F Barkhof

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. ncbi Imaging of white matter lesions
    Frederik Barkhof
    Department of Radiology, Vrije University Medical Centre, Amsterdam, The Netherlands
    Cerebrovasc Dis 13:21-30. 2002
  2. ncbi Predicting gadolinium enhancement status in MS patients eligible for randomized clinical trials
    F Barkhof
    Department of Radiology, VU Medical Centre, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Neurology 65:1447-54. 2005
  3. ncbi The significance of medial temporal lobe atrophy: a postmortem MRI study in the very old
    F Barkhof
    Department of Radiology, VU University Medical Centre, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Neurology 69:1521-7. 2007
  4. doi MRI monitoring of immunomodulation in relapse-onset multiple sclerosis trials
    Frederik Barkhof
    VU University Medical Centre, Amsterdam, The Netherlands
    Nat Rev Neurol 8:13-21. 2012
  5. doi An MRI rating scale for amyloid-related imaging abnormalities with edema or effusion
    F Barkhof
    Image Analysis Centre, Department of Radiology, VU University Medical Center, Amsterdam, The Netherlands
    AJNR Am J Neuroradiol 34:1550-5. 2013
  6. pmc Disturbed oscillatory brain dynamics in subcortical ischemic vascular dementia
    Elisabeth C W van Straaten
    Department of Clinical Neurophysiology, VU University Medical Center, De Boelelaan 1118, Amsterdam, 1081 HV, Netherlands
    BMC Neurosci 13:85. 2012
  7. pmc Visual assessment of posterior atrophy development of a MRI rating scale
    Esther L G E Koedam
    Department of Neurology and Alzheimer Centre, VU University Medical Centre, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Eur Radiol 21:2618-25. 2011
  8. pmc MRI characteristics are predictive for CDMS in monofocal, but not in multifocal patients with a clinically isolated syndrome
    Jessica M Nielsen
    MS Center, Department of Neurology, VU Medical Center, Amsterdam, The Netherlands
    BMC Neurol 9:19. 2009
  9. doi Imaging outcomes for neuroprotection and repair in multiple sclerosis trials
    Frederik Barkhof
    Department of Radiology and Amsterdam MS Center, VU University Medical Center, Amsterdam, The Netherlands
    Nat Rev Neurol 5:256-66. 2009
  10. ncbi Whole-brain T1-relaxation time measurements in multiple sclerosis
    Frederik Barkhof
    MR MS Center, Department of Radiology, VU Medical Center, Amsterdam, The Netherlands
    J Neurol 249:1451-2. 2002

Collaborators

Detail Information

Publications183 found, 100 shown here

  1. ncbi Imaging of white matter lesions
    Frederik Barkhof
    Department of Radiology, Vrije University Medical Centre, Amsterdam, The Netherlands
    Cerebrovasc Dis 13:21-30. 2002
    ..Spinal cord lesions are very common in MS, but do not occur in normal ageing nor in small vessel disease...
  2. ncbi Predicting gadolinium enhancement status in MS patients eligible for randomized clinical trials
    F Barkhof
    Department of Radiology, VU Medical Centre, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Neurology 65:1447-54. 2005
    ..Knowledge about predictors of enhancement status is important for the selection of patients for MRI monitored trials...
  3. ncbi The significance of medial temporal lobe atrophy: a postmortem MRI study in the very old
    F Barkhof
    Department of Radiology, VU University Medical Centre, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Neurology 69:1521-7. 2007
    ..Medial temporal lobe atrophy (MTA) is a sensitive radiologic marker for Alzheimer disease (AD) and associated with cognitive impairment. The value of MTA in the oldest old (>85 years old) is largely unknown...
  4. doi MRI monitoring of immunomodulation in relapse-onset multiple sclerosis trials
    Frederik Barkhof
    VU University Medical Centre, Amsterdam, The Netherlands
    Nat Rev Neurol 8:13-21. 2012
    ..Finally, we address safety considerations in the use of MRI in MS trials, and the safety-related responsibilities of the various parties involved in conducting such trials...
  5. doi An MRI rating scale for amyloid-related imaging abnormalities with edema or effusion
    F Barkhof
    Image Analysis Centre, Department of Radiology, VU University Medical Center, Amsterdam, The Netherlands
    AJNR Am J Neuroradiol 34:1550-5. 2013
    ..To assess the intensity of ARIA-E presentation, an MR imaging scale that is both reproducible and easily implemented would assist in monitoring and evaluating this adverse event...
  6. pmc Disturbed oscillatory brain dynamics in subcortical ischemic vascular dementia
    Elisabeth C W van Straaten
    Department of Clinical Neurophysiology, VU University Medical Center, De Boelelaan 1118, Amsterdam, 1081 HV, Netherlands
    BMC Neurosci 13:85. 2012
    ....
  7. pmc Visual assessment of posterior atrophy development of a MRI rating scale
    Esther L G E Koedam
    Department of Neurology and Alzheimer Centre, VU University Medical Centre, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Eur Radiol 21:2618-25. 2011
    ..To develop a visual rating scale for posterior atrophy (PA) assessment and to analyse whether this scale aids in the discrimination between Alzheimer's disease (AD) and other dementias...
  8. pmc MRI characteristics are predictive for CDMS in monofocal, but not in multifocal patients with a clinically isolated syndrome
    Jessica M Nielsen
    MS Center, Department of Neurology, VU Medical Center, Amsterdam, The Netherlands
    BMC Neurol 9:19. 2009
    ..Here we assess the predictive value of clinically defined dissemination in space at first presentation for time to clinically definite MS (CDMS)...
  9. doi Imaging outcomes for neuroprotection and repair in multiple sclerosis trials
    Frederik Barkhof
    Department of Radiology and Amsterdam MS Center, VU University Medical Center, Amsterdam, The Netherlands
    Nat Rev Neurol 5:256-66. 2009
    ..Power calculations show that these outcome measures can be applied with attainable sample sizes...
  10. ncbi Whole-brain T1-relaxation time measurements in multiple sclerosis
    Frederik Barkhof
    MR MS Center, Department of Radiology, VU Medical Center, Amsterdam, The Netherlands
    J Neurol 249:1451-2. 2002
  11. pmc The Holy Grail in diagnostic neuroradiology: 3T or 3D?
    Frederik Barkhof
    Eur Radiol 21:449-56. 2011
    ....
  12. doi MRI--the perfect surrogate marker for multiple sclerosis?
    Frederik Barkhof
    MS Center Amsterdam and Department of Radiology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Nat Rev Neurol 5:182-3. 2009
    ..Many short-term studies fail to appreciate the relationship between MRI and clinical findings, although such shortcomings might be argued to reflect a weakness of clinical measures, rather than of MRI...
  13. ncbi Validation of diagnostic magnetic resonance imaging criteria for multiple sclerosis and response to interferon beta1a
    Frederik Barkhof
    MS MRI Centre and Department of Radiology, VU Medical Centre, Amsterdam, The Netherlands
    Ann Neurol 53:718-24. 2003
    ..6 in patients with four positive criteria. However, the study was not powered to detect statistically significant treatment by variable interaction, and this remains an important issue for further study...
  14. ncbi Guidelines for brain imaging in vascular dementia clinical trials
    Frederik Barkhof
    Image Analysis Centre, VU Medical Centre, Amsterdam, The Netherlands
    Int Psychogeriatr 15:273-6. 2003
    ..In clinical trials, standardized acquisition protocols and central data analysis are mandatory. More work is needed to determine the natural progression in VaD and the possible use of MRI-based outcome measures...
  15. ncbi Remyelinated lesions in multiple sclerosis: magnetic resonance image appearance
    Frederik Barkhof
    Dutch MR MS Center, and Department of Radiology, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Arch Neurol 60:1073-81. 2003
    ..Various types of pathologic mechanisms in multiple sclerosis (MS) can alter magnetic resonance imaging (MRI) signals, and the appearance of remyelinated lesions on MRI is largely unknown...
  16. ncbi Assessing treatment effects on axonal loss--evidence from MRI monitored clinical trials
    Frederik Barkhof
    Department of Diagnostic Radiology, VU Medical Centre, De Boelelaan 1117, 7057, Amsterdam 1007 MB, The Netherlands
    J Neurol 251:IV6-12. 2004
    ..At the same time it illustrates the difficulties in understanding the mechanisms leading to axonal loss and persistent clinical deficit...
  17. ncbi Magnetic resonance imaging effects of interferon beta-1b in the BENEFIT study: integrated 2-year results
    Frederik Barkhof
    Department of Diagnostic Radiology and Image Analysis Center, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Arch Neurol 64:1292-8. 2007
    ....
  18. doi Ibudilast in relapsing-remitting multiple sclerosis: a neuroprotectant?
    F Barkhof
    Department of Radiology, VU University Medical Center, MB, Amsterdam, The Netherlands
    Neurology 74:1033-40. 2010
    ..This study evaluated the safety, tolerability, and effects on MRI parameters of 2 different doses of ibudilast in relapsing forms of MS...
  19. ncbi The clinico-radiological paradox in multiple sclerosis revisited
    Frederik Barkhof
    MR MS Center, Department of Radiology, VU Medical Center, 1007 MB Amsterdam, The Netherlands
    Curr Opin Neurol 15:239-45. 2002
    ..This corroborates with conventional wisdom that one should not rely on a single magnetic resonance measure, but take full advantage of the fact that magnetic resonance is able to provide multidimensional information...
  20. ncbi Hypointense lesions on T1-weighted spin-echo magnetic resonance imaging: relation to clinical characteristics in subgroups of patients with multiple sclerosis
    M A van Walderveen
    Magnetic Resonance Center for Multiple Sclerosis Research, University Hospital Vrije Universiteit, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Arch Neurol 58:76-81. 2001
    ..Clinical determinants of T1 lesions may differ between subgroups of patients with MS and subsequently may have implications for the selection of patients for clinical trials...
  21. ncbi Baseline predictors of rates of hippocampal atrophy in mild cognitive impairment
    L A van de Pol
    Department of Neurology, Alzheimer Centre, VU Medical Centre, Amsterdam, The Netherlands
    Neurology 69:1491-7. 2007
    ..We compared baseline clinical, neuropsychological, and MRI measures to characterize these MCI subgroups...
  22. pmc Baseline CSF p-tau levels independently predict progression of hippocampal atrophy in Alzheimer disease
    W J P Henneman
    Department of Radiology and Alzheimer Center, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Neurology 73:935-40. 2009
    ....
  23. doi Whole-brain atrophy rate in Alzheimer disease: identifying fast progressors
    J D Sluimer
    Department of Radiology and Alzheimer Centre, Vrije Universiteit Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Neurology 70:1836-41. 2008
    ..To assess which baseline clinical and MRI measures influence whole-brain atrophy rates, measured from serial MR imaging...
  24. doi New research criteria for the diagnosis of Alzheimer's disease applied in a memory clinic population
    F H Bouwman
    Alzheimer Center and Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 30:1-7. 2010
    ..This study applies the criteria in a memory clinic population, using clinical criteria as the reference criterion...
  25. ncbi [Alpha]B-crystallin genotype has impact on the multiple sclerosis phenotype
    T van Veen
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 61:1245-9. 2003
    ..Alpha]B-crystallin is a candidate autoantigen in MS, and there are three polymorphisms in the promoter region of the encoding gene (CRYAB): at positions -C249G, -C650G, and -A652G...
  26. pmc CSF biomarkers in frontotemporal lobar degeneration: relations with clinical characteristics, apolipoprotein E genotype, and neuroimaging
    Y A L Pijnenburg
    Alzheimer Center, Department of Neurology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 77:246-8. 2006
    ..CSF Abeta42 variability remained unexplained. Future research could study the role of ApoE genotype and Abeta42 in FTLD, as well as establish measures for disease intensity...
  27. pmc Hippocampal atrophy rates in Alzheimer disease: added value over whole brain volume measures
    W J P Henneman
    Department of Radiology, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 72:999-1007. 2009
    ..To investigate the added value of hippocampal atrophy rates over whole brain volume measurements on MRI in patients with Alzheimer disease (AD), patients with mild cognitive impairment (MCI), and controls...
  28. ncbi Predicting short-term disability progression in early multiple sclerosis: added value of MRI parameters
    A Minneboo
    MS Center of the VU University Medical Center, Department of Radiology, VU University Medical Center, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 79:917-23. 2008
    ..The aim of this study was to investigate whether adding MRI parameters to a model with only clinical parameters could improve these associations...
  29. ncbi Raloxifene exposure enhances brain activation during memory performance in healthy elderly males; its possible relevance to behavior
    R Goekoop
    Department of Neurology, VU University Medical Center, De Boelelaan 1117 1081 HV, Amsterdam, The Netherlands
    Neuroimage 25:63-75. 2005
    ..Further neuropsychological assessment is necessary to test the validity of these predictions...
  30. doi Postmortem verification of MS cortical lesion detection with 3D DIR
    A Seewann
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 78:302-8. 2012
    ..To assess the sensitivity and specificity of 3D double inversion recovery (DIR) MRI for detecting multiple sclerosis (MS) cortical lesions (CLs) using a direct postmortem MRI to histopathology comparison...
  31. doi Increased plasma 8,12-iso-iPF2alpha- VI levels in relapsing multiple sclerosis patients are not predictive of disease progression
    C E Teunissen
    Department of Clinical Chemistry, VU University Medical Center, The Netherlands
    Mult Scler 18:1092-8. 2012
    ..Oxidative stress plays an important role in multiple sclerosis (MS). Isoprostanes are biomarkers for oxidative stress and have been related to neurological disease progression...
  32. ncbi Incidence of cerebral microbleeds: a longitudinal study in a memory clinic population
    J D C Goos
    Alzheimer Center and Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 74:1954-60. 2010
    ..Cerebral microbleeds (MBs) are commonly observed in memory clinic patients. Little is known about occurrence of and risk factors for developing new MBs in this population...
  33. ncbi Magnetization transfer ratio measurement in multiple sclerosis normal-appearing brain tissue: limited differences with controls but relationships with clinical and MR measures of disease
    H Vrenken
    Department of Radiology, MR Center for MS Research, VU University Medical Center, Amsterdam, The Netherlands
    Mult Scler 13:708-16. 2007
    ..We conclude that disease-induced MTR changes were small in MS NAWM and NAGM, but did correlate with clinical decline, lesion volume and overall cerebral atrophy...
  34. ncbi CSF biomarkers and medial temporal lobe atrophy predict dementia in mild cognitive impairment
    F H Bouwman
    Department of Neurology, Alzheimer Centre, VU Medical Center, MB Amsterdam, The Netherlands
    Neurobiol Aging 28:1070-4. 2007
    ..To study CSF biomarkers, beta-amyloid(1-42) (Abeta(1-42)) and tau, and medial temporal lobe atrophy (MTA) on MRI in their ability to predict dementia in patients with mild cognitive impairment (MCI)...
  35. doi Accumulation of cortical lesions in MS: relation with cognitive impairment
    S D Roosendaal
    Department of Radiology, MS Center Amsterdam, VU University Medical Center, The Netherlands
    Mult Scler 15:708-14. 2009
    ..However, little is known about progression of GM lesions over time...
  36. ncbi Multiple sclerosis: Neurofilament light chain antibodies are correlated to cerebral atrophy
    M J Eikelenboom
    Department of Neurology, VU Medical Center, Amsterdam, The Netherlands
    Neurology 60:219-23. 2003
    ..To evaluate markers of axonal damage in CSF and serum of patients with different subtypes of MS in relation to measures of disease progression on MRI...
  37. ncbi Improved reliability of hippocampal atrophy rate measurement in mild cognitive impairment using fluid registration
    L A van de Pol
    Department of Neurology, Alzheimer Centre, VU Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Neuroimage 34:1036-41. 2007
    ..This method may be useful to quantify hippocampal volume change, given the reduction in operator time and improved precision...
  38. ncbi T(1) hypointense lesions in secondary progressive multiple sclerosis: effect of interferon beta-1b treatment
    F Barkhof
    MR MS centre, VU Medical Centre, Amsterdam, The Netherlands
    Brain 124:1396-402. 2001
    ..In patients with SP multiple sclerosis, IFNbeta-1b treatment reduces the development of hypointense T(1) lesions, suggesting that reduced axonal damage in lesions may play a part in the beneficial effect that is observed clinically...
  39. doi Association between MRI parameters and the MS severity scale: a 12 year follow-up study
    A Minneboo
    Department of Radiology, MS Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Mult Scler 15:632-7. 2009
    ..Until now, these studies are relatively sparse and, therefore, the predictive value of MRI parameters for clinical disability remains largely unknown...
  40. ncbi Cognitive slowing in multiple sclerosis is strongly associated with brain volume reduction
    R H C Lazeron
    Department of Neurology, Vrije Universiteit Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Mult Scler 12:760-8. 2006
    ..Since MS is characterized by cognitive slowing rather than impaired accuracy, we used the Amsterdam Neuropsychological Tasks (ANT) program, a computerized test proven to be very sensitive to cognitive slowing in MS patients...
  41. ncbi Lesional magnetization transfer ratio: a feasible outcome for remyelinating treatment trials in multiple sclerosis
    I J van den Elskamp
    Department of Radiology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Mult Scler 16:660-9. 2010
    ..Recovery of lesion MTR is a feasible outcome measure for future multicentre clinical trials measuring the effect of remyelinating agents...
  42. doi Can rate of brain atrophy in multiple sclerosis be explained by clinical and MRI characteristics?
    T Korteweg
    Department of Radiology, VU University Medical Centre, Amsterdam, The Netherlands
    Mult Scler 15:465-71. 2009
    ..Multiple sclerosis (MS) is characterized, besides focal lesions, by brain atrophy. The determinants of atrophy rates in individual patients are poorly understood...
  43. ncbi Diabetes mellitus, hypertension and medial temporal lobe atrophy: the LADIS study
    E S C Korf
    Alzheimer Center, Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Diabet Med 24:166-71. 2007
    ....
  44. ncbi Prevalence and severity of microbleeds in a memory clinic setting
    C Cordonnier
    Department of Neurology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 66:1356-60. 2006
    ..To determine prevalence and severity of microbleeds (MBs) in a large cohort of patients attending a memory clinic...
  45. ncbi Reduced resting-state brain activity in the "default network" in normal aging
    J S Damoiseaux
    Department of Neurology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Cereb Cortex 18:1856-64. 2008
    ..The relevance of these findings is illustrated by the correlation between reduced activity of one of these RSNs and less effective executive functioning/processing speed in the older group...
  46. doi Reliability and sensitivity of visual scales versus volumetry for evaluating white matter hyperintensity progression
    A A Gouw
    Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Cerebrovasc Dis 25:247-53. 2008
    ..However, the most suitable method for measuring WMH progression has not been established yet. We compared the reliability and sensitivity of cross-sectional and longitudinal visual scales with volumetry for measuring WMH progression...
  47. ncbi Normal-appearing white matter changes vary with distance to lesions in multiple sclerosis
    H Vrenken
    Department of Radiology, MR Center for MS Research, VU University Medical Center, Amsterdam, The Netherlands
    AJNR Am J Neuroradiol 27:2005-11. 2006
    ..We aimed to investigate the relationship of NAWM changes to the distance to the lesions...
  48. ncbi Patterns of enhancing lesion evolution in multiple sclerosis are uniform within patients
    A Minneboo
    MR Center for MS Research, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 65:56-61. 2005
    ..It is unclear whether the same applies to the evolution of lesions on T1-weighted MRI...
  49. ncbi Optimizing the association between disability and biological markers in MS
    N F Kalkers
    MS MRI Center, VU Medical Center, Amsterdam, The Netherlands
    Neurology 57:1253-8. 2001
    ..The authors studied the relation of brain volume measurements with the MS Functional Composite (MSFC) in an attempt to improve the clinico-radiologic association...
  50. doi Quantitative MR imaging and spectroscopy in congenital cytomegalovirus infection and periventricular leukomalacia suggests a comparable neuropathological substrate of the cerebral white matter lesions
    J P van der Voorn
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Neuropediatrics 40:168-73. 2009
    ..Congenital CMV infection and PVL affect the cerebral white matter in the same developmental period when immature oligodendrocytes are particularly vulnerable...
  51. pmc Cerebral atrophy as outcome measure in short-term phase 2 clinical trials in multiple sclerosis
    I J van den Elskamp
    Department of Radiology, MS Center Amsterdam, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Neuroradiology 52:875-81. 2010
    ....
  52. ncbi Anterior medial temporal lobe activation during attempted retrieval of encoded visuospatial scenes: an event-related fMRI study
    S A Rombouts
    Department of Clinical Physics and Informatics, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Neuroimage 14:67-76. 2001
    ..We conclude that the left posterior parahippocampal gyrus responds during encoding, while on the other hand the left anterior parahippocampal gyrus and the right anterior hippocampus were more strongly involved in retrieval...
  53. ncbi Neurological signs in relation to white matter hyperintensity volumes in memory clinic patients
    S S Staekenborg
    Department of Neurology and Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands s staekenborg vumc nl
    Dement Geriatr Cogn Disord 29:301-8. 2010
    ..To determine the frequency of neurological signs in a memory clinic population and to explore their associations with white matter hyperintensity (WMH)...
  54. doi Clinical correlations of brain lesion distribution in multiple sclerosis
    M M Vellinga
    Department of Neurology, MS Center Amsterdam, Amsterdam, The Netherlands
    J Magn Reson Imaging 29:768-73. 2009
    ..Hypothesizing that symptomatology may partly be determined by lesion location, this retrospective study explored relations between lesion location and disability using voxelwise analyses in standard space...
  55. doi Spontaneous MxA mRNA level predicts relapses in patients with recently diagnosed MS
    L F van der Voort
    VU Medical Center, Department of Neurology, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Neurology 75:1228-33. 2010
    ..To determine if myxovirus resistance protein A (MxA) mRNA is related to clinical disease activity in multiple sclerosis (MS)...
  56. ncbi Glucocorticoid receptor gene polymorphisms associated with more aggressive disease phenotype in MS
    L M L van Winsen
    Department of Neurology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    J Neuroimmunol 186:150-5. 2007
    ..We investigated the influence of these polymorphisms on clinical and MRI parameters. The ER22/23EK polymorphism was associated with a more aggressive MS phenotype, measured both clinically and on MRI...
  57. ncbi Simple versus complex assessment of white matter hyperintensities in relation to physical performance and cognition: the LADIS study
    A A Gouw
    Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Neurol 253:1189-96. 2006
    ..The most suitable method to assess WMH in relation to the clinical evaluation of disturbances in these areas has not yet been established...
  58. doi Heterogeneity of white matter hyperintensities in Alzheimer's disease: post-mortem quantitative MRI and neuropathology
    A A Gouw
    Department of Neurology, Alzheimer Center and Image Analysis Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Brain 131:3286-98. 2008
    ..Quantitative MRI techniques reveal differences in WMH between Alzheimer's disease and non-demented elderly, and are able to reflect the severity of the neuropathological changes involved...
  59. ncbi Active MRI lesion appearance in MS patients is preceded by fluctuations in circulating T-helper 1 and 2 cells
    J Killestein
    Department of Immunobiology, CLB and Laboratory of Experimental and Clinical Immunology of the University of Amsterdam, Amsterdam, The Netherlands
    J Neuroimmunol 118:286-94. 2001
    ..However, the exact mechanisms by which T cells and cytokines contribute to disease activity remain to be clarified...
  60. ncbi Classification of multiple sclerosis patients by latent class analysis of magnetic resonance imaging characteristics
    J N P Zwemmer
    Department of Neurology, MS Center, VU University Medical Center, Amsterdam, The Netherlands
    Mult Scler 12:565-72. 2006
    ..While clinical subtypes differ by magnetic resonance imaging (MRI) signature on a group level, a classification of individual MS patients based purely on MRI characteristics has not been presented so far...
  61. ncbi Cognitive performance in type 1 diabetes patients is associated with cerebral white matter volume
    A M Wessels
    Department of Medical Psychology, VU University Medical Centre, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Diabetologia 50:1763-9. 2007
    ....
  62. ncbi Postwithdrawal rebound increase in T2 lesional activity in natalizumab-treated MS patients
    M M Vellinga
    Department of Neurology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Neurology 70:1150-1. 2008
  63. ncbi Brain atrophy and lesion load as explaining parameters for cognitive impairment in multiple sclerosis
    R H C Lazeron
    MS Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Mult Scler 11:524-31. 2005
    ..In conclusion, cognitive impairment in MS is moderately dependent on amount (and distribution) of structural brain damage, especially in the more physically impaired patients group...
  64. ncbi T1 hypointensities and axonal loss
    F Barkhof
    Department of Radiology, Multiple Sclerosis MRI Research Centre Amsterdam, Vrije Universiteit Hospital, 1007 MB Amsterdam, The Netherlands
    Neuroimaging Clin N Am 10:739-52 ,ix. 2000
    ..They correlate better with clinical disability than T2-weighted images, are found in patients with progressive multiple sclerosis, and can be used as surrogate outcome measures in treatment trials...
  65. ncbi Global and local gray matter loss in mild cognitive impairment and Alzheimer's disease
    G B Karas
    Department of Diagnostic Radiology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Neuroimage 23:708-16. 2004
    ..Mild cognitive impairment (MCI) is thought to be the prodromal phase to Alzheimer's disease (AD). We analyzed patterns of gray matter (GM) loss to examine what characterizes MCI and what determines the difference with AD...
  66. doi Regional DTI differences in multiple sclerosis patients
    S D Roosendaal
    Department of Radiology, MS Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Neuroimage 44:1397-403. 2009
    ..TBSS can be useful in future studies with other MS patient samples to provide an unbiased localization of damage and generate location-specific hypotheses...
  67. ncbi Corpus callosum size correlates with asymmetric performance on a dichotic listening task in healthy aging but not in Alzheimer's disease
    L Gootjes
    Department of Clinical Neuropsychology, Vrije Universiteit, Amsterdam, The Netherlands
    Neuropsychologia 44:208-17. 2006
    ..Difficulties to attend specifically to the left ear during dichotic listening in some of the AD patients, points at decreased attention and executive functions and suggests that pathology of specifically the frontal areas is involved...
  68. ncbi Spinal cord abnormalities in recently diagnosed MS patients: added value of spinal MRI examination
    J C J Bot
    MR Center for MS Research, Departments of Radiology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Neurology 62:226-33. 2004
    ....
  69. doi White matter hyperintensities and medial temporal lobe atrophy in clinical subtypes of mild cognitive impairment: the DESCRIPA study
    L A van de Pol
    VUMC, Department of Neurology, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 80:1069-74. 2009
    ..Clinical subtypes of mild cognitive impairment (MCI) may represent different underlying aetiologies...
  70. doi Association of gait and balance disorders with age-related white matter changes: the LADIS study
    H Baezner
    Mannheim University Hospital, University of Heidelberg, Department of Neurology, Theodor Kutzer Ufer, D 68135 Mannheim, Germany
    Neurology 70:935-42. 2008
    ..We aimed at determining the influence of ARWMC on different objective measures of gait and balance...
  71. ncbi Model-free group analysis shows altered BOLD FMRI networks in dementia
    Serge A R B Rombouts
    Department of Physics and Medical Technology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Hum Brain Mapp 30:256-66. 2009
    ..The technique is more sensitive than the commonly applied model-based method. Consistent with other research, we show that networks of activation and deactivation show decreased reactivity in dementia...
  72. ncbi Interindividual differences of medial temporal lobe activation during encoding in an elderly population studied by fMRI
    M W G Vandenbroucke
    Department of Physics and Medical Technology, VU Medical Center, Amsterdam, The Netherlands
    Neuroimage 21:173-80. 2004
    ..Group analysis in standard space may not be appropriate for studies of a complex structure such as the MTL, particularly not in aging and dementia...
  73. ncbi Cholinergic challenge in Alzheimer patients and mild cognitive impairment differentially affects hippocampal activation--a pharmacological fMRI study
    Rutger Goekoop
    Department of Neurology Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Brain 129:141-57. 2006
    ....
  74. ncbi CCL5 and CCR5 genotypes modify clinical, radiological and pathological features of multiple sclerosis
    Tineke van Veen
    Department of Molecular Cell Biology and Immunology, VU University Medical Centre, Amsterdam, The Netherlands
    J Neuroimmunol 190:157-64. 2007
    ..In summary, our multifaceted study supports the notion that polymorphisms in CCL5 and CCR5 modify the course of MS...
  75. ncbi Visual rating scales for age-related white matter changes (leukoaraiosis): can the heterogeneity be reduced?
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Stroke 33:2827-33. 2002
    ..We aimed to compare 6 widely used rating scales for leukoaraiosis and to calculate conversion coefficients of the score of 1 scale in the score of a second scale...
  76. doi A three-year, multi-parametric MRI study in patients at presentation with CIS
    Maria A Rocca
    Neuroimaging Research Unit, Dept of Neurology, Scientific Institute and University Ospedale, San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
    J Neurol 255:683-91. 2008
    ..To define the extent of overall brain damage in patients with clinically isolated syndromes (CIS) suggestive of multiple sclerosis (MS) and to identify non-conventional magnetic resonance (MR) metrics predictive of evolution to definite MS...
  77. ncbi The FAS-670 polymorphism influences susceptibility to multiple sclerosis
    T van Veen
    Department of Neurology, VU Medical Centre, De Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands
    J Neuroimmunol 128:95-100. 2002
    ..We observed similar brain and lesion volumes in carriers and noncarriers of FAS-670*G. These data suggest that FAS-670*G decreases the risk of developing MS, but does not affect the course of disease...
  78. ncbi The contribution of medial temporal lobe atrophy and vascular pathology to cognitive impairment in vascular dementia
    Antonio J Bastos-Leite
    Image Analysis Center, VU University Medical Center, Amsterdam, The Netherlands
    Stroke 38:3182-5. 2007
    ..Therefore, our purpose was to investigate the relative contribution of cerebrovascular disease and MTA to cognitive impairment in patients fulfilling diagnostic criteria for VaD...
  79. ncbi Whole brain analysis of T2* weighted baseline FMRI signal in dementia
    Serge A R B Rombouts
    Department of Physics and Medical Technology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Hum Brain Mapp 28:1313-7. 2007
    ..We conclude that in FMRI studies of dementia, not only the dynamic BOLD signal (activation and deactivation) but also the average baseline signal is diminished in certain regions. The method we applied may also be used in task-rel..
  80. ncbi Frontal-striatal dysfunction during planning in obsessive-compulsive disorder
    Odile A van den Heuvel
    Departments of Psychiatry, Anatomy, and Radiology and Outpatient Clinic for Anxiety Disorders, GGZ Buitenamstel, VU University Medical Center, Amsterdam, The Netherlands
    Arch Gen Psychiatry 62:301-9. 2005
    ..In addition, neuropsychological studies in OCD have reported impairments in visuospatial tasks and executive functions, such as planning...
  81. doi Predicting progression in primary progressive multiple sclerosis: a 10-year multicenter study
    Zhaleh Khaleeli
    Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom
    Ann Neurol 63:790-3. 2008
    ..These predictors of long-term disability provide some insight into disease progression...
  82. ncbi Blood-brain barrier alterations in both focal and diffuse abnormalities on postmortem MRI in multiple sclerosis
    Catharina M P Vos
    Department of Pathology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Neurobiol Dis 20:953-60. 2005
    ..This study shows for the first time that in MS brain changes in the vasculature take place not only in focal lesions but also in DAWM as detected by postmortem MRI...
  83. ncbi Thalamic lesions in vascular dementia: low sensitivity of fluid-attenuated inversion recovery (FLAIR) imaging
    Antonio J Bastos Leite
    Department of Radiology, Vrije Universiteit Medical Center, Amsterdam, Netherlands
    Stroke 35:415-9. 2004
    ....
  84. ncbi Quantitative 1H-MRS of healthy human cortex, hippocampus, and thalamus: metabolite concentrations, quantification precision, and reproducibility
    Jeroen J G Geurts
    Department of Radiology, MR Center for MS Research, VU University Medical Center, Amsterdam, The Netherlands
    J Magn Reson Imaging 20:366-71. 2004
    ....
  85. ncbi CTLA-4 and CD28 gene polymorphisms in susceptibility, clinical course and progression of multiple sclerosis
    Tineke van Veen
    Department of Neurology, VU University Medical Centre, De Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands
    J Neuroimmunol 140:188-93. 2003
    ..We observed no effects of the polymorphisms on brain and lesion volumes. These data suggest that the polymorphisms under investigation do not affect the risk of developing MS and have no influence on the course of disease...
  86. ncbi Comparison of the Alzheimer's Disease Assessment Scale Cognitive Subscale and the Vascular Dementia Assessment Scale in differentiating elderly individuals with different degrees of white matter changes. The LADIS Study
    Raija Ylikoski
    Memory Research Unit, Department of Neurology, University of Helsinki, Helsinki, Finland
    Dement Geriatr Cogn Disord 24:73-81. 2007
    ..The objective of this study was to compare the results of the two scales among subjects with various degrees of white matter hyperintensities (WMHs)...
  87. ncbi Lack of association between antimyelin antibodies and progression to multiple sclerosis
    Jens Kuhle
    Department of Research, University Hospital, Basel, Switzerland
    N Engl J Med 356:371-8. 2007
    ..An increased risk of progression to clinically definite multiple sclerosis in patients with serum antibodies against myelin oligodendrocyte glycoprotein (MOG) and myelin basic protein (MBP) has been reported...
  88. pmc Increased cortical atrophy in patients with Alzheimer's disease and type 2 diabetes mellitus
    G J Biessels
    The Alzheimer Center, Department of Neurology, VU Medical Center, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 77:304-7. 2006
    ..The risk of Alzheimer's disease (AD) is increased in type 2 diabetes (DM2). This increased risk has been attributed to vascular comorbidity, but other mechanisms, such as accelerated ageing of the brain, have also been implicated...
  89. doi Persistent T1 hypointensity as an MRI marker for treatment efficacy in multiple sclerosis
    I J van den Elskamp
    Department of Radiology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Mult Scler 14:764-9. 2008
    ..At present, a power analysis using black hole (BH) evolution as primary outcome measure has not been performed...
  90. ncbi Raloxifene affects brain activation patterns in postmenopausal women during visual encoding
    S J Neele
    Department of Endocrinology, Academic Hospital Vrije Universiteit, 1007 MB Amsterdam, The Netherlands
    J Clin Endocrinol Metab 86:1422-4. 2001
    ..The mean recognition test and the simple photic stimulation test showed no treatment interactions. Our results show that raloxifene affects brain activation patterns upon visual encoding in postmenopausal women...
  91. pmc Subtraction MR images in a multiple sclerosis multicenter clinical trial setting
    Bastiaan Moraal
    Departments of Radiology, MS Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Radiology 250:506-14. 2009
    ....
  92. ncbi Raloxifene treatment enhances brain activation during recognition of familiar items: a pharmacological fMRI study in healthy elderly males
    Rutger Goekoop
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Neuropsychopharmacology 31:1508-18. 2006
    ..Behaviorally, such neurofunctional effects may actively block decreased memory performance as a result of context-dependency. The validity of these predictions can be tested in large-scale clinical trials...
  93. ncbi White matter lesions and hippocampal atrophy in Alzheimer's disease
    Frank Erik de Leeuw
    Alzheimer Center, Department of Neurology, VU Medical Center, Amsterdam, The Netherlands
    Neurology 62:310-2. 2004
    ..A linear relation was found between WML and HA, especially for WML in the frontal and parieto-occipital regions. The results suggest that vascular pathology and typical AD pathology (HA) are related...
  94. pmc Corpus callosum atrophy is associated with mental slowing and executive deficits in subjects with age-related white matter hyperintensities: the LADIS Study
    Hanna Jokinen
    Department of Psychology, University of Helsinki, Helsinki, Finland
    J Neurol Neurosurg Psychiatry 78:491-6. 2007
    ..Previous research has indicated that corpus callosum atrophy is associated with global cognitive decline in neurodegenerative diseases, but few studies have investigated specific cognitive functions...
  95. ncbi MRI and the diagnosis of multiple sclerosis: expanding the concept of "no better explanation"
    Arnaud Charil
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Lancet Neurol 5:841-52. 2006
    ..In this review we will report on the conclusions of this international consensus, which should represent a first step beyond the concept of "no better explanation", and inform future diagnostic criteria for multiple sclerosis...
  96. doi Tumor-volume changes after radiosurgery for vestibular schwannoma: implications for follow-up MR imaging protocol
    O W M Meijer
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    AJNR Am J Neuroradiol 29:906-10. 2008
    ..This study evaluates the volumetric changes of VS after radiosurgery and proposes a radiologic follow-up program...
  97. ncbi Treatment with laquinimod reduces development of active MRI lesions in relapsing MS
    C Polman
    Department of Neurology, VU Medical Centre, Amsterdam, The Netherlands
    Neurology 64:987-91. 2005
    ..The purpose of this study was to evaluate safety, tolerability, and efficacy on MRI lesions of two different doses of laquinimod compared with placebo in patients with relapsing MS...
  98. doi Ethics of placebo-controlled clinical trials in multiple sclerosis: a reassessment
    C H Polman
    Department of Neurology, Free University Medical Center in Amsterdam, PO Box 4075, 1007 MB Amsterdam, The Netherlands
    Neurology 70:1134-40. 2008
    ..Guidance is also provided on the ethics of alternative trial designs and the balance between study subject burden and risk, scientific rationale and interpretability of trial outcomes...
  99. doi At the heart of primary progressive multiple sclerosis: three cases with diffuse MRI abnormalities only
    J N P Zwemmer
    Department of Neurology, MS Center, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Mult Scler 14:428-30. 2008
    ..We propose that these cases represent the most pure form of PPMS, even though according to currently applied criteria this diagnosis can not be made in the absence of focal lesions on MRI...
  100. ncbi Diffusion-weighted MRI in severe neonatal hypoxic ischaemia: the white cerebrum
    R J Vermeulen
    Department of Child Neurology, VUMC, Amsterdam, The Netherlands
    Neuropediatrics 34:72-6. 2003
    ..25 +/- 0.06 micro m 2/msec). All infants died in the perinatal period. In summary, the "white cerebrum" on diffusion-weighted MRI indicates severe neonatal hypoxia-ischaemia and is the counterpart of the white cerebellum on CT...