R Boellaard

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. pmc Assessment of tumour size in PET/CT lung cancer studies: PET- and CT-based methods compared to pathology
    Patsuree Cheebsumon
    Department of Radiology and Nuclear Medicine, VU University Medical Center, PO Box 7057, Amsterdam, 1007MB, The Netherlands
    EJNMMI Res 2:56. 2012
  2. pmc Effects of rigid and non-rigid image registration on test-retest variability of quantitative [18F]FDG PET/CT studies
    Floris Hp van Velden
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    EJNMMI Res 2:10. 2012
  3. pmc Comparison of oxygen-15 PET and transcranial Doppler CO2-reactivity measurements in identifying haemodynamic compromise in patients with symptomatic occlusion of the internal carotid artery
    Suzanne Persoon
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, G03, 232, Utrecht, Heidelberglaan 100, 3584 CX, The Netherlands
    EJNMMI Res 2:30. 2012
  4. pmc Reproducibility of quantitative (R)-[11C]verapamil studies
    Daniëlle Me van Assema
    Department of Neurology and Alzheimer Center, PK 1Z035, VU University Medical Center, P, O, Box 7057, Amsterdam 1007 MB, The Netherlands
    EJNMMI Res 2:1. 2012
  5. pmc Bone formation rather than inflammation reflects ankylosing spondylitis activity on PET-CT: a pilot study
    Stefan T G Bruijnen
    Department of Rheumatology, VU University Medical Center, De Boelelaan 1117, Amsterdam, 1081 HV, The Netherlands
    Arthritis Res Ther 14:R71. 2012
  6. pmc Measurement of metabolic tumor volume: static versus dynamic FDG scans
    Patsuree Cheebsumon
    Department of Nuclear Medicine and PET Research, VU University Medical Center, P, O, Box 7057, Amsterdam, 1007 MB, The Netherlands
    EJNMMI Res 1:35. 2011
  7. pmc Day-to-day test-retest variability of CBF, CMRO2, and OEF measurements using dynamic 15O PET studies
    Jochem P Bremmer
    Department of Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Mol Imaging Biol 13:759-68. 2011
  8. pmc Image derived input functions: effects of motion on tracer kinetic analyses
    Jurgen E M Mourik
    Department of Nuclear Medicine and PET Research, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Mol Imaging Biol 13:25-31. 2011
  9. pmc Increased cerebral (R)-[(11)C]PK11195 uptake and glutamate release in a rat model of traumatic brain injury: a longitudinal pilot study
    Hedy Folkersma
    Neurosurgical Center Amsterdam, VU University Medical Center, De Boelelaan 1117, NL 1081 HV Amsterdam, The Netherlands
    J Neuroinflammation 8:67. 2011
  10. pmc Impact of [¹⁸F]FDG PET imaging parameters on automatic tumour delineation: need for improved tumour delineation methodology
    Patsuree Cheebsumon
    Department of Nuclear Medicine and PET Research, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 38:2136-44. 2011

Detail Information

Publications95

  1. pmc Assessment of tumour size in PET/CT lung cancer studies: PET- and CT-based methods compared to pathology
    Patsuree Cheebsumon
    Department of Radiology and Nuclear Medicine, VU University Medical Center, PO Box 7057, Amsterdam, 1007MB, The Netherlands
    EJNMMI Res 2:56. 2012
    ..abstract:..
  2. pmc Effects of rigid and non-rigid image registration on test-retest variability of quantitative [18F]FDG PET/CT studies
    Floris Hp van Velden
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    EJNMMI Res 2:10. 2012
    ..abstract:..
  3. pmc Comparison of oxygen-15 PET and transcranial Doppler CO2-reactivity measurements in identifying haemodynamic compromise in patients with symptomatic occlusion of the internal carotid artery
    Suzanne Persoon
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, G03, 232, Utrecht, Heidelberglaan 100, 3584 CX, The Netherlands
    EJNMMI Res 2:30. 2012
    ..abstract:..
  4. pmc Reproducibility of quantitative (R)-[11C]verapamil studies
    Daniëlle Me van Assema
    Department of Neurology and Alzheimer Center, PK 1Z035, VU University Medical Center, P, O, Box 7057, Amsterdam 1007 MB, The Netherlands
    EJNMMI Res 2:1. 2012
    ..abstract:..
  5. pmc Bone formation rather than inflammation reflects ankylosing spondylitis activity on PET-CT: a pilot study
    Stefan T G Bruijnen
    Department of Rheumatology, VU University Medical Center, De Boelelaan 1117, Amsterdam, 1081 HV, The Netherlands
    Arthritis Res Ther 14:R71. 2012
    ..In a pilot setting, the potential of PET-CT in imaging AS activity was tested using different tracers, with Magnetic Resonance Imaging (MRI) and conventional radiographs as reference...
  6. pmc Measurement of metabolic tumor volume: static versus dynamic FDG scans
    Patsuree Cheebsumon
    Department of Nuclear Medicine and PET Research, VU University Medical Center, P, O, Box 7057, Amsterdam, 1007 MB, The Netherlands
    EJNMMI Res 1:35. 2011
    ..abstract:..
  7. pmc Day-to-day test-retest variability of CBF, CMRO2, and OEF measurements using dynamic 15O PET studies
    Jochem P Bremmer
    Department of Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Mol Imaging Biol 13:759-68. 2011
    ....
  8. pmc Image derived input functions: effects of motion on tracer kinetic analyses
    Jurgen E M Mourik
    Department of Nuclear Medicine and PET Research, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Mol Imaging Biol 13:25-31. 2011
    ..To quantify the effects of motion affected image-derived input functions (IDIF) on the outcome of tracer kinetic analyses...
  9. pmc Increased cerebral (R)-[(11)C]PK11195 uptake and glutamate release in a rat model of traumatic brain injury: a longitudinal pilot study
    Hedy Folkersma
    Neurosurgical Center Amsterdam, VU University Medical Center, De Boelelaan 1117, NL 1081 HV Amsterdam, The Netherlands
    J Neuroinflammation 8:67. 2011
    ..The aim of the present study was to investigate microglia activation over time following traumatic brain injury (TBI) and to relate these findings to glutamate release...
  10. pmc Impact of [¹⁸F]FDG PET imaging parameters on automatic tumour delineation: need for improved tumour delineation methodology
    Patsuree Cheebsumon
    Department of Nuclear Medicine and PET Research, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 38:2136-44. 2011
    ..e. reconstruction parameters, noise levels and tumour characteristics, and thereby the need for standardization or inter-institute calibration...
  11. pmc Measuring response to therapy using FDG PET: semi-quantitative and full kinetic analysis
    Patsuree Cheebsumon
    Department of Nuclear Medicine and PET Research, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 38:832-42. 2011
    ..The goal of this study was to analyse and compare various semi-quantitative measures for response assessment with full kinetic analysis, specifically in assessment of novel therapies...
  12. doi request reprint Methodological aspects of multicenter studies with quantitative PET
    Ronald Boellaard
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    Methods Mol Biol 727:335-49. 2011
    ..In this chapter, the main causes affecting whole-body FDG PET quantification and strategies to minimize its inter-institute variability are addressed...
  13. ncbi request reprint Evaluation of basis function and linear least squares methods for generating parametric blood flow images using 15O-water and Positron Emission Tomography
    Ronald Boellaard
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    Mol Imaging Biol 7:273-85. 2005
    ..In this paper the performance of basis function and linear least squares methods for generating parametric flow data were evaluated...
  14. doi request reprint Standards for PET image acquisition and quantitative data analysis
    Ronald Boellaard
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Med 50:11S-20S. 2009
    ..Special attention is given to the rationale underlying certain recommendations and to some of the differences in various guidelines...
  15. ncbi request reprint Optimization of attenuation correction for positron emission tomography studies of thorax and pelvis using count-based transmission scans
    R Boellaard
    Clinical PET Center, VU University Medical Centre, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Phys Med Biol 49:N31-8. 2004
    ....
  16. ncbi request reprint Effects of noise, image resolution, and ROI definition on the accuracy of standard uptake values: a simulation study
    Ronald Boellaard
    PET Center, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Med 45:1519-27. 2004
    ..Therefore, an experimental and simulation study was performed to determine the effects of noise, image resolution, and region-of-interest (ROI) definition on the accuracy of SUVs...
  17. doi request reprint Need for standardization of 18F-FDG PET/CT for treatment response assessments
    Ronald Boellaard
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Med 52:93S-100S. 2011
    ..This article provides an overview of the need for standardization in relation to the specific use of SUVs and SUV changes in studies of treatment response assessments...
  18. pmc FDG PET and PET/CT: EANM procedure guidelines for tumour PET imaging: version 1.0
    Ronald Boellaard
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 37:181-200. 2010
    ....
  19. ncbi request reprint Use of an in-field-of-view shield to improve count rate performance of the single crystal layer high-resolution research tomograph PET scanner for small animal brain scans
    R Boellaard
    PET Center, VU University Medical Center, Amsterdam, The Netherlands
    Phys Med Biol 48:N335-42. 2003
    ..The latter is especially important when high activities are required for tracers with low brain uptake or when multiple animals are scanned simultaneously...
  20. doi request reprint The Netherlands protocol for standardisation and quantification of FDG whole body PET studies in multi-centre trials
    Ronald Boellaard
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 35:2320-33. 2008
    ..Therefore, standardisation of 2-[(18)F] fluoro-2-deoxy-D-glucose (FDG) PET whole body procedures is required in multi-centre trials...
  21. ncbi request reprint Characterization of a single LSO crystal layer high resolution research tomograph
    R Boellaard
    PET Centre, VU University Medical Centre, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Phys Med Biol 48:429-48. 2003
    ..The low count rate performance, due to the small amount of LSO, prohibits studies of the human brain, but is sufficient for studies in small laboratory animals...
  22. ncbi request reprint Experimental and clinical evaluation of iterative reconstruction (OSEM) in dynamic PET: quantitative characteristics and effects on kinetic modeling
    R Boellaard
    Clinical PET Center, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    J Nucl Med 42:808-17. 2001
    ..However, OSEM does not provide accurate image-derived input functions for FDG cardiac PET studies because of bias in regions located within a hotter background...
  23. ncbi request reprint Quantitative 89Zr immuno-PET for in vivo scouting of 90Y-labeled monoclonal antibodies in xenograft-bearing nude mice
    Iris Verel
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Med 44:1663-70. 2003
    ..In this study, the biodistribution of (89)Zr-labeled and (88)Y-labeled mAb ((88)Y as substitute for (90)Y) was compared and the quantitative imaging performance of (89)Zr immuno-PET was evaluated...
  24. doi request reprint Pharmaceutical preparation of oxygen-15 labelled molecular oxygen and carbon monoxide gasses in a hospital setting
    G Luurtsema
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Clin Pharm Ther 35:63-9. 2010
    ..Conclusion: An 11 MeV proton cyclotron combined with an in-house developed gas delivery system allows for the production and administration of sufficient amounts of [(15)O]-gasses for routine clinical PET studies in an hospital setting...
  25. doi request reprint Radiation dosimetry of 89Zr-labeled chimeric monoclonal antibody U36 as used for immuno-PET in head and neck cancer patients
    Pontus K E Börjesson
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Med 50:1828-36. 2009
    ..In addition, the performance of immuno-PET for detecting lymph node metastases was evaluated, as described previously...
  26. ncbi request reprint Evaluation of reference regions for (R)-[(11)C]PK11195 studies in Alzheimer's disease and mild cognitive impairment
    Marc A Kropholler
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 27:1965-74. 2007
    ..Most anatomic regions outperformed cluster analysis in terms of absence of both scan rejection and bias. Total cerebellum is the optimal reference region in this patient category...
  27. ncbi request reprint Effects of ROI definition and reconstruction method on quantitative outcome and applicability in a response monitoring trial
    Nanda C Krak
    Clinical PET Centre, VU University Medical Centre, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 32:294-301. 2005
    ..The main purpose of this study was to determine the effects of different ROI methods on quantitative outcome, using two reconstruction methods and the standard uptake value (SUV) as a simple quantitative measure of FDG uptake...
  28. ncbi request reprint Long-lived positron emitters zirconium-89 and iodine-124 for scouting of therapeutic radioimmunoconjugates with PET
    Iris Verel
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Cancer Biother Radiopharm 18:655-61. 2003
    ..In such approach (124)I-labeled MAbs are most suitable for scouting of (131)I- and (186)Re-labeled MAbs...
  29. ncbi request reprint Quantification of FDG PET studies using standardised uptake values in multi-centre trials: effects of image reconstruction, resolution and ROI definition parameters
    Marinke Westerterp
    Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 34:392-404. 2007
    ..In this study we evaluated whether SUVs, obtained at three different institutes, may be directly compared after calibration and correction for inter-institute differences...
  30. ncbi request reprint Evaluation of methods for generating parametric (R-[11C]PK11195 binding images
    Alie Schuitemaker
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 27:1603-15. 2007
    ..In pathological conditions with reduced flow rates or large variations in blood volume, the basis function method is preferred because it produces less bias and is more precise...
  31. ncbi request reprint 89Zr immuno-PET: comprehensive procedures for the production of 89Zr-labeled monoclonal antibodies
    Iris Verel
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    J Nucl Med 44:1271-81. 2003
    ..In this article, practical protocols for reproducible isolation of highly pure (89)Zr and the production of optimal-quality mAb-(89)Zr conjugates are provided...
  32. ncbi request reprint High-quality 124I-labelled monoclonal antibodies for use as PET scouting agents prior to 131I-radioimmunotherapy
    Iris Verel
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 31:1645-52. 2004
    ....
  33. doi request reprint Differential association of [11C]PIB and [18F]FDDNP binding with cognitive impairment
    N Tolboom
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    Neurology 73:2079-85. 2009
    ....
  34. doi request reprint Quantification of (R)-[11C]PK11195 binding in rheumatoid arthritis
    M A Kropholler
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 36:624-31. 2009
    ..This study evaluated methods for the quantification of (R)-[(11)C]PK11195 binding in the knee joints of RA patients...
  35. ncbi request reprint Reduced GABAA benzodiazepine receptor binding in veterans with post-traumatic stress disorder
    E Geuze
    Research Centre Military Mental Healthcare, Ministry of Defense, Utrecht, The Netherlands
    Mol Psychiatry 13:74-83, 3. 2008
    ....
  36. ncbi request reprint Characteristics of a new fully programmable blood sampling device for monitoring blood radioactivity during PET
    R Boellaard
    Clinical PET Centre, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Eur J Nucl Med 28:81-9. 2001
    ..With the continuous blood sampler radioactivity in blood can be measured accurately during the entire course of the PET scan. Furthermore, the system is fully programmable allowing adjustment of all parameters during a single PET scan...
  37. ncbi request reprint Measurement of left ventricular volumes and function with O-15-labeled carbon monoxide gated positron emission tomography: comparison with magnetic resonance imaging
    Hadassa A Hofman
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Cardiol 12:639-44. 2005
    ..The aim of this study was to compare LV volumes and function as measured by routinely acquired blood pool images by use of gated O-15-labeled CO PET with the reference technique, cardiovascular magnetic resonance imaging (MRI)...
  38. ncbi request reprint Initial experience with a prototype dual-crystal (LSO/NaI) dual-head coincidence camera in oncology
    Urvi Joshi
    Department of Nuclear Medicine, VU University Medical Centre, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 31:596-8. 2004
    ..The diameter of these lesions was estimated to be 0.5-1 cm. Initial results justify further evaluation of LSO-PS in specific clinical situations, especially if a role as an instrument of triage for PET is foreseen...
  39. ncbi request reprint Image-derived input functions for determination of MRGlu in cardiac (18)F-FDG PET scans
    A P van der Weerdt
    Department of Cardiology and PET Center, Institute for Cardiovascular Research-VU, VU Medical Center, Amsterdam, The Netherlands
    J Nucl Med 42:1622-9. 2001
    ..CONCLUSION: The ascending aorta is the structure of choice for defining IDIF and a large ROI (diameter, approximately 15 mm) should be used to minimize the effects of statistical noise...
  40. doi request reprint Simplified parametric methods for [18F]FDDNP studies
    Maqsood Yaqub
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    Neuroimage 49:433-41. 2010
    ..Furthermore, in simulations, RPM2 and MRTM2 provided the most accurate and precise BP(ND) estimates. RPM2 and MRTM2 are the methods of choice for parametric analysis of [(18)F]FDDNP studies...
  41. doi request reprint Reproducibility of quantitative 18F-3'-deoxy-3'-fluorothymidine measurements using positron emission tomography
    Adrianus J de Langen
    Department of Respiratory Medicine, VU University Medical Centre, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 36:389-95. 2009
    ..For serial imaging in individual patients, good reproducibility is essential. The purpose of the present study was to evaluate the reproducibility of quantitative [(18)F]FLT measurements...
  42. doi request reprint Noninvasive imaging of macrophages in rheumatoid synovitis using 11C-(R)-PK11195 and positron emission tomography
    Conny J van der Laken
    VU University Medical Center, Amsterdam, The Netherlands
    Arthritis Rheum 58:3350-5. 2008
    ..We undertook this study to investigate whether rheumatoid synovitis can be visualized by PET using the tracer 11C-(R)-PK11195, which binds to peripheral benzodiazepine receptors (PBRs) on macrophages...
  43. doi request reprint Image-derived input functions for PET brain studies
    Jurgen E M Mourik
    Department of Nuclear Medicine and PET Research, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 36:463-71. 2009
    ..To assess the robustness of a previously introduced method to obtain accurate image-derived input functions (IDIF) for three other tracers...
  44. doi request reprint Reference tissue models and blood-brain barrier disruption: lessons from (R)-[11C]PK11195 in traumatic brain injury
    Hedy Folkersma
    Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Med 50:1975-9. 2009
    ..The purpose of this study was to assess the validity of the simplified reference tissue model for analyzing (R)-[(11)C]PK11195 studies in traumatic brain injury (TBI), where blood-brain barrier disruptions are likely...
  45. doi request reprint Reduced parahippocampal and lateral temporal GABAA-[11C]flumazenil binding in major depression: preliminary results
    Ursula M H Klumpers
    Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 37:565-74. 2010
    ..Although GABA has been suggested to inhibit HPA axis activity, their relationship has never been studied at the level of the central GABA(A)-benzodiazepine receptor in depressed patients or in relation to antidepressant treatment...
  46. ncbi request reprint Impact of wavelet based denoising of [11C](R)-PK11195 time activity curves on accuracy and precision of kinetic analysis
    Maqsood Yaqub
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Med Phys 35:5069-78. 2008
    ..Wavelet denoising of TACs for [11C](R)-PK11195 PET studies is therefore useful when parametric Logan based V(T) is the parameter of interest...
  47. doi request reprint Accuracy of 3-dimensional reconstruction algorithms for the high-resolution research tomograph
    Floris H P van Velden
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Med 50:72-80. 2009
    ..The goal of this study was to evaluate quantitative accuracy of these iterative reconstruction algorithms, compared with 3-dimensional filtered backprojection (3D-FBP)...
  48. doi request reprint Interim positron emission tomography scan in multi-center studies: optimization of visual and quantitative assessments
    Josee M Zijlstra
    Department of Hematology, VU University Medical Center, Amsterdam, The Netherlands
    Leuk Lymphoma 50:1748-9. 2009
    ..In the Netherlands, a protocol for standardization and quantification of FDG-PET whole body studies has been defined for the accurate use of SUVs in FDG-PET multi-center studies. Here, we report a summary of the main issues...
  49. pmc Evaluation of tracer kinetic models for analysis of [18F]FDDNP studies
    Maqsood Yaqub
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Mol Imaging Biol 11:322-33. 2009
    ..Different pharmacokinetic methods for [18F]FDDNP studies were evaluated using both simulations and clinical data...
  50. doi request reprint HRRT versus HR+ human brain PET studies: an interscanner test-retest study
    Floris H P van Velden
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Med 50:693-702. 2009
    ..7 mm and approximately 7.0 mm for HRRT and HR+, respectively)...
  51. pmc In vivo validation of reconstruction-based resolution recovery for human brain studies
    Jurgen E M Mourik
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 30:381-9. 2010
    ....
  52. doi request reprint Relationship of cerebrospinal fluid markers to 11C-PiB and 18F-FDDNP binding
    Nelleke Tolboom
    Departments of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Nucl Med 50:1464-70. 2009
    ....
  53. pmc Test-retest variability of quantitative [11C]PIB studies in Alzheimer's disease
    Nelleke Tolboom
    Departments of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 36:1629-38. 2009
    ....
  54. pmc Partial volume correction strategies for quantitative FDG PET in oncology
    Nikie J Hoetjes
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 37:1679-87. 2010
    ..The purpose of the present study was to assess accuracy and precision of different partial volume correction (PVC) methods...
  55. doi request reprint Simplified parametric methods for [11C]PIB studies
    Maqsood Yaqub
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Neuroimage 42:76-86. 2008
    ..RPM2 and MRTM2 also provided best accuracy and precision in the simulation studies and are therefore the methods of choice for parametric analysis of clinical [11C]PIB studies...
  56. doi request reprint Microglia activation in recent-onset schizophrenia: a quantitative (R)-[11C]PK11195 positron emission tomography study
    Bart N Van Berckel
    Department of Psychiatry, Rudolf Magnus Institute for Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 64:820-2. 2008
    ..Microglia activation can be quantified in vivo using (R)-[(11)C]PK11195 and positron emission tomography (PET). The purpose of this study was to investigate whether microglia activation occurs in patients with recent-onset schizophrenia...
  57. doi request reprint Comparison of 3D-OP-OSEM and 3D-FBP reconstruction algorithms for High-Resolution Research Tomograph studies: effects of randoms estimation methods
    Floris H P van Velden
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Phys Med Biol 53:3217-30. 2008
    ..In the case of 3D-FBP, VRR showed similar results as DW for both phantom and clinical data, except that VRR showed a better standard deviation of 6-10%. Therefore, VRR should be used to correct for randoms in HRRT PET studies...
  58. ncbi request reprint Performance of immuno-positron emission tomography with zirconium-89-labeled chimeric monoclonal antibody U36 in the detection of lymph node metastases in head and neck cancer patients
    Pontus K E Börjesson
    Department of Otolaryngology Head and Neck Surgery, Nuclear Medicine and Positron Emission Tomography Research, Radiology, Amsterdam, The Netherlands
    Clin Cancer Res 12:2133-40. 2006
    ....
  59. ncbi request reprint Evaluation of reference tissue models for the analysis of [11C](R)-PK11195 studies
    Marc A Kropholler
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 26:1431-41. 2006
    ..82 and 0.78, respectively). SRTM(pl_corr) is optimal when an arterial plasma input curve is available. Simplified reference tissue model is the best alternative when no plasma input is available...
  60. ncbi request reprint Delayed contrast enhancement and perfusable tissue index in hypertrophic cardiomyopathy: comparison between cardiac MRI and PET
    Paul Knaapen
    Department of Cardiology, 6D 120 VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    J Nucl Med 46:923-9. 2005
    ..The present study compares the perfusable tissue index (PTI), an alternative marker of myocardial fibrosis obtained by PET, with DCE-CMR in HCM...
  61. ncbi request reprint Development of a tracer kinetic plasma input model for (R)-[11C]PK11195 brain studies
    Marc A Kropholler
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 25:842-51. 2005
    ..It was concluded that a two-tissue reversible compartment model with K(1)/k(2) fixed to whole cortex value is optimal for analyzing (R)-[(11)C]PK11195 PET brain studies...
  62. ncbi request reprint Amygdala activity in obsessive-compulsive disorder with contamination fear: a study with oxygen-15 water positron emission tomography
    Odile A van den Heuvel
    Department of Psychiatry, VU University Medical Center and GGZ Buitenamstel, Valeriusplein 9, 1075 BG Amsterdam, The Netherlands
    Psychiatry Res 132:225-37. 2004
    ..The findings of the present study are consistent with the hypothesis of decreased frontal-striatal control of limbic structures, specifically the amygdala, resulting in an inadequate fear response in OCD patients with contamination fear...
  63. ncbi request reprint Quantitative comparison of analytic and iterative reconstruction methods in 2- and 3-dimensional dynamic cardiac 18F-FDG PET
    Mark Lubberink
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, 1700 MB Amsterdam, The Netherlands
    J Nucl Med 45:2008-15. 2004
    ....
  64. ncbi request reprint Perfusable tissue index as a potential marker of fibrosis in patients with idiopathic dilated cardiomyopathy
    Paul Knaapen
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Med 45:1299-304. 2004
    ..Measurements of the PTI in DCM, however, have not been performed yet. This study was undertaken to test the hypothesis that the PTI is reduced in patients with DCM...
  65. ncbi request reprint Validation of a multiwell gamma-counter for measuring high-pressure liquid chromatography metabolite profiles
    Henri N J M Greuter
    PET Center, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Med Technol 32:28-32. 2004
    ..Fraction collector obtained HPLC samples that are counted in a separate high-sensitivity well counter can be an alternative to overcome poor counting statistics...
  66. ncbi request reprint Postinjection transmission scanning in myocardial 18F-FDG PET studies using both filtered backprojection and iterative reconstruction
    Arno P van der Weerdt
    Department of Cardiology, Room 6N120, Institute for Cardiovascular Research VU, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    J Nucl Med 45:169-75. 2004
    ..An additional aim of this study was to compare images reconstructed with both standard filtered backprojection (FBP) and an iterative reconstruction algorithm (ordered-subset maximization expectation [OSEM])...
  67. ncbi request reprint The perfusable tissue index: a marker of myocardial viability
    Paul Knaapen
    Department of Cardiology, University Medical Center, Amsterdam, The Netherlands
    J Nucl Cardiol 10:684-91. 2003
  68. ncbi request reprint Measurement of 18F-FDG concentrations in blood samples: comparison of direct calibration and standard solution methods
    Henri N J M Greuter
    PET Center, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    J Nucl Med Technol 31:206-9. 2003
    ..The purpose of this study was to compare the accuracy and reliability of 2 well counter methods for measuring the activity concentration of (18)F-FDG in blood samples...
  69. ncbi request reprint Attenuation correction of PET activation studies in the presence of task-related motion
    Odile A van den Heuvel
    Clinical PET Centre, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Neuroimage 19:1501-9. 2003
    ..Therefore, in our view, the IR method should be considered as a first choice for attenuation correction in PET activation studies...
  70. ncbi request reprint Experimental evaluation of iterative reconstruction versus filtered back projection for 3D [15O]water PET activation studies using statistical parametric mapping analysis
    Catalina T Mesina
    PET Center, VU University Medical Center, Amsterdam, The Netherlands
    Neuroimage 19:1170-9. 2003
    ..In conclusion, for PET activation studies use of OSEM4 x 16 seems to give the best tradeoff between signal detection and noise reduction...
  71. ncbi request reprint Matching PET and CT scans of the head and neck area: development of method and validation
    Bianca M Klabbers
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Med Phys 29:2230-8. 2002
    ....
  72. ncbi request reprint Evaluation of tracer kinetic models for quantification of P-glycoprotein function using (R)-[11C]verapamil and PET
    Mark Lubberink
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 27:424-33. 2007
    ....
  73. ncbi request reprint Hyperaemic microvascular resistance is not increased in viable myocardium after chronic myocardial infarction
    Koen M Marques
    Department of Cardiology, VU University Medical Centre, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Eur Heart J 28:2320-5. 2007
    ..The present study compared microvascular resistance (MR) of viable myocardium in infarct areas with those in reference areas in patients with chronic myocardial infarction (MI)...
  74. ncbi request reprint Does myocardial fibrosis hinder contractile function and perfusion in idiopathic dilated cardiomyopathy? PET and MR imaging study
    Paul Knaapen
    Department of Cardiology, VU University Medical Center, De Boelelaan 1117, Room 6D 120, 1081 HV Amsterdam, The Netherlands
    Radiology 240:380-8. 2006
    ....
  75. ncbi request reprint Effects of attenuation correction and reconstruction method on PET activation studies
    Catalina T Mesina
    PET Center, VU University Medical Center, Amsterdam, The Netherlands
    Neuroimage 20:898-908. 2003
    ..It is concluded that OSEM is a good alternative for FBP reconstructions providing SPM results with less noise...
  76. ncbi request reprint Microvascular function in viable myocardium after chronic infarction does not influence fractional flow reserve measurements
    Koen M Marques
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Med 48:1987-92. 2007
    ..Therefore, the correlation between FFR and RFR using H(2)(15)O PET was studied...
  77. ncbi request reprint Partial volume corrected image derived input functions for dynamic PET brain studies: methodology and validation for [11C]flumazenil
    Jurgen E M Mourik
    Department of Nuclear Medicine and PET Research, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Neuroimage 39:1041-50. 2008
    ..The proposed method appears to be suitable for analysing [(11)C]flumazenil data without the need for online arterial sampling...
  78. ncbi request reprint SPM analysis of parametric (R)-[11C]PK11195 binding images: plasma input versus reference tissue parametric methods
    Alie Schuitemaker
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, P O Box 7057, 1081 MB Amsterdam, The Netherlands
    Neuroimage 35:1473-9. 2007
    ..Vd images could only demonstrate differences in (R)-[11C]PK11195 binding when analysed with proportional scaling due to intersubject variation in K1/k2 (blood-brain barrier transport and non-specific binding)...
  79. ncbi request reprint Accuracy of 3D acquisition mode for myocardial FDG PET studies using a BGO-based scanner
    Arno P van der Weerdt
    Department of Cardiology, Institute for Cardiovascular Research VU, VU University Medical Centre, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 34:1439-46. 2007
    ..The aim of the present study was to evaluate the quantitative and qualitative accuracy of 3D PET acquisitions for myocardial FDG studies...
  80. ncbi request reprint Performance evaluation of the ECAT HRRT: an LSO-LYSO double layer high resolution, high sensitivity scanner
    Hugo W A M de Jong
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    Phys Med Biol 52:1505-26. 2007
    ..2 cm. A high quantitative agreement was met between HR+ and HRRT clinical data. In conclusion, the ECAT HRRT has excellent resolution and sensitivity properties, which is a crucial advantage in many research studies...
  81. ncbi request reprint Determinants of coronary microvascular dysfunction in symptomatic hypertrophic cardiomyopathy
    Paul Knaapen
    Department of Cardiology, VU University Medical Center, Institute for Cardiovascular Research, Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 294:H986-93. 2008
    ..These observations suggest that, in addition to reduced capillary density caused by hypertrophy, extravascular compressive forces contribute to microvascular dysfunction in HCM patients...
  82. doi request reprint Impact of attenuation correction strategies on the quantification of High Resolution Research Tomograph PET studies
    Floris H P van Velden
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    Phys Med Biol 53:99-118. 2008
    ..Using NEC-TR with segmentation or MAP-TR with an adjusted human brain prior showed less overestimation in both skull thickness and AC for these structures and are therefore the recommended methods for human brain studies...
  83. ncbi request reprint Quantification of dopamine transporter binding using [18F]FP-beta-CIT and positron emission tomography
    Maqsood Yaqub
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 27:1397-406. 2007
    ..SRTM is therefore the method of choice for quantitative [18F]FP-beta-CIT studies. SUVr might be an alternative for larger clinical trials...
  84. ncbi request reprint Optimization algorithms and weighting factors for analysis of dynamic PET studies
    Maqsood Yaqub
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    Phys Med Biol 51:4217-32. 2006
    ....
  85. ncbi request reprint Comparison of plasma input and reference tissue models for analysing [(11)C]flumazenil studies
    Ursula M H Klumpers
    Department of Psychiatry, VU University Medical Centre, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 28:579-87. 2008
    ..No fits were rejected using pons as reference tissue. Pons produced 23% higher BP(ND) values than white matter. In conclusion, for most clinical studies, SRTM with pons as reference tissue can be used for quantifying [(11)C]FMZ binding...
  86. ncbi request reprint (R)- and (S)-[11C]verapamil as PET-tracers for measuring P-glycoprotein function: in vitro and in vivo evaluation
    G Luurtsema
    PET Centre, VU University Medical Centre, Amsterdam, The Netherlands
    Nucl Med Biol 30:747-51. 2003
    ..Since (R)- and (S)-verapamil have equal transport for P-gp, the (R)-enantiomer seems to be the best and safest candidate as PET-tracer for measuring P-gp function in vivo...
  87. doi request reprint Importance of fluorodeoxyglucose-positron emission tomography (FDG-PET) and endoscopic ultrasonography parameters in predicting survival following surgery for esophageal cancer
    J M T Omloo
    Department of Surgery, Academic Medical Centre at the University of Amsterdam, Amsterdam, The Netherlands
    Endoscopy 40:464-71. 2008
    ..To assess the prognostic importance of standardized uptake value (SUV) for 18F-fluorodeoxyglucose (FDG) at positron emission tomography (PET) and of EUS parameters, in esophageal cancer patients primarily treated by surgery...
  88. doi request reprint CT-perfusion versus [(15)O]H2O PET in lung tumors: Effects of CT-perfusion methodology
    G M Kramer
    Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam 1081 HZ, The Netherlands
    Med Phys 40:052502. 2013
    ..This suggests that CTP can be used as a method to evaluate tumor perfusion in lung cancer...
  89. ncbi request reprint Impact of scar on water-perfusable tissue index in chronic ischemic heart disease: Evaluation with PET and contrast-enhanced MRI
    Paul Knaapen
    Department of Cardiology, 6D 120, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Mol Imaging Biol 8:245-51. 2006
    ..In addition, the optimal PTI threshold for detection of myocardial viability was defined when DCE-MRI was taken as a reference...
  90. ncbi request reprint Standardised FDG uptake: a prognostic factor for inoperable non-small cell lung cancer
    Gerben R Borst
    Department of Radiation Oncology, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Eur J Cancer 41:1533-41. 2005
    ....
  91. ncbi request reprint Population pharmacokinetic analysis for simultaneous determination of B (max) and K (D) in vivo by positron emission tomography
    Lia C Liefaard
    Division of Pharmacology, LACDR, Leiden University, P O Box 9502, 2300 RA, Leiden, The Netherlands
    Mol Imaging Biol 7:411-21. 2005
    ..A novel approach, using positron emission tomography (PET) and [C-11]flumazenil ([C-11]FMZ), was developed for simultaneous estimation of GABA(A)-receptor properties, characterized by B (max) and K (D)...
  92. ncbi request reprint Quantification of subendocardial and subepicardial blood flow using 15O-labeled water and PET: experimental validation
    Ornella Rimoldi
    Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, London, United Kingdom
    J Nucl Med 47:163-72. 2006
    ....
  93. doi request reprint Gap filling strategies for 3-D-FBP reconstructions of High-Resolution Research Tomograph scans
    Floris H P van Velden
    Department of Nuclear Medicine and PET Research, VU University Medical Center, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    IEEE Trans Med Imaging 27:934-42. 2008
    ..Therefore, use of confosp for filling sinogram gaps with both iterative and noniterative estimation of missing planes are recommended for quantitative 3-D-FBP of HRRT studies...
  94. ncbi request reprint 18FDG uptake in oesophageal adenocarcinoma: linking biology and outcome
    Marinke Westerterp
    Department of Surgery, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Cancer Res Clin Oncol 134:227-36. 2008
    ..The aim of the present study was to investigate biological parameters involved in 18FDG uptake in oesophageal adenocarcinoma for selection of patients with increased 18FDG uptake and prediction of prognostic value of 18FDG PET...
  95. ncbi request reprint Monitoring of response to pre-operative chemoradiation in combination with hyperthermia in oesophageal cancer by FDG-PET
    Marinke Westerterp
    Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Int J Hyperthermia 22:149-60. 2006
    ....