Manon van Engeland

Summary

Country: The Netherlands

Publications

  1. doi request reprint Viewing the epigenetics of colorectal cancer through the window of folic acid effects
    Manon van Engeland
    Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands
    Cancer Prev Res (Phila) 3:1509-12. 2010
  2. doi request reprint Colorectal cancer epigenetics: complex simplicity
    Manon van Engeland
    GROW School for Oncology and Developmental Biology, PO Box 616, 6200 Maastricht, The Netherlands
    J Clin Oncol 29:1382-91. 2011
  3. doi request reprint Associations of dietary methyl donor intake with MLH1 promoter hypermethylation and related molecular phenotypes in sporadic colorectal cancer
    Stefan de Vogel
    Department of Epidemiology, GROW, School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands
    Carcinogenesis 29:1765-73. 2008
  4. pmc Early onset MSI-H colon cancer with MLH1 promoter methylation, is there a genetic predisposition?
    Eddy H J van Roon
    Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    BMC Cancer 10:180. 2010
  5. doi request reprint Genetic variants of methyl metabolizing enzymes and epigenetic regulators: associations with promoter CpG island hypermethylation in colorectal cancer
    Stefan de Vogel
    Departments of Epidemiology, GROW School for Oncology and Developmental Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Cancer Epidemiol Biomarkers Prev 18:3086-96. 2009
  6. ncbi request reprint Identification of epigenetically silenced genes in tumor endothelial cells
    Debby M E I Hellebrekers
    Department of Pathology, Research Institute for Growth and Development, Maastricht University and University Hospital, Maastricht, The Netherlands
    Cancer Res 67:4138-48. 2007
  7. doi request reprint N-Myc downstream-regulated gene 4 (NDRG4): a candidate tumor suppressor gene and potential biomarker for colorectal cancer
    Veerle Melotte
    Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, The Netherlands
    J Natl Cancer Inst 101:916-27. 2009
  8. ncbi request reprint Integrated analysis of chromosomal, microsatellite and epigenetic instability in colorectal cancer identifies specific associations between promoter methylation of pivotal tumour suppressor and DNA repair genes and specific chromosomal alterations
    Sarah Derks
    Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, 6200 MD, The Netherlands
    Carcinogenesis 29:434-9. 2008
  9. doi request reprint Analytical sensitivity and stability of DNA methylation testing in stool samples for colorectal cancer detection
    Linda J W Bosch
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Cell Oncol (Dordr) 35:309-15. 2012
  10. doi request reprint Promoter CpG island hypermethylation- and H3K9me3 and H3K27me3-mediated epigenetic silencing targets the deleted in colon cancer (DCC) gene in colorectal carcinogenesis without affecting neighboring genes on chromosomal region 18q21
    Sarah Derks
    Department of Pathology, Maastricht University Medical Center, The Netherlands
    Carcinogenesis 30:1041-8. 2009

Detail Information

Publications56

  1. doi request reprint Viewing the epigenetics of colorectal cancer through the window of folic acid effects
    Manon van Engeland
    Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands
    Cancer Prev Res (Phila) 3:1509-12. 2010
    ..This perspective will place this study in context, looking at what it tells us and what it does not...
  2. doi request reprint Colorectal cancer epigenetics: complex simplicity
    Manon van Engeland
    GROW School for Oncology and Developmental Biology, PO Box 616, 6200 Maastricht, The Netherlands
    J Clin Oncol 29:1382-91. 2011
    ..This review integrates recent data on epigenetic regulation of gene expression in CRC and describes how the understanding of these processes will alter the management of CRC...
  3. doi request reprint Associations of dietary methyl donor intake with MLH1 promoter hypermethylation and related molecular phenotypes in sporadic colorectal cancer
    Stefan de Vogel
    Department of Epidemiology, GROW, School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands
    Carcinogenesis 29:1765-73. 2008
    ....
  4. pmc Early onset MSI-H colon cancer with MLH1 promoter methylation, is there a genetic predisposition?
    Eddy H J van Roon
    Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    BMC Cancer 10:180. 2010
    ..As this type of colon cancer is associated with high ages, young patients bearing this type of malignancy are rare and could provide additional insight into the etiology of sporadic MSI-H colon cancer...
  5. doi request reprint Genetic variants of methyl metabolizing enzymes and epigenetic regulators: associations with promoter CpG island hypermethylation in colorectal cancer
    Stefan de Vogel
    Departments of Epidemiology, GROW School for Oncology and Developmental Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Cancer Epidemiol Biomarkers Prev 18:3086-96. 2009
    ..The incomplete overlap between CIMP, MLH1 hypermethylation, and microsatellite instability indicates that these related "methylation phenotypes" may not be similar and should be investigated separately...
  6. ncbi request reprint Identification of epigenetically silenced genes in tumor endothelial cells
    Debby M E I Hellebrekers
    Department of Pathology, Research Institute for Growth and Development, Maastricht University and University Hospital, Maastricht, The Netherlands
    Cancer Res 67:4138-48. 2007
    ....
  7. doi request reprint N-Myc downstream-regulated gene 4 (NDRG4): a candidate tumor suppressor gene and potential biomarker for colorectal cancer
    Veerle Melotte
    Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, The Netherlands
    J Natl Cancer Inst 101:916-27. 2009
    ..Here we examined the role of N-Myc downstream-regulated gene 4 (NDRG4) as a novel tumor suppressor and biomarker in colorectal cancer...
  8. ncbi request reprint Integrated analysis of chromosomal, microsatellite and epigenetic instability in colorectal cancer identifies specific associations between promoter methylation of pivotal tumour suppressor and DNA repair genes and specific chromosomal alterations
    Sarah Derks
    Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, 6200 MD, The Netherlands
    Carcinogenesis 29:434-9. 2008
    ..Therefore, we conclude that promoter methylation of pivotal tumour suppressor and DNA repair genes is associated with specific patterns of chromosomal changes in CRC, which are different from methylation patterns in MSI tumours...
  9. doi request reprint Analytical sensitivity and stability of DNA methylation testing in stool samples for colorectal cancer detection
    Linda J W Bosch
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Cell Oncol (Dordr) 35:309-15. 2012
    ..In addition, we explored the detection of DNA methylation in fecal immunochemical test (FIT) fluid...
  10. doi request reprint Promoter CpG island hypermethylation- and H3K9me3 and H3K27me3-mediated epigenetic silencing targets the deleted in colon cancer (DCC) gene in colorectal carcinogenesis without affecting neighboring genes on chromosomal region 18q21
    Sarah Derks
    Department of Pathology, Maastricht University Medical Center, The Netherlands
    Carcinogenesis 30:1041-8. 2009
    ..Only active epigenetic marks were detected for MBD1, CXXC1, SMAD4 and MBD2. This study demonstrates specific epigenetic silencing of DCC in CRC as a focal process not affecting neighboring genes on chromosomal region 18q21...
  11. ncbi request reprint Dietary folate and APC mutations in sporadic colorectal cancer
    Stefan de Vogel
    Research Institute Growth and Development GROW, Department of Epidemiology, Maastricht University, Maastricht, The Netherlands
    J Nutr 136:3015-21. 2006
    ..These opposite results may indicate that folate enhances colorectal carcinogenesis through a distinct APC mutated pathway...
  12. doi request reprint A let-7 microRNA SNP in the KRAS 3'UTR is prognostic in early-stage colorectal cancer
    Kim M Smits
    Departments of Pathology and Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands
    Clin Cancer Res 17:7723-31. 2011
    ..Effects in early-stage CRC are however unknown. We studied KRAS-LCS6 genotype, hypothesizing that it might identify early-stage cases with a poor prognosis, and could potentially be used in therapy decision-making...
  13. ncbi request reprint Epigenetic regulation of tumor endothelial cell anergy: silencing of intercellular adhesion molecule-1 by histone modifications
    Debby M E I Hellebrekers
    Angiogenesis Laboratory, Research Institute for Growth and Development, Department of Pathology, Maastricht University and University Hospital, The Netherlands
    Cancer Res 66:10770-7. 2006
    ....
  14. doi request reprint Body size and colorectal cancer risk after 16.3 years of follow-up: an analysis from the Netherlands Cohort Study
    Laura A E Hughes
    Department of Epidemiology, Faculty of Health Medicine and Life Science, MaastrichtUniversity, Maastricht, The Netherlands
    Am J Epidemiol 174:1127-39. 2011
    ..Height was associated with risk of CRC, especially distal colon tumors (highest quintile vs. lowest: HR = 1.53, 95% CI: 1.03, 2.27; P-trend = 0.05), in women only...
  15. pmc Early life exposure to famine and colorectal cancer risk: a role for epigenetic mechanisms
    Laura A E Hughes
    Department of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands
    PLoS ONE 4:e7951. 2009
    ..Within the Netherlands Cohort Study on diet and cancer, we investigated the association between early life energy restriction and risk of subsequent CRC characterized by the (promoter) CpG island methylation phenotype (CIMP)...
  16. ncbi request reprint Dietary folate intake and k-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study
    Mirian Brink
    Research Institute Nutrition and Toxicology Research Institute Maastricht NUTRIM, Department of Epidemiology, Maastricht University, Maastricht, The Netherlands
    Int J Cancer 114:824-30. 2005
    ..09), but inversely associated with G>A transitions (RR = 0.08, 95% CI = 0.01-0.53). Our data suggest that the effect of folate on rectal cancer risk is different for men and women and depends on the K-ras mutation status of the tumor...
  17. doi request reprint Alcohol consumption, alcohol dehydrogenase 1C (ADH1C) genotype, and risk of colorectal cancer in the Netherlands Cohort Study on diet and cancer
    Brenda W C Bongaerts
    GROW School for Oncology and Developmental Biology, Department of Epidemiology, Maastricht University, The Netherlands
    Alcohol 45:217-25. 2011
    ..Nevertheless, the interaction deserves further investigation in larger genetic epidemiologic studies...
  18. doi request reprint Alcohol consumption and mutations or promoter hypermethylation of the von Hippel-Lindau gene in renal cell carcinoma
    Leo J Schouten
    Department of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Cancer Epidemiol Biomarkers Prev 17:3543-50. 2008
    ..58; 95% CI, 0.34-0.99). In this study, a not statistically significant inverse association was observed between alcohol and renal cell cancer. There was no statistical significant heterogeneity by VHL mutation or methylation status...
  19. doi request reprint DNA methylation of phosphatase and actin regulator 3 detects colorectal cancer in stool and complements FIT
    Linda J W Bosch
    Department of Pathology, VU University Medical Center, 1007 MB, Amsterdam, The Netherlands
    Cancer Prev Res (Phila) 5:464-72. 2012
    ..Adding PHACTR3 methylation to FIT increased sensitivity for CRC up to 15%. PHACTR3 is a new hypermethylated gene in CRC with a good performance in stool DNA testing and has complementary value to FIT...
  20. doi request reprint Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer
    Stefan de Vogel
    Departments of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands
    J Nutr 138:2372-8. 2008
    ..This is the 2nd prospective cohort study in which vitamin B-6 intake was associated with increased risk of rectal tumors in women, which might suggest that this vitamin enhances rectal cancer in women...
  21. doi request reprint The CpG island methylator phenotype in colorectal cancer: progress and problems
    Laura A E Hughes
    Dept of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, 6200MD Maastricht, The Netherlands
    Biochim Biophys Acta 1825:77-85. 2012
    ....
  22. doi request reprint GATA4 and GATA5 are potential tumor suppressors and biomarkers in colorectal cancer
    Debby M E I Hellebrekers
    Departments of Pathology and Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands
    Clin Cancer Res 15:3990-7. 2009
    ..Here, we evaluated GATA4/5 promoter methylation as potential biomarkers for noninvasive colorectal cancer detection, and investigated the role of GATA4/5 in colorectal cancer...
  23. pmc Prognostic significance of Gremlin1 (GREM1) promoter CpG island hypermethylation in clear cell renal cell carcinoma
    Iris J H van Vlodrop
    Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, PO Box 616, 6200 MD Maastricht, The Netherlands
    Am J Pathol 176:575-84. 2010
    ..59, respectively). The strong correlation between GREM1 region iii promoter methylation and increased malignancy and its correlation with active angiogenesis indicates a role for GREM1 in ccRCC carcinogenesis and tumor angiogenesis...
  24. pmc Body size, physical activity and risk of colorectal cancer with or without the CpG island methylator phenotype (CIMP)
    Laura A E Hughes
    Department of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands
    PLoS ONE 6:e18571. 2011
    ..We investigated how body size and physical activity influence the risk of the CpG island methylator phenotype (CIMP) in colorectal cancer (CRC)...
  25. ncbi request reprint Effects of dietary folate and alcohol intake on promoter methylation in sporadic colorectal cancer: the Netherlands cohort study on diet and cancer
    Manon van Engeland
    The Research Institute GROW, Department of Pathology, University Maastricht, 6200 MD Maastricht, The Netherlands
    Cancer Res 63:3133-7. 2003
    ..085). Despite the size limitations of this study, these data suggest that folate and alcohol intake may be associated with changes in promoter hypermethylation in CRC...
  26. doi request reprint Different angiogenic potential in low and high grade sporadic clear cell renal cell carcinoma is not related to alterations in the von Hippel-Lindau gene
    Marcella M Baldewijns
    Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands
    Cell Oncol 31:371-82. 2009
    ....
  27. doi request reprint VHL and HIF signalling in renal cell carcinogenesis
    Marcella M Baldewijns
    Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands
    J Pathol 221:125-38. 2010
    ..In this review, we discuss existing and novel findings about RCC carcinogenesis, with subsequent clinical implications...
  28. doi request reprint Tracking the molecular features of nonpolypoid colorectal neoplasms: a systematic review and meta-analysis
    Quirinus J M Voorham
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Am J Gastroenterol 108:1042-56. 2013
    ..We conducted a systematic review and meta-analysis to clarify the major biological events in NP-CRNs...
  29. doi request reprint Promoter CpG island methylation markers in colorectal cancer: the road ahead
    Muriel X G Draht
    Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands
    Epigenomics 4:179-94. 2012
    ..This review summarizes the current knowledge of hypermethylation biomarkers for CRC detection, progression and treatment outcome...
  30. doi request reprint Childhood and adolescent energy restriction and subsequent colorectal cancer risk: results from the Netherlands Cohort Study
    Laura A E Hughes
    Department of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands
    Int J Epidemiol 39:1333-44. 2010
    ..Energy restriction during childhood and adolescence is suggested to lower colorectal cancer (CRC) risk. We investigated this in the Netherlands Cohort Study...
  31. doi request reprint Analysis of promoter CpG island hypermethylation in cancer: location, location, location!
    Iris J H van Vlodrop
    Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands
    Clin Cancer Res 17:4225-31. 2011
    ..Here, we discuss the emerging evidence on the importance of the location of CpG dinucleotide hypermethylation in relation to gene expression and associations with clinicopathologic characteristics in cancer...
  32. doi request reprint Genetic and epigenetic alterations in the von hippel-lindau gene: the influence on renal cancer prognosis
    Kim M Smits
    Departmens of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands
    Clin Cancer Res 14:782-7. 2008
    ..We have evaluated the influence of (epi)genetic alterations in VHL on cause-specific survival in clear-cell renal cell cancer (ccRCC) in a large, population-based group of cases...
  33. doi request reprint The CpG island methylator phenotype: what's in a name?
    Laura A E Hughes
    Authors Affiliations Departments of Epidemiology and Pathology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht Department of Surgery, Orbis Medical Center, Sittard Geleen Department of Pathology, Leiden University Medical Center, Leiden Department of Neurology, Erasmus University Medical Center, Erasmus University, Rotterdam, the Netherlands Department of Mathematical Modeling, Statistics and Bioinformatics, Ghent University, Ghent, Belgium and The Johns Hopkins University School of Medicine, Baltimore, Maryland
    Cancer Res 73:5858-68. 2013
    ..The current perspective discusses the use of the term CIMP in cancer, its significance in clinical practice, and future directions that may aid in identifying the true cause and definition of CIMP in different forms of human neoplasia...
  34. pmc Epigenetic changes in Basal Cell Carcinoma affect SHH and WNT signaling components
    Tjinta Brinkhuizen
    Department of Dermatology, Maastricht University Medical Center, Maastricht, The Netherlands
    PLoS ONE 7:e51710. 2012
    ..Epigenetic alterations such as promoter hypermethylation silence tumor suppressor genes (TSG) in several malignancies...
  35. doi request reprint The adenoma hunt in colorectal cancer screening: defining the target
    Anke H Sillars-Hardebol
    Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands
    J Pathol 226:1-6. 2012
    ..Screening tests based on genomic changes that affect relevant biological and metabolic processes hold most promise in this respect...
  36. doi request reprint Test performance of immunologic fecal occult blood testing and sigmoidoscopy compared with primary colonoscopy screening for colorectal advanced adenomas
    Carolina A J Khalid-de Bakker
    Division of Gastroenterology Hepatology, Department of Internal Medicine, Maastricht University Medical Center, The Netherlands
    Cancer Prev Res (Phila) 4:1563-71. 2011
    ..This points to the existence of "low" FIT performance in subgroups and the need for more tailored screening strategies...
  37. ncbi request reprint Methylation-specific PCR unraveled
    Sarah Derks
    Research Institute GROW, Department of Pathology, University Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
    Cell Oncol 26:291-9. 2004
    ..This review discusses the critical parameters of MSP and presents an overview of the available MSP variants and the (clinical) applications...
  38. ncbi request reprint Dual targeting of epigenetic therapy in cancer
    Debby M E I Hellebrekers
    Tumor Biology Laboratory, Research Institute for Growth and Development GROW, Department of Pathology, Maastricht University and University Hospital Maastricht, Maastricht, The Netherlands
    Biochim Biophys Acta 1775:76-91. 2007
    ..Here we review the therapeutic potential of DNMT and HDAC inhibitors as anti-cancer drugs, as evaluated in clinical trials, and their angiostatic activities, apart from their inhibitory effects on tumor cells...
  39. ncbi request reprint Body size and risk for colorectal cancers showing BRAF mutations or microsatellite instability: a pooled analysis
    Laura A E Hughes
    Department of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands
    Int J Epidemiol 41:1060-72. 2012
    ..We investigated whether measures of anthropometry differentially influence risk of tumours according to BRAF c.1799T>A p.V600E mutation (BRAF) and microsatellite instability (MSI) status...
  40. pmc Comprehensive mutation analysis in colorectal flat adenomas
    Quirinus J M Voorham
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    PLoS ONE 7:e41963. 2012
    ..In the present study, we aimed to compare the mutation spectrum of 14 cancer genes, between these two phenotypes...
  41. doi request reprint Molecular tests for colorectal cancer screening
    Linda J W Bosch
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Clin Colorectal Cancer 10:8-23. 2011
    ..Evaluation in large well-controlled randomized trials is the next step needed to take molecular markers for CRC screening to the next level and warrant implementation in a screening setting...
  42. doi request reprint The N-myc downstream regulated gene (NDRG) family: diverse functions, multiple applications
    Veerle Melotte
    Department of Pathology, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands
    FASEB J 24:4153-66. 2010
    ..Finally, their role in disease and potential clinical applications (their role as detection or prognostic markers) are discussed...
  43. doi request reprint Pharmacoepigenomics in colorectal cancer: a step forward in predicting prognosis and treatment response
    Kim M Smits
    Department of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, The Netherlands
    Pharmacogenomics 9:1903-16. 2008
    ..This review describes the current knowledge on the prognostic and predictive value of epigenetic markers in colorectal cancer...
  44. doi request reprint Loss of SerpinA5 protein expression is associated with advanced-stage serous ovarian tumors
    Ingrid T G W Bijsmans
    Department of Pathology, GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands
    Mod Pathol 24:463-70. 2011
    ....
  45. pmc Promoter methylation of Wnt-antagonists in polypoid and nonpolypoid colorectal adenomas
    Quirinus J M Voorham
    Department of Pathology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    BMC Cancer 13:603. 2013
    ..The present study investigated promoter methylation of several Wnt-pathway antagonists in both nonpolypoid and polypoid adenomas...
  46. ncbi request reprint Promoter methylation precedes chromosomal alterations in colorectal cancer development
    Sarah Derks
    Department of Pathology, Research Institute GROW, University Maastricht, The Netherlands
    Cell Oncol 28:247-57. 2006
    ..Colorectal cancers are characterized by genetic and epigenetic alterations. This study aimed to explore the timing of promoter methylation and relationship with mutations and chromosomal alterations in colorectal carcinogenesis...
  47. doi request reprint Taxane resistance in breast cancer: a closed HER2 circuit?
    Joep P J de Hoon
    Division of Medical Oncology, Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands
    Biochim Biophys Acta 1825:197-206. 2012
    ..In conclusion, taxane resistance in breast cancer follows a multiplex establishment of drug cytotoxicity escape routes, which may be most efficiently therapeutically targeted by interference with their mutually governing signaling nodes...
  48. doi request reprint Genetics and epigenetics of cutaneous malignant melanoma: a concert out of tune
    Karin van den Hurk
    Department of Pathology, Maastricht University Medical Centre, Maastricht, The Netherlands
    Biochim Biophys Acta 1826:89-102. 2012
    ..Importantly, we point out that it is this interplay of genetics and epigenetics that effectively leads to distorted gene expression patterns in CMM...
  49. doi request reprint An exploration of pathways involved in lung carcinoid progression using gene expression profiling
    Dorian R A Swarts
    Department of Molecular Cell Biology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, PO Box 616, 6200 MD Maastricht, The Netherlands
    Carcinogenesis 34:2726-37. 2013
    ..We have identified novel pathways underlying malignant progression and validated several genes as being strong prognostic indicators, some of which could serve as putative therapeutic targets. ..
  50. doi request reprint CD44 and OTP are strong prognostic markers for pulmonary carcinoids
    Dorian R A Swarts
    Department of Molecular Cell Biology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands
    Clin Cancer Res 19:2197-207. 2013
    ....
  51. doi request reprint Genetics and epigenetics of renal cell cancer
    Marcella M L Baldewijns
    Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands
    Biochim Biophys Acta 1785:133-55. 2008
    ..In this review we discuss the background of RCC and the clinical applications of RCC genetics and epigenetics...
  52. ncbi request reprint Differential gene expression in ovarian tumors reveals Dusp 4 and Serpina 5 as key regulators for benign behavior of serous borderline tumors
    Nathalie L G Sieben
    Department of Pathology, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    J Clin Oncol 23:7257-64. 2005
    ..The purpose of this study was to further unravel the genetic pathways through which SBTs develop, with a special focus on explaining the generally benign SBT behavior. Materials and..
  53. ncbi request reprint Angiostatic activity of DNA methyltransferase inhibitors
    Debby M E I Hellebrekers
    Angiogenesis Laboratory, Research Institute for Growth and Development, Department of Pathology, Maastricht University and University Hospital, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Mol Cancer Ther 5:467-75. 2006
    ..In conclusion, our data show that DNMT inhibitors have angiostatic activity in addition to their inhibitory effects on tumor cells. This dual action of these compounds makes them promising anticancer therapeutics...
  54. ncbi request reprint K-ras mutations and RASSF1A promoter methylation in colorectal cancer
    Manon van Engeland
    Department of Pathology, University Maastricht, P O Box 616 6200 MD Maastricht, The Netherlands
    Oncogene 21:3792-5. 2002
    ..These data show that the majority of the studied CRCs with K-ras mutations lack RASSF1A promoter methylation, an event which occurs predominantly in K-ras wild-type CRCs (P=0.023, Chi-square test)...
  55. doi request reprint Frequent inactivation of cysteine dioxygenase type 1 contributes to survival of breast cancer cells and resistance to anthracyclines
    Jana Jeschke
    Department of Surgery, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Clin Cancer Res 19:3201-11. 2013
    ..Comprehensive functional analyses provide an understanding of the biologic significance of this vast amount of DNA methylation data that may allow the determination of key epigenetic events associated with tumorigenesis...
  56. pmc Characteristics of triple-negative breast cancer
    Tim C de Ruijter
    Division of Medical Oncology, Department of Internal Medicine, GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    J Cancer Res Clin Oncol 137:183-92. 2011
    ..The purpose of this review is to summarise the latest findings on TNBC concerning its relation and delineation to BBC, discuss the developmental pathways involved and address clinical implications for this complex type of breast cancer...