Research Topics
Species | Johannes H G M van BeekSummaryAffiliation: Vrije Universiteit Country: The Netherlands Publications
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Detail Information
Publications
Simulating the physiology of athletes during endurance sports events: modelling human energy conversion and metabolismJohannes H G M van Beek
Section Medical Genomics, Department of Clinical Genetics, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
Philos Transact A Math Phys Eng Sci 369:4295-315. 2011..Computational modelling of the human body, describing heat exchange and energy metabolism, makes simulation of endurance sports events feasible...- Robust modelling, measurement and analysis of human and animal metabolic systemsJohannes H G M van Beek
Section Medical Genomics, Department of Clinical Genetics, VU University Medical Centre, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
Philos Transact A Math Phys Eng Sci 367:1971-92. 2009..Combining modular, multiscale, ensemble and sloppy modelling approaches with in vivo flux measurements may prove indispensable for the modelling of the large human metabolic system... - Multiscale and modular analysis of cardiac energy metabolism: repairing the broken interfaces of isolated system componentsJohannes H G M van Beek
Centre for Intergrative BioInformatics, VU University, Amsterdam, The Netherlands
Ann N Y Acad Sci 1123:155-68. 2008..The CK system is very effective in decreasing maximum levels of ADP during systole and reducing average Pi levels over the whole cardiac cycle... - Adenine nucleotide-creatine-phosphate module in myocardial metabolic system explains fast phase of dynamic regulation of oxidative phosphorylationJohannes H G M van Beek
Dept of Molecular Cell Physiology, FALW, Vrije Universiteit, De Boelelaan 1085, 1081 HV Amsterdam
Am J Physiol Cell Physiol 293:C815-29. 2007.... - Analyzing the functional properties of the creatine kinase system with multiscale 'sloppy' modelingHannes Hettling
Centre for Integrative Bioinformatics VU, VU University Amsterdam, Amsterdam, The Netherlands
PLoS Comput Biol 7:e1002130. 2011..However, the contribution of CK to the transport of high-energy phosphate groups appears limited. Mitochondrial CK activity lowers cytosolic inorganic phosphate levels while cytosolic CK has the opposite effect... - Endotoxemia decreases matching of regional blood flow and O2 delivery to O2 uptake in the porcine left ventricleDavid J C Alders
Department of Intensive Care, Vrije Universiteit, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
Am J Physiol Heart Circ Physiol 300:H1459-66. 2011..Mismatching may underlie, at least in part, the myocardial depression of sepsis... - Activation time of myocardial oxidative phosphorylation in creatine kinase and adenylate kinase knockout miceLori A Gustafson
Laboratory for Physiology, Institute for Cardiovascular Research, Vrije Universiteit, 1081 BT Amsterdam, The Netherlands
Am J Physiol Heart Circ Physiol 282:H2259-64. 2002.... - Myocardial O2 consumption in porcine left ventricle is heterogeneously distributed in parallel to heterogeneous O2 deliveryDavid J C Alders
Institute for Cardiovascular Research, Vrije Universiteit, VU Medical Center, 1081 HV Amsterdam, The Netherlands
Am J Physiol Heart Circ Physiol 287:H1353-61. 2004..0001, n = 60). We calculate that, in the heart at normal workload, the variance of left ventricular oxygen delivery at submilliliter resolution is explained for 43% by heterogeneity in oxygen demand... - Regional sympathetic denervation affects the relation between canine local myocardial blood flow and oxygen consumptionDavid J C Alders
Laboratory for Physiology, Institute for Cardiovascular Research ICaR VU, VU University Medical Center, Amsterdam, The Netherlands
Exp Physiol 92:541-8. 2007..0182, Mann-Whitney U test. These results indicate that sympathetic tone under chloralose anaesthesia imposes a moderate vasoconstrictive effect in the myocardium that is not detected by comparison of the mean blood flow or resistance... - Electron density fingerprints (EDprints): virtual screening using assembled information of electron densityAlbert J Kooistra
Division of Medicinal Chemistry, Department of Chemistry and Pharmaceutical Sciences, Faculty of Sciences, Leiden Amsterdam Center for Drug Research, VU University Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands
J Chem Inf Model 50:1772-80. 2010.... - The mitochondrial outer membrane is not a major diffusion barrier for ADP in mouse heart skinned fibre bundlesOlav Kongas
Department of Mechanics and Applied Mathematics, Institute of Cybernetics, Tallinn Technical University, Akadeemia 21, 12618 Tallinn, Estonia
Pflugers Arch 447:840-4. 2004..We conclude that the affinity of mitochondria for ADP in mouse heart is of the same order of magnitude as that of isolated mitochondria, while the high apparent Km of the bundles is caused by diffusion gradients outside the mitochondria... - Glycolytic buffering affects cardiac bioenergetic signaling and contractile reserve similar to creatine kinaseGlenn J Harrison
Heart Foundation Research Centre, Griffith University, Gold Coast, Queensland 9726, Australia
Am J Physiol Heart Circ Physiol 285:H883-90. 2003..Glycolysis may therefore play a role similar to CK in heart muscle... - High K(m) of oxidative phosphorylation for ADP in skinned muscle fibers: where does it stem from?Olav Kongas
Laboratory for Physiology, Institute for Cardiovascular Research, Vrije Universiteit Medical Center 1081 BT Amsterdam, The Netherlands
Am J Physiol Cell Physiol 283:C743-51. 2002..We conclude that the affinity to ADP of in situ mitochondria in heart is of the same order of magnitude as that of isolated mitochondria...