Gerrit van Meer

Summary

Affiliation: Utrecht University
Country: The Netherlands

Publications

  1. pmc Pre- and post-Golgi translocation of glucosylceramide in glycosphingolipid synthesis
    David Halter
    Membrane Enzymology, Bijvoet Center, and Department of Cell Biology, University Medical Center Utrecht, Institute of Biomembranes, Utrecht University, 3584 Utrecht, Netherlands
    J Cell Biol 179:101-15. 2007
  2. pmc Membranes in motion
    Gerrit van Meer
    Department of Membrane Enzymology, Utrecht University, Utrecht, The Netherlands
    EMBO Rep 11:331-3. 2010
  3. doi request reprint Sphingolipid topology and the dynamic organization and function of membrane proteins
    Gerrit van Meer
    Bijvoet Center and Institute of Biomembranes, CH Utrecht, The Netherlands
    FEBS Lett 584:1800-5. 2010
  4. pmc Membrane lipids: where they are and how they behave
    Gerrit van Meer
    Bijvoet Center and Institute of Biomembranes, Utrecht University, 3584 CH Utrecht, The Netherlands
    Nat Rev Mol Cell Biol 9:112-24. 2008
  5. doi request reprint Hyperacidification of trans-Golgi network and endo/lysosomes in melanocytes by glucosylceramide-dependent V-ATPase activity
    Seléne van der Poel
    Membrane Enzymology, Bijvoet Center and Institute of Biomembranes, Utrecht University, Utrecht, The Netherlands
    Traffic 12:1634-47. 2011
  6. ncbi request reprint Membrane lipids and vesicular traffic
    Gerrit van Meer
    Department of Membrane Enzymology, Centre for Biomembranes and Lipid Enzymology, Institute of Biomembranes, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Curr Opin Cell Biol 16:373-8. 2004
  7. ncbi request reprint The way we view cellular (glyco)sphingolipids
    Sandra Hoetzl
    Membrane Enzymology, Bijvoet Center and Institute of Biomembranes, Utrecht University, Urecht, The Netherlands
    J Neurochem 103:3-13. 2007
  8. doi request reprint Glycolipid-dependent sorting of melanosomal from lysosomal membrane proteins by lumenal determinants
    Sophie Groux-Degroote
    Membrane Enzymology, Bijvoet Center and Institute of Biomembranes, Utrecht University, 3584CH Utrecht, The Netherlands
    Traffic 9:951-63. 2008
  9. ncbi request reprint Lipid microdomains, lipid translocation and the organization of intracellular membrane transport (Review)
    Joost C M Holthuis
    Department of Membrane Enzymology, Center for Biomembranes and Lipid Enzymology, Utrecht University, 3584 CH Utrecht, The Netherlands
    Mol Membr Biol 20:231-41. 2003
  10. ncbi request reprint The cell biology of glycosphingolipids
    Sophie Degroote
    Department of Membrane Enzymology, Institute of Biomembranes, H R Kruytgebouw, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Semin Cell Dev Biol 15:375-87. 2004

Collaborators

Detail Information

Publications20

  1. pmc Pre- and post-Golgi translocation of glucosylceramide in glycosphingolipid synthesis
    David Halter
    Membrane Enzymology, Bijvoet Center, and Department of Cell Biology, University Medical Center Utrecht, Institute of Biomembranes, Utrecht University, 3584 Utrecht, Netherlands
    J Cell Biol 179:101-15. 2007
    ..FAPP2 knockdown strongly reduces GM3 synthesis. Overall, we show that newly synthesized GlcCer enters two pathways: one toward the noncytosolic surface of a post-Golgi membrane and one via the ER toward the Golgi lumen LacCer synthase...
  2. pmc Membranes in motion
    Gerrit van Meer
    Department of Membrane Enzymology, Utrecht University, Utrecht, The Netherlands
    EMBO Rep 11:331-3. 2010
    ..Topics included the machinery responsible for the dynamic shape of organelles, the budding and fusion of vesicular carriers, and the intricate sorting systems that ensure the correct delivery of cellular components...
  3. doi request reprint Sphingolipid topology and the dynamic organization and function of membrane proteins
    Gerrit van Meer
    Bijvoet Center and Institute of Biomembranes, CH Utrecht, The Netherlands
    FEBS Lett 584:1800-5. 2010
    ..The few signaling sphingolipids in mammals must provide basic transmission principles that evolution has built upon for organizing the specific regulatory pathways tuned to the needs of the different cell types in the body...
  4. pmc Membrane lipids: where they are and how they behave
    Gerrit van Meer
    Bijvoet Center and Institute of Biomembranes, Utrecht University, 3584 CH Utrecht, The Netherlands
    Nat Rev Mol Cell Biol 9:112-24. 2008
    ..enzymes, translocases and transporters, plus the intrinsic physical phase behaviour of lipids and their interactions with membrane proteins, to create the unique compositions and multiple functionalities of their individual membranes?..
  5. doi request reprint Hyperacidification of trans-Golgi network and endo/lysosomes in melanocytes by glucosylceramide-dependent V-ATPase activity
    Seléne van der Poel
    Membrane Enzymology, Bijvoet Center and Institute of Biomembranes, Utrecht University, Utrecht, The Netherlands
    Traffic 12:1634-47. 2011
    ..These experiments establish, for the first time, a link between pH, glycosphingolipids and melanosome biogenesis in melanocytic MEB4 cells, to suggest a role for glycosphingolipids in hyperacidification in melanocytes...
  6. ncbi request reprint Membrane lipids and vesicular traffic
    Gerrit van Meer
    Department of Membrane Enzymology, Centre for Biomembranes and Lipid Enzymology, Institute of Biomembranes, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Curr Opin Cell Biol 16:373-8. 2004
    ..The current challenge is to understand how proteins control the metabolism and subcellular localization, and thereby the activity, of the various lipids...
  7. ncbi request reprint The way we view cellular (glyco)sphingolipids
    Sandra Hoetzl
    Membrane Enzymology, Bijvoet Center and Institute of Biomembranes, Utrecht University, Urecht, The Netherlands
    J Neurochem 103:3-13. 2007
    ..In the present paper, we critically evaluate the published data and discuss techniques and potential improvements...
  8. doi request reprint Glycolipid-dependent sorting of melanosomal from lysosomal membrane proteins by lumenal determinants
    Sophie Groux-Degroote
    Membrane Enzymology, Bijvoet Center and Institute of Biomembranes, Utrecht University, 3584CH Utrecht, The Netherlands
    Traffic 9:951-63. 2008
    ..In conclusion, the lumenal domain contains sorting information that guides Tyrp1 and probably tyrosinase to melanosomes by an intracellular route that excludes lysosomal proteins and requires glucosylceramide...
  9. ncbi request reprint Lipid microdomains, lipid translocation and the organization of intracellular membrane transport (Review)
    Joost C M Holthuis
    Department of Membrane Enzymology, Center for Biomembranes and Lipid Enzymology, Utrecht University, 3584 CH Utrecht, The Netherlands
    Mol Membr Biol 20:231-41. 2003
    ..This review will focus on how selective membrane transport relies on a dynamic interplay between membrane lipids and proteins...
  10. ncbi request reprint The cell biology of glycosphingolipids
    Sophie Degroote
    Department of Membrane Enzymology, Institute of Biomembranes, H R Kruytgebouw, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Semin Cell Dev Biol 15:375-87. 2004
    ..Apart from being involved in recognition and signaling on the cell surface, glycosphingolipids may fulfill unexpected roles on the cytosolic surface of cellular membranes...
  11. pmc The fate and function of glycosphingolipid glucosylceramide
    Gerrit van Meer
    Department of Membrane Enzymology, Institute of Biomembranes, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Philos Trans R Soc Lond B Biol Sci 358:869-73. 2003
    ....
  12. ncbi request reprint Natural phosphatidylcholine is actively translocated across the plasma membrane to the surface of mammalian cells
    Nanette Kälin
    Department of Membrane Enzymology, CBLE, Institute of Biomembranes, Padualaan 8, 3584 CH Utrecht, The Netherlands
    J Biol Chem 279:33228-36. 2004
    ....
  13. pmc Cellular lipidomics
    Gerrit van Meer
    Department of Membrane Enzymology, Bijvoet Center and Institute of Biomembranes, Utrecht University, The Netherlands
    EMBO J 24:3159-65. 2005
    ..Cellular lipidomics provides a framework for understanding and manipulating the vital role of lipids, especially in membrane transport and sorting and in cell signaling...
  14. pmc Membrane curvature sorts lipids. Stabilized lipid rafts in membrane transport
    Gerrit van Meer
    Department of Membrane Enzymology, Bijvoet Center and Institute of Biomembranes, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    EMBO Rep 6:418-9. 2005
  15. ncbi request reprint Protein-lipid interactions: paparazzi hunting for snap-shots
    Per Haberkant
    Membrane Enzymology, Bijvoet Center and Institute of Biomembranes, Utrecht University, NL 3584 CH Utrecht, The Netherlands
    Biol Chem 390:795-803. 2009
    ....
  16. ncbi request reprint ABC lipid transporters: extruders, flippases, or flopless activators?
    Gerrit van Meer
    Membrane Enzymology, Bijvoet Center and Institute of Biomembranes, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands
    FEBS Lett 580:1171-7. 2006
    ..If the lipid originated from the cytosolic membrane surface, this represents lipid flop and is probably a side activity of the transporters...
  17. pmc Drs2p-related P-type ATPases Dnf1p and Dnf2p are required for phospholipid translocation across the yeast plasma membrane and serve a role in endocytosis
    Thomas Pomorski
    Department of Membrane Enzymology, Center for Biomembranes and Lipid Enzymology, Utrecht University, The Netherlands
    Mol Biol Cell 14:1240-54. 2003
    ..Moreover, it appears that Dnf1p, Dnf2p and Drs2p each help regulate the transbilayer lipid arrangement in the plasma membrane, and that this regulation is critical for budding endocytic vesicles...
  18. doi request reprint Sphingolipid management by an orchestra of lipid transfer proteins
    Sylvia Neumann
    Bijvoet Center Institute of Biomembranes, Utrecht University, NL 3584 CH Utrecht, The Netherlands
    Biol Chem 389:1349-60. 2008
    ..Here we discuss recent findings that assign an important role to lipid transfer proteins in the regulation of sphingolipid metabolism, organization and function...
  19. ncbi request reprint The European lipidomics initiative: enabling technologies
    Gerrit van Meer
    Bijvoet Center, Utrecht University, Utrecht, The Netherlands
    Methods Enzymol 432:213-32. 2007
    ..The final challenge is to apply this knowledge in the diagnosis, monitoring, and cure of lipid-related diseases...
  20. ncbi request reprint Cell biology. The different hues of lipid rafts
    Gerrit van Meer
    Department of Membrane Enzymology, CBLE, Institute of Biomembranes, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Science 296:855-7. 2002