J M Dekker

Summary

Affiliation: Vrije Universiteit
Country: The Netherlands

Publications

  1. ncbi request reprint [Estimate of the number of new patients with type 2 diabetes mellitus in the Netherlands: at least 65,000 per year in the age group of 50 years and above]
    J M Dekker
    VU Medisch Centrum, Instituut voor Extramuraal Geneeskundig Onderzoek, Van der Boechorststraat 7, 1081 BT Amsterdam
    Ned Tijdschr Geneeskd 147:1419-23. 2003
  2. ncbi request reprint Low heart rate variability in a 2-minute rhythm strip predicts risk of coronary heart disease and mortality from several causes: the ARIC Study. Atherosclerosis Risk In Communities
    J M Dekker
    Division of Human Nutrition and Epidemiology, Wageningen Agricultural University, Wageningen, The Netherlands
    Circulation 102:1239-44. 2000
  3. ncbi request reprint [Finnish questionnaire reasonably good predictor of the incidence of diabetes in The Netherlands]
    M Alssema
    VU Medisch Centrum, afd Epidemiologie en Biostatistiek, EMGO Instituut, Van der Boechorststraat 7, 1081 BT Amsterdam
    Ned Tijdschr Geneeskd 152:2418-24. 2008
  4. ncbi request reprint Relation of impaired fasting and postload glucose with incident type 2 diabetes in a Dutch population: The Hoorn Study
    F de Vegt
    Institute for Research in Extramural Medicine, Vrije Universiteit, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    JAMA 285:2109-13. 2001
  5. ncbi request reprint A combination of high concentrations of serum triglyceride and non-high-density-lipoprotein-cholesterol is a risk factor for cardiovascular disease in subjects with abnormal glucose metabolism--The Hoorn Study
    G Bos
    Institute for Research in Extramural Medicine, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Diabetologia 46:910-6. 2003
  6. ncbi request reprint Postprandial glucose and not triglyceride concentrations are associated with carotid intima media thickness in women with normal glucose metabolism: the Hoorn prandial study
    M Alssema
    EMGO Institute, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Atherosclerosis 196:712-9. 2008
  7. doi request reprint Fasting proinsulin levels are significantly associated with 20 year cancer mortality rates. The Hoorn Study
    I Walraven
    EMGO Institute for Health and Care Research, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Diabetologia 56:1148-54. 2013
  8. ncbi request reprint [Metabolic syndrome: limited significance for clinical practice]
    J M Dekker
    VU Medisch Centrum, Van der Boechorststraat 7, 0081 BT Amsterdam
    Ned Tijdschr Geneeskd 149:855-8. 2005
  9. ncbi request reprint Hyperhomocysteinemia is associated with the presence of retinopathy in type 2 diabetes mellitus: the Hoorn study
    E K Hoogeveen
    Institute for Research in Extramural Medicine, Vrije Universiteit, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Arch Intern Med 160:2984-90. 2000
  10. ncbi request reprint Rates and risks for co-morbid depression in patients with Type 2 diabetes mellitus: results from a community-based study
    F Pouwer
    Diabetes Research Group, Department of Medical Psychology, Institute for Research in Extramural Medicine EMGO, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Diabetologia 46:892-8. 2003

Detail Information

Publications63

  1. ncbi request reprint [Estimate of the number of new patients with type 2 diabetes mellitus in the Netherlands: at least 65,000 per year in the age group of 50 years and above]
    J M Dekker
    VU Medisch Centrum, Instituut voor Extramuraal Geneeskundig Onderzoek, Van der Boechorststraat 7, 1081 BT Amsterdam
    Ned Tijdschr Geneeskd 147:1419-23. 2003
    ..To estimate the incidence of type-2 diabetes mellitus in the Netherlands, using figures which were observed in a population-based cohort study of diabetes, the Hoorn Study...
  2. ncbi request reprint Low heart rate variability in a 2-minute rhythm strip predicts risk of coronary heart disease and mortality from several causes: the ARIC Study. Atherosclerosis Risk In Communities
    J M Dekker
    Division of Human Nutrition and Epidemiology, Wageningen Agricultural University, Wageningen, The Netherlands
    Circulation 102:1239-44. 2000
    ..Low heart rate variability (HRV) is associated with a higher risk of death in patients with heart disease and in elderly subjects and with a higher incidence of coronary heart disease (CHD) in the general population...
  3. ncbi request reprint [Finnish questionnaire reasonably good predictor of the incidence of diabetes in The Netherlands]
    M Alssema
    VU Medisch Centrum, afd Epidemiologie en Biostatistiek, EMGO Instituut, Van der Boechorststraat 7, 1081 BT Amsterdam
    Ned Tijdschr Geneeskd 152:2418-24. 2008
    ..To establish whether the Finnish diabetes risk score for predicting the incidence of diabetes (FINDRISK) is also valid in the Netherlands, and to choose cut-off points suitable for the Dutch situation...
  4. ncbi request reprint Relation of impaired fasting and postload glucose with incident type 2 diabetes in a Dutch population: The Hoorn Study
    F de Vegt
    Institute for Research in Extramural Medicine, Vrije Universiteit, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    JAMA 285:2109-13. 2001
    ..002). CONCLUSION: In this study, the cumulative incidence of diabetes was strongly related to both IFG and IGT at baseline and, in particular, to the combined presence of IFG and IGT...
  5. ncbi request reprint A combination of high concentrations of serum triglyceride and non-high-density-lipoprotein-cholesterol is a risk factor for cardiovascular disease in subjects with abnormal glucose metabolism--The Hoorn Study
    G Bos
    Institute for Research in Extramural Medicine, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Diabetologia 46:910-6. 2003
    ..The aim of this study was to investigate the association of triglyceride and non-HDL-cholesterol concentrations with cardiovascular disease in subjects with normal and abnormal glucose metabolism...
  6. ncbi request reprint Postprandial glucose and not triglyceride concentrations are associated with carotid intima media thickness in women with normal glucose metabolism: the Hoorn prandial study
    M Alssema
    EMGO Institute, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Atherosclerosis 196:712-9. 2008
    ..Postprandial glucose levels might be a better indicator of risk than post-OGTT glucose levels or triglyceride levels...
  7. doi request reprint Fasting proinsulin levels are significantly associated with 20 year cancer mortality rates. The Hoorn Study
    I Walraven
    EMGO Institute for Health and Care Research, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Diabetologia 56:1148-54. 2013
    ..Proinsulin is possibly associated with cancer through activation of insulin receptor isoform A. We sought to investigate the associations between proinsulin and 20 year cancer mortality rates...
  8. ncbi request reprint [Metabolic syndrome: limited significance for clinical practice]
    J M Dekker
    VU Medisch Centrum, Van der Boechorststraat 7, 0081 BT Amsterdam
    Ned Tijdschr Geneeskd 149:855-8. 2005
    ..Its utility in clinical practice, however, is under debate. Reduction of obesity by life-style changes and treatment of individual risk factors is still the best line of action...
  9. ncbi request reprint Hyperhomocysteinemia is associated with the presence of retinopathy in type 2 diabetes mellitus: the Hoorn study
    E K Hoogeveen
    Institute for Research in Extramural Medicine, Vrije Universiteit, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Arch Intern Med 160:2984-90. 2000
    ..Retinopathy is the leading cause of blindness among patients with type 2 diabetes mellitus (DM). Hyperhomocysteinemia is a recently recognized risk factor for cardiovascular disease, independent of established risk factors...
  10. ncbi request reprint Rates and risks for co-morbid depression in patients with Type 2 diabetes mellitus: results from a community-based study
    F Pouwer
    Diabetes Research Group, Department of Medical Psychology, Institute for Research in Extramural Medicine EMGO, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Diabetologia 46:892-8. 2003
    ..We studied the prevalence and risk factors of co-morbid depression in a community-based sample of older adults, comparing Type 2 diabetic patients with healthy control subjects...
  11. ncbi request reprint [Estimating the individual risk of diabetes: not on the grounds of overweight only]
    E van 't Riet
    VU Medisch Centrum, EMGO Instituut, Van der Boechorststraat 7, kamer D 528, io8x BT Amsterdam
    Ned Tijdschr Geneeskd 152:2385-8. 2008
    ....
  12. ncbi request reprint [From the Cochrane Library and Diabetes Care: self-monitoring of blood glucose probably an effective way to improve glycaemic control in patients with type 2 diabetes not taking insulin]
    L M C Welschen
    VU Medisch Centrum, Instituut voor Extramuraal Geneeskundig Onderzoek EMGO, Van der Boechorststraat 7, 1081 BT Amsterdam
    Ned Tijdschr Geneeskd 150:1826-9. 2006
    ..There was scant data on patient-related outcomes, such as quality of life, well being and satisfaction. Therefore, more large long-term studies of high quality are needed...
  13. ncbi request reprint Meta-analysis of the relationship between alcohol consumption and coronary heart disease and mortality in type 2 diabetic patients
    L L J Koppes
    EMGO Institute, VU University Medical Center, Van der Boechorststraat 7, 1081, BT, Amsterdam, The Netherlands
    Diabetologia 49:648-52. 2006
    ..Meta-analyses could only be performed for total mortality, mortality from CHD, and CHD incidence, because the availability of articles on other complications was too limited...
  14. ncbi request reprint The 1997 American Diabetes Association criteria versus the 1985 World Health Organization criteria for the diagnosis of abnormal glucose tolerance: poor agreement in the Hoorn Study
    F de Vegt
    Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    Diabetes Care 21:1686-90. 1998
    ..We compared the 1997 ADA criteria with the 1985 World Health Organization (WHO) criteria with respect to the prevalence of diabetes and the cardiovascular risk profile in the population of the Hoorn Study..
  15. ncbi request reprint Leptin and variables of body adiposity, energy balance, and insulin resistance in a population-based study. The Hoorn Study
    J B Ruige
    Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    Diabetes Care 22:1097-104. 1999
    ..We therefore explored, in a large population-based study of 2,484 Caucasian subjects aged 50-74 years, the relationship between leptin and variables of body adiposity, energy balance, and insulin resistance...
  16. ncbi request reprint Independent and opposite associations of waist and hip circumferences with diabetes, hypertension and dyslipidemia: the AusDiab Study
    M B Snijder
    International Diabetes Institute, Caulfield, Victoria, Australia
    Int J Obes Relat Metab Disord 28:402-9. 2004
    ..In addition, as previous studies were performed in older persons, we investigated whether these associations were present across adult age groups...
  17. ncbi request reprint Perceived risk for Type 2 diabetes in participants in a stepwise population-screening programme
    M C Adriaanse
    Institute for Research in Extramural Medicine EMGO Institute, VU University Medical Centre, Amsterdam, The Netherlands
    Diabet Med 20:210-5. 2003
    ..To determine the risk perception of Type 2 diabetes in participants in a stepwise population-screening programme...
  18. ncbi request reprint Impact of diabetes duration and cardiovascular risk factors on mortality in type 2 diabetes: the Hoorn Study
    A M W Spijkerman
    Institute for Research in Extramural Medicine, VU University Medical Centre, Amsterdam, The Netherlands
    Eur J Clin Invest 32:924-30. 2002
    ..We studied mortality in relation to diabetes duration, and the contribution of other cardiovascular risk factors to the elevated risk...
  19. ncbi request reprint The prediction of visceral fat by dual-energy X-ray absorptiometry in the elderly: a comparison with computed tomography and anthropometry
    M B Snijder
    Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    Int J Obes Relat Metab Disord 26:984-93. 2002
    ..The aim of the present study is to investigate whether the dual-energy X-ray absorptiometry (DXA) method, possibly combined with anthropometry, offers a good alternative to CT for the prediction of visceral fat in the elderly...
  20. ncbi request reprint Insulin and risk of cardiovascular disease: a meta-analysis
    J B Ruige
    Institute for Research in Extramural Medicine and Endocrinology, Department of Epidemiology and Biostatistics, Vrije Universiteit, Amsterdam, The Netherlands
    Circulation 97:996-1001. 1998
    ..Our purposes were to estimate the strength of the longitudinal relationship between hyperinsulinemia and cardiovascular diseases (CVD) from the available literature and to identify study characteristics that modify this relationship...
  21. ncbi request reprint Screening for Type 2 diabetes: an exploration of subjects' perceptions regarding diagnosis and procedure
    M C Adriaanse
    Institute for Research in Extramural Medicine EMGO Institute, Amsterdam, The Netherlands
    Diabet Med 19:406-11. 2002
    ..To explore the psychological impact of a stepwise population-screening project for Type 2 diabetes...
  22. ncbi request reprint [Self-monitoring by patients with type-2 diabetes mellitus one year after initiation: user errors in a quarter of cases]
    G Nijpels
    VU Medisch Centrum, Van der Boechorststraat 7, 1081 BT Amsterdam
    Ned Tijdschr Geneeskd 147:1068-70. 2003
    ..To inventory the errors made during self-monitoring of blood-glucose values by diabetes patients...
  23. ncbi request reprint [Insulin resistance and diabetes type 2 in overweight children]
    C M Renders
    afd Sociale Geneeskunde, Instituut voor Extramuraal Geneeskundig Onderzoek, VU Medisch Centrum, Van der Boechorststraat 7, 1081 BT Amsterdam
    Ned Tijdschr Geneeskd 147:2060-3. 2003
    ..Early detection is very useful in obese children with two additional risk factors: diabetes type 2 in first- and second-degree relatives, members of certain ethnic groups or indications of insulin resistance...
  24. ncbi request reprint Low subcutaneous thigh fat is a risk factor for unfavourable glucose and lipid levels, independently of high abdominal fat. The Health ABC Study
    M B Snijder
    Institute for Research in Extramural Medicine, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Diabetologia 48:301-8. 2005
    ..Our secondary aim was to investigate which body composition characteristics (lean tissue, fat tissue) are reflected by anthropometric measures (waist and thigh circumference)...
  25. ncbi request reprint Elevated cholesteryl ester transfer protein concentration is associated with an increased risk for cardiovascular disease in women, but not in men, with Type 2 diabetes: the Hoorn Study
    M Alssema
    EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    Diabet Med 24:117-23. 2007
    ....
  26. ncbi request reprint Associations between depressive symptoms and insulin resistance: the Hoorn Study
    M C Adriaanse
    Faculty of Earth and Life Sciences, Institute of Health Sciences, Vrije University Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands
    Diabetologia 49:2874-7. 2006
    ..The aim of this study was to determine whether the association between symptoms of depression and insulin resistance varies across glucose tolerance status and between men and women...
  27. ncbi request reprint Inflammation and endothelial dysfunction are associated with retinopathy: the Hoorn Study
    M V Van Hecke
    Department of Ophthalmology, VU University Medical Centre, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Diabetologia 48:1300-6. 2005
    ..The aim of this study was to investigate the association of inflammation and endothelial dysfunction with prevalent retinopathy in individuals with and without type 2 diabetes...
  28. ncbi request reprint Dietary polyunsaturated fat intake is associated with low-density lipoprotein size, but not with susceptibility to oxidation in subjects with impaired glucose metabolism and type II diabetes: the Hoorn study
    G Bos
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Clin Nutr 61:205-11. 2007
    ..However, PUFA may increase the susceptibility of LDL to undergo oxidative modifications. The aim of this study was to analyze the association of habitual dietary fat intake with LDL size and oxidizability...
  29. ncbi request reprint Alanine aminotransferase and the 6-year risk of the metabolic syndrome in Caucasian men and women: the Hoorn Study
    R K Schindhelm
    Department of Endocrinology Diabetes Centre, VU University Medical Centre, Amsterdam, The Netherlands
    Diabet Med 24:430-5. 2007
    ..To study the association between alanine aminotransferase (ALT) and the 6-year risk of the metabolic syndrome in a population-based study in Caucasian men and women...
  30. ncbi request reprint Vitamin D status and parathyroid hormone levels in relation to blood pressure: a population-based study in older men and women
    M B Snijder
    Institute of Health Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
    J Intern Med 261:558-65. 2007
    ..Effects of poor vitamin D status on blood pressure may be mediated by elevated parathyroid hormone (PTH) levels...
  31. pmc Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms
    S A Schafer
    Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, Department of Internal Medicine, Eberhard Karls University of Tubingen, Otfried Muller Str 10, 72076, Tubingen, Germany
    Diabetologia 50:2443-50. 2007
    ..We studied whether a defect in the enteroinsular axis contributes to impaired insulin secretion in carriers of TCF7L2 polymorphisms...
  32. doi request reprint Does the constellation of risk factors with and without abdominal adiposity associate with different cardiovascular mortality risk?
    W Gao
    Department of Public Health, University of Helsinki, Mannerheimintie 172, 6th Floor, KTTL, 6krs, PL 41, Helsinki FIN 00014, Finland
    Int J Obes (Lond) 32:757-62. 2008
    ....
  33. ncbi request reprint Prognostic implications of retinopathy and a high plasma von Willebrand factor concentration in type 2 diabetic subjects with microalbuminuria
    A Jager
    Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    Nephrol Dial Transplant 16:529-36. 2001
    ....
  34. ncbi request reprint Deteriorating glucose tolerance status is associated with left ventricular dysfunction--the Hoorn Study
    R M A Henry
    Institute for Research in Extramural Medicine, VU University Medical Centre, Amsterdam, The Netherlands
    Neth J Med 66:110-7. 2008
    ..We investigated, in a population-based cohort (n=746), the association between glucose tolerance status and SDF and DDF ...
  35. doi request reprint Absence of an acute insulin response predicts onset of type 2 diabetes in a Caucasian population with impaired glucose tolerance
    G Nijpels
    Department of General Practice, Vrije Universiteit Medical Center, Van der Boechorststraat 7, Amsterdam
    J Clin Endocrinol Metab 93:2633-8. 2008
    ..However, few studies have used criterion standard measures to asses the predictive value of impaired insulin secretion and insulin resistance for the conversion to T2DM in a Caucasian IGT population...
  36. doi request reprint Symptoms of depression in people with impaired glucose metabolism or Type 2 diabetes mellitus: The Hoorn Study
    M C Adriaanse
    Institute of Health Sciences, Faculty of Earth and Life Sciences, VU University Amsterdam, The Netherlands
    Diabet Med 25:843-9. 2008
    ..To study the prevalence and risk factors of depressive symptoms, comparing subjects with normal glucose metabolism (NGM), impaired glucose metabolism (IGM) or Type 2 diabetes mellitus (DM2)...
  37. pmc Ankle brachial index combined with Framingham Risk Score to predict cardiovascular events and mortality: a meta-analysis
    F G R Fowkes
    JAMA 300:197-208. 2008
    ..Prediction models to identify healthy individuals at high risk of cardiovascular disease have limited accuracy. A low ankle brachial index (ABI) is an indicator of atherosclerosis and has the potential to improve prediction...
  38. ncbi request reprint No substantial psychological impact of the diagnosis of Type 2 diabetes following targeted population screening: The Hoorn Screening Study
    M C Adriaanse
    Institute for Research in Extramural Medicine EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    Diabet Med 21:992-8. 2004
    ..To examine the impact of the diagnosis of Type 2 diabetes on psychological well-being and perceived health status in subjects who participated in a targeted population-screening programme...
  39. ncbi request reprint Beyond postprandial hyperglycaemia: metabolic factors associated with cardiovascular disease
    R J Heine
    Diabetes Centre, Department of Endocrinology, VU University Medical Centre, Amsterdam, The Netherlands
    Diabetologia 45:461-75. 2002
    ..Drugs aiming at improving only postprandial glucose values are not likely to lower the excess mortality associated with Type II diabetes...
  40. ncbi request reprint S-adenosylhomocysteine and the ratio of S-adenosylmethionine to S-adenosylhomocysteine are not related to folate, cobalamin and vitamin B6 concentrations
    A Becker
    Department of Internal Medicine, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Eur J Clin Invest 33:17-25. 2003
    ..Therefore, it is relevant to know how these moieties are interrelated, and whether, as is the case for homocysteine, they are influenced by blood levels of folate, cobalamin or vitamin B6...
  41. ncbi request reprint The EGIR-RISC STUDY (The European group for the study of insulin resistance: relationship between insulin sensitivity and cardiovascular disease risk): I. Methodology and objectives
    S A Hills
    EGIR RISC Coordinating Office, Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, 56100, Pisa, Italy
    Diabetologia 47:566-70. 2004
    ....
  42. ncbi request reprint Health-related quality of life in the first year following diagnosis of Type 2 diabetes: newly diagnosed patients in general practice compared with screening-detected patients. The Hoorn Screening Study
    M C Adriaanse
    Institute for Research in Extramural Medicine EMGO Institute, VU University Medical Centre, Amsterdam, The Netherlands
    Diabet Med 21:1075-81. 2004
    ..To determine health-related quality of life (HRQoL) in the first year following diagnosis of Type 2 diabetes among newly diagnosed patients in general practice compared with patients detected by targeted population screening...
  43. ncbi request reprint Prevalence of macrovascular disease amongst type 2 diabetic patients detected by targeted screening and patients newly diagnosed in general practice: the Hoorn Screening Study
    A M W Spijkerman
    Institutes for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    J Intern Med 256:429-36. 2004
    ..The aim was to investigate whether diabetic patients identified by a targeted screening procedure differ from newly diagnosed diabetic patients in general practice with regard to the prevalence of macrovascular complications...
  44. ncbi request reprint Coffee consumption and incidence of impaired fasting glucose, impaired glucose tolerance, and type 2 diabetes: the Hoorn Study
    R M van Dam
    Department of Nutrition and Health, Faculty of Earth and Life Sciences, Vrije University Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands
    Diabetologia 47:2152-9. 2004
    ..Coffee contains several substances that may affect glucose metabolism. The aim of this study was to evaluate the relationship between habitual coffee consumption and the incidence of IFG, IGT and type 2 diabetes...
  45. ncbi request reprint Serum homocysteine levels are associated with the development of (micro)albuminuria: the Hoorn study
    A Jager
    Institute for Research in Extramural Medicine, Vrije Universiteit, Department of Clinical Epidemiology, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 21:74-81. 2001
    ..These data suggest that homocysteine may play a pathophysiological role in the development of (micro)albuminuria...
  46. ncbi request reprint Prevalences of hyperhomocysteinemia, unfavorable cholesterol profile and hypertension in European populations
    A de Bree
    Unilever Health Institute, Unilever Research and Development Vlaardingen, Olivier van Noortlaan 120, 3133 AT Vlaardingen, The Netherlands
    Eur J Clin Nutr 59:480-8. 2005
    ..Hyperhomocysteinemia (HHCY) is a risk factor for cardiovascular diseases (CVD). HHCY may interact with hypertension (HTEN) and an unfavorable cholesterol profile (UNFAVCHOL) to alter the risk of CVD...
  47. ncbi request reprint Homocysteine levels are not associated with cardiovascular autonomic function in elderly Caucasian subjects without or with type 2 diabetes mellitus: the Hoorn Study
    A M E Spoelstra-De Man
    Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    J Intern Med 258:536-43. 2005
    ..The objective of our study was to determine whether hyperhomocysteinaemia is associated with impaired cardiovascular autonomic function in an age-, sex-, and glucose tolerance-stratified sample of an elderly Caucasian population...
  48. ncbi request reprint Measures of cardiovascular autonomic nervous function: agreement, reproducibility, and reference values in middle age and elderly subjects
    J Gerritsen
    Department of Clinical Physics and Informatics, Vrije Universiteit Medical Centre, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Diabetologia 46:330-8. 2003
    ..Little is known about the agreement between these measures, and reference and reproducibility values for these measures have not been reported within the same group...
  49. ncbi request reprint Hyperhomocysteinaemia is associated with coronary events in type 2 diabetes
    A Becker
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    J Intern Med 253:293-300. 2003
    ..However, it is not known whether homocysteine increases risk of coronary events in type 2 diabetes. Therefore, we examined the combined effect of homocysteine and type 2 diabetes on risk of fatal and nonfatal coronary events...
  50. ncbi request reprint S-adenosylmethionine and 5-methyltetrahydrofolate are associated with endothelial function after controlling for confounding by homocysteine: the Hoorn Study
    A M W Spijkerman
    Institute for Research in Extramural Medicine, VU VU University Medical Center, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 25:778-84. 2005
    ....
  51. ncbi request reprint Why is soluble intercellular adhesion molecule-1 related to cardiovascular mortality?
    A Becker
    Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Eur J Clin Invest 32:1-8. 2002
    ..Classical cardiovascular risk factors (sub)clinical atherosclerosis, endothelial dysfunction and inflammation do not explain this excess risk...
  52. ncbi request reprint Impaired autonomic function is associated with increased mortality, especially in subjects with diabetes, hypertension, or a history of cardiovascular disease: the Hoorn Study
    J Gerritsen
    Department of Clinical Physics and Informatics, Vrije Universiteit, Amsterdam, The Netherlands
    Diabetes Care 24:1793-8. 2001
    ..Moreover, the results of the present study suggest that cardiac autonomic dysfunction in patients already at risk (diabetes, hypertension, or history of cardiovascular disease) may be especially hazardous...
  53. doi request reprint Influence of the ACE gene insertion/deletion polymorphism on insulin sensitivity and impaired glucose tolerance in healthy subjects
    Fabrice Bonnet
    Department of Medicine, Endocrinology Unit, Centre Hospitalier Universitaire, université Rennes, Rennes, France
    Diabetes Care 31:789-94. 2008
    ..The purpose of this study was to investigate the relationship between the ACE gene I/D polymorphism and both insulin sensitivity and glucose intolerance in a large cohort of healthy subjects...
  54. ncbi request reprint Associations of LDL size with in vitro oxidizability and plasma levels of in vivo oxidized LDL in Type 2 diabetic patients
    P G Scheffer
    Metabolic Laboratory, Department of Clinical Chemistry, VU University Medical Centre, Amsterdam, The Netherlands
    Diabet Med 20:563-7. 2003
    ..The aim of this study was to investigate the relationship of in vitro LDL oxidizability and circulating in vivo oxidized LDL with LDL particle size in Type 2 diabetic patients and healthy control subjects...
  55. ncbi request reprint The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases
    J Danesh
    Eur J Epidemiol 22:839-69. 2007
    ..It will, therefore, help to determine to what extent such associations are independent from possible confounding factors and to what extent such markers (separately and in combination) provide incremental predictive value...
  56. ncbi request reprint Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus
    L M 't Hart
    Diabetologia 46:1023-4. 2003
  57. ncbi request reprint Plasma homocysteine and S-adenosylmethionine in erythrocytes as determinants of carotid intima-media thickness: different effects in diabetic and non-diabetic individuals. The Hoorn Study
    A Becker
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, Netherlands
    Atherosclerosis 169:323-30. 2003
    ..We determined whether components of homocysteine metabolism are associated with intima-media thickness in individuals with and without type 2 diabetes...
  58. ncbi request reprint LDL oxidative modifications in well- or moderately controlled type 2 diabetes
    P G Scheffer
    Metabolic Laboratory, Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
    Diabetes Metab Res Rev 20:298-304. 2004
    ....
  59. ncbi request reprint Prevalence of variants in candidate genes for type 2 diabetes mellitus in The Netherlands: the Rotterdam study and the Hoorn study
    L M Hart
    Department of Molecular Cell Biology, Leiden University Medical Center, The Netherlands
    J Clin Endocrinol Metab 84:1002-6. 1999
    ..The large regional differences in allele frequency of the Arg972 allele of IRS-1 gene makes genetic association studies of this gene less reliable...
  60. ncbi request reprint Comment on: Schmidt MI, Duncan BB, Vigo A et al (2006) Leptin and incident type 2 diabetes: risk or protection? Diabetologia 49:2086-2096
    M B Snijder
    Diabetologia 50:234-6; author reply 237-8; discussion 239-40. 2007
  61. ncbi request reprint The Gly482Ser variant in the peroxisome proliferator-activated receptor gamma coactivator-1 is not associated with diabetes-related traits in non-diabetic German and Dutch populations
    M Stumvoll
    Department of Endocrinology, Metabolism and Pathobiochemistry, University of Tubingen, Germany
    Exp Clin Endocrinol Diabetes 112:253-7. 2004
    ..We conclude, that the Gly482Ser variant in PGC-1 is not associated with diabetes-related traits or skeletal muscle fiber type composition in a non-diabetic German and Dutch population...
  62. ncbi request reprint Fat food for a bad mood. Could we treat and prevent depression in Type 2 diabetes by means of omega-3 polyunsaturated fatty acids? A review of the evidence
    F Pouwer
    Vrije Universiteit Medical Centre, Department of Medical Psychology, EMGO Institute, Amsterdam, The Netherlands
    Diabet Med 22:1465-75. 2005
    ..The aim of the present paper was to review whether polyunsaturated fatty acids (PUFA) of the omega-3 family could be used for the prevention and treatment of depression in Type 2 diabetes...
  63. doi request reprint Evaluation of the one-minute exercise test to detect peripheral arterial disease
    E K Hoogeveen
    Vrije Universiteit University Medical Center, Amsterdam, and Jeroen Bosch Hospital, Den Bosch, The Netherlands
    Eur J Clin Invest 38:290-5. 2008
    ..We also investigated whether the combination of the ABPI at rest and the one-minute exercise test could replace DFV scanning...