C Jonker

Summary

Affiliation: Vrije Universiteit
Country: The Netherlands

Publications

  1. ncbi [Quality of life and dementia. I. Model of assessment of wellbeing in dementia patients]
    C Jonker
    Afdeling Psychiatrie en EMGO instituut, VUMC Amsterdam
    Tijdschr Gerontol Geriatr 32:252-8. 2001
  2. ncbi Does aspirin or other NSAIDs reduce the risk of cognitive decline in elderly persons? Results from a population-based study
    C Jonker
    Institute for Research in Extramural Medicine, Vrije Universiteit, Van der Boechorststraat 7 9, 1081 BT, Amsterdam, The Netherlands
    Neurobiol Aging 24:583-8. 2003
  3. ncbi A model for quality of life measures in patients with dementia: Lawton's next step
    C Jonker
    Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 18:159-64. 2004
  4. ncbi [Apolipoprotein E4 and memory decline in the elderly]
    C Jonker
    Vrije Universiteit, Afdeling Psychiatrie, Amsterdam
    Tijdschr Gerontol Geriatr 31:198-202. 2000
  5. ncbi [Introduction to the theme. Competence to make decisions in the elderly]
    Cees Jonker
    EMGO instituut Vumc, Van der Boechorststraat 7, 1081 BT Amsterdam
    Tijdschr Gerontol Geriatr 33:194-5. 2002
  6. ncbi APOE-epsilon4 is associated with memory decline in cognitively impaired elderly
    M G Dik
    Institute for Research in Extramural Medicine EMGO Institute, and the Department of Psychiatry, Vrije Universiteit, The Netherlands
    Neurology 54:1492-7. 2000
  7. ncbi Total cholesterol and oxysterols: early markers for cognitive decline in elderly?
    T N Van den Kommer
    Longitudinal Aging Study Amsterdam, EMGO Institute, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Neurobiol Aging 30:534-45. 2009
  8. doi The effect of anxiety and depression on decline of memory function in Alzheimer's disease
    E J M Bierman
    Department of Psychiatry, EMGO Institute, VU Medical Centre, Amsterdam, The Netherlands
    Int Psychogeriatr 21:1142-7. 2009
  9. ncbi Symptoms of anxiety and depression in the course of cognitive decline
    E J M Bierman
    Department of Psychiatry and EMGO Institute, VU Medical Centre, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 24:213-9. 2007
  10. ncbi Association between memory complaints and incident Alzheimer's disease in elderly people with normal baseline cognition
    M I Geerlings
    Department of Psychiatry, Vrije Universiteit, Amsterdam, The Netherlands
    Am J Psychiatry 156:531-7. 1999

Collaborators

Detail Information

Publications75

  1. ncbi [Quality of life and dementia. I. Model of assessment of wellbeing in dementia patients]
    C Jonker
    Afdeling Psychiatrie en EMGO instituut, VUMC Amsterdam
    Tijdschr Gerontol Geriatr 32:252-8. 2001
    ..The dementia-specific dimensions--individual characteristics, psychological, social and physical dimension, and environment--and domains are presented, and put in a hierarchical model...
  2. ncbi Does aspirin or other NSAIDs reduce the risk of cognitive decline in elderly persons? Results from a population-based study
    C Jonker
    Institute for Research in Extramural Medicine, Vrije Universiteit, Van der Boechorststraat 7 9, 1081 BT, Amsterdam, The Netherlands
    Neurobiol Aging 24:583-8. 2003
    ..To investigate the protective effect of NSAIDs and aspirin separately on cognitive decline in elderly subjects, controlling for consistent use of these agents over a prolonged period of time...
  3. ncbi A model for quality of life measures in patients with dementia: Lawton's next step
    C Jonker
    Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 18:159-64. 2004
    ..Dementia-specific dimensions and domains are presented. We identify psychological well-being as the core dimension for QOL of patients with dementia...
  4. ncbi [Apolipoprotein E4 and memory decline in the elderly]
    C Jonker
    Vrije Universiteit, Afdeling Psychiatrie, Amsterdam
    Tijdschr Gerontol Geriatr 31:198-202. 2000
    ..In particular cognitively impaired E4 carriers older than 75 years were at high risk of memory decline. Contrary to AD studies, our study suggests that the risk of ApoE4 on memory decline does not decrease with ageing...
  5. ncbi [Introduction to the theme. Competence to make decisions in the elderly]
    Cees Jonker
    EMGO instituut Vumc, Van der Boechorststraat 7, 1081 BT Amsterdam
    Tijdschr Gerontol Geriatr 33:194-5. 2002
  6. ncbi APOE-epsilon4 is associated with memory decline in cognitively impaired elderly
    M G Dik
    Institute for Research in Extramural Medicine EMGO Institute, and the Department of Psychiatry, Vrije Universiteit, The Netherlands
    Neurology 54:1492-7. 2000
    ..To investigate whether the association between APOE-epsilon4 and memory decline is modified by baseline cognition and age in a population-based elderly sample...
  7. ncbi Total cholesterol and oxysterols: early markers for cognitive decline in elderly?
    T N Van den Kommer
    Longitudinal Aging Study Amsterdam, EMGO Institute, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Neurobiol Aging 30:534-45. 2009
    ..002) and memory functioning (p=.045). The results implicate that lower total cholesterol may be considered as a frailty marker, predictive of lower cognitive functioning in elderly...
  8. doi The effect of anxiety and depression on decline of memory function in Alzheimer's disease
    E J M Bierman
    Department of Psychiatry, EMGO Institute, VU Medical Centre, Amsterdam, The Netherlands
    Int Psychogeriatr 21:1142-7. 2009
    ..The present study investigated whether symptoms of anxiety and depression predict decline of memory function in elderly people diagnosed with early stage AD...
  9. ncbi Symptoms of anxiety and depression in the course of cognitive decline
    E J M Bierman
    Department of Psychiatry and EMGO Institute, VU Medical Centre, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 24:213-9. 2007
    ..The present study investigates anxiety and depression in different phases of cognitive decline...
  10. ncbi Association between memory complaints and incident Alzheimer's disease in elderly people with normal baseline cognition
    M I Geerlings
    Department of Psychiatry, Vrije Universiteit, Amsterdam, The Netherlands
    Am J Psychiatry 156:531-7. 1999
    ..Therefore, the authors hypothesized that memory complaints would predict incident Alzheimer's disease in elderly subjects with no signs of cognitive impairment...
  11. doi Development of classification models for early identification of persons at risk for persistent cognitive decline
    T N Van den Kommer
    Longitudinal Aging Study Amsterdam and EMGO Institute, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    J Neurol 255:1486-94. 2008
    ..To develop two classification models for use in primary care to aid early identification of persons at risk for persistent cognitive decline...
  12. doi Homocysteine and inflammation: predictors of cognitive decline in older persons?
    T N Van den Kommer
    Longitudinal Aging Study Amsterdam and EMGO Institute, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    Neurobiol Aging 31:1700-9. 2010
    ..The results implicate that a combination of both risk factors may be used as a marker for cognitive impairment...
  13. ncbi Serum inflammatory proteins and cognitive decline in older persons
    M G Dik
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 64:1371-7. 2005
    ..To assess whether serum levels of the inflammatory proteins alpha(1)-antichymotrypsin (ACT), C-reactive protein (CRP), interleukin-6 (IL-6), and albumin are associated with cognitive decline in older persons...
  14. ncbi Depression and risk of cognitive decline and Alzheimer's disease. Results of two prospective community-based studies in The Netherlands
    M I Geerlings
    Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    Br J Psychiatry 176:568-75. 2000
    ..Depression may be associated with cognitive decline in elderly people with impaired cognition...
  15. ncbi Stroke and apolipoprotein E epsilon4 are independent risk factors for cognitive decline: A population-based study
    M G Dik
    Institute for Research in Extramural Medicine EMGO Institute, Department of Psychiatry, Vrije Universiteit, Amsterdam, Netherlands
    Stroke 31:2431-6. 2000
    ..In a population-based sample, using well-defined sensitive cognitive measures, this study investigates whether cognitive decline following stroke is worse for patients who carry the ApoE epsilon4 allele...
  16. ncbi Association between apolipoprotein E epsilon4 and the rate of cognitive decline in community-dwelling elderly individuals with and without dementia
    C Jonker
    Department of Psychiatry and the Institute of Extramural Health Research, Free University, Amsterdam, The Netherlands
    Arch Neurol 55:1065-9. 1998
    ....
  17. ncbi Education and incident Alzheimer's disease: a biased association due to selective attrition and use of a two-step diagnostic procedure?
    M I Geerlings
    Institute for Research in Extramural Medicine EMGO Institute, Vrije Universiteit, Amsterdam
    Int J Epidemiol 28:492-7. 1999
    ..Both phenomena may lead to misclassification, resulting in a biased association between level of education and AD. This study investigated to what extent these selection mechanisms may influence this association...
  18. ncbi Association of depression and gender with mortality in old age. Results from the Amsterdam Study of the Elderly (AMSTEL)
    R A Schoevers
    Department of Psychiatry, Vrije Universiteit Amsterdam, Valeriusplein 9, 1075 BG Amsterdam, The Netherlands
    Br J Psychiatry 177:336-42. 2000
    ..The association between depression and increased mortality risk in older persons may depend on the severity of the depressive disorder and gender...
  19. ncbi Risk factors for depression in later life; results of a prospective community based study (AMSTEL)
    R A Schoevers
    Department of Psychiatry, Vrije Universiteit Amsterdam, Valeriusplein 9, 1075 BG, Amsterdam, The Netherlands
    J Affect Disord 59:127-37. 2000
    ..The current prospective study tests an etiologic model for depression incidence, by assessing modifying effects of three types of vulnerability: genetic/familial vulnerability, organic vulnerability, and environmental vulnerability...
  20. ncbi [Predictors of dementia, the construction of classification trees]
    H C Comijs
    EMGO institute LASA, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam
    Tijdschr Gerontol Geriatr 37:237-42. 2006
    ..In persons without memory complaints, persons with cardiovascular diseases or diabetes were at increased risk of dementia. Further research is necessary before these classification trees can be implemented in general health care...
  21. ncbi Memory complaints and APOE-epsilon4 accelerate cognitive decline in cognitively normal elderly
    M G Dik
    Institute for Research in Extramural Medicine EMGO Institute, Academic Hospital, Vrije Universiteit, Amsterdam, The Netherlands
    Neurology 57:2217-22. 2001
    ..To investigate to what extent subjective memory complaints and APOE-epsilon4 allele carriage predict future cognitive decline in cognitively intact elderly persons, by evaluating both their separate and combined effects...
  22. ncbi The effect of chronic benzodiazepine use on cognitive functioning in older persons: good, bad or indifferent?
    E J M Bierman
    Department of Psychiatry, Institute for Research in Extramural Medicine EMGO Institute, VU Medical Centre, Amsterdam, The Netherlands
    Int J Geriatr Psychiatry 22:1194-200. 2007
    ..This study investigates the effects of benzodiazepine (BZ) use on cognitive performance in elderly persons in a longitudinal design...
  23. doi Depression and excess mortality: evidence for a dose response relation in community living elderly
    R A Schoevers
    VU University Medical Center, Department of Psychiatry, Amsterdam, The Netherlands
    Int J Geriatr Psychiatry 24:169-76. 2009
    ..Depression is associated with an increased mortality risk. It is not known to what extent depression characteristics such as severity and length of exposure to depression contribute to the association with excess mortality...
  24. doi Increased risk of mortality associated with social isolation in older men: only when feeling lonely? Results from the Amsterdam Study of the Elderly (AMSTEL)
    T J Holwerda
    Department of Psychiatry, ARKIN Institute of Mental Health Care, Amsterdam, The Netherlands
    Psychol Med 42:843-53. 2012
    ..The current study investigated whether social isolation and feelings of loneliness in older men and women were associated with increased mortality risk, controlling for depression and other potentially confounding factors...
  25. ncbi Effects of anxiety versus depression on cognition in later life
    E J M Bierman
    Dept of Psychiatry, Institute for Research in Extramural Medicine EMGO Institute of the Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Am J Geriatr Psychiatry 13:686-93. 2005
    ..The authors investigated the relationship between anxiety and cognition in older persons, taking account of comorbid depression...
  26. ncbi Comorbidity and risk-patterns of depression, generalised anxiety disorder and mixed anxiety-depression in later life: results from the AMSTEL study
    R A Schoevers
    Department of Psychiatry, VU University Medical Centre, Amsterdam, The Netherlands
    Int J Geriatr Psychiatry 18:994-1001. 2003
    ..Research is needed that investigates patterns of comorbidity and possibly different risk profiles for pure depression, pure generalised anxiety and mixed anxiety-depression in older people...
  27. ncbi The association between depressive symptoms and cognitive decline in community-dwelling elderly persons
    H C Comijs
    Institute for Research in Extramural Medicine, Vrije Universiteit, Van der Boechorststraat 7 9, 1081 BT Amsterdam, The Netherlands
    Int J Geriatr Psychiatry 16:361-7. 2001
    ..To investigate whether depressive symptoms predict specific types of cognitive decline in order to elucidate the association between late life depression and cognitive decline...
  28. ncbi Decision-making capacity of elderly patients assessed through the vignette method: imagination or reality?
    A Vellinga
    VU University Medical Centre, Centre for Medical Ethics and Philosophy, Amsterdam, The Netherlands
    Aging Ment Health 9:40-8. 2005
    ..We did not find any major differences between the hypothetical and realistic situation. Our findings do raise questions about the validity of hypothetical vignettes, however, especially when used with cognitively impaired persons...
  29. ncbi Effects of gender and age on the association of apolipoprotein E epsilon4 with bone mineral density, bone turnover and the risk of fractures in older people
    S M F Pluijm
    Institute for Research in Extramural Medicine EMGO Institute, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Osteoporos Int 13:701-9. 2002
    ....
  30. ncbi Subjective memory complaints in the elderly: depressive symptoms and future dementia
    B Schmand
    Amsterdam Study of the Elderly AMSTEL Project, Department of Psychiatry, Vrije Universiteit, The Netherlands
    Br J Psychiatry 171:373-6. 1997
    ..These complaints have some predictive power regarding the development of dementia. The present study attempted to replicate this finding, and investigated which variables determine subjective memory complaints...
  31. ncbi Memory complaints; the association with psycho-affective and health problems and the role of personality characteristics. A 6-year follow-up study
    H C Comijs
    Institute for Research in Extramural Medicine EMGO and the Department of Psychiatry, Vrije Universiteit, Amsterdam, The Netherlands
    J Affect Disord 72:157-65. 2002
    ..Furthermore, it is investigated whether personality characteristics have a modifying effect on the association of memory complaints with depressive and anxiety symptoms and physical health...
  32. ncbi Are memory complaints predictive for dementia? A review of clinical and population-based studies
    C Jonker
    Institute for Research in Extramural Medicine EMGO Institute, Vrije Universiteit, Amsterdam, The Netherlands
    Int J Geriatr Psychiatry 15:983-91. 2000
    ..To review studies that have reported on the prevalence of memory complaints and the relationship between memory complaints and impairment or decline (dementia) in elderly individuals...
  33. ncbi Competence to consent to treatment of geriatric patients: judgements of physicians, family members and the vignette method
    A Vellinga
    Center of Philosophy and Medical Ethics, VU University Medical Center, Amsterdam, The Netherlands
    Int J Geriatr Psychiatry 19:645-54. 2004
    ..In absence of a gold standard of methods to assess competence, three judgements of competency of geriatric patients are evaluated: the judgements of a physician, the judgement of a family member, and the judgement of an instrument...
  34. ncbi The natural history of late-life depression: results from the Amsterdam Study of the Elderly (AMSTEL)
    R A Schoevers
    Department of Psychiatry, VU University Medical Centre, LASA AMSTEL, Faculteit GNK, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    J Affect Disord 76:5-14. 2003
    ..This study examines whether risk factors related to incidence of depression are also related to prognosis, and whether a vulnerability-stress model can be established for prognosis...
  35. ncbi Hostility and coping capacity as risk factors of elder mistreatment
    H C Comijs
    Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    Soc Psychiatry Psychiatr Epidemiol 34:48-52. 1999
    ..These findings are important for prevention of an intervention in cases of elder mistreatment...
  36. doi Distinct brain systems underlie the processing of valence and arousal of affective pictures
    M M A Nielen
    Department of Psychiatry, VU University Medical Center Amsterdam, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Brain Cogn 71:387-96. 2009
    ....
  37. ncbi Do health factors affect memory performance in old age?
    M Jelicic
    Department of Psychiatry, Vrije Universiteit, Amsterdam, The Netherlands
    Int J Geriatr Psychiatry 14:572-6. 1999
    ..The aim of this study was to examine the effect of health factors on memory performance in a population-based sample of 679 older people (mean age=69.2 years)...
  38. ncbi Parahippocampal activation during successful recognition of words: a self-paced event-related fMRI study
    S M Daselaar
    Institute for Research in Extramural Medicine, Vrije Universiteit Medical Centre, vd Boechorstraat 7, 1081 BT Amsterdam, The Netherlands
    Neuroimage 13:1113-20. 2001
    ..This demonstrates the applicability of a self-paced event-related design within imaging studies of memory function...
  39. ncbi Neuroanatomical correlates of episodic encoding and retrieval in young and elderly subjects
    S M Daselaar
    Institute for Research in Extramural Medicine, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Brain 126:43-56. 2003
    ..The lack of differences observed in relation to retrieval success suggests that ageing does not affect the processes that support the actual recovery of information...
  40. ncbi Psychological distress of caregivers: the mediator effect of caregiving appraisal
    A M Pot
    Department of Psychiatry, Vrije Universiteit, Amsterdam, The Netherlands
    Patient Educ Couns 34:43-51. 1998
    ..Thus, it is inadequate to focus interventions merely on stressors in the caregiving situation, for non-spouse caregivers in particular. A reduction of perceived pressure from informal care is also needed...
  41. ncbi [Quality of life and dementia. II. Selection of a measurement instrument for wellbeing appropriate for the reference model]
    J T Van Der Steen
    Instituut voor Extramuraal Geneeskundig Onderzoek, afdeling Sociale Geneeskunde en Verpleeghuisgeneeskunde, VUMC, Amsterdam
    Tijdschr Gerontol Geriatr 32:259-64. 2001
    ..In contrast to the other instruments, the DQoL requires only the patient's own opinion. We plan further validation of the DQoL in Dutch demented patients...
  42. pmc Visual association test to detect early dementia of the Alzheimer type
    J Lindeboom
    Department of Medical Psychology, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 73:126-33. 2002
    ..The person is asked to name each object and, later, is presented with one object from the pair and asked to name the other...
  43. ncbi Immunological mechanisms and the spectrum of psychiatric syndromes in Alzheimer's disease
    P Eikelenboom
    Graduate School Neuroscience, Amsterdam, The Netherlands
    J Psychiatr Res 36:269-80. 2002
    ....
  44. ncbi The diagnostic value of electroencephalography in mild senile Alzheimer's disease
    J J Claus
    Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands
    Clin Neurophysiol 110:825-32. 1999
    ..We investigated the diagnostic value of the visually assessed electroencephalogram (EEG) in patients with mild Alzheimer's disease (AD), using the grand total of EEG (GTE) score...
  45. ncbi The relationship between generalized anxiety disorder, depression and mortality in old age
    Tjalling J Holwerda
    Department of Psychiatry, Mentrum Mental Health Care, Amsterdam, The Netherlands
    Int J Geriatr Psychiatry 22:241-9. 2007
    ..However, little is known about the relation between generalized anxiety disorder, mixed anxiety-depression (generalized anxiety disorder and depression) and excess mortality in the elderly...
  46. pmc The apolipoprotein E e4 polymorphism is strongly associated with poor mobility performance test results but not self-reported limitation in older people
    David Melzer
    Department of Public Health and Primary Care, University of Cambridge, UK
    J Gerontol A Biol Sci Med Sci 60:1319-23. 2005
    ....
  47. ncbi Subjective needs of people with dementia: a review of the literature
    Henriëtte G van der Roest
    Department of Psychiatry Alzheimer Center, VU Medical Center GGZ Buitenamstel, Amsterdam, The Netherlands
    Int Psychogeriatr 19:559-92. 2007
    ..Insight into the individual care needs of the growing number of people with dementia is necessary to deliver more customized care. Our study aims to provide an overview of the literature on the subjective needs of people with dementia...
  48. ncbi Clinically defined vascular depression in the general population
    Paul Naarding
    Spatie, Centre for Mental Health, Apeldoorn, The Netherlands
    Psychol Med 37:383-92. 2007
    ..It could have major implications for treatment if subjects at risk for such a depression could be easily identified by their clinical presentation in general practice...
  49. ncbi Contribution of metabolic syndrome components to cognition in older individuals
    Miranda G Dik
    EMGO Institute, VU University Medical Center, 1081 BT Amsterdam, The Netherlands
    Diabetes Care 30:2655-60. 2007
    ..However, it is not known what the roles of the individual components of the metabolic syndrome on cognition are...
  50. ncbi Suffering from dementia - the patient's perspective: a review of the literature
    Marike E De Boer
    Department of Nursing Home Medicine, Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Int Psychogeriatr 19:1021-39. 2007
    ..The views of people with dementia are vital in obtaining a real answer to the question of how the disease affects people's lives and whether it actually involves the suffering that so many fear...
  51. doi Diagnostic accuracy of consensus diagnostic criteria for frontotemporal dementia in a memory clinic population
    Yolande A L Pijnenburg
    Alzheimer Centre, VU University Medical Centre, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 25:157-64. 2008
    ..The goal of the present study was to evaluate the diagnostic accuracy of the core diagnostic criteria for frontotemporal dementia (FTD) [Neary D, et al: Neurology 1998;51:1546-1554] within a memory clinic population...
  52. ncbi Early assessment of dementia: the contribution of different memory components
    Pauline E J Spaan
    Department of Psychonomics, University of Amsterdam, Amsterdam, Netherlands
    Neuropsychology 19:629-40. 2005
    ..The authors conclude that in addition to testing episodic memory functioning, it is important to be aware of semantic and implicit memory deficits in the early assessment of dementia...
  53. ncbi A study on symptom profiles of late-life depression: the influence of vascular, degenerative and inflammatory risk-indicators
    Paul Naarding
    Spatie, Center for Mental Health, PO Box 926, 7300 BD Apeldoorn and Department of Psychiatry, University Medical Center St Radboud, Nijmegen, The Netherlands
    J Affect Disord 88:155-62. 2005
    ....
  54. ncbi The course of cognitive decline in older persons: results from the longitudinal aging study amsterdam
    Hannie C Comijs
    Department of Psychiatry, Institute for Research in Extramural Medicine EMGO Institute of the VU University Medical Center, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 17:136-42. 2004
    ..Of this group, 44% recovered from cognitive decline or stayed stable in the next 3 years. Especially older age, memory complaints and an increase of cardiovascular diseases at follow-up predict further deterioration...
  55. ncbi Do severity and duration of depressive symptoms predict cognitive decline in older persons? Results of the Longitudinal Aging Study Amsterdam
    Hannie C Comijs
    Department of Psychiatry, Institute for Research in Extramural Medicine EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    Aging Clin Exp Res 16:226-32. 2004
    ....
  56. ncbi Early life physical activity and cognition at old age
    Miranda Dik
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Exp Neuropsychol 25:643-53. 2003
    ..This finding supports the cognitive reserve hypothesis, and might suggest that early life physical activity may delay late-life cognitive deficits...
  57. ncbi Alzheimer's disease versus normal ageing: a review of the efficiency of clinical and experimental memory measures
    Pauline E J Spaan
    Department of Psychonomics, University of Amsterdam, Amsterdam, The Netherlands
    J Clin Exp Neuropsychol 25:216-33. 2003
    ..It is argued that traditional clinical memory tests alone are not best able at detecting AD at an early stage. More specifically, tasks calling upon semantic knowledge may aid to an earlier and more efficient assessment of AD...
  58. ncbi Insulin-like growth factor I (IGF-I) and cognitive decline in older persons
    Miranda G Dik
    Institute for Research in Extramural Medicine EMGO Institute, VU University Medical Center, 1081 BT, Amsterdam, The Netherlands
    Neurobiol Aging 24:573-81. 2003
    ..78; 95% CI, 1.19-2.68). In summary, this study suggests that IGF-I levels below 9.4 nmol/l are negatively associated with both the level and decline of information processing speed...
  59. ncbi The impact of change in cognitive functioning and cognitive decline on disability, well-being, and the use of healthcare services in older persons. Results of Longitudinal Aging Study Amsterdam
    Hannie C Comijs
    Institute for Research in Extramural Medicine and Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 19:316-23. 2005
    ..With the aging of the population, the number of persons with cognitive impairment is likely to increase, and appropriate services should be available to them...
  60. ncbi [The assessment of competence in cognitively impaired elderly persons: a closer look at the vignette method]
    Astrid Vellinga
    Afdeling Metamedica, Afdeling Psychiatrie, Instituut voor Extramuraal Geneeskundig Onderzoek EMGO VU Medisch Centrum, Van der Boechorststraat 7, 1081 BT Amsterdam
    Tijdschr Gerontol Geriatr 33:207-11. 2002
    ..We conclude that competence is less limited by cognitive impairment when assessed in a treatment situation with severe consequences. Therefore, the use of hypothetical vignettes should be carefully reconsidered...
  61. ncbi Memory performance and the growth hormone/insulin-like growth factor axis in elderly: a positron emission tomography study
    Lucia I Arwert
    Department of Endocrinology, VU University Medical Center, Amsterdam, The Netherlands
    Neuroendocrinology 81:31-40. 2005
    ..It is concluded that elderly with high IGF-I levels are capable of faster working memory performance and increased recruitment of task-associated prefrontal regions...
  62. ncbi Challenging the cholinergic system in mild cognitive impairment: a pharmacological fMRI study
    Rutger Goekoop
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Neuroimage 23:1450-9. 2004
    ..This should encourage further functional imaging studies to examine the status of neurotransmitter systems in disease...
  63. ncbi Course of minimal dementia and predictors of outcome
    Pieter Jelle Visser
    Department of Psychiatry and Neuropsychology, Institute of Brain and Behavior, University of Maastricht, Maastricht, The Netherlands
    Int J Geriatr Psychiatry 17:835-41. 2002
    ..Previous studies have indicated that not all subjects who meet the CAMDEX criteria of 'minimal dementia' progress to dementia. In the present study, predictors of outcome in minimally demented subjects were tested...
  64. ncbi Medial temporal lobe activity during semantic classification using a flexible fMRI design
    Sander M Daselaar
    Institute for Research in Extramural Medicine, Vrije Universiteit Medical Center, c o Secr EMGO Dept vd Boechorstraat 7, 1081 BT Amsterdam, The Netherlands
    Behav Brain Res 136:399-404. 2002
    ..Additional activity was seen in the right, and, at a slightly lower threshold, also in the left MTL, providing support for the involvement of the MTL in retrieval from semantic memory...
  65. ncbi Different cognitive functions in relation to falls among older persons. Immediate memory as an independent risk factor for falls
    Natasja M van Schoor
    Institute for Research in Extramural Medicine EMGO Institute, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    J Clin Epidemiol 55:855-62. 2002
    ..We conclude that "immediate memory" is an independent risk factor for recurrent falls in persons aged 75 years and older...
  66. ncbi Deep processing activates the medial temporal lobe in young but not in old adults
    Sander M Daselaar
    Center for Cognitive Neuroscience, Duke University, Box 90999, LSRC Bldg, Rm B243N, Durham, NC 27708, USA
    Neurobiol Aging 24:1005-11. 2003
    ..This finding is in line with the idea that age-related impairments in episodic encoding are, at least partly, due to an under-recruitment of the medial temporal lobe memory system...
  67. ncbi Similar network activated by young and old adults during the acquisition of a motor sequence
    Sander M Daselaar
    Center for Cognitive Neuroscience, Duke University, Box 90999, LSRC Bldg, Rm B243N, Durham, NC 27708, USA
    Neurobiol Aging 24:1013-9. 2003
    ....
  68. ncbi Initial complaints in frontotemporal lobar degeneration
    Yolande A L Pijnenburg
    Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 17:302-6. 2004
    ..The goal of this study was to investigate initial complaints of both patients and their caregivers at first specialist referral. Also, we tried to assess whether misrecognition of symptoms contributed to diagnostic delay...
  69. ncbi SPM analysis of parametric (R)-[11C]PK11195 binding images: plasma input versus reference tissue parametric methods
    Alie Schuitemaker
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, P O Box 7057, 1081 MB Amsterdam, The Netherlands
    Neuroimage 35:1473-9. 2007
    ..Vd images could only demonstrate differences in (R)-[11C]PK11195 binding when analysed with proportional scaling due to intersubject variation in K1/k2 (blood-brain barrier transport and non-specific binding)...
  70. ncbi Evaluation of methods for generating parametric (R-[11C]PK11195 binding images
    Alie Schuitemaker
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 27:1603-15. 2007
    ..In pathological conditions with reduced flow rates or large variations in blood volume, the basis function method is preferred because it produces less bias and is more precise...
  71. ncbi Instruments to assess decision-making capacity: an overview
    Astrid Vellinga
    Center for Ethics and Philosophy of Life, VU University Medical Center, Amsterdam, The Netherlands
    Int Psychogeriatr 16:397-419. 2004
    ..The main objective of this article is to evaluate and describe instruments for assessing decision-making capacity in psychiatry and psychogeriatrics, and to evaluate them for use in daily practice...
  72. ncbi Moderately elevated plant sterol levels are associated with reduced cardiovascular risk--the LASA study
    Klaus Fassbender
    Department of Neurology, University Clinic of the Saarland, Kirrberger Str, D 68421 Homburg, Germany
    Atherosclerosis 196:283-8. 2008
    ..These data suggest that plant sterols could have neutral or even protective effects on development of coronary heart disease, which have to be confirmed in interventional trials...
  73. ncbi Aging affects both perceptual and lexical/semantic components of word stem priming: An event-related fMRI study
    Sander M Daselaar
    Center for Cognitive Neuroscience, Duke University, Box 90999, LSRC Bldg, Rm B243N, Durham, NC 27708, USA
    Neurobiol Learn Mem 83:251-62. 2005
    ..These findings suggest that, converse to current psychological views, aging affects both perceptual and lexical/semantic components of repetition priming...
  74. ncbi The emotional impact of psychiatric symptoms in dementia on partner caregivers: do caregiver, patient, and situation characteristics make a difference?
    Franka J M Meiland
    Department of Psychiatry, Institute for Research in Extramural Medicine, Alzheimer Center, VU Medical Center, Amsterdam, The Netherlands
    Alzheimer Dis Assoc Disord 19:195-201. 2005
    ....
  75. ncbi Evaluation of reference regions for (R)-[(11)C]PK11195 studies in Alzheimer's disease and mild cognitive impairment
    Marc A Kropholler
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 27:1965-74. 2007
    ..Most anatomic regions outperformed cluster analysis in terms of absence of both scan rejection and bias. Total cerebellum is the optimal reference region in this patient category...