T Jager

Summary

Affiliation: Vrije Universiteit
Country: The Netherlands

Publications

  1. ncbi request reprint Elucidating the routes of exposure for organic chemicals in the earthworm, Eisenia andrei (Oligochaeta)
    Tjalling Jager
    Department of Theoretical Biology, Vrije Universiteit Amsterdam, De Boelelaan 1085, NL 1081 HV Amsterdam, The Netherlands
    Environ Sci Technol 37:3399-404. 2003
  2. ncbi request reprint Bioaccumulation of organic chemicals in contaminated soils: evaluation of bioassays with earthworms
    Tjalling Jager
    Vrije Universiteit Amsterdam, Department of Theoretical Biology, De Boelelaan 1085, Amsterdam, The Netherlands
    Environ Sci Technol 39:293-8. 2005
  3. ncbi request reprint Simultaneous modeling of multiple end points in life-cycle toxicity tests
    Tjalling Jager
    Department of Theoretical Biology, Vrije Universiteit, De Boelelaan 1085, NL 1081 HV, Amsterdam, The Netherlands
    Environ Sci Technol 38:2894-900. 2004
  4. ncbi request reprint Modeling receptor kinetics in the analysis of survival data for organophosphorus pesticides
    Tjalling Jager
    Department of Theoretical Biology, Vrije Universiteit, De Boelelaan 1085, NL 1081 HV, Amsterdam, The Netherlands
    Environ Sci Technol 39:8307-14. 2005
  5. ncbi request reprint Making sense of ecotoxicological test results: towards application of process-based models
    Tjalling Jager
    FALW Department of Theoretical Biology, Vrije Universiteit Amsterdam, De Boelelaan 1085, NL 1081 HV, Amsterdam, The Netherlands
    Ecotoxicology 15:305-14. 2006
  6. ncbi request reprint Chronic exposure to chlorpyrifos reveals two modes of action in the springtail Folsomia candida
    Tjalling Jager
    Department of Theoretical Biology, Vrije Universiteit, De Boelelaan 1085, NL 1081 HV, Amsterdam, The Netherlands
    Environ Pollut 145:452-8. 2007
  7. doi request reprint A biology-based approach for quantitative structure-activity relationships (QSARs) in ecotoxicity
    Tjalling Jager
    FALW Department of Theoretical Biology, Vrije Universiteit Amsterdam, The Netherlands
    Ecotoxicology 18:187-96. 2009
  8. pmc A biology-based approach for mixture toxicity of multiple endpoints over the life cycle
    Tjalling Jager
    FALW Department of Theoretical Biology, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands
    Ecotoxicology 19:351-61. 2010
  9. pmc Extrapolating toxic effects on individuals to the population level: the role of dynamic energy budgets
    Tjalling Jager
    Department of Theoretical Biology, Vrije Universiteit, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    Philos Trans R Soc Lond B Biol Sci 365:3531-40. 2010
  10. ncbi request reprint Modeling ingestion as an exposure route for organic chemicals in earthworms (Oligochaeta)
    T Jager
    Laboratory for Ecotoxicology, National Institute of Public Health and the Environment RIVM, P O Box 1, NL 3720 BA, Bilthoven, The Netherlands
    Ecotoxicol Environ Saf 57:30-8. 2004

Detail Information

Publications35

  1. ncbi request reprint Elucidating the routes of exposure for organic chemicals in the earthworm, Eisenia andrei (Oligochaeta)
    Tjalling Jager
    Department of Theoretical Biology, Vrije Universiteit Amsterdam, De Boelelaan 1085, NL 1081 HV Amsterdam, The Netherlands
    Environ Sci Technol 37:3399-404. 2003
    ..The rate constant across the skin decreases with K(ow) but was generally higher than data derived from water-only exposure. The relationship with hydrophobicity was less clear for the rate constant across the gut wall...
  2. ncbi request reprint Bioaccumulation of organic chemicals in contaminated soils: evaluation of bioassays with earthworms
    Tjalling Jager
    Vrije Universiteit Amsterdam, Department of Theoretical Biology, De Boelelaan 1085, Amsterdam, The Netherlands
    Environ Sci Technol 39:293-8. 2005
    ..caliginosa, as well as to those in the field-collected worms. Nevertheless, E. andrei accumulated slightly more than the other species and appeared to be more sensitive to the conditions in soil from one of our sites...
  3. ncbi request reprint Simultaneous modeling of multiple end points in life-cycle toxicity tests
    Tjalling Jager
    Department of Theoretical Biology, Vrije Universiteit, De Boelelaan 1085, NL 1081 HV, Amsterdam, The Netherlands
    Environ Sci Technol 38:2894-900. 2004
    ..As the analysis is process based, population responses under food limitation can be explored, which depends critically on the selected mode of action...
  4. ncbi request reprint Modeling receptor kinetics in the analysis of survival data for organophosphorus pesticides
    Tjalling Jager
    Department of Theoretical Biology, Vrije Universiteit, De Boelelaan 1085, NL 1081 HV, Amsterdam, The Netherlands
    Environ Sci Technol 39:8307-14. 2005
    ..We observed thatthe no-effect concentration estimated from the receptor model is basically identical to the value from standard DEBtox, illustrating the robustness of this summary statistic...
  5. ncbi request reprint Making sense of ecotoxicological test results: towards application of process-based models
    Tjalling Jager
    FALW Department of Theoretical Biology, Vrije Universiteit Amsterdam, De Boelelaan 1085, NL 1081 HV, Amsterdam, The Netherlands
    Ecotoxicology 15:305-14. 2006
    ..This discussion is illustrated with effects data for Daphnia magna, analyzed by the DEBtox model...
  6. ncbi request reprint Chronic exposure to chlorpyrifos reveals two modes of action in the springtail Folsomia candida
    Tjalling Jager
    Department of Theoretical Biology, Vrije Universiteit, De Boelelaan 1085, NL 1081 HV, Amsterdam, The Netherlands
    Environ Pollut 145:452-8. 2007
    ..It appears that CPF interacts with senescence by increasing oxidative damage. This assumption fits the data well, but has little consequences for the predicted response at the population level...
  7. doi request reprint A biology-based approach for quantitative structure-activity relationships (QSARs) in ecotoxicity
    Tjalling Jager
    FALW Department of Theoretical Biology, Vrije Universiteit Amsterdam, The Netherlands
    Ecotoxicology 18:187-96. 2009
    ..Different modes of action resulted in different patterns in the parameter estimates, and therefore, the toxicity data by themselves reveal insight into the actual mechanism of toxic action...
  8. pmc A biology-based approach for mixture toxicity of multiple endpoints over the life cycle
    Tjalling Jager
    FALW Department of Theoretical Biology, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands
    Ecotoxicology 19:351-61. 2010
    ..We illustrate our method with the interpretation of partial life-cycle data for two polycyclic aromatic hydrocarbons in Daphnia magna...
  9. pmc Extrapolating toxic effects on individuals to the population level: the role of dynamic energy budgets
    Tjalling Jager
    Department of Theoretical Biology, Vrije Universiteit, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    Philos Trans R Soc Lond B Biol Sci 365:3531-40. 2010
    ..The DEB3 model allows for a completely consistent assessment of toxic effects and therefore greater confidence in extrapolating, but poses greater demands on the available data...
  10. ncbi request reprint Modeling ingestion as an exposure route for organic chemicals in earthworms (Oligochaeta)
    T Jager
    Laboratory for Ecotoxicology, National Institute of Public Health and the Environment RIVM, P O Box 1, NL 3720 BA, Bilthoven, The Netherlands
    Ecotoxicol Environ Saf 57:30-8. 2004
    ..The model is particularly useful when the organism's food source is specifically contaminated and EP cannot be applied...
  11. ncbi request reprint Relating environmental availability to bioavailability: soil-type-dependent metal accumulation in the oligochaete Eisenia andrei
    W J Peijnenburg
    Laboratory for Ecotoxicology, National Institute of Public Health and the Environment, Bilthoven, 3720 BA, The Netherlands
    Ecotoxicol Environ Saf 44:294-310. 1999
    ....
  12. ncbi request reprint Prediction of daphnid survival after in situ exposure to complex mixtures
    J Baas
    Department of Theoretical Biology, Vrije Universiteit of Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    Environ Sci Technol 43:6064-9. 2009
    ..Hence it is a powerful tool to link the chemical and ecological status of surface waters...
  13. ncbi request reprint Prediction of metal bioavailability in Dutch field soils for the oligochaete Enchytraeus crypticus
    W J Peijnenburg
    Laboratory for Ecotoxicology, National Institute of Public Health and the Environment, Bilthoven, 3720 BA, The Netherlands
    Ecotoxicol Environ Saf 43:170-86. 1999
    ..A semi-mechanistic approach yielded further evidence of pore water-related uptake, modulated by competition between H+ and metal ions at the active sites of the membranes...
  14. ncbi request reprint Impact of metal pools and soil properties on metal accumulation in Folsomia candida (Collembola)
    M Vijver
    National Institute of Public Health and the Environment, Laboratory for Ecotoxicology, Bilthoven, The Netherlands
    Environ Toxicol Chem 20:712-20. 2001
    ..candida), although a reduction of uncertainties in metal risk assessment can be reached by consistent use of body residues rather than external concentrations...
  15. doi request reprint A review of DEB theory in assessing toxic effects of mixtures
    Jan Baas
    Vrije Universiteit of Amsterdam, Department of Theoretical Biology, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    Sci Total Environ 408:3740-5. 2010
    ..We expect this approach to help in identifying key mechanisms and enable to focus further research in cooperation with modelers and experimentalists to improve our understanding of the mechanisms underlying mixture toxicity...
  16. ncbi request reprint Opportunities for a probabilistic risk assessment of chemicals in the European Union
    T Jager
    Laboratory for Ecotoxicology, National Institute of Public Health and the Environment RIVM, Bilthoven, Netherlands
    Chemosphere 43:257-64. 2001
    ..Furthermore, representatives of EU Member States and the chemical industry were interviewed to find out their views on applying uncertainty analysis to risk assessment of industrial chemicals...
  17. doi request reprint Understanding toxicity as processes in time
    Jan Baas
    Vrije Universiteit of Amsterdam, Department of Theoretical Biology, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    Sci Total Environ 408:3735-9. 2010
    ..Given the fact that toxicity data for single compounds show clear patterns in time, it is to be expected that effects of mixtures will also be strongly dependent on time. The few examples that have been published support this statement...
  18. doi request reprint From food-dependent statistics to metabolic parameters, a practical guide to the use of dynamic energy budget theory
    S A L M Kooijman
    Department of Theoretical Biology, Vrije Universiteit, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
    Biol Rev Camb Philos Soc 83:533-52. 2008
    ..We illustrate the methods using data on daphnids and molluscs...
  19. ncbi request reprint Scaling relationships based on partition coefficients and body sizes have similarities and interactions
    S A L M Kooijman
    Faculty Earth and Life Sciences, Vrije Universiteit, 1081 HV, Amsterdam, The Netherlands
    SAR QSAR Environ Res 18:315-30. 2007
    ..The strength of the theory is in the combination of why metabolic transformation depends both on the BCF and the body size. We illustrate the application of the theory with several data sets from the literature...
  20. ncbi request reprint Availability of polycyclic aromatic hydrocarbons to earthworms (Eisenia andrei, Oligochaeta) in field-polluted soils and soil-sediment mixtures
    Tjalling Jager
    Laboratory for Ecotoxicology, National Institute of Public Health and the Environment RIVM, PO Box 1, NL 3720 BA Bilthoven, The Netherlands
    Environ Toxicol Chem 22:767-75. 2003
    ..However, risk assessment can conservatively rely on equilibrium partitioning, but accurate prediction requires quantification of the kinetics of bioavailability...
  21. doi request reprint A model to analyze effects of complex mixtures on survival
    Jan Baas
    Department of Theoretical Biology, Vrije Universiteit of Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    Ecotoxicol Environ Saf 72:669-76. 2009
    ..The simulation showed that due to the combined effect of the compounds in the mixture effects can be seen at very low concentrations...
  22. ncbi request reprint The relationship between elimination rates and partition coefficients
    S A L M Kooijman
    Department of Theoretical Biology, Faculty of Earth and Life Sciences, Vrije Universiteit, De Boelelaan 1087, 1081 HV Amsterdam, Netherlands
    Chemosphere 57:745-53. 2004
    ..The daphnia data showed less scatter than the fish data, possibly due to the small variance in body sizes, since elimination rates are inversely proportional to body length. The square root relationship fitted these data best...
  23. ncbi request reprint Monitoring approaches to assess bioaccessibility and bioavailability of metals: matrix issues
    W J G M Peijnenburg
    Laboratory for Ecotoxicology, National Institute of Public Health and the Environment, P O Box 1, 3720 BA, Bilthoven, The Netherlands
    Ecotoxicol Environ Saf 56:63-77. 2003
    ..Instead, we recommend that a critical assessment of the endpoints of determination become the basis for a need-specific monitoring strategy...
  24. ncbi request reprint Comparison of two screening level risk assessment approaches for six disinfectants and pharmaceuticals
    Annemarie P van Wezel
    National Institute for Public Health and the Environment, Bilthoven, BA, The Netherlands
    Chemosphere 47:1113-28. 2002
    ..It is concluded that the RIRA has a higher discriminative value and yields more information compared to the PTB-criterion...
  25. ncbi request reprint Novel view on predicting acute toxicity: decomposing toxicity data in species vulnerability and chemical potency
    Tjalling Jager
    National Institute for Public Health and Environment RIVM, Laboratory for Ecological Risk Assessment, PO Box 1, NL 3720 BA, Bilthoven, The Netherlands
    Ecotoxicol Environ Saf 67:311-22. 2007
    ..The proposed approach has potential for predicting toxicity for untested species-compound combinations; however, there is a need for a better definition of 'mode of action' in ecotoxicology...
  26. ncbi request reprint Short-term ecological risks of depositing contaminated sediment on arable soil
    Willie Peijnenburg
    Laboratory for Ecological Risk Assessment, National Institute of Public Health and the Environment, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Ecotoxicol Environ Saf 60:1-14. 2005
    ....
  27. pmc Juvenile food limitation in standardized tests: a warning to ecotoxicologists
    Elke I Zimmer
    Department of Theoretical Biology, Faculty of Earth and Life Sciences, Vrije Universiteit, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands
    Ecotoxicology 21:2195-204. 2012
    ....
  28. ncbi request reprint Solid-phase microextraction to predict bioavailability and accumulation of organic micropollutants in terrestrial organisms after exposure to a field-contaminated soil
    Leon van der Wal
    Institute for Risk Assessment Sciences, Utrecht University, P O Box 801 76, 3508 TD Utrecht, The Netherlands
    Environ Sci Technol 38:4842-8. 2004
    ..These results show that measuring concentrations of hydrophobic chemicals in a PDMS-coated fiber represents a simple tool to estimate internal concentrations of chemicals in biota exposed to soil...
  29. ncbi request reprint Prediction of ecological no-effect concentrations for initial risk assessment: combining substance-specific data and database information
    Willem Roelofs
    Department of Environmental Studies, University of Nijmegen, 6500 GL, Nijmegen, The Netherlands
    Environ Toxicol Chem 22:1387-93. 2003
    ..Sample calculations indicate that the proposed method may provide a good alternative for currently applied methods for initial risk assessment, particularly if few toxicity data are available...
  30. ncbi request reprint Physiological modes of action of toxic chemicals in the nematode Acrobeloides nanus
    Olga Alda Alvarez
    Laboratory of Nematology, Wageningen University, Binnenhaven 5, 6709 PD Wageningen, The Netherlands
    Environ Toxicol Chem 25:3230-7. 2006
    ..This highlights the importance of the interactions between a chemical and the biological characteristics of the organism in determination of the resulting physiological modes of action...
  31. ncbi request reprint Modeling responses of Daphnia magna to pesticide pulse exposure under varying food conditions: intrinsic versus apparent sensitivity
    Barry J Pieters
    Department of System Ecotoxicology, Centre for Environmental Research UFZ, Permoserstrasse 15, 04318, Leipzig, Germany
    Ecotoxicology 15:601-8. 2006
    ..This study implies that the effect of pesticide application in the field depends on the trophic state of the receiving water body, but also that full recovery of survivors is possible after FV application...
  32. ncbi request reprint Temporal dynamics of effect concentrations
    Olga Alda Alvarez
    Laboratory of Nematology, Wageningen University, Binnenhaven 5, 6709 PD Wageningen, The Netherlands
    Environ Sci Technol 40:2478-84. 2006
    ..The interpretation of the results from toxicity tests can be improved through process-based modeling, as demonstrated on the current data set...
  33. ncbi request reprint Metal uptake from soils and soil-sediment mixtures by larvae of Tenebrio molitor (L.) (Coleoptera)
    Martina Vijver
    Laboratory of Ecological Risk Assessment, National Institute of Public Health and the Environment, P O Box 1, BA 3720 Bilthoven, Netherlands
    Ecotoxicol Environ Saf 54:277-89. 2003
    ..These characteristics appear as similarities among multivariate functions as derived for the beetle...
  34. ncbi request reprint Sorption kinetics and microbial biodegradation activity of hydrophobic chemicals in sewage sludge: model and measurements based on free concentrations
    Elsa Artola-Garicano
    Institute for Risk Assessment Sciences, Toxicology Division, Utrecht University, P O Box 80 176, NL 3508 TD Utrecht, The Netherlands
    Environ Sci Technol 37:116-22. 2003
    ..This information can be used by sewage treatment plant managers to decide whether the microbial biodegradation activity itself or the desorption from organic carbon to the aqueous phase should be improved...
  35. ncbi request reprint Temperature-dependent effects of cadmium on Daphnia magna: accumulation versus sensitivity
    Evelyn H W Heugens
    Department of Aquatic Ecology and Ecotoxicology, Faculty of Science, University of Amsterdam, P O Box 94084, 1090 GB Amsterdam, The Netherlands
    Environ Sci Technol 37:2145-51. 2003
    ..Since temperature has such a major impact on toxicity, a temperature correction may be necessary when translating toxicity data from the laboratory to the field...