Research Topics
Genomes and GenesSpecies | Zoltan BochdanovitsSummaryAffiliation: VU University Medical Center Country: The Netherlands Publications
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Detail Information
Publications
Empirical assessment of the validity of the 'fundamental theorem of the HapMap' in the light of 'cryptic' tagging of multiple susceptibility lociZoltan Bochdanovits
Section Medical Genomics, Department of Clinical Genetics, VUMC, Amsterdam, The Netherlands
Eur J Hum Genet 16:525-9. 2008..On the basis of our results, a safe bet is to use a sample that is 10% larger than otherwise deemed necessary...
Genome-wide prediction of functional gene-gene interactions inferred from patterns of genetic differentiation in mice and menZoltan Bochdanovits
Section Medical Genomics, Department of Clinical Genetics, Vrije Universiteit Medisch Centrum VUMC, Amsterdam, The Netherlands
PLoS ONE 3:e1593. 2008....- A Functional polymorphism under positive evolutionary selection in ADRB2 is associated with human intelligence with opposite effects in the young and the elderlyZoltan Bochdanovits
Department of Clinical Genetics, Section of Medical Genomics, VU Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
Behav Genet 39:15-23. 2009..This result illustrates the relevance of comparative genomics to detect genes that are involved in human behavior... - A fine-mapping study of 7 top scoring genes from a GWAS for major depressive disorderEva C Verbeek
Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands
PLoS ONE 7:e37384. 2012..9E-7 but was not genome wide significant. Although our study did not identify a more strongly associated variant, the results for PCLO suggest that the causal variant is in high LD with rs2715147, rs2715148 and rs2522833... - Variation at GRN 3'-UTR rs5848 is not associated with a risk of frontotemporal lobar degeneration in Dutch populationJavier Simon-Sanchez
Department of Clinical Genetics, Section of Medical Genomics, VU University Medical Centre, Amsterdam, The Netherlands
PLoS ONE 4:e7494. 2009.... - Global similarity with local differences in linkage disequilibrium between the Dutch and HapMap-CEU populationsLuba Pardo
Medical Genomics Section, Department of Clinical Genetics, Vrije University Medical Center, Amsterdam, The Netherlands
Eur J Hum Genet 17:802-10. 2009..This poor concordance in LD block structure suggests that large samples are required for robust estimations of local LD block structure in populations... - Transcriptional plasticity of a soil arthropod across different ecological conditionsTjalf E de Boer
Department of Ecological Science, VU University, Amsterdam, The Netherlands
Mol Ecol 20:1144-54. 2011..candida strongly responds. The broad range of conditions over which this soil-living detritivore is able to survive and reproduce, indicates a strategy of high plasticity, which comes with extensive gene expression regulation... - Glucocorticoid receptor gene polymorphisms and childhood adversity are associated with depression: New evidence for a gene-environment interactionPierre M Bet
Department of Clinical Pharmacology and Pharmacy, VU University Medical Center, Amsterdam, The Netherlands
Am J Med Genet B Neuropsychiatr Genet 150:660-9. 2009..This G x E interaction also influenced HPA-axis markers providing support for the involvement of the HPA-axis in both stress regulation and the pathogenesis of depression... - Adaptive differences in gene expression associated with heavy metal tolerance in the soil arthropod Orchesella cinctaDick Roelofs
Institute of Ecological Science, VU University Amsterdam, Amsterdam, The Netherlands
Mol Ecol 18:3227-39. 2009..We confirmed the micro-evolutionary processes occurring in soil arthropod populations and suggest a major contribution of gene regulation to the evolution of a stress-adapted phenotype... - Genome-wide association study confirms extant PD risk loci among the DutchJavier Simon-Sanchez
Department of Clinical Genetics, Section of Medical Genomics, VU University Medical Centre, Amsterdam, The Netherlands
Eur J Hum Genet 19:655-61. 2011..22 × 10(-4), OR = 1.51; HLA, rs4248166: P = 4.39 × 10(-5), OR = 1.36; and MAPT, rs3785880: P = 1.9 × 10(-3), OR = 1.19)... - The complete automation of cell culture: improvements for high-throughput and high-content screeningShushant Jain
VUMC Clinical Genetics, Amsterdam, The Netherlands
J Biomol Screen 16:932-9. 2011..The authors demonstrate that such a system is able to successfully maintain different cell lines in culture for extended periods of time as well as significantly increasing throughput, accuracy, and reproducibility of HT and HC screens... - Cervical dystonia and genetic common variation in the dopamine pathwayJustus L Groen
Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Parkinsonism Relat Disord 19:346-9. 2013..Possibly, risk alleles in this pathway may be rarer than detectable in this study, or might be located in downstream dopamine signaling pathway. Alternatively, found dopamine level changes are secondary to the dystonia disease processes... - Do consanguineous parents of a child affected by an autosomal recessive disease have more DNA identical-by-descent than similarly-related parents with healthy offspring? Design of a case-control studyMarieke E Teeuw
Department of Clinical Genetics, Section Community Genetics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
BMC Med Genet 11:113. 2010.... - Comprehensive mRNA expression profiling distinguishes tauopathies and identifies shared molecular pathwaysIraad F Bronner
Section Medical Genomics, Department of Clinical Genetics, VU University Medical Center, and Center for Neurogenomics and Cognitive Research, VU University Medical Center and VU University, Amsterdam, The Netherlands
PLoS ONE 4:e6826. 2009....