Department of Rheumatology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    BMC Musculoskelet Disord 15:28. 2014
    ..This systematic review aims to summarise the existing literature on validity of patient reported outcomes to measure stiffness in RA low disease activity states, to aid the choice for a measurement instrument...
  54. doi request reprint Confounding by indication probably distorts the relationship between steroid use and cardiovascular disease in rheumatoid arthritis: results from a prospective cohort study
    Alper M van Sijl
    Department of Rheumatology, VU University Medical Center, Amsterdam, The Netherlands
    PLoS ONE 9:e87965. 2014
    ..To evaluate the risk of cardiovascular disease in patients with rheumatoid arthritis exposed to glucocorticoids...
  55. ncbi request reprint Cost effectiveness and cost utility of acetylcysteine versus dimethyl sulfoxide for reflex sympathetic dystrophy
    Hiske E M van Dieten
    Department of Clinical Epidemiology and Biostatistics, Vrije Universiteit, Amsterdam, Netherlands
    Pharmacoeconomics 21:139-48. 2003
    ..To determine the cost effectiveness and cost utility of acetylcysteine versus dimethyl sulfoxide (DMSO) for patients with reflex sympathetic dystrophy (RSD), from a societal viewpoint...
  56. ncbi request reprint Prevention or retardation of joint damage in rheumatoid arthritis: issues of definition, evaluation and interpretation of plain radiographs
    Maarten Boers
    Department of Clinical Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands
    Drugs 62:1717-24. 2002
    ....
  57. ncbi request reprint [Prednisone for rheumatoid arthritis: the detriment of the doubt]
    Maarten Boers
    VU Medisch Centrum, afd Epidemiologie and Biostatistiek, Amsterdam, The Netherlands
    Ned Tijdschr Geneeskd 155:A5069. 2012
    ..Existing treatment guidelines need to be urgently updated to reflect these findings...
  58. ncbi request reprint Making an impact on mortality in rheumatoid arthritis: targeting cardiovascular comorbidity
    Maarten Boers
    Department of Clinical Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands
    Arthritis Rheum 50:1734-9. 2004
  59. pmc The rate of NSAID-induced endoscopic ulcers increases linearly but not exponentially with age: a pooled analysis of 12 randomised trials
    Maarten Boers
    Department of Clinical Epidemiology and Biostatistics, VU University Medical Center 9B 118, PO Box 7507, 1007 MB Amsterdam, The Netherlands
    Ann Rheum Dis 66:417-8. 2007
    ..Thus, it is concluded that increasing age is associated with both more frequent and more serious NSAID gastropathy...
  60. ncbi request reprint Scope for improvement in the quality of reporting of systematic reviews. From the Cochrane Musculoskeletal Group
    Beverley Shea
    EMGO Institute, Department of Clinical Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands
    J Rheumatol 33:9-15. 2006
    ..To assess the quality of reporting in Cochrane musculoskeletal systematic reviews (excluding back and injury reviews)...
  61. ncbi request reprint Use of the American College of Rheumatology N (ACR-N) index of improvement in rheumatoid arthritis: argument in opposition
    Maarten Boers
    VU University Medical Center, Amsterdam, The Netherlands
    Arthritis Rheum 52:1642-5. 2005
  62. ncbi request reprint Costs of treating bleeding and perforated peptic ulcers in The Netherlands
    Helena de Leest
    Department of Rheumatology, VU University Medical Center, Amsterdam, The Netherlands
    J Rheumatol 31:788-91. 2004
    ..We estimated the direct costs of hospital treatment of bleeding and perforated ulcers in a university hospital, from data in discharge letters and the hospital management information system...
  63. pmc At what age could screening for familial retinoblastoma be stopped? A register based study 1945-98
    A C Moll
    Department of Ophthalmology, Vrije Universiteit, Amsterdam, Netherlands
    Br J Ophthalmol 84:1170-2. 2000
    ..To evaluate until what age children in families with retinoblastoma should be screened...
  64. ncbi request reprint Diagnostic accuracy of 18F-fluorodeoxyglucose positron emission tomography in the follow-up of papillary or follicular thyroid cancer
    L Hooft
    Vrije Universiteit Medical Centre, Department of Nuclear Medicine, 1007 MB Amsterdam, The Netherlands
    J Clin Endocrinol Metab 86:3779-86. 2001
    ..However, implementation of positron emission tomography in a routine diagnostic algorithm requires additional evidence...
  65. ncbi request reprint Combination treatment in autoimmune diseases. Methodology of combination trials
    M Boers
    Department of Clinical Epidemiology and Biostatistics, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Springer Semin Immunopathol 23:27-33. 2001
    ..This article outlines possible strategies based on the primary choice between maximization of efficacy or minimization of toxicity. Strategies are illustrated with examples from trial experience in the field of rheumatoid arthritis...
  66. doi request reprint Quantitative radiographic features of early knee osteoarthritis: development over 5 years and relationship with symptoms in the CHECK cohort
    Margot B Kinds
    Rheumatology and Clinical Immunology, the Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    J Rheumatol 40:58-65. 2013
    ....
  67. doi request reprint A call for pragmatic treatment trials in rheumatoid arthritis
    Maarten Boers
    Department of Clinical Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands
    Nat Clin Pract Rheumatol 4:292-3. 2008
  68. ncbi request reprint Incidence of retinoblastoma in children born after in-vitro fertilisation
    Annette C Moll
    Department of Ophthalmology, Vrije Universiteit Medical Centre, 1081 HV, Amsterdam, Netherlands
    Lancet 361:309-10. 2003
    ..2 [95% CI 2.4-17.0], and 4.9 [1.6-11.3], for 1% and 1.5% rates, respectively). This possible association of an increased risk of retinoblastoma in a population-based study needs to be established...
  69. ncbi request reprint Methods to monitor response to chemotherapy in non-small cell lung cancer with 18F-FDG PET
    Corneline J Hoekstra
    Clinical PET Centre, VU University Medical Centre, Amsterdam, The Netherlands
    J Nucl Med 43:1304-9. 2002
    ..The aim of this study was to select those methods that would qualify for further assessment in a future prospective response-monitoring study by comparing results with patient outcome...
  70. doi request reprint Arthritis development in patients with arthralgia is strongly associated with anti-citrullinated protein antibody status: a prospective cohort study
    W H Bos
    Jan van Breemen Instituut, Amsterdam, The Netherlands
    Ann Rheum Dis 69:490-4. 2010
    ..Anti-citrullinated protein antibodies (ACPA) are associated with increased risk for rheumatoid arthritis...
  71. pmc Influence of glucocorticoids and disease activity on total and high density lipoprotein cholesterol in patients with rheumatoid arthritis
    M Boers
    Department of Clinical Epidemiology and Biostatistics, VU University Medical Centre, Amsterdam, The Netherlands
    Ann Rheum Dis 62:842-5. 2003
    ..Glucocorticoids induce hypercholesterolaemia, a cardiovascular risk factor, in patients with diseases other than rheumatoid arthritis (RA), but the data in RA are contradictory...
  72. ncbi request reprint Imaging in rheumatoid arthritis: results of group discussions
    E T Molenaar
    Department of Rheumatology, VU University Hospital, Amsterdam, The Netherlands
    J Rheumatol 26:749-51. 1999
    ..Priorities for further research in imaging studies were: (1) pathologies versus features on radiographs; (2) relation with longterm outcome; and (3) definition of minimum clinically important difference...
  73. doi request reprint Rheumatoid arthritis versus diabetes as a risk factor for cardiovascular disease: a cross-sectional study, the CARRE Investigation
    V P van Halm
    Department of Rheumatology, VU University Medical Center, Amsterdam 1007 MB, The Netherlands
    Ann Rheum Dis 68:1395-400. 2009
    ..A study was undertaken to investigate the associations between RA and type 2 diabetes (DM2), a well-established cardiovascular risk factor, on the one hand, and cardiovascular disease (CVD) on the other...
  74. ncbi request reprint Second primary tumors in hereditary retinoblastoma: a register-based study, 1945-1997: is there an age effect on radiation-related risk?
    A C Moll
    Department of Ophthalmology, Vrije Universiteit, Amsterdam, The Netherlands
    Ophthalmology 108:1109-14. 2001
    ..The aim of this study is to evaluate the influence of age at external beam irradiation (EBRT) on the occurrence of second primary tumors (SPTs) inside and outside the irradiation field in hereditary retinoblastoma patients...
  75. ncbi request reprint Rheumatoid arthritis. Treatment of early disease
    M Boers
    Department of Clinical Epidemiology and Biostatistics, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Rheum Dis Clin North Am 27:405-14, x. 2001
    ..In the future, corticosteroids will be an important component of such treatment strategies...
  76. ncbi request reprint Effectiveness of positron emission tomography in the preoperative assessment of patients with suspected non-small-cell lung cancer: the PLUS multicentre randomised trial
    Harm Van Tinteren
    Comprehensive Cancer Centre Amsterdam, Amsterdam, Netherlands
    Lancet 359:1388-93. 2002
    ..We did a randomised controlled trial in patients with suspected non-small-cell lung cancer, who were scheduled for surgery after conventional workup, to test whether PET with 18FDG reduces number of futile thoracotomies...
  77. ncbi request reprint The café fire on New Year's Eve in Volendam, the Netherlands: description of events
    L Welling
    Department of Surgery, Academic Medical Center, P O Box 22660, 1100 DD, Amsterdam, The Netherlands
    Burns 31:548-54. 2005
    ..The aim of this study was to provide insight into medical and organisational requirements of a major burns incident...
  78. ncbi request reprint Medical management after indoor fires: a review
    L Welling
    Department of Surgery, Academic Medical Centre, 1100 DD, P O Box 22660, Amsterdam, The Netherlands
    Burns 31:673-8. 2005
    ....
  79. ncbi request reprint EMEA guidelines for trials in osteoporosis: design implications
    M Boers
    Department of Clinical Epidemiology and Biostatistics, Free University Hospital, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Neth J Med 60:310-4. 2002
    ..These issues are briefly discussed in the context of the new European guidelines for the study of drugs for the indication prevention and treatment of postmenopausal osteoporosis...
  80. ncbi request reprint OMERACT: an international initiative to improve outcome measurement in rheumatology
    M Boers
    Department of Clinical Epidemiology and Biostatistics, PK 6Z 181, VU University Medical Center, Box 7057, 1007 MB Amsterdam, The Netherlands
    Clin Exp Rheumatol 23:S10-3. 2005
    ..Recommendations include core sets of measures for most of the major rheumatologic conditions. Since 2002 patients have been actively engaged in the process. OMERACT 8 will take place in Malta, May 2006 (www.omeract.org)...
  81. ncbi request reprint A consensus process on management of major burns accidents: lessons learned from the café fire in Volendam, The Netherlands
    L Welling
    Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands
    J Health Organ Manag 20:243-52. 2006
    ..Based on the findings in these investigations, a multidisciplinary research group started a consensus study. The aim of this study was to further identify areas of improvement in the care after mass burns incidents...
  82. ncbi request reprint Toward less futile surgery in non-small cell lung cancer? A randomized clinical trial to evaluate the cost-effectiveness of positron emission tomography
    H VAN Tinteren
    Comprehensive Cancer Center Amsterdam, Amsterdam, The Netherlands
    Control Clin Trials 22:89-98. 2001
    ..The trial randomized 188 patients from nine hospitals in 1 year. Patient enrollment has been stopped and data collection is in progress. The results will be published in 2001. Control Clin Trials 2001;22:89-98..