Affiliation: VU University Medical Center
Country: The Netherlands
- Endothelial dysfunction and diabetes: roles of hyperglycemia, impaired insulin signaling and obesityWineke Bakker
Laboratory of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Van der Boechorststraat 7, 1081BT Amsterdam, The Netherlands
Cell Tissue Res 335:165-89. 2009..Hence, an initial dysfunction of endothelial cells underlies metabolic and vascular alterations that contribute to the development of type 2 diabetes...
- Paracrine regulation of vascular tone, inflammation and insulin sensitivity by perivascular adipose tissueEtto C Eringa
Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
Vascul Pharmacol 56:204-9. 2012..An altered profile of adipokine and cytokine production by PVAT of resistance arteries may also contribute to or modulate hypertension, but a causal role in hypertension has still to be established...
- Perivascular adipose tissue control of insulin-induced vasoreactivity in muscle is impaired in db/db miceRick I Meijer
Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
Diabetes 62:590-8. 2013..PVAT from obese mice inhibits insulin-induced vasodilation, which can be restored by inhibition of JNK...
- Protein kinase C theta activation induces insulin-mediated constriction of muscle resistance arteriesWineke Bakker
Laboratory of Physiology, Institute for Cardiovascular Research, Vrije Universiteit Medical Center, Van der Boechorststraat 7, 1081BT Amsterdam, Netherlands
Diabetes 57:706-13. 2008..In this study, we investigated whether PKC theta activation impairs insulin-mediated vasoreactivity and insulin signaling in muscle resistance arteries...