Ka Wan Li

Summary

Affiliation: Vrije Universiteit
Country: The Netherlands

Publications

  1. ncbi request reprint Quantitative proteomics and protein network analysis of hippocampal synapses of CaMKIIalpha mutant mice
    Ka Wan Li
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Faculty of Earth and Life Sciences, Vrije Universiteit, Amsterdam, The Netherlands
    J Proteome Res 6:3127-33. 2007
  2. ncbi request reprint Subcellular proteomics in neuroscience
    Ka Wan Li
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, VU University Amsterdam, The Netherlands
    Front Biosci 13:4416-25. 2008
  3. ncbi request reprint Proteomics of synapse
    Ka Wan Li
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Faculty of Earth and Life Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands
    Anal Bioanal Chem 387:25-8. 2007
  4. doi request reprint Interaction proteomics of the AMPA receptor: towards identification of receptor sub-complexes
    Ka Wan Li
    Department of Molecular and Cellular Neurobiology, Faculty of Earth and Life Sciences, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, De Boelelaan 1085, Amsterdam, 1081 HV, The Netherlands
    Amino Acids 44:1247-51. 2013
  5. ncbi request reprint Intermittent administration of morphine alters protein expression in rat nucleus accumbens
    Ka Wan Li
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit, Amsterdam, The Netherlands
    Proteomics 6:2003-8. 2006
  6. ncbi request reprint Organelle proteomics of rat synaptic proteins: correlation-profiling by isotope-coded affinity tagging in conjunction with liquid chromatography-tandem mass spectrometry to reveal post-synaptic density specific proteins
    Ka Wan Li
    Department of Molecular and Cellular Neurobiology, Center of Neurogenomics and Cognitive Research, Faculty of Earth and Life Sciences, Vrije Universiteit, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    J Proteome Res 4:725-33. 2005
  7. doi request reprint Proteomics of brain synapses and molecular dissection of synaptic subdomains
    Ka Wan Li
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Faculty of Earth and Life Sciences, Vrije Universiteit, Amsterdam, The Netherlands
    Proteomics Clin Appl 1:1476-84. 2007
  8. doi request reprint Mass spectrometric analysis of molluscan neuropeptides
    Ka Wan Li
    Department of Molecular and Cellular Neurobiology, Centre for Neurogenomics and Cognitive Research, Faculty of Earth and Life Sciences, VU University Amsterdam, Amsterdam, The Nederlands
    Methods Mol Biol 615:49-56. 2010
  9. ncbi request reprint Proteomics analysis of rat brain postsynaptic density. Implications of the diverse protein functional groups for the integration of synaptic physiology
    Ka Wan Li
    Department of Molecular and Cellular Neurobiology, Research Institute of Neurosciences, Vrije Universiteit, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    J Biol Chem 279:987-1002. 2004
  10. doi request reprint Prefrontal cortex AMPA receptor plasticity is crucial for cue-induced relapse to heroin-seeking
    Michel C van den Oever
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, VU University Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    Nat Neurosci 11:1053-8. 2008

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Quantitative proteomics and protein network analysis of hippocampal synapses of CaMKIIalpha mutant mice
    Ka Wan Li
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Faculty of Earth and Life Sciences, Vrije Universiteit, Amsterdam, The Netherlands
    J Proteome Res 6:3127-33. 2007
    ..g., receptors and ion channels, scaffolding proteins, cytoskeletal proteins, signaling proteins, adhesion molecules, and proteins of synaptic vesicles and those involved in membrane recycling...
  2. ncbi request reprint Subcellular proteomics in neuroscience
    Ka Wan Li
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, VU University Amsterdam, The Netherlands
    Front Biosci 13:4416-25. 2008
    ..In this review we describe the most commonly used methods to prepare brain subcellular fractions suitable for proteomics analysis, and highlight the various approaches for quantitative neuroproteomics...
  3. ncbi request reprint Proteomics of synapse
    Ka Wan Li
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Faculty of Earth and Life Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands
    Anal Bioanal Chem 387:25-8. 2007
  4. doi request reprint Interaction proteomics of the AMPA receptor: towards identification of receptor sub-complexes
    Ka Wan Li
    Department of Molecular and Cellular Neurobiology, Faculty of Earth and Life Sciences, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, De Boelelaan 1085, Amsterdam, 1081 HV, The Netherlands
    Amino Acids 44:1247-51. 2013
    ..The other AMPAR interactors, present in lower amount, may form the outer shell of the AMPAR with a range in size and variability...
  5. ncbi request reprint Intermittent administration of morphine alters protein expression in rat nucleus accumbens
    Ka Wan Li
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit, Amsterdam, The Netherlands
    Proteomics 6:2003-8. 2006
    ....
  6. ncbi request reprint Organelle proteomics of rat synaptic proteins: correlation-profiling by isotope-coded affinity tagging in conjunction with liquid chromatography-tandem mass spectrometry to reveal post-synaptic density specific proteins
    Ka Wan Li
    Department of Molecular and Cellular Neurobiology, Center of Neurogenomics and Cognitive Research, Faculty of Earth and Life Sciences, Vrije Universiteit, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    J Proteome Res 4:725-33. 2005
    ....
  7. doi request reprint Proteomics of brain synapses and molecular dissection of synaptic subdomains
    Ka Wan Li
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Faculty of Earth and Life Sciences, Vrije Universiteit, Amsterdam, The Netherlands
    Proteomics Clin Appl 1:1476-84. 2007
    ..It is anticipated that these analyses will yield novel insights into the organization of the synapse, and will generate testable hypotheses of synapse function and regulation both in health and disease...
  8. doi request reprint Mass spectrometric analysis of molluscan neuropeptides
    Ka Wan Li
    Department of Molecular and Cellular Neurobiology, Centre for Neurogenomics and Cognitive Research, Faculty of Earth and Life Sciences, VU University Amsterdam, Amsterdam, The Nederlands
    Methods Mol Biol 615:49-56. 2010
    ..Tens to hundreds of peptides from the tissue extract can be detected and characterized in a single analysis...
  9. ncbi request reprint Proteomics analysis of rat brain postsynaptic density. Implications of the diverse protein functional groups for the integration of synaptic physiology
    Ka Wan Li
    Department of Molecular and Cellular Neurobiology, Research Institute of Neurosciences, Vrije Universiteit, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    J Biol Chem 279:987-1002. 2004
    ..Together, these results imply that the postsynaptic density may have the ability to function (semi-) autonomously and may direct various cellular functions in order to integrate synaptic physiology...
  10. doi request reprint Prefrontal cortex AMPA receptor plasticity is crucial for cue-induced relapse to heroin-seeking
    Michel C van den Oever
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, VU University Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    Nat Neurosci 11:1053-8. 2008
    ..As reexposure to conditioned stimuli is a major cause for heroin relapse, inhibition of GluR2 endocytosis may provide a new target for the treatment of heroin addiction...
  11. pmc Proteomics, ultrastructure, and physiology of hippocampal synapses in a fragile X syndrome mouse model reveal presynaptic phenotype
    Patricia Klemmer
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, 1081 HV Amsterdam, The Netherlands
    J Biol Chem 286:25495-504. 2011
    ....
  12. doi request reprint Changes in molecular composition of rat medial prefrontal cortex synapses during adolescent development
    Danielle S Counotte
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research CNCR, Neuroscience Campus Amsterdam, VU University, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    Eur J Neurosci 32:1452-60. 2010
    ..We conclude that the molecular composition of synapses, and more specifically the synaptic release machinery, of the medial prefrontal cortex changes drastically during adolescent development...
  13. doi request reprint Identifying true protein complex constituents in interaction proteomics: the example of the DMXL2 protein complex
    Ka Wan Li
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, Amsterdam, The Netherlands
    Proteomics 12:2428-32. 2012
    ..Together, our approach enables the use of a wide range of available antibodies in large-scale protein interaction proteomics, while gaining specificity of the interactions...
  14. doi request reprint Synaptic proteome changes in a DNA repair deficient ercc1 mouse model of accelerated aging
    Marlene J Végh
    Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    J Proteome Res 11:1855-67. 2012
    ....
  15. ncbi request reprint A proteomics approach to identify long-term molecular changes in rat medial prefrontal cortex resulting from sucrose self-administration
    Michel C van den Oever
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    J Proteome Res 5:147-54. 2006
    ..We show that self-administration of sucrose produces long-lasting molecular neuroadaptations in the mPFC that may be involved in reward-related information processing...
  16. doi request reprint Lasting synaptic changes underlie attention deficits caused by nicotine exposure during adolescence
    Danielle S Counotte
    Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, VU University, Amsterdam, The Netherlands
    Nat Neurosci 14:417-9. 2011
    ..Restoring mGluR2 activity in vivo by local infusion of a group II mGluR agonist in adult rats that received nicotine as adolescents rescued attentional disturbances...
  17. pmc The synaptic proteome during development and plasticity of the mouse visual cortex
    Martijn Dahlhaus
    Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands
    Mol Cell Proteomics 10:M110.005413. 2011
    ..Altogether, this study identified many novel candidate plasticity proteins and signaling pathways that mediate synaptic plasticity during critical developmental periods or restrict it in adulthood...
  18. ncbi request reprint Proteomics of the injured rat sciatic nerve reveals protein expression dynamics during regeneration
    Connie R Jimenez
    Department of Molecular and Cellular Neurobiology, Research Institute Neurosciences Amsterdam, Faculty of Earth and Life Sciences, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
    Mol Cell Proteomics 4:120-32. 2005
    ..In conclusion, this study highlights the complexity and temporal aspect of the molecular process underlying nerve regeneration and points to the importance of glial and inflammatory determinants...
  19. pmc Interaction proteomics of synapse protein complexes
    Ka Wan Li
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    Anal Bioanal Chem 397:3195-202. 2010
    ..Moreover, we discuss the experimental feasibility of performing global analysis of the synapse protein interactome...
  20. pmc Synapse associated protein 102 (SAP102) binds the C-terminal part of the scaffolding protein neurobeachin
    Juliane Lauks
    Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 7:e39420. 2012
    ....
  21. doi request reprint Synapse proteomics: current status and quantitative applications
    Ka Wan Li
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Faculty of Earth and Life Sciences, VU University Amsterdam, The Netherlands
    Expert Rev Proteomics 5:353-60. 2008
    ..These analyses generate testable hypotheses of synapse function and regulation both in health and disease...
  22. ncbi request reprint Granularin, a novel molluscan opsonin comprising a single vWF type C domain is up-regulated during parasitation
    August B Smit
    Graduate School Neurosciences Amsterdam, Institute of Neuroscience, Department of Molecular and Cellular Neurobiology, Vrije Universiteit, Amsterdam, The Netherlands
    FASEB J 18:845-7. 2004
    ..Purified granularin stimulates phagocytosis of foreign particles by blood hemocytes. Together, our data indicate that granularin represents a novel protein that acts as an opsonin in the molluscan internal defense response...
  23. doi request reprint Automated serum peptide profiling using novel magnetic C18 beads off-line coupled to MALDI-TOF-MS
    Connie R Jimenez
    OncoProteomics Laboratory, Department of Medical Oncology, VU Medical Center, Amsterdam, The Netherlands Department of Molecular and Cellular Neurobiology, Center for Medical Systems Biology Neurogenomics and Cognitive Research, Vrije Universteit, Amsterdam, The Netherlands
    Proteomics Clin Appl 1:598-604. 2007
    ..In conjunction with the KingFisher® 96, the whole serum peptide capture procedure is high-throughput (˜20 min per isolation of 96 samples in parallel), thereby facilitating large-scale disease profiling studies...
  24. ncbi request reprint Retrograde labeling of single neurons in conjunction with MALDI high-energy collision-induced dissociation MS/MS analysis for peptide profiling and structural characterization
    Zineb El Filali
    Department of Molecular and Cellular Neurobiology, Faculty of Earth and Life Sciences, Graduate School Neurosciences Amsterdam, Vrije Universiteit, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    Anal Chem 75:2996-3000. 2003
    ..From a single neuron, six molecular ion species were further characterized with MALDI time-of-flight/time-of-flight mass spectrometry, which demonstrates that the peptides are derived from a previously reported -FLRFamide precursor...
  25. ncbi request reprint Dynorphin displaces binding at the glycine site of the NMDA receptor in the rat striatum
    Pieter Voorn
    Department of Anatomy and Neurosciences, ICEN, Vrije Universiteit Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Neurosci Lett 415:55-8. 2007
    ..This may contribute to the long-term changes in behavioral responsiveness seen after dopamine depletion and treatment with dopaminomimetics which are associated with substantial changes in striatal dynorphin metabolism...
  26. doi request reprint Comparison of molecular species of various transphosphatidylated phosphatidylserine (PS) with bovine cortex PS by mass spectrometry
    Su Chen
    Chain on Neurotrophin Biotechnology Inc, Research and Development, 41 Bayberry Drive, Malta, NY 12020, USA
    Chem Phys Lipids 152:46-56. 2008
    ....
  27. ncbi request reprint Mass spectrometric identification of molecular species of phosphatidylcholine and lysophosphatidylcholine extracted from shark liver
    Su Chen
    Chainon Neurotrophin Biotechnology Inc, 41 Bayberry Drive, Malta, New York 12020, USA
    J Agric Food Chem 55:9670-7. 2007
    ..These results establish that high contents of ether DHA-PC and DHA-LysoPC species can be obtained from shark liver...
  28. ncbi request reprint Differential transport and local translation of cytoskeletal, injury-response, and neurodegeneration protein mRNAs in axons
    Dianna Willis
    Nemours Biomedical Research, Alfred I duPont Hospital for Children, Wilmington, Delaware 19803, USA
    J Neurosci 25:778-91. 2005
    ..Neurotrophins selectively increased transport of beta-actin, peripherin, and vimentin mRNAs from the cell body into the axons rather than changing transcription or mRNA survival in the axonal compartment...
  29. pmc Phosphorylation of androgen receptor isoforms
    Hao Yun Wong
    Department of Reproduction and Development, Erasmus MC, P O Box 1738, 3000 DR, Rotterdam, The Netherlands
    Biochem J 383:267-76. 2004
    ..After mutagenesis of these sites, no major change in functional activity of the AR was observed...