Inge van Rooy

Summary

Affiliation: Utrecht University
Country: The Netherlands

Publications

  1. doi Comparison of five different targeting ligands to enhance accumulation of liposomes into the brain
    Inge van Rooy
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, P O BOX 80082, 3508 TB Utrecht, The Netherlands
    J Control Release 150:30-6. 2011
  2. ncbi Preparation and characterization of liposomal formulations of neurotensin-degrading enzyme inhibitors
    Inge van Rooy
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands
    Int J Pharm 416:448-52. 2011
  3. pmc In vivo methods to study uptake of nanoparticles into the brain
    Inge van Rooy
    Department of Pharmaceutics Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands
    Pharm Res 28:456-71. 2011
  4. pmc Identification of peptide ligands for targeting to the blood-brain barrier
    Inge van Rooy
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, P O BOX 80082, 3508 TB, Utrecht, The Netherlands
    Pharm Res 27:673-82. 2010
  5. doi Attaching the phage display-selected GLA peptide to liposomes: factors influencing target binding
    Inge van Rooy
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, P O BOX 80082, 3508 TB Utrecht, The Netherlands
    Eur J Pharm Sci 45:330-5. 2012
  6. ncbi Fusogenic peptides enhance endosomal escape improving siRNA-induced silencing of oncogenes
    Sabrina Oliveira
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80 082, 3508 TB Utrecht, The Netherlands
    Int J Pharm 331:211-4. 2007
  7. ncbi Synthetic delivery systems for intravenous administration of nucleic acids
    Raymond M Schiffelers
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands
    Nanomedicine (Lond) 2:169-81. 2007
  8. ncbi siRNA-mediated inhibition of angiogenesis
    Raymond M Schiffelers
    Utrecht Institute for Pharmaceutical Sciences, Room Z 735 A, Department of Pharmaceutics, Utrecht University, PO Box 80 082, 3508 TB, Utrecht, The Netherlands
    Expert Opin Biol Ther 5:359-68. 2005

Detail Information

Publications8

  1. doi Comparison of five different targeting ligands to enhance accumulation of liposomes into the brain
    Inge van Rooy
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, P O BOX 80082, 3508 TB Utrecht, The Netherlands
    J Control Release 150:30-6. 2011
    ..3 times higher. Additionally, these results show that many targeting ligands that have been described for brain targeting, do not target to the brain in vivo when coupled to a liposomal delivery vehicle...
  2. ncbi Preparation and characterization of liposomal formulations of neurotensin-degrading enzyme inhibitors
    Inge van Rooy
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands
    Int J Pharm 416:448-52. 2011
    ..For C2, the release was rapid in both HBS and BSA at 37°C. In conclusion, the formulation of NTDE inhibitors C1 and C2 in liposomes has been demonstrated and holds promise to deliver NTDE inhibitors in vivo...
  3. pmc In vivo methods to study uptake of nanoparticles into the brain
    Inge van Rooy
    Department of Pharmaceutics Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands
    Pharm Res 28:456-71. 2011
    ..Here we discuss the techniques generally used to measure nanoparticle uptake in addition to the techniques used for CNS compounds. Techniques include visualization methods, behavioral tests, and quantitative methods...
  4. pmc Identification of peptide ligands for targeting to the blood-brain barrier
    Inge van Rooy
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, P O BOX 80082, 3508 TB, Utrecht, The Netherlands
    Pharm Res 27:673-82. 2010
    ..Transport of drugs to the brain is limited by the blood-brain barrier. New, specific brain endothelium ligands can facilitate brain-specific delivery of drugs...
  5. doi Attaching the phage display-selected GLA peptide to liposomes: factors influencing target binding
    Inge van Rooy
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, P O BOX 80082, 3508 TB Utrecht, The Netherlands
    Eur J Pharm Sci 45:330-5. 2012
    ....
  6. ncbi Fusogenic peptides enhance endosomal escape improving siRNA-induced silencing of oncogenes
    Sabrina Oliveira
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80 082, 3508 TB Utrecht, The Netherlands
    Int J Pharm 331:211-4. 2007
    ..For both targets, strong enhancement of gene silencing activity was noted after addition of diINF-7 fusogenic peptide, identifying endosomal escape as a limiting factor for siRNA silencing efficiency...
  7. ncbi Synthetic delivery systems for intravenous administration of nucleic acids
    Raymond M Schiffelers
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands
    Nanomedicine (Lond) 2:169-81. 2007
    ....
  8. ncbi siRNA-mediated inhibition of angiogenesis
    Raymond M Schiffelers
    Utrecht Institute for Pharmaceutical Sciences, Room Z 735 A, Department of Pharmaceutics, Utrecht University, PO Box 80 082, 3508 TB, Utrecht, The Netherlands
    Expert Opin Biol Ther 5:359-68. 2005
    ..This is especially important as clinical studies indicate a profound heterogeneity of the angiogenic vasculature...