Christel M Middeldorp

Summary

Affiliation: Vrije Universiteit
Country: The Netherlands

Publications

  1. pmc The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data
    C M Middeldorp
    Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands
    Transl Psychiatry 1:e50. 2011
  2. pmc Suggestive linkage on chromosome 2, 8, and 17 for lifetime major depression
    Christel M Middeldorp
    Department of Biological Psychology, VU University, Amsterdam, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 150:352-8. 2009
  3. pmc Anxiety and depression in children and adults: influence of serotonergic and neurotrophic genes?
    C M Middeldorp
    Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands
    Genes Brain Behav 9:808-16. 2010
  4. pmc An association between Epac-1 gene variants and anxiety and depression in two independent samples
    Christel M Middeldorp
    Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 153:214-9. 2010
  5. doi request reprint The serotonin transporter gene length polymorphism (5-HTTLPR) and life events: no evidence for an interaction effect on neuroticism and anxious depressive symptoms
    Christel M Middeldorp
    Department of Biological Psychology, VU University Amsterdam, The Netherlands
    Twin Res Hum Genet 13:544-9. 2010
  6. doi request reprint Life events, anxious depression and personality: a prospective and genetic study
    C M Middeldorp
    Department of Biological Psychology, Vrije Universiteit, Van der Boechorststraat 1, Amsterdam, The Netherlands
    Psychol Med 38:1557-65. 2008
  7. ncbi request reprint Linkage on chromosome 14 in a genome-wide linkage study of a broad anxiety phenotype
    C M Middeldorp
    Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands
    Mol Psychiatry 13:84-9. 2008
  8. ncbi request reprint Family based association analyses between the serotonin transporter gene polymorphism (5-HTTLPR) and neuroticism, anxiety and depression
    Christel M Middeldorp
    Department of Biological Psychology, Vrije Universiteit Amsterdam, Van der Boechorststraat 1, Amsterdam, 1081 BT, The Netherlands
    Behav Genet 37:294-301. 2007
  9. ncbi request reprint Sex differences in symptoms of depression in unrelated individuals and opposite-sex twin and sibling pairs
    Christel M Middeldorp
    Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
    Twin Res Hum Genet 9:632-6. 2006
  10. ncbi request reprint Familial clustering of major depression and anxiety disorders in Australian and Dutch twins and siblings
    Christel M Middeldorp
    Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands
    Twin Res Hum Genet 8:609-15. 2005

Detail Information

Publications34

  1. pmc The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data
    C M Middeldorp
    Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands
    Transl Psychiatry 1:e50. 2011
    ..This study suggests shared genetic risk factors for neuroticism and MDD on the one hand and for extraversion and BD on the other...
  2. pmc Suggestive linkage on chromosome 2, 8, and 17 for lifetime major depression
    Christel M Middeldorp
    Department of Biological Psychology, VU University, Amsterdam, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 150:352-8. 2009
    ..Further replication is needed to establish the relevance of our linkage finding on chromosome 2...
  3. pmc Anxiety and depression in children and adults: influence of serotonergic and neurotrophic genes?
    C M Middeldorp
    Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands
    Genes Brain Behav 9:808-16. 2010
    ..Overall, there has been no convincing evidence, so far, for a role of genetic variation in these pathways in the development of anxiety and depression...
  4. pmc An association between Epac-1 gene variants and anxiety and depression in two independent samples
    Christel M Middeldorp
    Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 153:214-9. 2010
    ..The divergent results could be due to differences in linkage disequilibrium between the investigated SNPs and a functional polymorphism in the Dutch and USA sample...
  5. doi request reprint The serotonin transporter gene length polymorphism (5-HTTLPR) and life events: no evidence for an interaction effect on neuroticism and anxious depressive symptoms
    Christel M Middeldorp
    Department of Biological Psychology, VU University Amsterdam, The Netherlands
    Twin Res Hum Genet 13:544-9. 2010
    ....
  6. doi request reprint Life events, anxious depression and personality: a prospective and genetic study
    C M Middeldorp
    Department of Biological Psychology, Vrije Universiteit, Van der Boechorststraat 1, Amsterdam, The Netherlands
    Psychol Med 38:1557-65. 2008
    ..The effect of genes that influence environmental exposure might be mediated through personality and we therefore also examined the association between life events and personality (neuroticism and extraversion)...
  7. ncbi request reprint Linkage on chromosome 14 in a genome-wide linkage study of a broad anxiety phenotype
    C M Middeldorp
    Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands
    Mol Psychiatry 13:84-9. 2008
    ..Two homolog genes lie in this region -Dlk1 (delta-like 1 homolog, Drosophila) and Rtl1 (retrotransposon-like 1). Future association studies of these genes are warranted...
  8. ncbi request reprint Family based association analyses between the serotonin transporter gene polymorphism (5-HTTLPR) and neuroticism, anxiety and depression
    Christel M Middeldorp
    Department of Biological Psychology, Vrije Universiteit Amsterdam, Van der Boechorststraat 1, Amsterdam, 1081 BT, The Netherlands
    Behav Genet 37:294-301. 2007
    ..No additive effect of the s allele was found for DSM-IV depression. Our results strongly suggest that there is no straightforward association between 5-HTTLPR and neuroticism, anxiety and depression...
  9. ncbi request reprint Sex differences in symptoms of depression in unrelated individuals and opposite-sex twin and sibling pairs
    Christel M Middeldorp
    Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
    Twin Res Hum Genet 9:632-6. 2006
    ..This signifies that men and women are alike in their symptom profiles for major depression and genes for depression are probably expressed in the same way in the two sexes...
  10. ncbi request reprint Familial clustering of major depression and anxiety disorders in Australian and Dutch twins and siblings
    Christel M Middeldorp
    Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands
    Twin Res Hum Genet 8:609-15. 2005
    ..Furthermore, different genetic risk factors appear to contribute to the vulnerability for panic disorder and/or agoraphobia in men and women. No other sex differences were found...
  11. ncbi request reprint A twin-family study of the association between employment, burnout and anxious depression
    Christel M Middeldorp
    Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherland
    J Affect Disord 90:163-9. 2006
    ..Earlier studies have shown that employment and burnout are related to anxiety and depression. This twin-family study investigates to what extent these associations are caused by shared etiological factors...
  12. ncbi request reprint Twin and genetic effects on life events
    Christel M Middeldorp
    Department of Biological Psychology, Vrije Universiteit, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands
    Twin Res Hum Genet 8:224-31. 2005
    ..Familial resemblance of illness and death of a significant other was mainly due to common environment. For the other life events, it was not possible to distinguish between genetic and common environmental effects...
  13. ncbi request reprint The co-morbidity of anxiety and depression in the perspective of genetic epidemiology. A review of twin and family studies
    C M Middeldorp
    Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
    Psychol Med 35:611-24. 2005
    ..The aim of this paper is to evaluate the theory of Gray and McNaughton using the results of genetic epidemiological studies...
  14. ncbi request reprint Familial clustering in burnout: a twin-family study
    C M Middeldorp
    Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
    Psychol Med 35:113-20. 2005
    ..Finally, we tried to identify specific risk factors for burnout...
  15. pmc Influence of candidate genes on attention problems in children: a longitudinal study
    Catherina E M van Beijsterveldt
    Department of Biological Psychology, VU University Amsterdam, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands
    Behav Genet 41:155-64. 2011
    ..None of the SNPs showed a significant association with AP. The lowest p-value was found for the rs6265 SNP in the BDNF gene (p = 0.035). Overall, our results suggest no evidence for a role of these genes in childhood AP...
  16. doi request reprint Genetic and environmental stability in attention problems across the lifespan: evidence from the Netherlands twin register
    Kees Jan Kan
    Vrije Universiteit, Amsterdam, The Netherlands
    J Am Acad Child Adolesc Psychiatry 52:12-25. 2013
    ....
  17. ncbi request reprint Heritability of anxious-depressive and withdrawn behavior: age-related changes during adolescence
    Diane J Lamb
    Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands
    J Am Acad Child Adolesc Psychiatry 49:248-55. 2010
    ..To explain the differential course of anxiety and depression in individuals from childhood to adulthood by examining age-related changes in the genetic and environmental etiology of anxious and depressive symptoms...
  18. doi request reprint Childhood and adolescent anxiety and depression: beyond heritability
    Sanja Franić
    Vrije Universiteit Amsterdam, Faculty of Psychology and Education, Department of Biological Psychology, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands
    J Am Acad Child Adolesc Psychiatry 49:820-9. 2010
    ..To review the methodology of behavior genetics studies addressing research questions that go beyond simple heritability estimation and illustrate these using representative research on childhood and adolescent anxiety and depression...
  19. doi request reprint Strong effects of environmental factors on prevalence and course of major depressive disorder are not moderated by 5-HTTLPR polymorphisms in a large Dutch sample
    Wouter J Peyrot
    Department of Psychiatry, Neuroscience Campus Amsterdam and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    J Affect Disord 146:91-9. 2013
    ....
  20. doi request reprint The Young Netherlands Twin Register (YNTR): longitudinal twin and family studies in over 70,000 children
    Catharina E M van Beijsterveldt
    Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands
    Twin Res Hum Genet 16:252-67. 2013
    ....
  21. pmc Heritability of self-reported phobic fear
    Marijn A Distel
    Department of Biological Psychology, VU University, Van der Boechorststraat 1, Amsterdam, 1081 BT, The Netherlands
    Behav Genet 38:24-33. 2008
    ..For social fear in participants aged 26-65 only additive genetic effects were detected. Broad-sense heritability estimates ranged from 36 to 51% and were similar for men and women...
  22. doi request reprint Effects of chorionicity and zygosity on triplet birth weight
    Diane J Lamb
    Department of Biological Psychology, VU University Amsterdam, The Netherlands
    Twin Res Hum Genet 15:149-57. 2012
    ..We conclude that having shared a chorion, rather than being monozygotic, increases the risk of a low birth weight...
  23. pmc Sex differences in genetic architecture of complex phenotypes?
    Jacqueline M Vink
    Netherlands Twin Register, Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 7:e47371. 2012
    ..We conclude that for most traits that were examined, the current evidence is that same the genes are operating in men and women...
  24. doi request reprint Gene-environment interaction in teacher-rated internalizing and externalizing problem behavior in 7- to 12-year-old twins
    Diane J Lamb
    Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
    J Child Psychol Psychiatry 53:818-25. 2012
    ..A unique feature of teacher ratings of twins is that some pairs are rated by different and others are rated by the same teacher. This offers the opportunity to assess gene-environment interaction...
  25. ncbi request reprint Estimating non-response bias in family studies: application to mental health and lifestyle
    Jacqueline M Vink
    Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
    Eur J Epidemiol 19:623-30. 2004
    ..Results suggest that, even for studies with moderate response rates, data collected on health, personality and lifestyle are relatively unbiased...
  26. doi request reprint Evidence for a causal association of low birth weight and attention problems
    Maria M Groen-Blokhuis
    VU University, Department of Biological Psychology, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands
    J Am Acad Child Adolesc Psychiatry 50:1247-54.e2. 2011
    ..The etiology of this association is unclear. We investigate whether there is a causal influence of birth weight (BW) on AP and whether the BW effect is mediated by catch-up growth (CUG) in low-BW children...
  27. doi request reprint Borderline personality traits and adult attention-deficit hyperactivity disorder symptoms: a genetic analysis of comorbidity
    Marijn A Distel
    Department of Biological Psychology, VU University Amsterdam, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 156:817-25. 2011
    ..The genetic and environmental correlations between BPT and ADHD symptoms were 0.72 and 0.51, respectively. The shared etiology between BPT and ADHD symptoms is thus a likely cause for the comorbidity of the two disorders...
  28. doi request reprint Crying without a cause and being easily upset in two-year-olds: heritability and predictive power of behavioral problems
    Maria M Groen-Blokhuis
    Department of Biological Psychology, VU University Amsterdam, The Netherlands
    Twin Res Hum Genet 14:393-400. 2011
    ..A substantial influence of genetic factors was found for the two items, which are predictive of later behavioral problems...
  29. doi request reprint Genetic risk score analysis indicates migraine with and without comorbid depression are genetically different disorders
    Lannie Ligthart
    Department of Biological Psychology, VU University, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands
    Hum Genet 133:173-86. 2014
    ..The subgroup of individuals with comorbid MDD and migraine were genetically most similar to MDD patients. These results indicate that in at least a subset of migraine patients with MDD, migraine may be a symptom or consequence of MDD. ..
  30. pmc Birth weight in a large series of triplets
    Diane J Lamb
    Department of Biological Psychology, VU University, The Netherlands
    BMC Pediatr 11:24. 2011
    ..The objective of this study is to examine factors associated with birth weight in a large, population-based sample of triplets registered with the Netherlands Twin Register (NTR)...
  31. doi request reprint Life events and borderline personality features: the influence of gene-environment interaction and gene-environment correlation
    M A Distel
    Department of Biological Psychology, VU University Amsterdam, The Netherlands
    Psychol Med 41:849-60. 2011
    ..As the presence of genotype-environment correlation (rGE) can lead to spurious findings of genotype-environment interaction (G × E), we also test whether BPD features increase the likelihood of exposure to life events...
  32. doi request reprint A prospective study of the effects of breastfeeding and FADS2 polymorphisms on cognition and hyperactivity/attention problems
    Maria M Groen-Blokhuis
    Department of Biological Psychology, VU University, Amsterdam, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 162:457-65. 2013
    ..In general, the benefits of breastfeeding were small and did not interact with SNPs in FADS2...
  33. pmc Adolescent self-report of emotional and behavioral problems: interactions of genetic factors with sex and age
    Meike Bartels
    Department of Biological Psychology, VU University, Amsterdam, The Netherlands
    J Can Acad Child Adolesc Psychiatry 20:35-52. 2011
    ..The aim of the current study was to investigate the sex and age effects on the mean levels and the genetic architecture of adolescent self-reported emotional and behavioral problems...
  34. doi request reprint Genome-wide linkage analysis of multiple measures of neuroticism of 2 large cohorts from Australia and the Netherlands
    Naomi R Wray
    Department of Genetic Epidemiology, Queensland Institute of Medical Research, 300 Herston Rd, Brisbane, Australia 4029
    Arch Gen Psychiatry 65:649-58. 2008
    ..Studying this personality dimension can give insights into the etiology of these important psychiatric disorders...