L J van Doorn

Summary

Country: The Netherlands

Publications

  1. pmc Comparison of human papillomavirus detection between freshly frozen tissue and paraffin embedded tissue of invasive cervical cancer
    Michael Odida
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Infect Agent Cancer 5:15. 2010
  2. pmc Analysis of hepatitis C virus isolates by serotyping and genotyping
    L J van Doorn
    Diagnostic Center SSDZ, Department of Molecular Biology, GA Delft, The Netherlands
    J Clin Microbiol 34:1784-7. 1996
  3. pmc Detection and genotyping of human rotavirus VP4 and VP7 genes by reverse transcriptase PCR and reverse hybridization
    Leen Jan van Doorn
    DDL Diagnostic Laboratory, Fonteijnenburghlaan 7, 2275 CX Voorburg, The Netherlands
    J Clin Microbiol 47:2704-12. 2009
  4. pmc Highly effective detection of human papillomavirus 16 and 18 DNA by a testing algorithm combining broad-spectrum and type-specific PCR
    Leen Jan van Doorn
    DDL Diagnostic Laboratory, Fonteijnenburghlaan 5, 2275 CX, Voorburg, The Netherlands
    J Clin Microbiol 44:3292-8. 2006
  5. ncbi request reprint Molecular detection and genotyping of human papillomavirus
    L J van Doorn
    Delft Diagnostic Laboratory, R de Graafweg 7, 2625 AD Delft, The Netherlands
    Expert Rev Mol Diagn 1:394-402. 2001
  6. ncbi request reprint Detection of Helicobacter pylori virulence-associated genes
    L J van Doorn
    Delft Diagnostic Laboratory, R de Graafweg 7, 2625 AD Delft, The Netherlands
    Expert Rev Mol Diagn 1:290-8. 2001
  7. pmc Accurate prediction of macrolide resistance in Helicobacter pylori by a PCR line probe assay for detection of mutations in the 23S rRNA gene: multicenter validation study
    L J van Doorn
    Delft Diagnostic Laboratory, Delft, The Netherlands
    Antimicrob Agents Chemother 45:1500-4. 2001
  8. pmc The efficacy of laboratory diagnosis of Helicobacter pylori infections in gastric biopsy specimens is related to bacterial density and vacA, cagA, and iceA genotypes
    L J van Doorn
    Delft Diagnostic Laboratory, Diagnostic Center SSDZ, Delft, The Netherlands
    J Clin Microbiol 38:13-7. 2000
  9. pmc Rapid detection, by PCR and reverse hybridization, of mutations in the Helicobacter pylori 23S rRNA gene, associated with macrolide resistance
    L J van Doorn
    Delft Diagnostic Laboratory, Delft, The Netherlands
    Antimicrob Agents Chemother 43:1779-82. 1999
  10. pmc Distinct variants of Helicobacter pylori cagA are associated with vacA subtypes
    L J van Doorn
    Delft Diagnostic Laboratory, 2625 AD Delft, The Netherlands
    J Clin Microbiol 37:2306-11. 1999

Collaborators

Detail Information

Publications29

  1. pmc Comparison of human papillomavirus detection between freshly frozen tissue and paraffin embedded tissue of invasive cervical cancer
    Michael Odida
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Infect Agent Cancer 5:15. 2010
    ..There were 171 pairs of paraffin embedded and freshly frozen samples analyzed from cervical carcinoma cases from Kampala, Uganda...
  2. pmc Analysis of hepatitis C virus isolates by serotyping and genotyping
    L J van Doorn
    Diagnostic Center SSDZ, Department of Molecular Biology, GA Delft, The Netherlands
    J Clin Microbiol 34:1784-7. 1996
    ..The novel serotyping assay offers an alternative method to distinguish the major types of HCV, although the sensitivity of the assay may be limited by the immunocompetence of the infected host...
  3. pmc Detection and genotyping of human rotavirus VP4 and VP7 genes by reverse transcriptase PCR and reverse hybridization
    Leen Jan van Doorn
    DDL Diagnostic Laboratory, Fonteijnenburghlaan 7, 2275 CX Voorburg, The Netherlands
    J Clin Microbiol 47:2704-12. 2009
    ..This novel method permits highly accurate detection and identification of human rotavirus infections in stool samples. This validated assay could be useful for large-scale epidemiological and clinical trials...
  4. pmc Highly effective detection of human papillomavirus 16 and 18 DNA by a testing algorithm combining broad-spectrum and type-specific PCR
    Leen Jan van Doorn
    DDL Diagnostic Laboratory, Fonteijnenburghlaan 5, 2275 CX, Voorburg, The Netherlands
    J Clin Microbiol 44:3292-8. 2006
    ..This combination of assays is more accurate than either method alone, and the novel algorithm offers a highly accurate and effective method for the analysis of HPV infections...
  5. ncbi request reprint Molecular detection and genotyping of human papillomavirus
    L J van Doorn
    Delft Diagnostic Laboratory, R de Graafweg 7, 2625 AD Delft, The Netherlands
    Expert Rev Mol Diagn 1:394-402. 2001
    ..This review describes the different molecular methods available for human papillomavirus detection and identification of genotypes...
  6. ncbi request reprint Detection of Helicobacter pylori virulence-associated genes
    L J van Doorn
    Delft Diagnostic Laboratory, R de Graafweg 7, 2625 AD Delft, The Netherlands
    Expert Rev Mol Diagn 1:290-8. 2001
    ..Together with our increasing knowledge about the human genome, typing of H. pylori will facilitate the management of gastroenterological pathologies...
  7. pmc Accurate prediction of macrolide resistance in Helicobacter pylori by a PCR line probe assay for detection of mutations in the 23S rRNA gene: multicenter validation study
    L J van Doorn
    Delft Diagnostic Laboratory, Delft, The Netherlands
    Antimicrob Agents Chemother 45:1500-4. 2001
    ..pylori strains. In conclusion, our data confirmed the very strong association between 23S rDNA mutations and macrolide resistance and showed that the PCR-LiPA permits accurate and reliable diagnosis of macrolide resistance in H. pylori...
  8. pmc The efficacy of laboratory diagnosis of Helicobacter pylori infections in gastric biopsy specimens is related to bacterial density and vacA, cagA, and iceA genotypes
    L J van Doorn
    Delft Diagnostic Laboratory, Diagnostic Center SSDZ, Delft, The Netherlands
    J Clin Microbiol 38:13-7. 2000
    ..pylori genotypes. These observations may be explained by different bacterial densities, as established by the distinct genotypes of H. pylori, and confirm that the biologies of strains with such genotypes are considerably different...
  9. pmc Rapid detection, by PCR and reverse hybridization, of mutations in the Helicobacter pylori 23S rRNA gene, associated with macrolide resistance
    L J van Doorn
    Delft Diagnostic Laboratory, Delft, The Netherlands
    Antimicrob Agents Chemother 43:1779-82. 1999
    ..Results were highly concordant, but PCR-LiPA appears to be more sensitive for the simultaneous detection of multiple mutants...
  10. pmc Distinct variants of Helicobacter pylori cagA are associated with vacA subtypes
    L J van Doorn
    Delft Diagnostic Laboratory, 2625 AD Delft, The Netherlands
    J Clin Microbiol 37:2306-11. 1999
    ..These results show the epidemiological relationship between cagA and vacA at the subtype level and indicate the existence of distinct H. pylori lineages that are not uniformly distributed over the globe...
  11. pmc Rapid identification of thermotolerant Campylobacter jejuni, Campylobacter coli, Campylobacter lari, and Campylobacter upsaliensis from various geographic locations by a GTPase-based PCR-reverse hybridization assay
    L J van Doorn
    Delft Diagnostic Laboratory, Delft, The Netherlands
    J Clin Microbiol 37:1790-6. 1999
    ..In conclusion, a simple method has been developed for rapid and highly specific identification of thermotolerant Campylobacter species...
  12. ncbi request reprint Sequence analysis of hepatitis C virus genotypes 1 to 5 reveals multiple novel subtypes in the Benelux countries
    L J van Doorn
    Department of Molecular Biology, Diagnostic Center SSDZ, Delft, The Netherlands
    J Gen Virol 76:1871-6. 1995
    ..In contrast to previous reports from Europe, HCV isolates from the cohort constituted a highly heterogeneous population of virus variants, especially within genotypes 2 and 4...
  13. ncbi request reprint Serological and molecular analysis of hepatitis C virus envelope regions 1 and 2 during acute and chronic infections in chimpanzees
    L J van Doorn
    Delft Diagnostic Laboratory, The Netherlands
    J Med Virol 52:441-50. 1997
    ..There was no clear temporal relationship between sequence evolution of the E1 region, changes in viral load, and the production of antibodies to the envelope proteins...
  14. pmc Typing of Helicobacter pylori vacA gene and detection of cagA gene by PCR and reverse hybridization
    L J van Doorn
    Delft Diagnostic Laboratory, The Netherlands
    J Clin Microbiol 36:1271-6. 1998
    ..001). There was a significant association between the presence of ulcers or gastric carcinoma and the presence of vacA type sl (sla or slb; P = 0.008) and cagA (P = 0.003) genes...
  15. ncbi request reprint Rapid identification of diverse Campylobacter lari strains isolated from mussels and oysters using a reverse hybridization line probe assay
    L J van Doorn
    Diagnostic Centre SSDZ, Department of Molecular Biology, Delft, The Netherlands
    J Appl Microbiol 84:545-50. 1998
    ..jejuni, C. coli and C. upsaliensis. Based on the sequence information, a novel PCR-LiPA was developed that permits specific and rapid detection of the different C. lari variants...
  16. ncbi request reprint Clinical relevance of the cagA, vacA, and iceA status of Helicobacter pylori
    L J van Doorn
    Delft Diagnostic Laboratory, The Netherlands
    Gastroenterology 115:58-66. 1998
    ..The aim of this study was to assess the relationships between H. pylori cagA, vacA, and iceA status and severity of disease...
  17. ncbi request reprint Geographic distribution of vacA allelic types of Helicobacter pylori
    L J van Doorn
    Delft Diagnostic Laboratory, Delft, The Netherlands
    Gastroenterology 116:823-30. 1999
    ..Distinct allelic types of Helicobacter pylori vacA have been defined. The geographic distribution of vacA alleles and cagA was assessed in this study...
  18. pmc Expanding allelic diversity of Helicobacter pylori vacA
    L J van Doorn
    Delft Diagnostic Laboratory, 2625 AD Delft, The Netherlands
    J Clin Microbiol 36:2597-603. 1998
    ..This PCR-LiPA method permits rapid analysis of the vacA and cagA status of H. pylori strains for clinical and epidemiological studies and will facilitate identification of any further variations...
  19. doi request reprint High-throughput genotyping of high-risk HPV by the digene HPV Genotyping LQ Test using GP5+/6+-PCR and xMAP technology
    D T Geraets
    DDL Diagnostic Laboratory, Fonteynenburghlaan 7, 2275 CX Voorburg, The Netherlands
    J Clin Virol 46:S21-6. 2009
    ..Therefore, the development of robust, high-throughput genotyping assays is important...
  20. pmc Assessment of Helicobacter pylori vacA and cagA genotypes and host serological response
    C Figueiredo
    Delft Diagnostic Laboratory, Delft, The Netherlands
    J Clin Microbiol 39:1339-44. 2001
    ..pylori are heterogeneous and, with the exception of anti-CagA antibodies, show no relation to the H. pylori vacA and cagA genotypes. Detection of anti-CagA antibodies is strongly dependent on the test used...
  21. ncbi request reprint Population genetics of Helicobacter pylori in the southern part of Switzerland analysed by sequencing of four housekeeping genes (atpD, glnA, scoB and recA), and by vacA, cagA, iceA and IS605 genotyping
    N Maggi SolcĂ 
    Istituto Cantonale Batteriosierologico, Via Ospedale 6, 6904 Lugano, Switzerland Delft Diagnostic Laboratory, R de Graafweg 7, 2625 AD Delft, The Netherlands
    Microbiology 147:1693-707. 2001
    ..In contrast, the South African strains clustered together only in the atpD tree. Presumably, recombination at the different loci has masked the evolutionary relationship among the strains...
  22. doi request reprint Universal human papillomavirus genotyping by the digene HPV Genotyping RH and LQ Tests
    D T Geraets
    DDL Diagnostic Laboratory, Fonteynenburghlaan 7, 2275 CX, Voorburg, The Netherlands
    J Clin Virol 50:276-80. 2011
    ..Subsequent hrHPV genotyping might contribute to better risk stratification. The majority of hrHPV tests do not include identification of individual hrHPV genotypes...
  23. doi request reprint High genotyping concordance between the digene HPV Genotyping RH Test and the Reverse Line Blot genotyping assay on GP5+/6+-PCR products
    D T Geraets
    DDL Diagnostic Laboratory, Fonteynenburghlaan 7, 2275 CX Voorburg, The Netherlands
    J Clin Virol 46:S16-20. 2009
    ..e., HPV 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73, and 82). Recognition of HR HPV at the individual type level may be valuable in clinical management of HR HPV-positive women...
  24. ncbi request reprint Comparative analysis of human papillomavirus infections in cervical scrapes and biopsy specimens by general SPF(10) PCR and HPV genotyping
    W G Quint
    Delft Diagnostic Laboratory, Reinier de Graafweg 7, 2625 AD Delft, The Netherlands
    J Pathol 194:51-8. 2001
    ..Analysis of cervical scrapes accurately reflects the spectrum of HPV genotypes in the patient's cervical region, even with a sampling interval between the cervical scrape and the biopsy specimen...
  25. doi request reprint Comparison of three genotyping methods to identify Chlamydia trachomatis genotypes in positive men and women
    K D Quint
    DDL Diagnostic Laboratory, Voorburg, The Netherlands
    Mol Cell Probes 24:266-70. 2010
    ..The pmpH real-time PCR is suitable as second assay to differentiate between an LGV and non-LGV infection, but not as primary detection assay, due to its low sensitivity for non-LGV strains...
  26. ncbi request reprint Serological methods for diagnosis of Helicobacter pylori infection and monitoring of eradication therapy
    P Herbrink
    Diagnostic Centre SSDZ, Medical Laboratories, Delft, The Netherlands
    Eur J Clin Microbiol Infect Dis 19:164-73. 2000
    ..To monitor eradication of Helicobacter pylori infection following therapy, quantitative enzyme immunoassays can be used, especially in patients with high pretreatment antibody titres...
  27. doi request reprint Prevalence and associated factors of betapapillomavirus infections in individuals without cutaneous squamous cell carcinoma
    Maurits N C de Koning
    DDL Diagnostic Laboratory, Voorburg, The Netherlands
    J Gen Virol 90:1611-21. 2009
    ..Age and (duration of) immunosuppression were identified as betaPV infection-associated factors, whereas characteristics related to sun exposure and skin type were not...
  28. ncbi request reprint [Vaccination against human papillomavirus for the prevention of cervical cancer]
    W G V Quint
    DDL Diagnostic Laboratory, Voorburg
    Ned Tijdschr Geneeskd 150:1380-4. 2006
    ..In a population with an existing community-based screening program for cervical cancer, a vaccine preventing persisting infection with high-risk HPV will further reduce the incidence of HPV-related cervical cancer...
  29. ncbi request reprint Isolation and identification of Campylobacter species by use of selective enrichment, nucleic acid amplification methods, and gene probes
    A van Belkum
    Erasmus University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases, Rotterdam, The Netherlands
    Methods Mol Biol 179:101-11. 2002