Willem van Eden

Summary

Affiliation: Utrecht University
Country: The Netherlands

Publications

  1. ncbi Heat shock proteins induce T cell regulation of chronic inflammation
    F Hauet-Broere
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Yalelaan 1, 3584CL, The Netherlands
    Ann Rheum Dis 65:iii65-8. 2006
  2. ncbi Balancing the immune system: Th1 and Th2
    W van Eden
    Division of Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands
    Ann Rheum Dis 61:ii25-8. 2002
  3. ncbi Arthritis protective regulatory potential of self-heat shock protein cross-reactive T cells
    W van Eden
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht, The Netherlands
    Cell Stress Chaperones 5:452-7. 2000
  4. ncbi [Life in a clean environment: risky if we have to believe the 'hygiene hypothesis']
    Willem van Eden
    Hoofdafdeling Immunologie en lnfectieziekten, Faculteit der Diergeneeskunde, Universiteit Utrecht, Postbus 80165, 3508 TD, Utrecht
    Tijdschr Diergeneeskd 130:209-13. 2005
  5. ncbi Immunity to heat shock proteins and arthritic disorders
    W van Eden
    Institute of Infectious Diseases and Immunology, Utrecht University, The Netherlands
    Infect Dis Obstet Gynecol 7:49-54. 1999
  6. ncbi Heat-shock proteins induce T-cell regulation of chronic inflammation
    Willem van Eden
    Division of Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584CL Utrecht, The Netherlands
    Nat Rev Immunol 5:318-30. 2005
  7. ncbi Autoantigen-specific IL-10-transduced T cells suppress chronic arthritis by promoting the endogenous regulatory IL-10 response
    Teun Guichelaar
    Department of Infectious Diseases and Immunology, Utrecht University, Yalelaan 1, Utrecht, The Netherlands
    J Immunol 180:1373-81. 2008
  8. ncbi A novel heat-shock protein coinducer boosts stress protein Hsp70 to activate T cell regulation of inflammation in autoimmune arthritis
    Lotte Wieten
    Institute of Infectious Diseases and Immunology, Utrecht University, 3584 CL Utrecht, The Netherlands
    Arthritis Rheum 62:1026-35. 2010
  9. ncbi Cartilage proteoglycan-specific T cells as vectors of immunomodulatory biologicals in chronic proteoglycan-induced arthritis
    Teun Guichelaar
    Division of Immunology, Department of Infectious Diseases and Immunology, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands
    Mol Immunol 45:3526-35. 2008
  10. ncbi Oral or nasal antigen induces regulatory T cells that suppress arthritis and proliferation of arthritogenic T cells in joint draining lymph nodes
    Femke Broere
    Division of Immunology, Institute of Infectious Diseases and Immunology, University of Utrecht, Utrecht, The Netherlands
    J Immunol 181:899-906. 2008

Collaborators

Detail Information

Publications70

  1. ncbi Heat shock proteins induce T cell regulation of chronic inflammation
    F Hauet-Broere
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Yalelaan 1, 3584CL, The Netherlands
    Ann Rheum Dis 65:iii65-8. 2006
    ..Recent findings in experimental asthma and atherosclerosis have indicated that the field of application of such immunotherapy can be broader than just autoimmunity...
  2. ncbi Balancing the immune system: Th1 and Th2
    W van Eden
    Division of Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands
    Ann Rheum Dis 61:ii25-8. 2002
  3. ncbi Arthritis protective regulatory potential of self-heat shock protein cross-reactive T cells
    W van Eden
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht, The Netherlands
    Cell Stress Chaperones 5:452-7. 2000
    ..2 on microbial hsp600 specific T cells in response to self hsp60. Through a preferred interaction with CTLA-4 on proinflammatory T cells this may constitute an effector mechanism of regulation. Also, regulatory T cells produced IL10...
  4. ncbi [Life in a clean environment: risky if we have to believe the 'hygiene hypothesis']
    Willem van Eden
    Hoofdafdeling Immunologie en lnfectieziekten, Faculteit der Diergeneeskunde, Universiteit Utrecht, Postbus 80165, 3508 TD, Utrecht
    Tijdschr Diergeneeskd 130:209-13. 2005
  5. ncbi Immunity to heat shock proteins and arthritic disorders
    W van Eden
    Institute of Infectious Diseases and Immunology, Utrecht University, The Netherlands
    Infect Dis Obstet Gynecol 7:49-54. 1999
    ..One such antigen defined in AA is the 60kD heat shock protein. Both T-cell vaccination approaches and active antigen immunizations and antigen toleration approaches have turned out to be effective in suppressing AA...
  6. ncbi Heat-shock proteins induce T-cell regulation of chronic inflammation
    Willem van Eden
    Division of Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584CL Utrecht, The Netherlands
    Nat Rev Immunol 5:318-30. 2005
    ..In this Review, we discuss the unique characteristics of HSPs that endow them with these immunoregulatory qualities...
  7. ncbi Autoantigen-specific IL-10-transduced T cells suppress chronic arthritis by promoting the endogenous regulatory IL-10 response
    Teun Guichelaar
    Department of Infectious Diseases and Immunology, Utrecht University, Yalelaan 1, Utrecht, The Netherlands
    J Immunol 180:1373-81. 2008
    ..This is the first demonstration that such targeted suppression of proinflammatory lymphocyte responses in chronic autoimmunity by IL-10-transduced T cells specific for a natural Ag can occur via the endogenous regulatory IL-10 response...
  8. ncbi A novel heat-shock protein coinducer boosts stress protein Hsp70 to activate T cell regulation of inflammation in autoimmune arthritis
    Lotte Wieten
    Institute of Infectious Diseases and Immunology, Utrecht University, 3584 CL Utrecht, The Netherlands
    Arthritis Rheum 62:1026-35. 2010
    ..This study was undertaken to test the hypothesis that boosting of endogenous HSP expression can restore effective immunoregulation through T cells specific for stress proteins...
  9. ncbi Cartilage proteoglycan-specific T cells as vectors of immunomodulatory biologicals in chronic proteoglycan-induced arthritis
    Teun Guichelaar
    Division of Immunology, Department of Infectious Diseases and Immunology, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands
    Mol Immunol 45:3526-35. 2008
    ..Although all of the tested biologicals can suppress in a wide range of different inflammatory disorders, especially IL-10 would therefore serve as a promising candidate to be used in cellular gene therapy for chronic arthritis...
  10. ncbi Oral or nasal antigen induces regulatory T cells that suppress arthritis and proliferation of arthritogenic T cells in joint draining lymph nodes
    Femke Broere
    Division of Immunology, Institute of Infectious Diseases and Immunology, University of Utrecht, Utrecht, The Netherlands
    J Immunol 181:899-906. 2008
    ..Herein we show that both oral and nasal Ag application induced Tr cells, which had a direct inhibitory effect on already established pathogenic B and T cell responses...
  11. ncbi Matrix metalloproteinases as targets for the immune system during experimental arthritis
    Jolanda H M van Bilsen
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    J Immunol 172:5063-8. 2004
    ..This finding sheds new light on the pathophysiological role of MMPs during arthritis and opens novel possibilities for Ag-specific immunotherapy...
  12. ncbi IL-10 is critically involved in mycobacterial HSP70 induced suppression of proteoglycan-induced arthritis
    Lotte Wieten
    Institute of Infectious Diseases and Immunology, Division of Immunology, Utrecht University, Utrecht, The Netherlands
    PLoS ONE 4:e4186. 2009
    ..Therefore, the possible protective potential of HSP70 and its mechanisms were studied in proteoglycan (PG) induced arthritis (PGIA), a chronic and relapsing, T cell mediated murine model of arthritis...
  13. ncbi Uptake of membrane molecules from T cells endows antigen-presenting cells with novel functional properties
    Esther N M Nolte-'t Hoen
    Department of Infectious Diseases and Immunology, Division of Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Eur J Immunol 34:3115-25. 2004
    ..Our data provide evidence that T cells use intercellular molecule transfer to mediate cell contact-dependent regulation of T cell responses via modulation of the APC...
  14. ncbi Identification and monitoring of effector and regulatory T cells during experimental arthritis based on differential expression of CD25 and CD134
    Esther N M Nolte-'t Hoen
    Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 2, 3584CM Utrecht, The Netherlands
    J Leukoc Biol 83:112-21. 2008
    ..Analysis of the function, phenotype, and amount of the CD4+ T cell subsets in different lymph node stations revealed spatiotemporal differences in effector cell and Treg compartments during experimental arthritis...
  15. ncbi Reduced immune reaction prevents immunopathology after challenge with avian influenza virus: a transcriptomics analysis of adjuvanted vaccines
    Sylvia S Reemers
    Department of Infectious Diseases and Immunology, Faculty Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands
    Vaccine 28:6351-60. 2010
    ..We show that a limited number of differentially expressed genes correlates with reduced immune activation and subsequently reduced immunopathology after challenge with AIV...
  16. ncbi Identification of a CD4+CD25+ T cell subset committed in vivo to suppress antigen-specific T cell responses without additional stimulation
    Esther N M Nolte-'t Hoen
    Department of Infectious Diseases and Immunology, Division of Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Eur J Immunol 34:3016-27. 2004
    ..This suggests that the presence of CD4+CD25+CD134+ T cells indicates sites of active immune suppression...
  17. ncbi CD134 as target for specific drug delivery to auto-aggressive CD4+ T cells in adjuvant arthritis
    Elmieke P J Boot
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Arthritis Res Ther 7:R604-15. 2005
    ..Thus, CD134 can be used as a marker for auto-aggressive CD4+ T cells early in arthritis, and specific liposomal targeting of drugs to these cells via CD134 can be employed to downregulate disease development...
  18. ncbi Heat shock protein 60 and adjuvant arthritis: a model for T cell regulation in human arthritis
    Berent J Prakken
    Department of Paediatric Immunology, University Medical Centre Utrecht, Wilhelmina Children's Hospital, Home Mailbox KC.03.063.0, PO Box 85090, 3508 AB, Utrecht, The Netherlands
    Springer Semin Immunopathol 25:47-63. 2003
    ..Thus hsp60, or peptides derived from hsp60, are suitable candidates for immune therapy in chronic arthritis...
  19. ncbi Immune response of cattle immunized with a conjugate of the glycolipid glucose monomycolate and protein
    Thi Kim Anh Nguyen
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584CL, Utrecht, The Netherlands
    Vet Immunol Immunopathol 142:265-70. 2011
    ..In conclusion, the generation of isotype-switched anti lipid antibodies appears to require more than providing peptide epitopes for T helper cells to support glycolipid specific B cells in antibody production...
  20. ncbi Early host responses to avian influenza A virus are prolonged and enhanced at transcriptional level depending on maturation of the immune system
    Sylvia S Reemers
    Department of Infectious Diseases and Immunology, Faculty Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands
    Mol Immunol 47:1675-85. 2010
    ....
  21. ncbi Biologics and postbiologics: novel immunotherapeutics for the induction and maintenance of remission
    Willem van Eden
    Institute of Infectious Diseases and Immunology, Utrecht University, Yalelaan 1, 3584CL Utrecht, The Netherlands
    Drug Discov Today 15:71-7. 2010
    ..A novel class of drugs able to induce and maintain tolerance will be paralleled with the notion that combination therapy appropriately tailored to patient subpopulations may hold the promise of less costly and more effective therapy...
  22. ncbi Immunoregulation of autoimmune diseases
    Willem van Eden
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    Hum Immunol 67:446-53. 2006
    ..Peptide-based intervention, including clinical trials with HSP60 and HSP70 peptides, is now an area of intensive clinical research...
  23. ncbi Massive, sustained gammadelta T cell migration from the bovine skin in vivo
    Ildiko Van Rhijn
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands
    J Leukoc Biol 81:968-73. 2007
    ..As this massive gammadelta T cell migration was observed during 14 days, constant replenishment of these cells must take place. Our data suggest that gammadelta T cells in tissues fulfill more than exclusively local functions...
  24. ncbi Increased arthritis susceptibility in cartilage proteoglycan-specific T cell receptor-transgenic mice
    Suzanne E Berlo
    Utrecht University, Utrecht, The Netherlands
    Arthritis Rheum 54:2423-33. 2006
    ..This type of mouse could also be used to develop new immunomodulatory strategies in T cell-mediated autoimmune diseases...
  25. ncbi Immunopotentiating heat shock proteins: negotiators between innate danger and control of autoimmunity
    Willem van Eden
    Division of Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 2584CL, Utrecht, The Netherlands
    Vaccine 21:897-901. 2003
    ....
  26. ncbi Low cross-reactivity of T-cell responses against lipids from Mycobacterium bovis and M. avium paratuberculosis during natural infection
    Ildiko Van Rhijn
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University Utrecht, Utrecht, The Netherlands
    Eur J Immunol 39:3031-41. 2009
    ..bovis. The bacterial species-specific nature of the CD1-restricted, adaptive T-cell response affects the approach to development of lipid based immunodiagnostic tests...
  27. ncbi Searching for the cartilage-associated mimicry epitope in adjuvant arthritis
    Jolanda H M van Bilsen
    Faculty of Veterinary Medicine, Department of Infectious Diseases and Immunology, Utrecht University, The Netherlands
    Autoimmunity 35:201-10. 2002
    ..Although several of these self-epitopes were recognized by arthritogenic T cells, no cross-reactivity was found between T cells specific for these self-epitopes and Mt. hsp65(178-186) specific T cells...
  28. ncbi Stress proteins as inducers and targets of regulatory T cells in arthritis
    Willem van Eden
    Division of Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Int Rev Immunol 24:181-97. 2005
    ..Furthermore, in patients, heat-shock-protein-(HSP-) activated T cells were shown to display regulatory phenotypes consistent with CD4+ CD25+ T regulatory cells...
  29. ncbi Highly diverse TCR delta chain repertoire in bovine tissues due to the use of up to four D segments per delta chain
    Ildiko Van Rhijn
    Department of Infection and Immunity, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands
    Mol Immunol 44:3155-61. 2007
    ....
  30. ncbi Identification of a CD4 T cell epitope in the pneumonia virus of mice glycoprotein and characterization of its role in protective immunity
    Erwin A W Claassen
    Division of Immunology, Faculty of Veterinary Science, University of Utrecht, Utrecht, The Netherlands
    Virology 368:17-25. 2007
    ....
  31. ncbi The mycobacterial glycolipid glucose monomycolate induces a memory T cell response comparable to a model protein antigen and no B cell response upon experimental vaccination of cattle
    Thi Kim Anh Nguyen
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, Utrecht, The Netherlands
    Vaccine 27:4818-25. 2009
    ..Also, KLH induced strong antibody responses whereas GMM did not. These data suggest that non-overlapping T cell populations are targeted and demonstrate the potential of glycolipids as a special class of subunit vaccine candidates...
  32. ncbi Identification of new populations of chicken natural killer (NK) cells
    Christine A Jansen
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, Utrecht, The Netherlands
    Dev Comp Immunol 34:759-67. 2010
    ..In conclusion, we generated new monoclonal antibodies and developed two functional assays which will enhance our understanding of the role of NK-cells in healthy and diseased chickens...
  33. ncbi Stress, heat shock proteins, and autoimmunity: how immune responses to heat shock proteins are to be used for the control of chronic inflammatory diseases
    Willem van Eden
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Yalelaan 1, Utrecht University, 3584CL Utrecht, The Netherlands
    Ann N Y Acad Sci 1113:217-37. 2007
    ....
  34. ncbi Effector and regulatory T cells derived from the same T cell clone differ in MHC class II-peptide multimer binding
    Maria Grazia Amoroso
    Department of Infectious Diseases and Immunology, Division of Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Eur J Immunol 34:3359-69. 2004
    ..We here demonstrate for the first time differential MHC class II-peptide multimer binding by regulatory (anergic) and effector T cells with identical TCR...
  35. ncbi Hsp70 expression and induction as a readout for detection of immune modulatory components in food
    Lotte Wieten
    Department of Infectious Diseases and Immunology, Utrecht University, The Netherlands
    Cell Stress Chaperones 15:25-37. 2010
    ..These assay systems are generally applicable to identify compounds that affect the Hsp level in cells of the immune system...
  36. ncbi Nasal administration of arthritis-related T cell epitopes of heat shock protein 60 as a promising way for immunotherapy in chronic arthritis
    B Prakken
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht, The Netherlands
    Biotherapy 10:205-11. 1998
    ..The present findings may in our view offer novel prospects for immunotherapy through nasal administration of (analogue) peptides, with a mimicry relationship with joint specific cartilage proteoglycan epitopes...
  37. ncbi Tolerogenic dendritic cells that inhibit autoimmune arthritis can be induced by a combination of carvacrol and thermal stress
    Rachel Spiering
    Department of Infectious Diseases and Immunology, Utrecht University, Utrecht, The Netherlands
    PLoS ONE 7:e46336. 2012
    ..Herewith carvacrol seems to offer novel opportunities for the development of a dietary based intervention in chronic inflammatory diseases...
  38. ncbi PLGA, PLGA-TMC and TMC-TPP Nanoparticles Differentially Modulate the Outcome of Nasal Vaccination by Inducing Tolerance or Enhancing Humoral Immunity
    Chantal Keijzer
    Department of Infectious Diseases and Immunology, Utrecht University, Utrecht, The Netherlands
    PLoS ONE 6:e26684. 2011
    ..The exploitation of this differential regulation of nanoparticles to modulate nasal immune responses can lead to innovative vaccine development for prophylactic or therapeutic vaccination in infectious or autoimmune diseases...
  39. ncbi The bovine CD1 family contains group 1 CD1 proteins, but no functional CD1d
    Ildiko Van Rhijn
    Department of Infection and Immunity, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    J Immunol 176:4888-93. 2006
    ..Cattle can be used as a model to study group 1 CD1-restricted T cell immunity, including its role in the defense against mycobacterial infections that occur naturally in this species...
  40. ncbi Progressive bovine paratuberculosis is associated with local loss of CD4(+) T cells, increased frequency of gamma delta T cells, and related changes in T-cell function
    Ad Koets
    Immunology Division, Department of Infectious Diseases and Immunology, Utrecht University, Utrecht, The Netherlands
    Infect Immun 70:3856-64. 2002
    ....
  41. ncbi Mycobacterium paratuberculosis heat shock protein 70 as a tool in control of paratuberculosis
    M Langelaar
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Division of Immunology, Utrecht, The Netherlands
    Vet Immunol Immunopathol 87:239-44. 2002
    ..DC interacting with rHsp70 in addition showed high expression of MHC I, MHC II, Myd-1 (CD172a) and CD40. Further research will focus on loading of the rHsp70 with M.a.p. antigen for presentation in MHC class I...
  42. ncbi Differential changes in heat shock protein-, lipoarabinomannan-, and purified protein derivative-specific immunoglobulin G1 and G2 isotype responses during bovine Mycobacterium avium subsp. paratuberculosis infection
    A P Koets
    Department of Immunology, Institute of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Infect Immun 69:1492-8. 2001
    ....
  43. ncbi Mycobacterium avium ssp. paratuberculosis recombinant heat shock protein 70 interaction with different bovine antigen-presenting cells
    M F M Langelaar
    Department of Infectious Diseases and Immunology, Utrecht University, Utrecht, Netherlands
    Scand J Immunol 61:242-50. 2005
    ..These data suggest that rHsp70-based vaccines may be useful for the successful immunization of cattle...
  44. ncbi Heat-shock protein-specific T-cell responses in various stages of bovine paratuberculosis
    A P Koets
    Department of Immunology, Institute of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    Vet Immunol Immunopathol 70:105-15. 1999
    ..Furthermore, this study shows that HSP70, being a well-defined antigen in comparison with PPD antigens, can be used to monitor cell-mediated immune responses in studies regarding the immunopathogenesis of bovine paratuberculosis...
  45. ncbi Induction of IL-10 and inhibition of experimental arthritis are specific features of microbial heat shock proteins that are absent for other evolutionarily conserved immunodominant proteins
    B J Prakken
    Institute of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht, The Netherlands
    J Immunol 167:4147-53. 2001
    ..Thus, the protective effect of conserved immunodominant proteins in experimental arthritis seems to be a specific feature of hsp. Therefore, hsp may offer unique possibilities for immunological intervention in inflammatory diseases...
  46. ncbi Regulatory T cells that recognize a ubiquitous stress-inducible self-antigen are long-lived suppressors of autoimmune arthritis
    Martijn J C van Herwijnen
    Department of Infectious Diseases and Immunology, Utrecht University, 3584 CL Utrecht, The Netherlands
    Proc Natl Acad Sci U S A 109:14134-9. 2012
    ....
  47. ncbi A case of mistaken identity: HSPs are no DAMPs but DAMPERs
    Willem van Eden
    Department of Infectious Diseases and Immunology, Utrecht University, Utrecht, Netherlands
    Cell Stress Chaperones 17:281-92. 2012
    ..Nat Rev Immunol 11:565-c1, 2011). With this perspective and reflection article, we hope to elaborate on this debate and provide additional thoughts to further ignite this discussion on this critical and evolving issue...
  48. ncbi Immunomodulatory effects of antigen-pulsed macrophages in a murine model of allergic asthma
    Edith M Janssen
    Department of Pharmacology and Pathophysiology, Faculty of Pharmacy, Utrecht University, Utrecht, The Netherlands
    Am J Respir Cell Mol Biol 27:257-64. 2002
    ..Our data suggest that IL-10 production by allergen presenting Mphi plays a crucial role in successful immunotherapy...
  49. ncbi XToll, a recombinant chaperonin 10 as an anti-inflammatory immunomodulator
    Willem van Eden
    University of Utrecht, Institute of Infectious Diseases and Immunology, Yalelaan 1, 3584CL Utrecht, The Netherlands
    Curr Opin Investig Drugs 9:523-33. 2008
    ..By May 2005, a phase IIa trial for Crohn's disease had been terminated due to slow recruitment. The company has not disclosed plans for future development for this indication...
  50. ncbi Ligand-induced differential cross-regulation of Toll-like receptors 2, 4 and 5 in intestinal epithelial cells
    Remon A M H van Aubel
    Department of Infectious Diseases and Immunology, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands
    Mol Immunol 44:3702-14. 2007
    ..Together, our results demonstrate that the expression and function of TLR in intestinal cells are highly dynamic and tightly regulated in response to encountered bacterial stimuli...
  51. ncbi Immune regulation in adjuvant-induced arthritis: possible implications for innovative therapeutic strategies in arthritis
    Willem van Eden
    University of Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 48:1788-96. 2003
  52. ncbi Cell stress induced HSP are targets of regulatory T cells: a role for HSP inducing compounds as anti-inflammatory immuno-modulators?
    Lotte Wieten
    Division of Immunology, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University of Utrecht, Yalelaan 1, 3584CL Utrecht, The Netherlands
    FEBS Lett 581:3716-22. 2007
    ..Previously, we have demonstrated that such T cells can be induced by conserved sequences of microbial HSP. Now we propose that drug induced up-regulation of endogenous HSP can contribute to anti-inflammatory T cell regulation...
  53. ncbi The spontaneous remission of juvenile idiopathic arthritis is characterized by CD30+ T cells directed to human heat-shock protein 60 capable of producing the regulatory cytokine interleukin-10
    I M De Kleer
    University Medical Center Utrecht, Wilhelmina Children's Hospital, Utrecht, The Netherlands
    Arthritis Rheum 48:2001-10. 2003
    ..These findings suggest that in oligoarticular JIA patients, human Hsp60-specific CD4+ cells have a regulatory function and contribute to disease remission...
  54. ncbi Peptide-induced nasal tolerance for a mycobacterial heat shock protein 60 T cell epitope in rats suppresses both adjuvant arthritis and nonmicrobially induced experimental arthritis
    B J Prakken
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht, The Netherlands
    Proc Natl Acad Sci U S A 94:3284-9. 1997
    ..Therefore, tolerance for a disease-triggering, microbial cartilage-mimicking epitope may cause resistance to arthritis irrespective of the actual trigger leading to development of the disease...
  55. ncbi Inhibition of experimental autoimmune myasthenia gravis by major histocompatibility complex class II competitor peptides results not only in a suppressed but also in an altered immune response
    M H Wauben
    Institute of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    Eur J Immunol 26:2866-75. 1996
    ..Furthermore, the administration of such peptides in vivo not only passively inhibits T cell activation, but also functionally alters the immune response...
  56. ncbi Cellular host transcriptional responses to influenza A virus in chicken tracheal organ cultures differ from responses in in vivo infected trachea
    Sylvia S Reemers
    Department of Infectious Diseases and Immunology, Faculty Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands
    Vet Immunol Immunopathol 132:91-100. 2009
    ..Our study implicates that although the TOC model is suitable for culturing of virus and lectin or virus binding studies, it is not suitable for measuring early immune responses upon viral infection at host transcriptional level...
  57. ncbi Heat-shock protein T-cell epitopes trigger a spreading regulatory control in a diversified arthritogenic T-cell response
    W van Eden
    Institute of Infectious Diseases and Immunology, Veterinary Faculty, University of Utrecht, The Netherlands
    Immunol Rev 164:169-74. 1998
    ..Alternatively, the cross-recognised self-hsp epitope could have the regulatory qualities of an altered peptide ligand or a partial agonist for T cells that see the microbial homologue as the full agonist...
  58. ncbi Naive transgenic T cells expressing cartilage proteoglycan-specific TCR induce arthritis upon in vivo activation
    Suzanne E Berlo
    Department of Infectious Diseases and Immunology, Division of Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, The Netherlands
    J Autoimmun 25:172-80. 2005
    ..In addition the model may be used for the development of immune modulating strategies in T cell-mediated autoimmune diseases...
  59. ncbi Successful immunotherapy with matrix metalloproteinase-derived peptides in adjuvant arthritis depends on the timing of peptide administration
    Jolanda H M van Bilsen
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    Arthritis Res 4:R2. 2002
    ..The present study shows the possible usefulness of MMP peptides for immunotherapy. However, a clear understanding of proper timing of peptide administration is crucial for the development of such therapies...
  60. ncbi Functional CD1d and/or NKT cell invariant chain transcript in horse, pig, African elephant and guinea pig, but not in ruminants
    Frank A Looringh van Beeck
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University Utrecht, Utrecht, The Netherlands
    Mol Immunol 46:1424-31. 2009
    ..Despite the discovery of a highly homologous NKT/CD1d system in pig and horse, our data suggest that functional CD1D and CD1d-restricted NKT cells are not universally present in mammals...
  61. ncbi Induction of antigen specific CD4+ T cell responses by invariant chain based DNA vaccines
    E A van Tienhoven
    Institute of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3508 TD, Utrecht, The Netherlands
    Vaccine 19:1515-9. 2001
    ..In addition, we showed that intradermal immunisation of Lewis rats with these constructs induced antigen specific T cells in vivo. Therefore, our Ii-gene constructs can be used to immunise for defined CD4+ T cell epitope sequences...
  62. ncbi ELISPOT and intracellular cytokine staining: novel assays for quantifying T cell responses in the chicken
    M P Ariaans
    Faculty of Veterinary Medicine, Department of Infectious Diseases and Immunology, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands
    Dev Comp Immunol 32:1398-404. 2008
    ..Although cells were detected at only low frequencies, polyclonal stimulation of peripheral blood mononuclear cell (PBMC) or spleen cells resulted in a significant increase in ChIFN-gamma production by CD4+ and CD8+ cells...
  63. ncbi Adjuvant arthritis in the rat
    W van Eden
    Institute of Infectious Diseases and Immunology, Utrecht, The Netherlands
    Curr Protoc Immunol . 2001
    ..This unit describes the induction and evaluation of AA and the preparation of adjuvant used to induce AA...
  64. ncbi Mechanisms of disease: the hygiene hypothesis revisited
    Francisco Guarner
    University Hospital Vall d Hebron, Barcelona, Spain
    Nat Clin Pract Gastroenterol Hepatol 3:275-84. 2006
    ..The use of probiotics, prebiotics, helminths or microbe-derived immunoregulatory vaccines might, therefore, become a valuable approach to disease prevention...
  65. ncbi Inhibition of adjuvant-induced arthritis by interleukin-10-driven regulatory cells induced via nasal administration of a peptide analog of an arthritis-related heat-shock protein 60 T cell epitope
    Berent J Prakken
    University of California San Diego, La Jolla, California, USA
    Arthritis Rheum 46:1937-46. 2002
    ....
  66. ncbi Heat shock proteins in juvenile idiopathic arthritis: keys for understanding remitting arthritis and candidate antigens for immune therapy
    Berent Prakken
    Department of Pediatric Immunology, University Medical Center Utrecht, University Hospital for Children and Youth, PO Box 85090, Utrecht 3508 AB, The Netherlands
    Curr Rheumatol Rep 4:466-73. 2002
    ..Taken together, these data imply that immune modulation with hsps can be an effective way to restore natural occurring T cell responses, and, thus, treat JIA and rheumatoid arthritis...
  67. ncbi Cross-reactive mycobacterial and self hsp60 epitope recognition in I-A(g7) expressing NOD, NOD-asp and Biozzi AB/H mice
    Astrid G S van Halteren
    Department of Immunohematology and Blood Transfusion, Leids Universitair Medisch Centrum, The Netherlands
    J Autoimmun 18:139-47. 2002
    ..Yet, proliferation of hsp60 autoreactive T cells is solely measured in combination with insulitis and as such serves as a surrogate marker for islet inflammation...
  68. ncbi Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease
    Kamran Ghoreschi
    Department of Dermatology and Allergology, Ludwig-Maximilians University Munich, Munich, Germany
    Nat Med 9:40-6. 2003
    ..Thus, IL-4 therapy can induce Th2 differentiation in human CD4+ T cells and has promise as a potential treatment for psoriasis, a prototypic Th1-associated autoimmune disease...
  69. ncbi The beta 2-adrenergic agonist salbutamol potentiates oral induction of tolerance, suppressing adjuvant arthritis and antigen-specific immunity
    Pieter M Cobelens
    Department of Immunology, Laboratory for Psychoneuroimmunology, University Medical Center Utrecht, The Netherlands
    J Immunol 169:5028-35. 2002
    ..In conclusion, salbutamol can be of great clinical benefit for the treatment of autoimmune diseases by promoting oral tolerance induction...
  70. ncbi [Natural immunity: objective and measurable]
    Willem van Eden
    Tijdschr Diergeneeskd 132:767-8. 2007