Research Topics
Genomes and GenesSpecies | Danielle PosthumaSummaryAffiliation: Vrije Universiteit Country: The Netherlands Publications
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Publications
Twin-singleton differences in intelligence?D Posthuma
Department of Biological Psychology, Vrije Universiteit Amsterdam, The Netherlands
Twin Res 3:83-7. 2000..It is concluded that twin studies provide reliable estimates of heritabilities of intellectual abilities which can be generalised to the singleton population...- Introduction to the special issue: human linkage studies for behavioral traitsD Posthuma
Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
Behav Genet 36:1-3. 2006..Three papers concentrate on emotionality, depression and loneliness and examine chromosomes 2q and 12q. The papers in this issue represent a summary of the first large scale linkage enterprises of human behavioral traits... 
A note on permutation tests for genetic association analysis of quantitative traits when variances are heterogeneousDanielle Posthuma
Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
Genet Epidemiol 33:710-6. 2009..We show that the best procedure involves an implicit adjustment of the original data for the effects in the model before permutation, and that other methods, some of which seemed appropriate a priori, are relatively biased...
A genomewide scan for intelligence identifies quantitative trait loci on 2q and 6pDanielle Posthuma
Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
Am J Hum Genet 77:318-26. 2005..3-22.3 (LOD score 3.20 for full-scale IQ and 2.33 for verbal IQ), overlapping marginally with the 6p22.3-21.31 region implicated in reading disability and dyslexia...- Genetic components of functional connectivity in the brain: the heritability of synchronization likelihoodDanielle Posthuma
Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Hum Brain Mapp 26:191-8. 2005..The significant heritability found here suggests that SL can be used to examine the genetic susceptibility to these conditions... - Human cytokine response to ex vivo amyloid-beta stimulation is mediated by genetic factorsDanielle Posthuma
Department of Biological Psychology, Vrije Universiteit Amsterdam, The Netherlands
Twin Res Hum Genet 8:132-7. 2005..We conclude that genes influencing amyloid-beta-induced cytokine response may provide clues to the progression of AD pathology... - Combined linkage and association tests in mxD Posthuma
Department of Biological Psychology, Vrije Universiteit Amsterdam, Van der Boechorststraat 1, 1081 BT The Netherlands
Behav Genet 34:179-96. 2004..These extensions can be implemented when parental genotypes are available or unavailable... - Theory and practice in quantitative geneticsDanielle Posthuma
Department of Biological Psychology, Vrije Universiteit Amsterdam, The Netherlands
Twin Res 6:361-76. 2003..For using the former program a web-library (available from http://www.psy.vu.nl/mxbib) has been developed of freely available scripts that can be used to conduct all genetic analyses described in this paper... - Genetic correlations between brain volumes and the WAIS-III dimensions of verbal comprehension, working memory, perceptual organization, and processing speedDanielle Posthuma
Department of Biological Psychology, Vrije Universiteit, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands
Twin Res 6:131-9. 2003..e., do genes influence brain volume which in turn influences intelligence, or alternatively, do genes influence intelligence which in turn influences brain volume), or the presence or absence of pleiotropy has not been resolved yet... - Replicated linkage for eye color on 15q using comparative ratings of sibling pairsDanielle Posthuma
Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
Behav Genet 36:12-7. 2006..A. Teasdale, R. D, and Box, N. F. (2001). Gene 277:49-62]. Our results demonstrate that comparative measures on relatives can be used in genetic linkage analysis... - A note on the statistical power in extended twin designsD Posthuma
Department of Biological Psychology, Vrije Universiteit Amsterdam, Netherlands
Behav Genet 30:147-58. 2000..e. including families with twins and one or two additional siblings increases the statistical power to detect sources of variance due to additive and non-additive genetic influences, and common environment... - Genetic analysis of IQ, processing speed and stimulus-response incongruency effectsD Posthuma
Department of Biological Psychology, Vrije Universiteit Amsterdam, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands
Biol Psychol 61:157-82. 2002..It is concluded that measures of the ability to perform well under conditions of stimulus-response incongruency are viable endophenotypes of cognitive ability... - Multivariate genetic analysis of brain structure in an extended twin designD Posthuma
Department of Biological Psychology, Vrije Universiteit Amsterdam, The Netherlands
Behav Genet 30:311-9. 2000..The applied method is presented as a general approach for the analysis of intermediate phenotypes in which the effects of correlated variables on the observed scores are modeled through multivariate analysis... - Are smarter brains running faster? Heritability of alpha peak frequency, IQ, and their interrelationD Posthuma
Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
Behav Genet 31:567-79. 2001..There was no evidence of a genetic correlation between alpha peak frequency and any of the four WAIS dimensions: Smarter brains do not seem to run faster... - Perceptual speed and IQ are associated through common genetic factorsD Posthuma
Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
Behav Genet 31:593-602. 2001..This factor is hypothesized to reflect the influence of genetic factors that determine axonal myelination in the central nervous system... - Genome-wide scan for blood pressure in Australian and Dutch subjects suggests linkage at 5P, 14Q, and 17PJouke Jan Hottenga
Department of Biological Psychology and the Center for Neurogenomics and Clinical Research, Vrije Universiteit, Amsterdam, The Netherlands
Hypertension 49:832-8. 2007..21 for systolic blood pressure was observed on chromosome 13q34. These results replicate earlier findings and add to a slowly emerging picture of multiple loci contributing to quantitative blood pressure variation... - Attention problems, inhibitory control, and intelligence index overlapping genetic factors: a study in 9-, 12-, and 18-year-old twinsTinca J C Polderman
Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands
Neuropsychology 23:381-91. 2009..Genetic factors that influenced IQ also influenced inhibitory control. We conclude that the association between AP and inhibitory control as reported in the literature may largely derive from genetic factors that are shared with IQ... - A longitudinal twin study on IQ, executive functioning, and attention problems during childhood and early adolescenceTinca J C Polderman
Department of Biological Psychology, Vrije Universiteit Amsterdam, The Netherlands
Acta Neurol Belg 106:191-207. 2006..IQ performance at age 5 was the best predictor of IQ at age 12. IQ at both ages was influenced by the same genes, whose influence was amplified during development... - Genome-wide linkage scan for exercise participation in Dutch sibling pairsMarleen H M de Moor
Department of Biological Psychology, Vrije Universiteit Amsterdam, The Netherlands
Eur J Hum Genet 15:1252-9. 2007..Most likely, a large number of genes with each small effects affect exercise participation in males and females. Large collaborative samples are needed to detect these effects... - Netherlands Twin Register: from twins to twin familiesDorret I Boomsma
Department of Biological Psychology, Vrije Universiteit, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands
Twin Res Hum Genet 9:849-57. 2006..In this paper we give an update on the YNTR and ANTR phenotyping and on the ongoing ANTR biobank studies... - Individual differences in processing speed and working memory speed as assessed with the Sternberg memory scanning taskAnna A E Vinkhuyzen
Department of Biological Psychology, VU University Amsterdam, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands
Behav Genet 40:315-26. 2010..We conclude that genetic influences on working memory performance are more likely to act upon basic processing speed and (pre)motoric processes than on the speed with which an item is retrieved from short term memory... - Genetic analyses of the stability of executive functioning during childhoodTinca J C Polderman
Department of Biological Psychology, VU University Amsterdam, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands
Biol Psychol 76:11-20. 2007..Also, genetic variation was the most important explanation for individual differences in executive functioning at both ages... - Heritability of "small-world" networks in the brain: a graph theoretical analysis of resting-state EEG functional connectivityDirk J A Smit
Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands
Hum Brain Mapp 29:1368-78. 2008..It is asserted that C, L, and a small-world organization are viable markers of genetic differences in brain organization... - Gene-environment interaction in adults' IQ scores: measures of past and present environmentSophie van der Sluis
Department of Biological Psychology, VU University Amsterdam, Van der Boechorststraat 1, Amsterdam 1081 BT, The Netherlands
Behav Genet 38:348-60. 2008..Contrary to studies in children, however, the variance attributable to additive genetic effects was stable across all levels of the moderators under study. Most results were replicated for VIQ and PIQ... - QTLs for height: results of a full genome scan in Dutch sibling pairsGonneke Willemsen
Department of Biological Psychology, Vrije Universiteit, Van der Boechorststraat 1, Amsterdam 1081 BT, The Netherlands
Eur J Hum Genet 12:820-8. 2004..Several chromosomal regions are now implied in the variance in height, but further study is needed to draw definite conclusions with regard to the significance of these regions for adult height... - Heritability of daytime ambulatory blood pressure in an extended twin designNina Kupper
Department of Biological Psychology, Vrije Universiteit, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands
Hypertension 45:80-5. 2005..We conclude that exclusion of (medicated) hypertensives removes part of the true genetic variance in ambulatory blood pressure... - Genome-wide linkage scan to identify Loci for age at first cigarette in Dutch sibling pairsJacqueline M Vink
Department of Biological Psychology, Vrije Universiteit, BT Amsterdam, The Netherlands
Behav Genet 36:100-11. 2006..This peak encloses the D1A dopamine receptor gene which is a functional candidate gene for smoking behavior... - Power calculations using exact data simulation: a useful tool for genetic study designsSophie van der Sluis
Department of Biological Psychology, VU University Amsterdam, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands
Behav Genet 38:202-11. 2008..The method is applied to three genetic designs for illustrative purposes... - Phenotypic and genetic correlations between evoked EEG/ERP measures during the response anticipation period of a delayed response taskDirk J A Smit
Biological Psychology, Cognitive Research, VU University Amsterdam, 1081 BT Amsterdam, The Netherlands
Psychophysiology 46:344-56. 2009..Response anticipation reliably evokes an SCP, upper alpha synchronization and theta desynchronization, but variation in these measures reflects different (genetic) sources... - A Functional polymorphism under positive evolutionary selection in ADRB2 is associated with human intelligence with opposite effects in the young and the elderlyZoltan Bochdanovits
Department of Clinical Genetics, Section of Medical Genomics, VU Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
Behav Genet 39:15-23. 2009..This result illustrates the relevance of comparative genomics to detect genes that are involved in human behavior... - Environmental factors determine where the Dutch live: results from the Netherlands twin registerGonneke Willemsen
Department of Biological Psychology, Vrije Universiteit Amsterdam, The Netherlands
Twin Res Hum Genet 8:312-7. 2005..Future studies in European and other populations will reveal whether these results are specific to the Dutch population... - Genetic contribution to the P3 in young and middle-aged adultsDirk J A Smit
Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
Twin Res Hum Genet 10:335-47. 2007..Age differences are restricted to differences in means and variances, but the proportion of genetic variance as part of the total variance of midline P3 amplitude and latency does not change from young to middle-aged adulthood... - Heritability and stability of resting blood pressureJouke Jan Hottenga
Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
Twin Res Hum Genet 8:499-508. 2005..It was concluded that whole genome scans for resting blood pressure can safely pool data from males and females, laboratory and ambulatory recordings, and different age cohorts... - A general test for gene-environment interaction in sib pair-based association analysis of quantitative traitsSophie van der Sluis
Biological Psychology, VU University Amsterdam, Van der Boechorststraat 1, Room 2B 37, Amsterdam, The Netherlands
Behav Genet 38:372-89. 2008..Admixture effects of realistic effect size lead only to very small stratification effects in the G x E component, so impractically large numbers of sib pairs are required to detect such stratification... - A genetic analysis of ambulatory cardiorespiratory couplingNina Kupper
Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
Psychophysiology 42:202-12. 2005..This overlap in genes can be exploited to increase the power of linkage studies to detect genetic variation influencing cardiovascular disease risk... - Detecting genotype-environment interaction in monozygotic twin data: comparing the Jinks and Fulker test and a new test based on Marginal Maximum Likelihood estimationSophie van der Sluis
Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
Twin Res Hum Genet 9:377-92. 2006..However, after a normalizing transformation, the Jinks and Fulker test performed slightly better. Some possible future extensions of the MML-based test are briefly discussed... - Genetic linkage and association analysis for loneliness in Dutch twin and sibling pairs points to a region on chromosome 12q23-24Dorret I Boomsma
Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
Behav Genet 36:137-46. 2006..043). We review evidence for linkage in this region for psychiatric disorders and discuss our findings within this context... - Netherlands Twin Register: a focus on longitudinal researchDorret I Boomsma
Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
Twin Res 5:401-6. 2002..Large cohorts of phenotyped family members from the general population are very valuable for genetic epidemiological studies and permit selection of informative families for gene finding studies... 
Exploring the functional role of the CHRM2 gene in human cognition: results from a dense genotyping and brain expression studyFlorencia M Gosso
Dept of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
BMC Med Genet 8:66. 2007..The aim of this study is the identification of functional (non)coding variants underlying cognitive phenotypic variation...- A note on false positives and power in G × E modelling of twin dataSophie van der Sluis
Complex Trait Genetics, Department of Functional Genomics, Center for Neurogenomics and Cognitive Research CNCR, FALW VUA, Neuroscience Campus Amsterdam, VU University Medical Center VUmc, Amsterdam, The Netherlands
Behav Genet 42:170-86. 2012..If such moderation can be ruled out, subsequent use of the extended univariate moderation model, as proposed in this paper, is recommended as this model is more powerful than the full bivariate moderation model... - Catechol O-methyl transferase and dopamine D2 receptor gene polymorphisms: evidence of positive heterosis and gene-gene interaction on working memory functioningM Florencia Gosso
Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
Eur J Hum Genet 16:1075-82. 2008..We conclude that the effects of a single polymorphism in a dopaminergic gene on a well-defined cognitive trait may easily remain hidden if the interaction with age and other genes in the pathway are not taken into account... - Global similarity with local differences in linkage disequilibrium between the Dutch and HapMap-CEU populationsLuba Pardo
Medical Genomics Section, Department of Clinical Genetics, Vrije University Medical Center, Amsterdam, The Netherlands
Eur J Hum Genet 17:802-10. 2009..This poor concordance in LD block structure suggests that large samples are required for robust estimations of local LD block structure in populations... - Across the continuum of attention skills: a twin study of the SWAN ADHD rating scaleTinca J C Polderman
Department of Biological Psychology, Vrije Universiteit of Amsterdam, The Netherlands
J Child Psychol Psychiatry 48:1080-7. 2007..Items of the SWAN are scored on a seven-point scale, with in the middle 'average behavior' and on the extremes 'far below average' and 'far above average'... - A longitudinal genetic study of vocabulary knowledge in adultsStéphanie M van den Berg
Department of Biological Psychology, Vrije Universiteit Amsterdam, The Netherlands
Twin Res 7:284-91. 2004..Results were similar for the two sexes, except that males generally outperformed females. Results were also similar for two age cohorts, except that the older cohort generally outperformed the younger cohort... - Heritability of ambulatory heart rate variabilityNina H M Kupper
Vrije Universiteit, Amsterdam, The Netherlands
Circulation 110:2792-6. 2004..To date, the contribution of genetic and environmental factors to the variance in HRV has not been investigated during prolonged periods of ambulatory monitoring in a naturalistic setting... - The ATXN1 and TRIM31 genes are related to intelligence in an ADHD background: evidence from a large collaborative study totaling 4,963 subjectsThais S Rizzi
Department of Functional Genomics, CNCR, Neuroscience Campus Amsterdam, VU University and VU Medical Center, Amsterdam, The Netherlands
Am J Med Genet B Neuropsychiatr Genet 156:145-57. 2011.... - Accounting for sequential trial effects in the flanker task: conflict adaptation or associative priming?Sander Nieuwenhuis
Department of Cognitive Psychology, Vrije Universiteit Amsterdam, The Netherlands
Mem Cognit 34:1260-72. 2006..This pattern of results provides strong evidence that the conflict adaptation effect reflects associative stimulus-response priming instead of conflict-driven adaptations in cognitive control... - Genetic analyses of teacher ratings of problem behavior in 5-year-old twinsTinca J C Polderman
Department of Biological Psychology, Vrije Universiteit of Amsterdam, Amsterdam, Netherlands
Twin Res Hum Genet 9:122-30. 2006..Heritability was 63% for Attention problems, around 45% for Withdrawn, Social Problems, Aggressive Behavior and Rule Breaking Behavior, and around 30% for Anxious/Depressed, Thought Problems and Somatic Complaints... - The heritability of aptitude and exceptional talent across different domains in adolescents and young adultsAnna A E Vinkhuyzen
Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands
Behav Genet 39:380-92. 2009..Genetic factors contribute to a large extent to variation in aptitude and talent across different domains of intellectual, creative, and sports abilities... - Interaction between experience seeking and genetic and environmental influences on general cognitive abilityAnna A E Vinkhuyzen
Complex Trait Genetics, Department of Functional Genomics and Department of Clinical Genetics, Center for Neurogenomics and Cognitive Research CNCR, FALW VUA, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The, Netherlands
Twin Res Hum Genet 15:87-96. 2012..These findings have implications for future studies on the association between ES and general cognitive ability, and for future research on the genetics of cognitive ability... - Reconsidering the heritability of intelligence in adulthood: taking assortative mating and cultural transmission into accountAnna A E Vinkhuyzen
Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands
Behav Genet 42:187-98. 2012..This non-additive nature of genetic influences on intelligence needs to be accommodated in future GWAS studies for intelligence... - Functional gene group analysis reveals a role of synaptic heterotrimeric G proteins in cognitive abilityDina Ruano
Department of Medical Genomics, VU Medical Center, Neuroscience Campus Amsterdam VU University, Amsterdam, The Netherlands
Am J Hum Genet 86:113-25. 2010..The reported association of synaptic heterotrimeric G proteins with cognitive ability clearly points to a new direction in the study of the genetic basis of cognitive ability... - Phenotypic complexity, measurement bias, and poor phenotypic resolution contribute to the missing heritability problem in genetic association studiesSophie van der Sluis
Functional Genomics Section, Department of Clinical Genetics, Center for Neurogenomics and Cognitive Research, VU University and VU University Medical Center, Amsterdam, The Netherlands
PLoS ONE 5:e13929. 2010..Explanations of this 'missing heritability' have been mainly genetic, such as genetic heterogeneity and complex (epi-)genetic mechanisms... - Genome-wide association study of exercise behavior in Dutch and American adultsMarleen H M de Moor
Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands
Med Sci Sports Exerc 41:1887-95. 2009..The objective of this study was to identify genetic variants that are associated with adult leisure time exercise behavior using genome-wide association (GWA) in two independent samples... - TATES: Efficient Multivariate Genotype-Phenotype Analysis for Genome-Wide Association StudiesSophie van der Sluis
Department of Functional Genomics and Department of Clinical Genetics, VU Medical Center, Amsterdam, The Netherlands
PLoS Genet 9:e1003235. 2013.... - Event-related alpha and theta responses in a visuo-spatial working memory taskMarcel C M Bastiaansen
Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands
Clin Neurophysiol 113:1882-93. 2002..To explore the reactivity of the theta and alpha rhythms during visuo-spatial working memory... - Genetic and environmental factors affecting self-rated health from age 16-25: a longitudinal study of Finnish twinsKarri Silventoinen
Department of Public Health, University of Helsinki, P O Box 41, Mannerheimintie 172, FIN 00014, Helsinki, Finland
Behav Genet 37:326-33. 2007..An important challenge for further research is to identify environmental influences contributing to self-rated health independently of, or in interaction with, genetic factors... - Genetic contributions to human brain morphology and intelligenceHilleke E Hulshoff Pol
Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
J Neurosci 26:10235-42. 2006..35). These findings point to a neural network that shares a common genetic origin with human intelligence... - Sexual dimorphism in innate immunityGeorge Moxley
McGuire VAMC, Richmond, VA 23249, USA
Arthritis Rheum 46:250-8. 2002..To establish whether variation in innate immunity, as measured by the level of tumor necrosis factor (TNF) in lipopolysaccharide (LPS)-stimulated whole-blood culture, is related to sex or HLA... - The ongoing adaptive evolution of ASPM and Microcephalin is not explained by increased intelligenceNitzan Mekel-Bobrov
Department of Human Genetics, Howard Hughes Medical Institute, University of Chicago, Chicago, IL 60637, USA
Hum Mol Genet 16:600-8. 2007.... - Physical activity and cognitive function in a cross-section of younger and older community-dwelling individualsCharles H Hillman
Department of Kinesiology and Community Health, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Health Psychol 25:678-87. 2006..Findings suggest that physical activity may be beneficial to both general and selective aspects of cognition, particularly among older adults... - Perceptual speed does not cause intelligence, and intelligence does not cause perceptual speedMichelle Luciano
Queensland Institute of Medical Research, Herston, Brisbane, QLD 4029, Australia
Biol Psychol 70:1-8. 2005..This finding of a common genetic factor provides a better target for identifying genes involved in cognition than genes which are unique to specific traits... - Imaging the genetics of brain structure and functionEco de Geus
Biol Psychol 79:1-8. 2008....