Willem van Eden

Summary

Affiliation: Utrecht University
Country: The Netherlands

Publications

  1. pmc Heat shock proteins induce T cell regulation of chronic inflammation
    F Hauet-Broere
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Yalelaan 1, 3584CL, The Netherlands
    Ann Rheum Dis 65:iii65-8. 2006
  2. ncbi request reprint [Life in a clean environment: risky if we have to believe the 'hygiene hypothesis']
    Willem van Eden
    Hoofdafdeling Immunologie en lnfectieziekten, Faculteit der Diergeneeskunde, Universiteit Utrecht, Postbus 80165, 3508 TD, Utrecht
    Tijdschr Diergeneeskd 130:209-13. 2005
  3. ncbi request reprint Heat-shock proteins induce T-cell regulation of chronic inflammation
    Willem van Eden
    Division of Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584CL Utrecht, The Netherlands
    Nat Rev Immunol 5:318-30. 2005
  4. pmc Immunity to heat shock proteins and arthritic disorders
    W van Eden
    Institute of Infectious Diseases and Immunology, Utrecht University, The Netherlands
    Infect Dis Obstet Gynecol 7:49-54. 1999
  5. pmc Arthritis protective regulatory potential of self-heat shock protein cross-reactive T cells
    W van Eden
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht, The Netherlands
    Cell Stress Chaperones 5:452-7. 2000
  6. pmc Balancing the immune system: Th1 and Th2
    W van Eden
    Division of Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands
    Ann Rheum Dis 61:ii25-8. 2002
  7. ncbi request reprint Autoantigen-specific IL-10-transduced T cells suppress chronic arthritis by promoting the endogenous regulatory IL-10 response
    Teun Guichelaar
    Department of Infectious Diseases and Immunology, Utrecht University, Yalelaan 1, Utrecht, The Netherlands
    J Immunol 180:1373-81. 2008
  8. ncbi request reprint Oral or nasal antigen induces regulatory T cells that suppress arthritis and proliferation of arthritogenic T cells in joint draining lymph nodes
    Femke Broere
    Division of Immunology, Institute of Infectious Diseases and Immunology, University of Utrecht, Utrecht, The Netherlands
    J Immunol 181:899-906. 2008
  9. doi request reprint Cartilage proteoglycan-specific T cells as vectors of immunomodulatory biologicals in chronic proteoglycan-induced arthritis
    Teun Guichelaar
    Division of Immunology, Department of Infectious Diseases and Immunology, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands
    Mol Immunol 45:3526-35. 2008
  10. doi request reprint A novel heat-shock protein coinducer boosts stress protein Hsp70 to activate T cell regulation of inflammation in autoimmune arthritis
    Lotte Wieten
    Institute of Infectious Diseases and Immunology, Utrecht University, 3584 CL Utrecht, The Netherlands
    Arthritis Rheum 62:1026-35. 2010

Collaborators

Detail Information

Publications80

  1. pmc Heat shock proteins induce T cell regulation of chronic inflammation
    F Hauet-Broere
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Yalelaan 1, 3584CL, The Netherlands
    Ann Rheum Dis 65:iii65-8. 2006
    ..Recent findings in experimental asthma and atherosclerosis have indicated that the field of application of such immunotherapy can be broader than just autoimmunity...
  2. ncbi request reprint [Life in a clean environment: risky if we have to believe the 'hygiene hypothesis']
    Willem van Eden
    Hoofdafdeling Immunologie en lnfectieziekten, Faculteit der Diergeneeskunde, Universiteit Utrecht, Postbus 80165, 3508 TD, Utrecht
    Tijdschr Diergeneeskd 130:209-13. 2005
  3. ncbi request reprint Heat-shock proteins induce T-cell regulation of chronic inflammation
    Willem van Eden
    Division of Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584CL Utrecht, The Netherlands
    Nat Rev Immunol 5:318-30. 2005
    ..In this Review, we discuss the unique characteristics of HSPs that endow them with these immunoregulatory qualities...
  4. pmc Immunity to heat shock proteins and arthritic disorders
    W van Eden
    Institute of Infectious Diseases and Immunology, Utrecht University, The Netherlands
    Infect Dis Obstet Gynecol 7:49-54. 1999
    ..One such antigen defined in AA is the 60kD heat shock protein. Both T-cell vaccination approaches and active antigen immunizations and antigen toleration approaches have turned out to be effective in suppressing AA...
  5. pmc Arthritis protective regulatory potential of self-heat shock protein cross-reactive T cells
    W van Eden
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht, The Netherlands
    Cell Stress Chaperones 5:452-7. 2000
    ..2 on microbial hsp600 specific T cells in response to self hsp60. Through a preferred interaction with CTLA-4 on proinflammatory T cells this may constitute an effector mechanism of regulation. Also, regulatory T cells produced IL10...
  6. pmc Balancing the immune system: Th1 and Th2
    W van Eden
    Division of Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands
    Ann Rheum Dis 61:ii25-8. 2002
  7. ncbi request reprint Autoantigen-specific IL-10-transduced T cells suppress chronic arthritis by promoting the endogenous regulatory IL-10 response
    Teun Guichelaar
    Department of Infectious Diseases and Immunology, Utrecht University, Yalelaan 1, Utrecht, The Netherlands
    J Immunol 180:1373-81. 2008
    ..This is the first demonstration that such targeted suppression of proinflammatory lymphocyte responses in chronic autoimmunity by IL-10-transduced T cells specific for a natural Ag can occur via the endogenous regulatory IL-10 response...
  8. ncbi request reprint Oral or nasal antigen induces regulatory T cells that suppress arthritis and proliferation of arthritogenic T cells in joint draining lymph nodes
    Femke Broere
    Division of Immunology, Institute of Infectious Diseases and Immunology, University of Utrecht, Utrecht, The Netherlands
    J Immunol 181:899-906. 2008
    ..Herein we show that both oral and nasal Ag application induced Tr cells, which had a direct inhibitory effect on already established pathogenic B and T cell responses...
  9. doi request reprint Cartilage proteoglycan-specific T cells as vectors of immunomodulatory biologicals in chronic proteoglycan-induced arthritis
    Teun Guichelaar
    Division of Immunology, Department of Infectious Diseases and Immunology, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands
    Mol Immunol 45:3526-35. 2008
    ..Although all of the tested biologicals can suppress in a wide range of different inflammatory disorders, especially IL-10 would therefore serve as a promising candidate to be used in cellular gene therapy for chronic arthritis...
  10. doi request reprint A novel heat-shock protein coinducer boosts stress protein Hsp70 to activate T cell regulation of inflammation in autoimmune arthritis
    Lotte Wieten
    Institute of Infectious Diseases and Immunology, Utrecht University, 3584 CL Utrecht, The Netherlands
    Arthritis Rheum 62:1026-35. 2010
    ..This study was undertaken to test the hypothesis that boosting of endogenous HSP expression can restore effective immunoregulation through T cells specific for stress proteins...
  11. ncbi request reprint Matrix metalloproteinases as targets for the immune system during experimental arthritis
    Jolanda H M van Bilsen
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    J Immunol 172:5063-8. 2004
    ..This finding sheds new light on the pathophysiological role of MMPs during arthritis and opens novel possibilities for Ag-specific immunotherapy...
  12. pmc IL-10 is critically involved in mycobacterial HSP70 induced suppression of proteoglycan-induced arthritis
    Lotte Wieten
    Institute of Infectious Diseases and Immunology, Division of Immunology, Utrecht University, Utrecht, The Netherlands
    PLoS ONE 4:e4186. 2009
    ..Therefore, the possible protective potential of HSP70 and its mechanisms were studied in proteoglycan (PG) induced arthritis (PGIA), a chronic and relapsing, T cell mediated murine model of arthritis...
  13. doi request reprint PLGA nanoparticles enhance the expression of retinaldehyde dehydrogenase enzymes in dendritic cells and induce FoxP3(+) T-cells in vitro
    Chantal Keijzer
    Department of Infectious Diseases and Immunology, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands
    J Control Release 168:35-40. 2013
    ....
  14. ncbi request reprint Uptake of membrane molecules from T cells endows antigen-presenting cells with novel functional properties
    Esther N M Nolte-'t Hoen
    Department of Infectious Diseases and Immunology, Division of Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Eur J Immunol 34:3115-25. 2004
    ..Our data provide evidence that T cells use intercellular molecule transfer to mediate cell contact-dependent regulation of T cell responses via modulation of the APC...
  15. ncbi request reprint Identification and monitoring of effector and regulatory T cells during experimental arthritis based on differential expression of CD25 and CD134
    Esther N M Nolte-'t Hoen
    Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 2, 3584CM Utrecht, The Netherlands
    J Leukoc Biol 83:112-21. 2008
    ..Analysis of the function, phenotype, and amount of the CD4+ T cell subsets in different lymph node stations revealed spatiotemporal differences in effector cell and Treg compartments during experimental arthritis...
  16. pmc Regulatory T cells that recognize a ubiquitous stress-inducible self-antigen are long-lived suppressors of autoimmune arthritis
    Martijn J C van Herwijnen
    Department of Infectious Diseases and Immunology, Utrecht University, 3584 CL Utrecht, The Netherlands
    Proc Natl Acad Sci U S A 109:14134-9. 2012
    ....
  17. doi request reprint Reduced immune reaction prevents immunopathology after challenge with avian influenza virus: a transcriptomics analysis of adjuvanted vaccines
    Sylvia S Reemers
    Department of Infectious Diseases and Immunology, Faculty Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands
    Vaccine 28:6351-60. 2010
    ..We show that a limited number of differentially expressed genes correlates with reduced immune activation and subsequently reduced immunopathology after challenge with AIV...
  18. ncbi request reprint Identification of a CD4+CD25+ T cell subset committed in vivo to suppress antigen-specific T cell responses without additional stimulation
    Esther N M Nolte-'t Hoen
    Department of Infectious Diseases and Immunology, Division of Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Eur J Immunol 34:3016-27. 2004
    ..This suggests that the presence of CD4+CD25+CD134+ T cells indicates sites of active immune suppression...
  19. pmc Tolerogenic dendritic cells that inhibit autoimmune arthritis can be induced by a combination of carvacrol and thermal stress
    Rachel Spiering
    Department of Infectious Diseases and Immunology, Utrecht University, Utrecht, The Netherlands
    PLoS ONE 7:e46336. 2012
    ..Herewith carvacrol seems to offer novel opportunities for the development of a dietary based intervention in chronic inflammatory diseases...
  20. ncbi request reprint Heat shock protein 60 and adjuvant arthritis: a model for T cell regulation in human arthritis
    Berent J Prakken
    Department of Paediatric Immunology, University Medical Centre Utrecht, Wilhelmina Children s Hospital, Home Mailbox KC 03 063 0, PO Box 85090, 3508 AB, Utrecht, The Netherlands
    Springer Semin Immunopathol 25:47-63. 2003
    ..Thus hsp60, or peptides derived from hsp60, are suitable candidates for immune therapy in chronic arthritis...
  21. doi request reprint Immune response of cattle immunized with a conjugate of the glycolipid glucose monomycolate and protein
    Thi Kim Anh Nguyen
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584CL, Utrecht, The Netherlands
    Vet Immunol Immunopathol 142:265-70. 2011
    ..In conclusion, the generation of isotype-switched anti lipid antibodies appears to require more than providing peptide epitopes for T helper cells to support glycolipid specific B cells in antibody production...
  22. doi request reprint Glycans from avian influenza virus are recognized by chicken dendritic cells and are targets for the humoral immune response in chicken
    Eveline D de Geus
    Department Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584CL Utrecht, The Netherlands Electronic address
    Mol Immunol 56:452-62. 2013
    ..This novel approach in avian influenza research may contribute to the development of a broad spectrum vaccine and improves our mechanistic understanding of innate and adaptive responses to glycans. ..
  23. pmc CD134 as target for specific drug delivery to auto-aggressive CD4+ T cells in adjuvant arthritis
    Elmieke P J Boot
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Arthritis Res Ther 7:R604-15. 2005
    ..Thus, CD134 can be used as a marker for auto-aggressive CD4+ T cells early in arthritis, and specific liposomal targeting of drugs to these cells via CD134 can be employed to downregulate disease development...
  24. doi request reprint Early host responses to avian influenza A virus are prolonged and enhanced at transcriptional level depending on maturation of the immune system
    Sylvia S Reemers
    Department of Infectious Diseases and Immunology, Faculty Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands
    Mol Immunol 47:1675-85. 2010
    ....
  25. ncbi request reprint Searching for the cartilage-associated mimicry epitope in adjuvant arthritis
    Jolanda H M van Bilsen
    Faculty of Veterinary Medicine, Department of Infectious Diseases and Immunology, Utrecht University, The Netherlands
    Autoimmunity 35:201-10. 2002
    ..Although several of these self-epitopes were recognized by arthritogenic T cells, no cross-reactivity was found between T cells specific for these self-epitopes and Mt. hsp65(178-186) specific T cells...
  26. doi request reprint Biologics and postbiologics: novel immunotherapeutics for the induction and maintenance of remission
    Willem van Eden
    Institute of Infectious Diseases and Immunology, Utrecht University, Yalelaan 1, 3584CL Utrecht, The Netherlands
    Drug Discov Today 15:71-7. 2010
    ..A novel class of drugs able to induce and maintain tolerance will be paralleled with the notion that combination therapy appropriately tailored to patient subpopulations may hold the promise of less costly and more effective therapy...
  27. ncbi request reprint Immunoregulation of autoimmune diseases
    Willem van Eden
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    Hum Immunol 67:446-53. 2006
    ..Peptide-based intervention, including clinical trials with HSP60 and HSP70 peptides, is now an area of intensive clinical research...
  28. doi request reprint Stress proteins are used by the immune system for cognate interactions with anti-inflammatory regulatory T cells
    Willem van Eden
    Division of Immunology, Dept Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Yalelaan 1, 3584 CL Utrecht, The Netherlands
    FEBS Lett 587:1951-8. 2013
    ....
  29. ncbi request reprint Immunopotentiating heat shock proteins: negotiators between innate danger and control of autoimmunity
    Willem van Eden
    Division of Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 2584CL, Utrecht, The Netherlands
    Vaccine 21:897-901. 2003
    ....
  30. ncbi request reprint Massive, sustained gammadelta T cell migration from the bovine skin in vivo
    Ildiko Van Rhijn
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands
    J Leukoc Biol 81:968-73. 2007
    ..As this massive gammadelta T cell migration was observed during 14 days, constant replenishment of these cells must take place. Our data suggest that gammadelta T cells in tissues fulfill more than exclusively local functions...
  31. pmc Low cross-reactivity of T-cell responses against lipids from Mycobacterium bovis and M. avium paratuberculosis during natural infection
    Ildiko Van Rhijn
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University Utrecht, Utrecht, The Netherlands
    Eur J Immunol 39:3031-41. 2009
    ..bovis. The bacterial species-specific nature of the CD1-restricted, adaptive T-cell response affects the approach to development of lipid based immunodiagnostic tests...
  32. ncbi request reprint Increased arthritis susceptibility in cartilage proteoglycan-specific T cell receptor-transgenic mice
    Suzanne E Berlo
    Utrecht University, Utrecht, The Netherlands
    Arthritis Rheum 54:2423-33. 2006
    ..To better understand the role of antigen (arthritogenic epitope)-specific T cells in the development of autoimmune arthritis...
  33. doi request reprint Heat shock proteins can be targets of regulatory T cells for therapeutic intervention in rheumatoid arthritis
    Martijn J C van Herwijnen
    Department of Infectious Diseases and Immunology, Utrecht University, Utrecht, The Netherlands
    Int J Hyperthermia 29:448-54. 2013
    ..This makes HSPs attractive candidates for therapeutic intervention in chronic autoimmune diseases, with the ultimate goal of inducing long-lasting tolerance...
  34. doi request reprint Peritoneal cavity B-1a cells promote peripheral CD4+ T-cell activation
    Bram Margry
    Department of Infectious Diseases and Immunology, Utrecht University, Utrecht, The Netherlands
    Eur J Immunol 43:2317-26. 2013
    ..This, to our knowledge previously undescribed, immuno-logical pathway potentially plays a role in the presentation of gut microbiota-derived Ags to peripheral T cells. ..
  35. ncbi request reprint Effector and regulatory T cells derived from the same T cell clone differ in MHC class II-peptide multimer binding
    Esther N M Nolte-'t Hoen
    Department of Infectious Diseases and Immunology, Division of Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Eur J Immunol 34:3359-69. 2004
    ..We here demonstrate for the first time differential MHC class II-peptide multimer binding by regulatory (anergic) and effector T cells with identical TCR...
  36. doi request reprint Identification of new populations of chicken natural killer (NK) cells
    Christine A Jansen
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, Utrecht, The Netherlands
    Dev Comp Immunol 34:759-67. 2010
    ..In conclusion, we generated new monoclonal antibodies and developed two functional assays which will enhance our understanding of the role of NK-cells in healthy and diseased chickens...
  37. ncbi request reprint Identification of a CD4 T cell epitope in the pneumonia virus of mice glycoprotein and characterization of its role in protective immunity
    Erwin A W Claassen
    Division of Immunology, Faculty of Veterinary Science, University of Utrecht, Utrecht, The Netherlands
    Virology 368:17-25. 2007
    ....
  38. ncbi request reprint Highly diverse TCR delta chain repertoire in bovine tissues due to the use of up to four D segments per delta chain
    Ildiko Van Rhijn
    Department of Infection and Immunity, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands
    Mol Immunol 44:3155-61. 2007
    ....
  39. pmc The mycobacterial glycolipid glucose monomycolate induces a memory T cell response comparable to a model protein antigen and no B cell response upon experimental vaccination of cattle
    Thi Kim Anh Nguyen
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, Utrecht, The Netherlands
    Vaccine 27:4818-25. 2009
    ..Also, KLH induced strong antibody responses whereas GMM did not. These data suggest that non-overlapping T cell populations are targeted and demonstrate the potential of glycolipids as a special class of subunit vaccine candidates...
  40. ncbi request reprint Stress proteins as inducers and targets of regulatory T cells in arthritis
    Willem van Eden
    Division of Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Int Rev Immunol 24:181-97. 2005
    ..Furthermore, in patients, heat-shock-protein-(HSP-) activated T cells were shown to display regulatory phenotypes consistent with CD4+ CD25+ T regulatory cells...
  41. pmc Activated peritoneal cavity B-1a cells possess regulatory B cell properties
    Bram Margry
    Department of Infectious Diseases and Immunology, Utrecht University, Utrecht, The Netherlands
    PLoS ONE 9:e88869. 2014
    ....
  42. pmc Differential lung NK cell responses in avian influenza virus infected chickens correlate with pathogenicity
    Christine A Jansen
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Sci Rep 3:2478. 2013
    ..This suggests that decreased NK-cell activation may be one of the mechanisms associated with the enhanced pathogenicity of H5N1 viruses. ..
  43. ncbi request reprint Stress, heat shock proteins, and autoimmunity: how immune responses to heat shock proteins are to be used for the control of chronic inflammatory diseases
    Willem van Eden
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Yalelaan 1, Utrecht University, 3584CL Utrecht, The Netherlands
    Ann N Y Acad Sci 1113:217-37. 2007
    ....
  44. pmc Hsp70 expression and induction as a readout for detection of immune modulatory components in food
    Lotte Wieten
    Department of Infectious Diseases and Immunology, Utrecht University, The Netherlands
    Cell Stress Chaperones 15:25-37. 2010
    ..These assay systems are generally applicable to identify compounds that affect the Hsp level in cells of the immune system...
  45. ncbi request reprint Nasal administration of arthritis-related T cell epitopes of heat shock protein 60 as a promising way for immunotherapy in chronic arthritis
    B Prakken
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht, The Netherlands
    Biotherapy 10:205-11. 1998
    ..The present findings may in our view offer novel prospects for immunotherapy through nasal administration of (analogue) peptides, with a mimicry relationship with joint specific cartilage proteoglycan epitopes...
  46. doi request reprint Membrane-bound metallothionein 1 of murine dendritic cells promotes the expansion of regulatory T cells in vitro
    Rachel Spiering
    Department of Infectious Diseases and Immunology, Utrecht University, 3584 CL Utrecht, The Netherlands
    Toxicol Sci 138:69-75. 2014
    ..On the basis of this, MT1 can be used as a new marker for functionally tolerogenic DCs. Additionally, we have found a new mechanism for tolerogenic DCs to exert their immune regulatory function. ..
  47. pmc PLGA, PLGA-TMC and TMC-TPP nanoparticles differentially modulate the outcome of nasal vaccination by inducing tolerance or enhancing humoral immunity
    Chantal Keijzer
    Department of Infectious Diseases and Immunology, Utrecht University, Utrecht, The Netherlands
    PLoS ONE 6:e26684. 2011
    ..The exploitation of this differential regulation of nanoparticles to modulate nasal immune responses can lead to innovative vaccine development for prophylactic or therapeutic vaccination in infectious or autoimmune diseases...
  48. ncbi request reprint The bovine CD1 family contains group 1 CD1 proteins, but no functional CD1d
    Ildiko Van Rhijn
    Department of Infection and Immunity, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    J Immunol 176:4888-93. 2006
    ..Cattle can be used as a model to study group 1 CD1-restricted T cell immunity, including its role in the defense against mycobacterial infections that occur naturally in this species...
  49. pmc Progressive bovine paratuberculosis is associated with local loss of CD4(+) T cells, increased frequency of gamma delta T cells, and related changes in T-cell function
    Ad Koets
    Immunology Division, Department of Infectious Diseases and Immunology, Utrecht University, Utrecht, The Netherlands
    Infect Immun 70:3856-64. 2002
    ....
  50. pmc Differential changes in heat shock protein-, lipoarabinomannan-, and purified protein derivative-specific immunoglobulin G1 and G2 isotype responses during bovine Mycobacterium avium subsp. paratuberculosis infection
    A P Koets
    Department of Immunology, Institute of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Infect Immun 69:1492-8. 2001
    ....
  51. ncbi request reprint Induction of IL-10 and inhibition of experimental arthritis are specific features of microbial heat shock proteins that are absent for other evolutionarily conserved immunodominant proteins
    B J Prakken
    Institute of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht, The Netherlands
    J Immunol 167:4147-53. 2001
    ..Thus, the protective effect of conserved immunodominant proteins in experimental arthritis seems to be a specific feature of hsp. Therefore, hsp may offer unique possibilities for immunological intervention in inflammatory diseases...
  52. ncbi request reprint Heat-shock protein-specific T-cell responses in various stages of bovine paratuberculosis
    A P Koets
    Department of Immunology, Institute of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    Vet Immunol Immunopathol 70:105-15. 1999
    ..Furthermore, this study shows that HSP70, being a well-defined antigen in comparison with PPD antigens, can be used to monitor cell-mediated immune responses in studies regarding the immunopathogenesis of bovine paratuberculosis...
  53. ncbi request reprint Mycobacterium avium ssp. paratuberculosis recombinant heat shock protein 70 interaction with different bovine antigen-presenting cells
    M F M Langelaar
    Department of Infectious Diseases and Immunology, Utrecht University, Utrecht, Netherlands
    Scand J Immunol 61:242-50. 2005
    ..These data suggest that rHsp70-based vaccines may be useful for the successful immunization of cattle...
  54. ncbi request reprint Mycobacterium paratuberculosis heat shock protein 70 as a tool in control of paratuberculosis
    M Langelaar
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Division of Immunology, Utrecht, The Netherlands
    Vet Immunol Immunopathol 87:239-44. 2002
    ..DC interacting with rHsp70 in addition showed high expression of MHC I, MHC II, Myd-1 (CD172a) and CD40. Further research will focus on loading of the rHsp70 with M.a.p. antigen for presentation in MHC class I...
  55. pmc Heat shock protein expression analysis in canine osteosarcoma reveals HSP60 as a potentially relevant therapeutic target
    Gayathri T Selvarajah
    Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 104, 3584 CM, Utrecht, The Netherlands
    Cell Stress Chaperones 18:607-22. 2013
    ..It is concluded that overexpression of HSP60 is associated with a poor prognosis of OS and should be evaluated as a new target for therapy...
  56. pmc A case of mistaken identity: HSPs are no DAMPs but DAMPERs
    Willem van Eden
    Department of Infectious Diseases and Immunology, Utrecht University, Utrecht, Netherlands
    Cell Stress Chaperones 17:281-92. 2012
    ..Nat Rev Immunol 11:565-c1, 2011). With this perspective and reflection article, we hope to elaborate on this debate and provide additional thoughts to further ignite this discussion on this critical and evolving issue...
  57. ncbi request reprint Ligand-induced differential cross-regulation of Toll-like receptors 2, 4 and 5 in intestinal epithelial cells
    Remon A M H van Aubel
    Department of Infectious Diseases and Immunology, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands
    Mol Immunol 44:3702-14. 2007
    ..Together, our results demonstrate that the expression and function of TLR in intestinal cells are highly dynamic and tightly regulated in response to encountered bacterial stimuli...
  58. ncbi request reprint Cell stress induced HSP are targets of regulatory T cells: a role for HSP inducing compounds as anti-inflammatory immuno-modulators?
    Lotte Wieten
    Division of Immunology, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University of Utrecht, Yalelaan 1, 3584CL Utrecht, The Netherlands
    FEBS Lett 581:3716-22. 2007
    ..Previously, we have demonstrated that such T cells can be induced by conserved sequences of microbial HSP. Now we propose that drug induced up-regulation of endogenous HSP can contribute to anti-inflammatory T cell regulation...
  59. ncbi request reprint Immunomodulatory effects of antigen-pulsed macrophages in a murine model of allergic asthma
    Edith M Janssen
    Department of Pharmacology and Pathophysiology, Faculty of Pharmacy, Utrecht University, Utrecht, The Netherlands
    Am J Respir Cell Mol Biol 27:257-64. 2002
    ..Our data suggest that IL-10 production by allergen presenting Mphi plays a crucial role in successful immunotherapy...
  60. ncbi request reprint Immune regulation in adjuvant-induced arthritis: possible implications for innovative therapeutic strategies in arthritis
    Willem van Eden
    University of Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 48:1788-96. 2003
  61. ncbi request reprint XToll, a recombinant chaperonin 10 as an anti-inflammatory immunomodulator
    Willem van Eden
    University of Utrecht, Institute of Infectious Diseases and Immunology, Yalelaan 1, 3584CL Utrecht, The Netherlands
    Curr Opin Investig Drugs 9:523-33. 2008
    ..By May 2005, a phase IIa trial for Crohn's disease had been terminated due to slow recruitment. The company has not disclosed plans for future development for this indication...
  62. ncbi request reprint Inhibition of experimental autoimmune myasthenia gravis by major histocompatibility complex class II competitor peptides results not only in a suppressed but also in an altered immune response
    M H Wauben
    Institute of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    Eur J Immunol 26:2866-75. 1996
    ..Furthermore, the administration of such peptides in vivo not only passively inhibits T cell activation, but also functionally alters the immune response...
  63. pmc Peptide-induced nasal tolerance for a mycobacterial heat shock protein 60 T cell epitope in rats suppresses both adjuvant arthritis and nonmicrobially induced experimental arthritis
    B J Prakken
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht, The Netherlands
    Proc Natl Acad Sci U S A 94:3284-9. 1997
    ..Therefore, tolerance for a disease-triggering, microbial cartilage-mimicking epitope may cause resistance to arthritis irrespective of the actual trigger leading to development of the disease...
  64. ncbi request reprint The spontaneous remission of juvenile idiopathic arthritis is characterized by CD30+ T cells directed to human heat-shock protein 60 capable of producing the regulatory cytokine interleukin-10
    I M De Kleer
    University Medical Center Utrecht, Wilhelmina Children s Hospital, Utrecht, The Netherlands
    Arthritis Rheum 48:2001-10. 2003
    ..To test the hypothesis that T cell reactivity to self heat-shock protein 60 (Hsp60) in patients with remitting juvenile idiopathic arthritis (JIA) is part of an antiinflammatory, regulatory mechanism...
  65. doi request reprint Cellular host transcriptional responses to influenza A virus in chicken tracheal organ cultures differ from responses in in vivo infected trachea
    Sylvia S Reemers
    Department of Infectious Diseases and Immunology, Faculty Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands
    Vet Immunol Immunopathol 132:91-100. 2009
    ..Our study implicates that although the TOC model is suitable for culturing of virus and lectin or virus binding studies, it is not suitable for measuring early immune responses upon viral infection at host transcriptional level...
  66. ncbi request reprint Naive transgenic T cells expressing cartilage proteoglycan-specific TCR induce arthritis upon in vivo activation
    Suzanne E Berlo
    Department of Infectious Diseases and Immunology, Division of Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, The Netherlands
    J Autoimmun 25:172-80. 2005
    ..In addition the model may be used for the development of immune modulating strategies in T cell-mediated autoimmune diseases...
  67. ncbi request reprint Heat-shock protein T-cell epitopes trigger a spreading regulatory control in a diversified arthritogenic T-cell response
    W van Eden
    Institute of Infectious Diseases and Immunology, Veterinary Faculty, University of Utrecht, The Netherlands
    Immunol Rev 164:169-74. 1998
    ..Alternatively, the cross-recognised self-hsp epitope could have the regulatory qualities of an altered peptide ligand or a partial agonist for T cells that see the microbial homologue as the full agonist...
  68. pmc T cell recognition of naturally presented epitopes of self-heat shock protein 70
    Huib de Jong
    Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Cell Stress Chaperones 19:569-78. 2014
    ..The identification of these naturally presented epitopes and the response they elicit in the normal immune system make them potential candidates to study during inflammatory conditions as well as in autoimmune diseases. ..
  69. pmc Successful immunotherapy with matrix metalloproteinase-derived peptides in adjuvant arthritis depends on the timing of peptide administration
    Jolanda H M van Bilsen
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    Arthritis Res 4:R2. 2002
    ..The present study shows the possible usefulness of MMP peptides for immunotherapy. However, a clear understanding of proper timing of peptide administration is crucial for the development of such therapies...
  70. pmc Functional CD1d and/or NKT cell invariant chain transcript in horse, pig, African elephant and guinea pig, but not in ruminants
    Frank A Looringh van Beeck
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University Utrecht, Utrecht, The Netherlands
    Mol Immunol 46:1424-31. 2009
    ..Despite the discovery of a highly homologous NKT/CD1d system in pig and horse, our data suggest that functional CD1D and CD1d-restricted NKT cells are not universally present in mammals...
  71. doi request reprint ELISPOT and intracellular cytokine staining: novel assays for quantifying T cell responses in the chicken
    M P Ariaans
    Faculty of Veterinary Medicine, Department of Infectious Diseases and Immunology, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands
    Dev Comp Immunol 32:1398-404. 2008
    ..Although cells were detected at only low frequencies, polyclonal stimulation of peripheral blood mononuclear cell (PBMC) or spleen cells resulted in a significant increase in ChIFN-gamma production by CD4+ and CD8+ cells...
  72. ncbi request reprint Induction of antigen specific CD4+ T cell responses by invariant chain based DNA vaccines
    E A van Tienhoven
    Institute of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3508 TD, Utrecht, The Netherlands
    Vaccine 19:1515-9. 2001
    ..In addition, we showed that intradermal immunisation of Lewis rats with these constructs induced antigen specific T cells in vivo. Therefore, our Ii-gene constructs can be used to immunise for defined CD4+ T cell epitope sequences...
  73. ncbi request reprint Adjuvant arthritis in the rat
    W van Eden
    Institute of Infectious Diseases and Immunology, Utrecht, The Netherlands
    Curr Protoc Immunol . 2001
    ..This unit describes the induction and evaluation of AA and the preparation of adjuvant used to induce AA...
  74. ncbi request reprint Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease
    Kamran Ghoreschi
    Department of Dermatology and Allergology, Ludwig Maximilians University Munich, Munich, Germany
    Nat Med 9:40-6. 2003
    ..Thus, IL-4 therapy can induce Th2 differentiation in human CD4+ T cells and has promise as a potential treatment for psoriasis, a prototypic Th1-associated autoimmune disease...
  75. ncbi request reprint Mechanisms of disease: the hygiene hypothesis revisited
    Francisco Guarner
    University Hospital Vall d Hebron, Barcelona, Spain
    Nat Clin Pract Gastroenterol Hepatol 3:275-84. 2006
    ..The use of probiotics, prebiotics, helminths or microbe-derived immunoregulatory vaccines might, therefore, become a valuable approach to disease prevention...
  76. ncbi request reprint Heat shock proteins in juvenile idiopathic arthritis: keys for understanding remitting arthritis and candidate antigens for immune therapy
    Berent Prakken
    Department of Pediatric Immunology, University Medical Center Utrecht, University Hospital for Children and Youth, PO Box 85090, Utrecht 3508 AB, The Netherlands
    Curr Rheumatol Rep 4:466-73. 2002
    ..Taken together, these data imply that immune modulation with hsps can be an effective way to restore natural occurring T cell responses, and, thus, treat JIA and rheumatoid arthritis...
  77. ncbi request reprint Inhibition of adjuvant-induced arthritis by interleukin-10-driven regulatory cells induced via nasal administration of a peptide analog of an arthritis-related heat-shock protein 60 T cell epitope
    Berent J Prakken
    University of California San Diego, La Jolla, California, USA
    Arthritis Rheum 46:1937-46. 2002
    ..To prevent and treat experimental arthritis via nasal administration of an altered peptide ligand (APL) from the major arthritogenic epitope in adjuvant-induced arthritis (AIA) and to explore the mechanisms involved...
  78. ncbi request reprint Cross-reactive mycobacterial and self hsp60 epitope recognition in I-A(g7) expressing NOD, NOD-asp and Biozzi AB/H mice
    Astrid G S van Halteren
    Department of Immunohematology and Blood Transfusion, Leids Universitair Medisch Centrum, The Netherlands
    J Autoimmun 18:139-47. 2002
    ..Yet, proliferation of hsp60 autoreactive T cells is solely measured in combination with insulitis and as such serves as a surrogate marker for islet inflammation...
  79. ncbi request reprint The beta 2-adrenergic agonist salbutamol potentiates oral induction of tolerance, suppressing adjuvant arthritis and antigen-specific immunity
    Pieter M Cobelens
    Department of Immunology, Laboratory for Psychoneuroimmunology, University Medical Center Utrecht, The Netherlands
    J Immunol 169:5028-35. 2002
    ..In conclusion, salbutamol can be of great clinical benefit for the treatment of autoimmune diseases by promoting oral tolerance induction...
  80. ncbi request reprint [Natural immunity: objective and measurable]
    Willem van Eden
    Tijdschr Diergeneeskd 132:767-8. 2007