Joen Luirink

Summary

Affiliation: Vrije Universiteit
Country: The Netherlands

Publications

  1. pmc Early encounters of a nascent membrane protein: specificity and timing of contacts inside and outside the ribosome
    Edith N G Houben
    Department of Molecular Microbiology, Institute of Molecular Cell Biology, Vrije Universiteit, 1081 HV Amsterdam, Netherlands
    J Cell Biol 170:27-35. 2005
  2. ncbi request reprint SRP-mediated protein targeting: structure and function revisited
    Joen Luirink
    Department of Molecular Microbiology, Vrije Universiteit, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
    Biochim Biophys Acta 1694:17-35. 2004
  3. ncbi request reprint Biogenesis of inner membrane proteins in Escherichia coli
    Joen Luirink
    Department of Microbiology, Institute of Molecular Cell Biology, Vrije Universiteit, 1081 HV Amsterdam, The Netherlands
    Annu Rev Microbiol 59:329-55. 2005
  4. pmc Interplay of signal recognition particle and trigger factor at L23 near the nascent chain exit site on the Escherichia coli ribosome
    Ronald S Ullers
    Department of Molecular Microbiology, Vrije Universiteit, 1081 HV Amsterdam, The Netherlands
    J Cell Biol 161:679-84. 2003
  5. doi request reprint Biogenesis of inner membrane proteins in Escherichia coli
    Joen Luirink
    Section of Molecular Microbiology, Department of Molecular Cell Biology, VU University, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    Biochim Biophys Acta 1817:965-76. 2012
  6. ncbi request reprint Flexibility in targeting and insertion during bacterial membrane protein biogenesis
    Edwin van Bloois
    Department of Molecular Microbiology, Institute of Molecular Cell Biology, Vrije Universiteit, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    Biochem Biophys Res Commun 362:727-33. 2007
  7. ncbi request reprint YidC and SecY mediate membrane insertion of a Type I transmembrane domain
    Edith N G Houben
    Department of Microbiology, Institute of Molecular Biological Sciences, Vrije Universiteit, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
    J Biol Chem 277:35880-6. 2002
  8. ncbi request reprint Distinct requirements for translocation of the N-tail and C-tail of the Escherichia coli inner membrane protein CyoA
    Edwin van Bloois
    Department of Molecular Microbiology, Institute of Molecular Cell Biology, Vrije Universiteit, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
    J Biol Chem 281:10002-9. 2006
  9. ncbi request reprint Sequence-specific interactions of nascent Escherichia coli polypeptides with trigger factor and signal recognition particle
    Ronald S Ullers
    Department of Molecular Microbiology, Institute of Molecular Cell Biology, Vrije Universiteit, 1081 HV Amsterdam, The Netherlands
    J Biol Chem 281:13999-4005. 2006
  10. ncbi request reprint The Sec-independent function of Escherichia coli YidC is evolutionary-conserved and essential
    Edwin van Bloois
    Department of Molecular Microbiology, Institute of Molecular Cell Biology, Vrije Universiteit, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
    J Biol Chem 280:12996-3003. 2005

Collaborators

Detail Information

Publications53

  1. pmc Early encounters of a nascent membrane protein: specificity and timing of contacts inside and outside the ribosome
    Edith N G Houben
    Department of Molecular Microbiology, Institute of Molecular Cell Biology, Vrije Universiteit, 1081 HV Amsterdam, Netherlands
    J Cell Biol 170:27-35. 2005
    ..Intraribosomal contacts of the nascent chain were not influenced by the presence of a functional TM in the ribosome...
  2. ncbi request reprint SRP-mediated protein targeting: structure and function revisited
    Joen Luirink
    Department of Molecular Microbiology, Vrije Universiteit, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
    Biochim Biophys Acta 1694:17-35. 2004
    ..An impressive amount of new information especially on the prokaryotic SRP is integrated into the current picture of the SRP pathway...
  3. ncbi request reprint Biogenesis of inner membrane proteins in Escherichia coli
    Joen Luirink
    Department of Microbiology, Institute of Molecular Cell Biology, Vrije Universiteit, 1081 HV Amsterdam, The Netherlands
    Annu Rev Microbiol 59:329-55. 2005
    ..This review deals mainly with recent structural and biochemical data from various experimental systems that offer new insight into the different stages of biogenesis of E. coli IMPs...
  4. pmc Interplay of signal recognition particle and trigger factor at L23 near the nascent chain exit site on the Escherichia coli ribosome
    Ronald S Ullers
    Department of Molecular Microbiology, Vrije Universiteit, 1081 HV Amsterdam, The Netherlands
    J Cell Biol 161:679-84. 2003
    ..The results suggest a role for L23 in the targeting of IMPs as an attachment site for TF and SRP that is close to the emerging nascent chain...
  5. doi request reprint Biogenesis of inner membrane proteins in Escherichia coli
    Joen Luirink
    Section of Molecular Microbiology, Department of Molecular Cell Biology, VU University, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    Biochim Biophys Acta 1817:965-76. 2012
    ..This article is part of a Special Issue entitled: Biogenesis/Assembly of Respiratory Enzyme Complexes...
  6. ncbi request reprint Flexibility in targeting and insertion during bacterial membrane protein biogenesis
    Edwin van Bloois
    Department of Molecular Microbiology, Institute of Molecular Cell Biology, Vrije Universiteit, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    Biochem Biophys Res Commun 362:727-33. 2007
    ..The modified model IMPs were analyzed for altered routing using an in vivo protease mapping approach. The data suggest a facultative use of different combinations of factors...
  7. ncbi request reprint YidC and SecY mediate membrane insertion of a Type I transmembrane domain
    Edith N G Houben
    Department of Microbiology, Institute of Molecular Biological Sciences, Vrije Universiteit, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
    J Biol Chem 277:35880-6. 2002
    ..Upon elongation, nascent Lep remains close to YidC and comes into contact with lipids as well. Our results suggest a role for YidC in both the reception and lipid partitioning of type I TMs...
  8. ncbi request reprint Distinct requirements for translocation of the N-tail and C-tail of the Escherichia coli inner membrane protein CyoA
    Edwin van Bloois
    Department of Molecular Microbiology, Institute of Molecular Cell Biology, Vrije Universiteit, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
    J Biol Chem 281:10002-9. 2006
    ..Translocation of the large C-terminal periplasmic domain requires the Sec translocon and SecA, suggesting that for this particular IMP the Sec translocon might operate downstream of YidC...
  9. ncbi request reprint Sequence-specific interactions of nascent Escherichia coli polypeptides with trigger factor and signal recognition particle
    Ronald S Ullers
    Department of Molecular Microbiology, Institute of Molecular Cell Biology, Vrije Universiteit, 1081 HV Amsterdam, The Netherlands
    J Biol Chem 281:13999-4005. 2006
    ..Importantly and in contrast to published data, the SRP appears perfectly capable of distinguishing SA sequences from signal sequences in secretory proteins at this early stage in biogenesis...
  10. ncbi request reprint The Sec-independent function of Escherichia coli YidC is evolutionary-conserved and essential
    Edwin van Bloois
    Department of Molecular Microbiology, Institute of Molecular Cell Biology, Vrije Universiteit, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
    J Biol Chem 280:12996-3003. 2005
    ..Together, our data indicate that the Sec-independent function of YidC is conserved and essential for cell growth...
  11. ncbi request reprint Signal recognition particle (SRP)-mediated targeting and Sec-dependent translocation of an extracellular Escherichia coli protein
    Robert Sijbrandi
    Department of Molecular Microbiology, Vrije Universiteit, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
    J Biol Chem 278:4654-9. 2003
    ..We propose that these autotransporters preferentially use the co-translational SRP/Sec route to avoid adverse effects of the exposure of their mature domains in the cytoplasm...
  12. ncbi request reprint Crystal structure of hemoglobin protease, a heme binding autotransporter protein from pathogenic Escherichia coli
    Ben R Otto
    Department of Molecular Microbiology, Faculty of Earth and Life Sciences, Vrije Universiteit de Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    J Biol Chem 280:17339-45. 2005
    ..The crystal structure of the complete passenger domain of Hbp (110 kDa) is presented, which is the first structure from this class of serine proteases and the largest parallel beta-helical structure yet solved...
  13. doi request reprint The Bam (Omp85) complex is involved in secretion of the autotransporter haemoglobin protease
    Ana Sauri
    Department of Molecular Microbiology, Institute of Molecular Cell Biology, VU University, 1081 HV Amsterdam, The Netherlands
    Microbiology 155:3982-91. 2009
    ..The data suggest a critical role for this general machinery in the translocation of autotransporters across the outer membrane...
  14. pmc The conserved third transmembrane segment of YidC contacts nascent Escherichia coli inner membrane proteins
    Zhong Yu
    Department of Molecular Microbiology, Institute of Molecular Cell Biology, VU University, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    J Biol Chem 283:34635-42. 2008
    ....
  15. pmc The two membrane segments of leader peptidase partition one by one into the lipid bilayer via a Sec/YidC interface
    Edith N G Houben
    Department of Molecular Microbiology, Institute of Molecular Cell Biology, Vrije Universiteit, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
    EMBO Rep 5:970-5. 2004
    ..We propose that YidC assists the lipid partitioning of single TMs...
  16. ncbi request reprint Limited tolerance towards folded elements during secretion of the autotransporter Hbp
    Wouter S P Jong
    Department of Molecular Microbiology, Institute of Molecular Cell Biology, Vrije Universiteit, 1081 HV Amsterdam, The Netherlands
    Mol Microbiol 63:1524-36. 2007
    ..The data suggest that Hbp can fold in the periplasm but must retain a certain degree of flexibility and/or modest width to allow translocation across the outer membrane...
  17. ncbi request reprint Saccharomyces cerevisiae Cox18 complements the essential Sec-independent function of Escherichia coli YidC
    Edwin van Bloois
    Department of Molecular Microbiology, Institute of Molecular Cell Biology, Vrije Universiteit, Amsterdam, The Netherlands
    FEBS J 274:5704-13. 2007
    ..coli, we show here that Cox18 is able to complement the essential Sec-independent function of YidC. This identifies Cox18 as a bona fide member of the YidC/Oxa1/Alb3 family...
  18. pmc A conserved aromatic residue in the autochaperone domain of the autotransporter Hbp is critical for initiation of outer membrane translocation
    Zora Soprova
    Department of Molecular Microbiology, Institute of Molecular Cell Biology, VU University, 1081 HV Amsterdam, The Netherlands
    J Biol Chem 285:38224-33. 2010
    ..Further analysis revealed that Trp(1015) is most likely required for initiation of processive folding of the β-helix at the cell surface, which drives sequential translocation of the Hbp passenger across the OM...
  19. doi request reprint Detection of cross-links between FtsH, YidC, HflK/C suggests a linked role for these proteins in quality control upon insertion of bacterial inner membrane proteins
    Edwin van Bloois
    Department of Molecular Microbiology, Institute of Molecular Cell Biology, Vrije Universiteit, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
    FEBS Lett 582:1419-24. 2008
    ..These results suggest that FtsH and YidC have a linked role in the quality control of IMPs...
  20. pmc Contribution of the FtsQ transmembrane segment to localization to the cell division site
    Dirk Jan Scheffers
    Molecular Microbiology, Institute for Molecular Cell Biology, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands
    J Bacteriol 189:7273-80. 2007
    ..Our results indicate that the FtsQ TMS plays a role in FtsQ localization to the division site...
  21. doi request reprint Autotransporter β-domains have a specific function in protein secretion beyond outer-membrane targeting
    Ana Sauri
    Section of Molecular Microbiology, Department of Molecular Cell Biology, VU University, 1081 HV Amsterdam, The Netherlands
    J Mol Biol 412:553-67. 2011
    ..Our results show that efficient passenger secretion requires a specific β-domain that not only functions as a targeting device but also is directly involved in the translocation of the passenger to the cell surface...
  22. ncbi request reprint Trigger factor interacts with the signal peptide of nascent Tat substrates but does not play a critical role in Tat-mediated export
    Wouter S P Jong
    Department of Molecular Microbiology, Institute of Molecular Cell Biology, Vrije Universiteit, Amsterdam, The Netherlands
    Eur J Biochem 271:4779-87. 2004
    ..Despite this exclusive and prolonged contact, depletion or overexpression of TF had little effect on the kinetics and efficiency of the Tat export process...
  23. pmc YidC is involved in the biogenesis of the secreted autotransporter hemoglobin protease
    Wouter S P Jong
    Section of Molecular Microbiology, Department of Molecular Cell Biology, VU University, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    J Biol Chem 285:39682-90. 2010
    ..The large periplasmic domain of YidC is not critical for this novel functionality as it can be deleted without affecting Hbp biogenesis...
  24. doi request reprint YidC is required for the assembly of the MscL homopentameric pore
    Ovidiu I Pop
    Section Molecular Microbiology, Department of Molecular Cell Biology, VU University, Amsterdam, The Netherlands
    FEBS J 276:4891-9. 2009
    ..The data are consistent with the view that YidC functions as a membrane-based chaperone 'module' to facilitate assembly of a subset of protein complexes in the inner membrane of E. coli...
  25. doi request reprint Pbp, a cell-surface exposed plasminogen binding protein of Bacteroides fragilis
    Robert Sijbrandi
    Department of Molecular Microbiology, Faculty of Earth and Life Sciences, VU University Amsterdam de Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    Microbes Infect 10:514-21. 2008
    ..coli and B. fragilis. Pbp-like proteins were also detected in some other Bacteroides subspecies. The role of this potential B. fragilis virulence factor in pathogenicity is discussed...
  26. ncbi request reprint F(1)F(0) ATP synthase subunit c is targeted by the SRP to YidC in the E. coli inner membrane
    Edwin van Bloois
    Department of Molecular Microbiology, Institute of Molecular Cell Biology, Vrije Universiteit, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
    FEBS Lett 576:97-100. 2004
    ..The data suggest that F0c is targeted by the SRP to the membrane, where it inserts at YidC in a Sec-independent mechanism. F0c appears to be the first natural substrate of this novel pathway...
  27. pmc Activators of the glutamate-dependent acid resistance system alleviate deleterious effects of YidC depletion in Escherichia coli
    Zhong Yu
    Department of Molecular Microbiology, Institute of Molecular Cell Biology, VU University Amsterdam, Amsterdam 1081 HV, The Netherlands
    J Bacteriol 193:1308-16. 2011
    ....
  28. pmc A structurally informed autotransporter platform for efficient heterologous protein secretion and display
    Wouter S P Jong
    Section Molecular Microbiology, Department of Molecular Cell Biology, Faculty of Earth and Life Sciences, VU University, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands
    Microb Cell Fact 11:85. 2012
    ....
  29. pmc Role for Escherichia coli YidD in membrane protein insertion
    Zhong Yu
    Section of Molecular Microbiology, Department of Molecular Cell Biology, Vrije Universiteit, Amsterdam 1081 HV, Netherlands
    J Bacteriol 193:5242-51. 2011
    ..Furthermore, in vitro cross-linking showed that YidD is in proximity of a nascent inner membrane protein during its localization in the Sec-YidC translocon, suggesting that YidD might be involved in the insertion process...
  30. ncbi request reprint Characterization of an iron-regulated alpha-enolase of Bacteroides fragilis
    Robert Sijbrandi
    Department of Molecular Microbiology, Vrije Universiteit, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    Microbes Infect 7:9-18. 2005
    ..Plasminogen-binding to B. fragilis cells did occur but was not P46 dependent. A 60-kDa protein was identified as a putative plasminogen-binding protein in B. fragilis...
  31. pmc Fine-mapping the contact sites of the Escherichia coli cell division proteins FtsB and FtsL on the FtsQ protein
    H Bart van den Berg van Saparoea
    Section of Molecular Microbiology, Department of Molecular Cell Biology, Amsterdam Institute of Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
    J Biol Chem 288:24340-50. 2013
    ..The identification of contact sites in the FtsQBL complex will guide future development of interaction inhibitors that block cell division. ..
  32. pmc SecB is a bona fide generalized chaperone in Escherichia coli
    Ronald S Ullers
    Department of Molecular Microbiology, Vrije Universiteit, 1081 HV, Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 101:7583-8. 2004
    ..Taken together, our data demonstrate that SecB acts as a bona fide generalized chaperone...
  33. doi request reprint Extracellular production of recombinant proteins using bacterial autotransporters
    Wouter S P Jong
    Section Molecular Microbiology, Department of Molecular Cell Biology, Faculty of Earth and Life Sciences, VU University, 1081 HV Amsterdam, Netherlands
    Curr Opin Biotechnol 21:646-52. 2010
    ..Here we discuss recent progress in the structural and mechanistic analysis of this pathway and the implications for future development of a versatile platform for secretion and display of heterologous proteins...
  34. doi request reprint Estimating the size of the active translocation pore of an autotransporter
    Ana Sauri
    Section of Molecular Microbiology, Department of Molecular Cell Biology, VU University, 1081 HVAmsterdam, The Netherlands
    J Mol Biol 416:335-45. 2012
    ..7 nm. If the β-domain functions as the translocator, it must be forced into an expanded conformation during passenger translocation...
  35. ncbi request reprint Targeting, insertion, and localization of Escherichia coli YidC
    Malene L Urbanus
    Department of Microbiology, Institute for Molecular Biological Sciences, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
    J Biol Chem 277:12718-23. 2002
    ..In addition, YidC is shown to be relatively abundant compared with other components involved in IMP assembly and is predominantly localized at the poles of the cell...
  36. doi request reprint Getting across the cell envelope: mycobacterial protein secretion
    Aniek D van der Woude
    Department of Molecular Microbiology, Institute of Molecular Cell Biology, VU University, Amsterdam, The Netherlands
    Curr Top Microbiol Immunol 374:109-34. 2013
    ..Here, we discuss our current knowledge about the mechanisms and substrates of these different protein translocation systems and their role in mycobacterial physiology and virulence. ..
  37. doi request reprint Channel properties of the translocator domain of the autotransporter Hbp of Escherichia coli
    Virginie Roussel-Jazédé
    Department of Molecular Microbiology, Institute of Biomembranes, Utrecht University, Utrecht, The Netherlands
    Mol Membr Biol 28:158-70. 2011
    ..In addition, we could show that the α-helix contributes to the stability of TDs...
  38. doi request reprint The conserved extension of the Hbp autotransporter signal peptide does not determine targeting pathway specificity
    Wouter S P Jong
    Department of Molecular Microbiology, Institute of Molecular Cell Biology, VU University Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    Biochem Biophys Res Commun 368:522-7. 2008
    ....
  39. pmc Unexpected link between lipooligosaccharide biosynthesis and surface protein release in Mycobacterium marinum
    Aniek D van der Woude
    Department of Medical Microbiology and Infection Control, VU University Medical Center, 1081 HV Amsterdam, The Netherlands
    J Biol Chem 287:20417-29. 2012
    ..This mutant showed a marked increase in virulence as compared with the wild-type strain, suggesting that LOS-IV plays a role in the modulation of mycobacterial virulence...
  40. ncbi request reprint Analysis of SecA2-dependent substrates in Mycobacterium marinum identifies protein kinase G (PknG) as a virulence effector
    Aniek D van der Woude
    Department of Medical Microbiology and Infection Control, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands Department of Molecular Microbiology, Institute of Molecular Cell Biology, VU University, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands
    Cell Microbiol 16:280-95. 2014
    ..These results suggest that SecA2-dependent membrane localization of PknG is an important determinant for M. marinum virulence. ..
  41. pmc Escherichia coli hemoglobin protease autotransporter contributes to synergistic abscess formation and heme-dependent growth of Bacteroides fragilis
    Ben R Otto
    Department of Molecular Microbiology, Institute of Molecular Biological Sciences, Amsterdam, The Netherlands
    Infect Immun 70:5-10. 2002
    ..In conclusion, results suggest the synergy of abscess formation by E. coli and B. fragilis can be partly explained by the capacity of B. fragilis to intercept Hbp and iron from heme to overcome the iron restrictions imposed by the host...
  42. doi request reprint Composition of the type VII secretion system membrane complex
    Edith N G Houben
    Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, The Netherlands
    Mol Microbiol 86:472-84. 2012
    ..These are the first data on a T7S membrane complex and, given the high conservation of its components, our data can likely be generalized to most mycobacterial T7S systems...
  43. ncbi request reprint Biogenesis of MalF and the MalFGK(2) maltose transport complex in Escherichia coli requires YidC
    Samuel Wagner
    Center for Biomembrane Research, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden
    J Biol Chem 283:17881-90. 2008
    ..Our data indicate that YidC supports the folding of MalF into a stable conformation before it is incorporated into the maltose transport complex...
  44. ncbi request reprint Type VII secretion--mycobacteria show the way
    Abdallah M Abdallah
    Department of Medical Microbiology, VU Medical Centre, Amsterdam 1081BT, The Netherlands
    Nat Rev Microbiol 5:883-91. 2007
    ..Given the unique composition of this secretion system, and its general importance, we propose that, in line with the accepted nomenclature, it should be called type VII secretion...
  45. ncbi request reprint The presence of a helix breaker in the hydrophobic core of signal sequences of secretory proteins prevents recognition by the signal-recognition particle in Escherichia coli
    Hendrik Adams
    Department of Molecular Microbiology and Institute of Biomembranes, Utrecht University, The Netherlands
    Eur J Biochem 269:5564-71. 2002
    ..Together, these data indicate that the helix breaker in cleavable signal sequences prevents recognition by SRP and is thereby, together with the hydrophobicity of the signal sequence, a determinant of the targeting pathway...
  46. ncbi request reprint Versatility of inner membrane protein biogenesis in Escherichia coli
    Linda Fröderberg
    Department of Biochemistry and Biophysics, Arrhenius Laboratories, Stockholm University, SE 106 91 Stockholm, Sweden
    Mol Microbiol 47:1015-27. 2003
    ..This indicates that IMP assembly is much more versatile than previously thought...
  47. ncbi request reprint Defective translocation of a signal sequence mutant in a prlA4 suppressor strain of Escherichia coli
    Hendrik Adams
    Department of Molecular Microbiology and Institute of Biomembranes, Utrecht University, The Netherlands
    Eur J Biochem 269:5572-80. 2002
    ..Together, these data suggest that SecB and SRP substrates are differently processed at the SecYEG translocon...
  48. ncbi request reprint Targeting and insertion of heterologous membrane proteins in E. coli
    Amanda Raine
    Department of Pharmaceutical Biosciences, Uppsala University, BMC, Box 591, 75124, Uppsala, Sweden
    Biochimie 85:659-68. 2003
    ..coli membrane proteins. No significant pausing of protein elongation was observed in the presence of E. coli SRP, in line with the suggestion that translational arrest requires an Alu domain, which is absent in SRP from E. coli...
  49. ncbi request reprint Signal peptide hydrophobicity is critical for early stages in protein export by Bacillus subtilis
    Geeske Zanen
    Department of Pharmaceutical Biology, University of Groningen, The Netherlands
    FEBS J 272:4617-30. 2005
    ..Thus, signal peptide hydrophobicity appears to be more critical for the efficiency of early stages in protein export in B. subtilis than in E. coli...
  50. ncbi request reprint Evolution of mitochondrial oxa proteins from bacterial YidC. Inherited and acquired functions of a conserved protein insertion machinery
    Marc Preuss
    Institut fur Physiologische Chemie, Universitat Munchen, Butenandtstrasse 5, 81377 Munchen, Germany
    J Biol Chem 280:13004-11. 2005
    ..Our observations suggest that during evolution of mitochondria from their bacterial ancestors the two descendents of YidC functionally segregated to perform two distinct activities, one co-translational and one post-translational...
  51. ncbi request reprint Targeting and translocation of two lipoproteins in Escherichia coli via the SRP/Sec/YidC pathway
    Linda Fröderberg
    Department of Biochemistry and Biophysics, Arrhenius Laboratories, Stockholm University, SE 106 91 Stockholm, Sweden
    J Biol Chem 279:31026-32. 2004
    ..Furthermore, we show that YidC plays an important role in the targeting/translocation of both lipoproteins...
  52. pmc The ribosome and YidC. New insights into the biogenesis of Escherichia coli inner membrane proteins
    Jan Willem L de Gier
    Department of Biochemistry and Biophysics, Arrhenius Laboratories, Stockholm University, SE 106 91 Stockholm, Sweden
    EMBO Rep 4:939-43. 2003
    ..Lateral transport seems to be assisted by the IMP YidC. In this article, we discuss recent observations that point to a key role for the ribosome in IMP targeting and to the diverse roles of YidC in IMP assembly...
  53. ncbi request reprint A specific secretion system mediates PPE41 transport in pathogenic mycobacteria
    Abdallah M Abdallah
    Department of Medical Microbiology and Infection Control, VU Medical Centre, Amsterdam, The Netherlands
    Mol Microbiol 62:667-79. 2006
    ..This PPE secretion system is also involved in the virulence of pathogenic mycobacteria, as the ESX-5 mutant of M. marinum was affected in spreading to uninfected macrophages...