C Jonker

..The dementia-specific dimensions--individual characteristics, psychological, social and physical dimension, and environment--and domains are presented, and put in a hierarchical model...

..To investigate the protective effect of NSAIDs and aspirin separately on cognitive decline in elderly subjects, controlling for consistent use of these agents over a prolonged period of time...

..Dementia-specific dimensions and domains are presented. We identify psychological well-being as the core dimension for QOL of patients with dementia...

..In particular cognitively impaired E4 carriers older than 75 years were at high risk of memory decline. Contrary to AD studies, our study suggests that the risk of ApoE4 on memory decline does not decrease with ageing...

..To investigate whether the association between APOE-epsilon4 and memory decline is modified by baseline cognition and age in a population-based elderly sample...

..002) and memory functioning (p=.045). The results implicate that lower total cholesterol may be considered as a frailty marker, predictive of lower cognitive functioning in elderly...

..The present study investigated whether symptoms of anxiety and depression predict decline of memory function in elderly people diagnosed with early stage AD...

..The present study investigates anxiety and depression in different phases of cognitive decline...

..Therefore, the authors hypothesized that memory complaints would predict incident Alzheimer's disease in elderly subjects with no signs of cognitive impairment...

..To develop two classification models for use in primary care to aid early identification of persons at risk for persistent cognitive decline...

..The results implicate that a combination of both risk factors may be used as a marker for cognitive impairment...

..To assess whether serum levels of the inflammatory proteins alpha(1)-antichymotrypsin (ACT), C-reactive protein (CRP), interleukin-6 (IL-6), and albumin are associated with cognitive decline in older persons...

..Depression may be associated with cognitive decline in elderly people with impaired cognition...

..In a population-based sample, using well-defined sensitive cognitive measures, this study investigates whether cognitive decline following stroke is worse for patients who carry the ApoE epsilon4 allele...

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..Both phenomena may lead to misclassification, resulting in a biased association between level of education and AD. This study investigated to what extent these selection mechanisms may influence this association...

..The association between depression and increased mortality risk in older persons may depend on the severity of the depressive disorder and gender...

..The current prospective study tests an etiologic model for depression incidence, by assessing modifying effects of three types of vulnerability: genetic/familial vulnerability, organic vulnerability, and environmental vulnerability...

..In persons without memory complaints, persons with cardiovascular diseases or diabetes were at increased risk of dementia. Further research is necessary before these classification trees can be implemented in general health care...

..To investigate to what extent subjective memory complaints and APOE-epsilon4 allele carriage predict future cognitive decline in cognitively intact elderly persons, by evaluating both their separate and combined effects...

..This study investigates the effects of benzodiazepine (BZ) use on cognitive performance in elderly persons in a longitudinal design...

..Depression is associated with an increased mortality risk. It is not known to what extent depression characteristics such as severity and length of exposure to depression contribute to the association with excess mortality...

..The current study investigated whether social isolation and feelings of loneliness in older men and women were associated with increased mortality risk, controlling for depression and other potentially confounding factors...

..The authors investigated the relationship between anxiety and cognition in older persons, taking account of comorbid depression...

..Research is needed that investigates patterns of comorbidity and possibly different risk profiles for pure depression, pure generalised anxiety and mixed anxiety-depression in older people...

..To investigate whether depressive symptoms predict specific types of cognitive decline in order to elucidate the association between late life depression and cognitive decline...

..We did not find any major differences between the hypothetical and realistic situation. Our findings do raise questions about the validity of hypothetical vignettes, however, especially when used with cognitively impaired persons...

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..These complaints have some predictive power regarding the development of dementia. The present study attempted to replicate this finding, and investigated which variables determine subjective memory complaints...

..Furthermore, it is investigated whether personality characteristics have a modifying effect on the association of memory complaints with depressive and anxiety symptoms and physical health...

..To review studies that have reported on the prevalence of memory complaints and the relationship between memory complaints and impairment or decline (dementia) in elderly individuals...

..In absence of a gold standard of methods to assess competence, three judgements of competency of geriatric patients are evaluated: the judgements of a physician, the judgement of a family member, and the judgement of an instrument...

..This study examines whether risk factors related to incidence of depression are also related to prognosis, and whether a vulnerability-stress model can be established for prognosis...

..These findings are important for prevention of an intervention in cases of elder mistreatment...

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..The aim of this study was to examine the effect of health factors on memory performance in a population-based sample of 679 older people (mean age=69.2 years)...

..This demonstrates the applicability of a self-paced event-related design within imaging studies of memory function...

..The lack of differences observed in relation to retrieval success suggests that ageing does not affect the processes that support the actual recovery of information...

..Thus, it is inadequate to focus interventions merely on stressors in the caregiving situation, for non-spouse caregivers in particular. A reduction of perceived pressure from informal care is also needed...

..In contrast to the other instruments, the DQoL requires only the patient's own opinion. We plan further validation of the DQoL in Dutch demented patients...

..The person is asked to name each object and, later, is presented with one object from the pair and asked to name the other...

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..We investigated the diagnostic value of the visually assessed electroencephalogram (EEG) in patients with mild Alzheimer's disease (AD), using the grand total of EEG (GTE) score...

..However, little is known about the relation between generalized anxiety disorder, mixed anxiety-depression (generalized anxiety disorder and depression) and excess mortality in the elderly...

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..Insight into the individual care needs of the growing number of people with dementia is necessary to deliver more customized care. Our study aims to provide an overview of the literature on the subjective needs of people with dementia...

..It could have major implications for treatment if subjects at risk for such a depression could be easily identified by their clinical presentation in general practice...

..However, it is not known what the roles of the individual components of the metabolic syndrome on cognition are...

..The views of people with dementia are vital in obtaining a real answer to the question of how the disease affects people's lives and whether it actually involves the suffering that so many fear...

..The goal of the present study was to evaluate the diagnostic accuracy of the core diagnostic criteria for frontotemporal dementia (FTD) [Neary D, et al: Neurology 1998;51:1546-1554] within a memory clinic population...

..The authors conclude that in addition to testing episodic memory functioning, it is important to be aware of semantic and implicit memory deficits in the early assessment of dementia...

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..Of this group, 44% recovered from cognitive decline or stayed stable in the next 3 years. Especially older age, memory complaints and an increase of cardiovascular diseases at follow-up predict further deterioration...

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..This finding supports the cognitive reserve hypothesis, and might suggest that early life physical activity may delay late-life cognitive deficits...

..It is argued that traditional clinical memory tests alone are not best able at detecting AD at an early stage. More specifically, tasks calling upon semantic knowledge may aid to an earlier and more efficient assessment of AD...

..78; 95% CI, 1.19-2.68). In summary, this study suggests that IGF-I levels below 9.4 nmol/l are negatively associated with both the level and decline of information processing speed...

..With the aging of the population, the number of persons with cognitive impairment is likely to increase, and appropriate services should be available to them...

..We conclude that competence is less limited by cognitive impairment when assessed in a treatment situation with severe consequences. Therefore, the use of hypothetical vignettes should be carefully reconsidered...

..It is concluded that elderly with high IGF-I levels are capable of faster working memory performance and increased recruitment of task-associated prefrontal regions...

..This should encourage further functional imaging studies to examine the status of neurotransmitter systems in disease...

..Previous studies have indicated that not all subjects who meet the CAMDEX criteria of 'minimal dementia' progress to dementia. In the present study, predictors of outcome in minimally demented subjects were tested...

..Additional activity was seen in the right, and, at a slightly lower threshold, also in the left MTL, providing support for the involvement of the MTL in retrieval from semantic memory...

..We conclude that "immediate memory" is an independent risk factor for recurrent falls in persons aged 75 years and older...

..This finding is in line with the idea that age-related impairments in episodic encoding are, at least partly, due to an under-recruitment of the medial temporal lobe memory system...

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..In our cohort, memory complaints occurred relatively often. A multidisciplinary approach, including a structured behavioral interview, is important to recognize symptoms of FTLD...

..Vd images could only demonstrate differences in (R)-[11C]PK11195 binding when analysed with proportional scaling due to intersubject variation in K1/k2 (blood-brain barrier transport and non-specific binding)...

..In pathological conditions with reduced flow rates or large variations in blood volume, the basis function method is preferred because it produces less bias and is more precise...

..The main objective of this article is to evaluate and describe instruments for assessing decision-making capacity in psychiatry and psychogeriatrics, and to evaluate them for use in daily practice...

..These data suggest that plant sterols could have neutral or even protective effects on development of coronary heart disease, which have to be confirmed in interventional trials...

..These findings suggest that, converse to current psychological views, aging affects both perceptual and lexical/semantic components of repetition priming...

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..Most anatomic regions outperformed cluster analysis in terms of absence of both scan rejection and bias. Total cerebellum is the optimal reference region in this patient category...