H F A Vasen

Summary

Country: The Netherlands

Publications

  1. ncbi Decision analysis in the surgical treatment of patients with familial adenomatous polyposis: a Dutch-Scandinavian collaborative study including 659 patients
    H F Vasen
    The Netherlands Foundation for the Detection of Hereditary Tumours, Leiden, The Netherlands
    Gut 49:231-5. 2001
  2. ncbi MSH2 mutation carriers are at higher risk of cancer than MLH1 mutation carriers: a study of hereditary nonpolyposis colorectal cancer families
    H F Vasen
    Netherlands Foundation for the Detection of Hereditary Tumors, Leiden University Medical Centre
    J Clin Oncol 19:4074-80. 2001
  3. ncbi Identification of HNPCC by molecular analysis of colorectal and endometrial tumors
    H F A Vasen
    Department of Gastroenterology, Leiden University Medical Centre, Leiden, The Netherlands
    Dis Markers 20:207-13. 2004
  4. ncbi Early detection of breast and ovarian cancer in families with BRCA mutations
    H F A Vasen
    Department of Clinical Oncology, Leiden University Medical Center, The Netherlands
    Eur J Cancer 41:549-54. 2005
  5. ncbi Risk of developing pancreatic cancer in families with familial atypical multiple mole melanoma associated with a specific 19 deletion of p16 (p16-Leiden)
    H F Vasen
    The Netherlands Foundation for the Detection of Hereditary Tumours, Leiden, The Netherlands
    Int J Cancer 87:809-11. 2000
  6. ncbi Clinical description of the Lynch syndrome [hereditary nonpolyposis colorectal cancer (HNPCC)]
    H F A Vasen
    Department of Gastroenterology, Leiden University Medical Centre, Leiden, The Netherlands
    Fam Cancer 4:219-25. 2005
  7. ncbi [Periodic colonoscopic examinations of persons with a positive family history for colorectal cancer. Work Group 'Hereditary non-polyposis- colon-rectum cancers']
    H F Vasen
    Stichting Opsporing Erfelijke Tumoren, p a Leids Universitair Medisch Centrum, Leiden
    Ned Tijdschr Geneeskd 143:1211-4. 1999
  8. ncbi Recommendations to improve identification of hereditary and familial colorectal cancer in Europe
    H F A Vasen
    Department of Gastroenterology, Leiden University Medical Centre, 2333 AA Leiden, The Netherlands
    Fam Cancer 9:109-15. 2010
  9. ncbi Guidelines for the clinical management of familial adenomatous polyposis (FAP)
    H F A Vasen
    Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Rijnsburgerweg 10, 2333 AA Leiden, The Netherlands
    Gut 57:704-13. 2008
  10. ncbi Germline mutations in APC and MUTYH are responsible for the majority of families with attenuated familial adenomatous polyposis
    M Nielsen
    Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Clin Genet 71:427-33. 2007

Collaborators

Detail Information

Publications47

  1. ncbi Decision analysis in the surgical treatment of patients with familial adenomatous polyposis: a Dutch-Scandinavian collaborative study including 659 patients
    H F Vasen
    The Netherlands Foundation for the Detection of Hereditary Tumours, Leiden, The Netherlands
    Gut 49:231-5. 2001
    ....
  2. ncbi MSH2 mutation carriers are at higher risk of cancer than MLH1 mutation carriers: a study of hereditary nonpolyposis colorectal cancer families
    H F Vasen
    Netherlands Foundation for the Detection of Hereditary Tumors, Leiden University Medical Centre
    J Clin Oncol 19:4074-80. 2001
    ..The aims of the present study were to compare the risk of developing colorectal, endometrial, and other cancers between families with the various MMR-gene mutations...
  3. ncbi Identification of HNPCC by molecular analysis of colorectal and endometrial tumors
    H F A Vasen
    Department of Gastroenterology, Leiden University Medical Centre, Leiden, The Netherlands
    Dis Markers 20:207-13. 2004
    ..Our studies showed that MSI and IHC analysis of colorectal and endometrial cancer, are reliable cost-effective tools that can be used to identify patients with HNPCC...
  4. ncbi Early detection of breast and ovarian cancer in families with BRCA mutations
    H F A Vasen
    Department of Clinical Oncology, Leiden University Medical Center, The Netherlands
    Eur J Cancer 41:549-54. 2005
    ..However, because these women have a high-risk of developing breast cancer, they still have a substantial risk of developing metastatic disease under surveillance. Surveillance for ovarian cancer was not effective...
  5. ncbi Risk of developing pancreatic cancer in families with familial atypical multiple mole melanoma associated with a specific 19 deletion of p16 (p16-Leiden)
    H F Vasen
    The Netherlands Foundation for the Detection of Hereditary Tumours, Leiden, The Netherlands
    Int J Cancer 87:809-11. 2000
    ..p16 mutation carriers have a considerable risk of developing pancreatic cancer. Further studies should evaluate the value of surveillance of the pancreas in these high-risk families...
  6. ncbi Clinical description of the Lynch syndrome [hereditary nonpolyposis colorectal cancer (HNPCC)]
    H F A Vasen
    Department of Gastroenterology, Leiden University Medical Centre, Leiden, The Netherlands
    Fam Cancer 4:219-25. 2005
    ..These guidelines describe practically all clinical conditions in which there is suspicion of the Lynch syndrome and in which a search for MSI is indicated...
  7. ncbi [Periodic colonoscopic examinations of persons with a positive family history for colorectal cancer. Work Group 'Hereditary non-polyposis- colon-rectum cancers']
    H F Vasen
    Stichting Opsporing Erfelijke Tumoren, p a Leids Universitair Medisch Centrum, Leiden
    Ned Tijdschr Geneeskd 143:1211-4. 1999
    ..The total number of people in the Netherlands in this high risk group is estimated at 10,000. The authors conclude that prospective studies are needed to assess the cost-effectiveness of such a programme...
  8. ncbi Recommendations to improve identification of hereditary and familial colorectal cancer in Europe
    H F A Vasen
    Department of Gastroenterology, Leiden University Medical Centre, 2333 AA Leiden, The Netherlands
    Fam Cancer 9:109-15. 2010
    ..The cost-effectiveness of this approach should be further evaluated. All countries with a CRC population screening program should obtain a full family history as part of patient assessment...
  9. ncbi Guidelines for the clinical management of familial adenomatous polyposis (FAP)
    H F A Vasen
    Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Rijnsburgerweg 10, 2333 AA Leiden, The Netherlands
    Gut 57:704-13. 2008
    ..The guidelines described herein may be helpful in the appropriate management of FAP families. In order to improve the care of these families further, prospective controlled studies should be undertaken...
  10. ncbi Germline mutations in APC and MUTYH are responsible for the majority of families with attenuated familial adenomatous polyposis
    M Nielsen
    Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Clin Genet 71:427-33. 2007
    ....
  11. ncbi Somatic APC mosaicism: an underestimated cause of polyposis coli
    F J Hes
    Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Gut 57:71-6. 2008
    ..The patient with 10 or more adenomas in the colon poses a diagnostic challenge. Beside germline mutations in the APC and MUTYH genes, only four cases of mosaic APC mutations have been reported...
  12. ncbi Decision analysis in the surgical treatment of colorectal cancer due to a mismatch repair gene defect
    W H de Vos tot Nederveen Cappel
    Department of Gastroenterology, Leiden University Medical Centre Leiden, The Netherlands
    Gut 52:1752-5. 2003
    ..For older patients, hemicolectomy may be an option as there is no appreciable difference in LE...
  13. ncbi Evidence for accelerated colorectal adenoma--carcinoma progression in MUTYH-associated polyposis?
    M H Nieuwenhuis
    The Netherlands Foundation for the Detection of Hereditary Tumours, Leiden, The Netherlands
    Gut 61:734-8. 2012
    ..We evaluated the natural history of the disease and the outcome of colorectal surveillance and management...
  14. ncbi What is the appropriate screening protocol in Lynch syndrome?
    A E de Jong
    The Netherlands Foundation for the Detection of Hereditary Tumours, Leiden University Medical Center, Poortgebouw Zuid, 2333 AA, Leiden, The Netherlands
    Fam Cancer 5:373-8. 2006
    ..The aim of this study was to address these issues...
  15. ncbi Extending the p16-Leiden tumour spectrum by respiratory tract tumours
    R A Oldenburg
    Center of Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    J Med Genet 41:e31. 2004
  16. ncbi Clinical findings with implications for genetic testing in families with clustering of colorectal cancer
    J T Wijnen
    Department of Human Genetics, Leiden University Medical Center, The Netherlands
    N Engl J Med 339:511-8. 1998
    ..We assessed the prevalence of MSH2 and MLH1 mutations in families suspected of having hereditary nonpolyposis colorectal cancer and evaluated whether clinical findings can predict the outcome of genetic testing...
  17. ncbi Family history is neglected in the work-up of patients with colorectal cancer: a quality assessment using cancer registry data
    D A van Dijk
    The Netherlands Foundation for the Detection of Hereditary Tumours, Leiden University Medical Centre, Leiden, The Netherlands
    Fam Cancer 6:131-4. 2007
    ..0001). We conclude that the family history is neglected in the majority of patients with colorectal cancer and MSI-analysis is only performed in a small proportion of the patients that meet the guidelines for this analysis...
  18. ncbi High frequency of copy-neutral LOH in MUTYH-associated polyposis carcinomas
    A Middeldorp
    Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands
    J Pathol 216:25-31. 2008
    ..The results presented in this study suggest that copy-neutral LOH is an important mechanism in the tumorigenesis of MAP...
  19. ncbi High detection rate of adenomas in familial colorectal cancer
    A E van der Meulen-de Jong
    Department of Gastroenterology, Leiden University Medical Center, Leiden, The Netherlands
    Gut 60:73-6. 2011
    ..However, information about the yield of surveillance is limited. The aim of the present study was to evaluate the outcome of surveillance and to identify risk factors for the development of adenomas...
  20. ncbi Risk of colorectal and endometrial cancer for carriers of mutations of the hMLH1 and hMSH2 gene: correction for ascertainment
    F Quehenberger
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Centre, Leiden, The Netherlands
    J Med Genet 42:491-6. 2005
    ..5% (11.1% to 70.3%). CONCLUSIONS: Current estimates of the CRC risk of mutations to the hMLH1 and hMSH2 locus should be replaced by considerably lower risks which account for the selection of the families...
  21. ncbi Can the identification of high risk groups increase the effectiveness of colon cancer screening programmes?
    H F A Vasen
    The Netherlands Foundation for the Detection of Hereditary Tumours and Department of Gastroenterology, Leiden University Medical Centre, Leiden, The Netherlands
    Z Gastroenterol 46:S41-2. 2008
  22. ncbi Duodenal carcinoma in MUTYH-associated polyposis
    M Nielsen
    Centre for Human and Clinical Genetics, LUMC, Leiden, The Netherlands
    J Clin Pathol 59:1212-5. 2006
    ..Studies in larger series of MAP patients are needed to investigate the risk of upper-gastro-intestinal malignancies and to determine further guidelines for endoscopical surveillance...
  23. ncbi Evaluation of management of desmoid tumours associated with familial adenomatous polyposis in Dutch patients
    M H Nieuwenhuis
    The Netherlands Foundation for the Detection of Hereditary Tumours, Rijnsburgerweg 10, Poortgebouw Zuid, 2333 AA Leiden, The Netherlands
    Br J Cancer 104:37-42. 2011
    ..The optimal treatment of desmoid tumours is controversial. We evaluated desmoid management in Dutch familial adenomatous polyposis (FAP) patients...
  24. ncbi The frequency of a positive family history for colorectal cancer: a population-based study in the Netherlands
    A E de Jong
    The Netherlands Foundation for the Detection of Hereditary Tumours and the Department of Gastroenterology, Leiden University Medical Centre, Leiden, The Netherlands
    Neth J Med 64:367-70. 2006
    ..CONCLUSION: The prevalence of a positive family history of CRC is substantial. Identification of this high-risk group by obtaining a thorough family history is the first step in targeting preventive measures...
  25. ncbi Double balloon endoscopy for detection of small-bowel adenomas in familial adenomatous polyposis after pancreaticoduodenectomy according to Whipple
    A M J Langers
    Department of Gastroenterology, Leiden University Medical Center, Leiden, The Netherlands
    Endoscopy 40:773-4. 2008
    ..This is the first description of the use of DBE for this indication, and emphasizes the need for surveillance of the small bowel after surgery, especially in the area of the biliary anastomosis...
  26. ncbi Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer)
    H F A Vasen
    Department of Gastroenterology, Leiden University Medical Centre, Leiden, The Netherlands
    J Med Genet 44:353-62. 2007
    ..The guidelines described in this manuscript may be helpful for the appropriate management of families with Lynch syndrome. Prospective controlled studies should be undertaken to improve further the care of these families...
  27. ncbi Is colorectal surveillance indicated in patients with PTEN mutations?
    M H Nieuwenhuis
    Netherlands Foundation for the Detection of Hereditary Tumors, Leiden, The Netherlands
    Colorectal Dis 14:e562-6. 2012
    ..We assessed the lifetime risk of benign and malignant gastrointestinal lesions in patients with a proven PTEN mutation...
  28. ncbi Survival of patients with ovarian cancer due to a mismatch repair defect
    Th E M Crijnen
    The Netherlands Foundation for the Detection of Hereditary Tumors, Leiden University Medical Center, Poortgebouw Zuid, 2333 AA, Leiden, The Netherlands
    Fam Cancer 4:301-5. 2005
    ..The cumulative 5-year-survival rates were 64.2 and 58.1% respectively. CONCLUSION: On the basis of our findings, we recommend to treat OC-HNPCC similar to sporadic OC...
  29. ncbi Bannayan-Riley-Ruvalcaba syndrome: further delineation of the phenotype and management of PTEN mutation-positive cases
    Y M C Hendriks
    Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Fam Cancer 2:79-85. 2003
    ..In addition, we propose a yearly haemoglobin test from early infancy for the early detection of intestinal hamartomas, which are likely to give severe complications, especially in BRRS cases...
  30. ncbi Review article: The Lynch syndrome (hereditary nonpolyposis colorectal cancer)
    H F A Vasen
    Department of Gastroenterology and Medical Oncology, Leiden University Medical Centre, Leiden, The Netherlands
    Aliment Pharmacol Ther 26:113-26. 2007
    ..The syndrome is due to a mutation in one of the mismatch repair (MMR) genes: MSH2, MLH1, MSH6 and PMS2...
  31. ncbi Worldwide survey among polyposis registries of surgical management of severe duodenal adenomatosis in familial adenomatous polyposis
    W H de Vos tot Nederveen Cappel
    The Netherlands Foundation for the Detection of Hereditary Tumours and Department of Gastroenterology, Leiden University Medical Center, Leiden, The Netherlands
    Br J Surg 90:705-10. 2003
    ..CONCLUSION: Surgery for duodenal adenomatosis should take place before endoscopic biopsy reveals invasive cancer. Even after extensive surgical procedures, small bowel adenomas may occur, emphasizing the need for chemoprevention...
  32. ncbi Correlations between mutation site in APC and phenotype of familial adenomatous polyposis (FAP): a review of the literature
    M H Nieuwenhuis
    The Netherlands Foundation for the Detection of Hereditary Tumours, Leiden University Medical Centre, The Netherlands
    Crit Rev Oncol Hematol 61:153-61. 2007
    ..No consistent correlations were found for upper gastrointestinal tumours. Genotype-phenotype correlations in FAP will be useful in decisions concerning screening and surgical management of FAP...
  33. ncbi Prediction of a mismatch repair gene defect by microsatellite instability and immunohistochemical analysis in endometrial tumours from HNPCC patients
    W J de Leeuw
    Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    J Pathol 192:328-35. 2000
    ..The present study indicates that assessment of altered protein staining combined with MSI analysis of endometrial tumours might direct the mutational analysis of MMR genes...
  34. ncbi Screening for BRCA2 mutations in 81 Dutch breast-ovarian cancer families
    T Peelen
    Department of Human Genetics, Leiden University Medical Center, The Netherlands
    Br J Cancer 82:151-6. 2000
    ..No aberrations were found in the restriction patterns. Thus, contrary to BRCA1, large genomic rearrangements within the BRCA2 gene do not represent a major mutation mechanism among Dutch breast cancer families...
  35. ncbi Multiplicity in polyp count and extracolonic manifestations in 40 Dutch patients with MYH associated polyposis coli (MAP)
    M Nielsen
    J Med Genet 42:e54. 2005
    ..The frequent occurrence of additional extraintestinal manifestations, such as breast cancer among female MAP patients, should be thoroughly investigated...
  36. ncbi Cancer risks in BRCA2 families: estimates for sites other than breast and ovary
    C J van Asperen
    J Med Genet 42:711-9. 2005
    ..Larger databases with extended follow up are needed to provide insight into mutation specific risks of selected carriers in BRCA2 families...
  37. ncbi Genetic testing in hereditary non-polyposis colorectal cancer families with a MSH2, MLH1, or MSH6 mutation
    A Wagner
    J Med Genet 39:833-7. 2002
  38. ncbi Meat consumption and meat preparation in relation to colorectal adenomas among sporadic and HNPCC family patients in The Netherlands
    D W Voskuil
    Division of Human Nutrition and Epidemiology, Wageningen University, PO Box 8129, 6700 EV, Wageningen, The Netherlands
    Eur J Cancer 38:2300-8. 2002
    ..Some characteristics of habitual meat preparation in the Netherlands may, however, increase the risk of sporadic adenomas...
  39. ncbi [Recommendations for the management of women with an increased genetic risk of gynaecological cancer]
    R H M Verheijen
    afd Verloskunde en Gynaecologie, VU Medisch Centrum, Postbus 7057, 1007 MB Amsterdam
    Ned Tijdschr Geneeskd 146:2414-8. 2002
    ..Recommendations for surveillance and prevention should only be given after genetic-risk counselling, based on a detailed family study and DNA-based diagnosis...
  40. ncbi Experience of discharge from colonoscopy of mutation negative HNPCC family members
    E M A Bleiker
    J Med Genet 40:e55. 2003
  41. ncbi Cost effectiveness of a new strategy to identify HNPCC patients
    W Kievit
    Department of Medical Technology, University Medical Centre Nijmegen, 417 Human Genetics, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Gut 54:97-102. 2005
    ..CONCLUSIONS: MSI testing in a selection of newly diagnosed CRC patients was shown to be cost effective and a feasible method to identify patients at risk for HNPCC who are not recognised by family history...
  42. ncbi [Characterisation of families with hereditary prostate cancer in the Netherlands]
    H J Meulenbeld
    Stichting Opsporing Erfelijke Tumoren, Poortgebouw Zuid, Rijnsburgerweg 10, 2333 AA Leiden
    Ned Tijdschr Geneeskd 146:1938-42. 2002
    ..The mean age of death due to prostate cancer was 71 years (54-84). The mean value of prostate specific antigen (PSA), known for 47 (17%) of the HPC patients, was 36.8 ng/ml (2.1-280)...
  43. ncbi [Desmoid tumors in patients with familial adenomatous polyposis]
    A Pikaar
    Leids Universitair Medisch Centrum (LUMC, afd. Klinische Oncologie en afd. Maag, Darm- en Leverziekten, Leiden
    Ned Tijdschr Geneeskd 146:1355-9. 2002
    ..Radiotherapy may play a role in the treatment of irresectable extra-abdominal or abdominal wall tumours, or as adjuvant treatment of tumours with positive margins...
  44. ncbi Increased risk of colorectal neoplasia in asymptomatic liver-transplant recipients
    J J Koornstra
    Gut 56:892-3. 2007
  45. ncbi Is surveillance of the small bowel indicated for Lynch syndrome families?
    G L ten Kate
    Dutch HNPCC Registry, Department of Gastroenterology of the Leiden University Medical Centre Leiden, Netherlands
    Gut 56:1198-201. 2007
    ..To advise on screening for this tumour it is paramount to be informed about the lifetime risk. The aim of this study was to calculate the lifetime risk of SBC in LS and to identify possible risk factors...
  46. ncbi [From gene to disease; MutYH-associated polyposis coli (MAP)]
    M Nielsen
    Centrum voor Humane en Klinische Genetica, Leids Universitair Medisch Centrum, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 149:2970-2. 2005
    ..MutYH polyposis differs from familial adenomatous polyposis coli in its mode of transmission, later age of onset, a less florid form of polyposis, and fewer extra colonic manifestations...
  47. ncbi An alternative to prophylactic colectomy for colon cancer prevention in HNPCC syndrome
    H F A Vasen
    Gut 54:1501-2. 2005