Research Topics
| P C SouvereinSummaryAffiliation: Utrecht University Country: The Netherlands Publications
| Collaborators
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Detail Information
Publications
Use of beta-blockers and the risk of hip/femur fracture in the United Kingdom and The NetherlandsF De Vries
Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Universiteit Utrecht, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
Calcif Tissue Int 80:69-75. 2007....- Linking community pharmacy dispensing data to prescribing data of general practitionersStefan R Florentinus
Department of Pharmacoepidemiology and Pharmacotherapy, Institute for Pharmaceutical Sciences, Utrecht University, Faculty of Pharmaceutical Sciences, Utrecht, The Netherlands
BMC Med Inform Decis Mak 6:18. 2006..However, most of these databases consist either of prescribing, dispensing or administrative data and therefore lack insight in the interaction between the several health professionals around the patient... 
Evaluating adverse cardiovascular effects of drug treatment for benign prostatic hyperplasia (BPH): methodological considerationsP C Souverein
Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht, The Netherlands
J Clin Epidemiol 54:518-24. 2001..This question is an important challenge to observational research and once again stresses the need for control of possible biases in choosing an appropriate study design...- Use of antiepileptic drugs and risk of fractures: case-control study among patients with epilepsyP C Souverein
Department of Pharmacoepidemiology and Pharmacotherapy, Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
Neurology 66:1318-24. 2006..To study the association between use of antiepileptic drugs (AEDs) and risk of fractures... - Treatment of benign prostatic hyperplasia and occurrence of prostatic surgery and acute urinary retention: a population-based cohort study in the NetherlandsP C Souverein
Department Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands
Eur Urol 47:505-10. 2005..We sought to expand on data of an earlier pharmacy-based study by obtaining more information on BPH disease parameters by using a Dutch GP-based research database... - Incidence of fractures among epilepsy patients: a population-based retrospective cohort study in the General Practice Research DatabasePatrick C Souverein
Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
Epilepsia 46:304-10. 2005..To compare the incidence of various fractures in a cohort of patients with epilepsy with a reference cohort of patients not having epilepsy... 
Use of oral glucocorticoids and risk of cardiovascular and cerebrovascular disease in a population based case-control studyP C Souverein
Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, PO Box 80082, 3508 TB Utrecht, The Netherlands
Heart 90:859-65. 2004..To assess whether use of oral glucocorticoids is associated with cardiovascular and cerebrovascular morbidity...- Use of alpha-blockers and the risk of hip/femur fracturesP C Souverein
Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands
J Intern Med 254:548-54. 2003..To study the association between use of alpha-blockers and risk of hip/femur fractures... - Drug treatment of benign prostatic hyperplasia and hospital admission for BPH-related surgeryP C Souverein
Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, P O BOX 80082, 3508 TB, Utrecht, The Netherlands
Eur Urol 43:528-34. 2003..To investigate whether there is a difference in the risk of progressing to BPH-related prostatic surgery between patients using alpha-blockers and patients using the 5-alpha-reductase inhibitors (5-ARIs)... - Study of the association between ischemic heart disease and use of alpha-blockers and finasteride indicated for the treatment of benign prostatic hyperplasiaP C Souverein
Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, PO Box 80082, 3508 TB, Utrecht, The Netherlands
Eur Urol 42:254-61. 2002.... - Incidence and determinants of sildenafil (dis)continuation: the Dutch cohort of sildenafil usersP C Souverein
Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht, The Netherlands
Int J Impot Res 14:259-65. 2002.... - The Dutch cohort of sildenafil users: baseline characteristicsP C Souverein
Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands
BJU Int 87:648-53. 2001..To identify a Dutch cohort of sildenafil users and describe their baseline characteristics... 
Changes in outpatient lithium treatment in the Netherlands during 1996-2005I Wilting
Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Faculty of Science, Utrecht, The Netherlands
J Affect Disord 111:94-9. 2008..The objectives of the present study were to investigate in outpatients in the Netherlands between 1996 and 2005, changes in 1) the incidence and prevalence of lithium use and 2) lithium use patterns (discontinuation, add-on, and switch)...- Effect of oral antiplatelet agents on major bleeding in users of coumarinsTom Schalekamp
Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands
Thromb Haemost 100:1076-83. 2008..Concurrent use of clopidogrel or dipyridamole and coumarins is probably not safer than concurrent use of aspirin and coumarins... - Changes in medication associated with epilepsy-related hospitalisation: a case-crossover studyKim B Handoko
Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands
Pharmacoepidemiol Drug Saf 16:189-96. 2007..To assess the association between changes in medication and epilepsy-related hospitalisation... - Use of serotonergic drugs and the risk of bleedingB M Verdel
Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands
Clin Pharmacol Ther 89:89-96. 2011..The association between antipsychotic drugs and gastrointestinal bleeding may warrant further research, in view of the fact that this association was rather unexpected... - Dopaminergic drugs and the risk of hip or femur fracture: a population-based case-control studyM E L Arbouw
Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Universiteit Utrecht, P O BOX 80082, 3508 TB, Utrecht, The Netherlands
Osteoporos Int 22:2197-204. 2011..Concomitant use of antidepressants further increased this risk. Fracture risk assessment may be warranted in elderly users of dopaminergic drugs... - The association between exposure to COX-2 inhibitors and schizophrenia deterioration. A nested case-control studyP Stolk
Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands
Pharmacopsychiatry 40:111-5. 2007..COX-2 inhibitors (COX-2i) have been reported to have beneficial effects on schizophrenia. This observational study assesses the association between exposure to COX-2i or/and NSAIDs and schizophrenia deterioration... - Angiotensin-converting enzyme inhibitor use and pneumonia risk in a general populationE M W van de Garde
Dept of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute of Pharmaceutical Sciences UIPS, Sorbonnelaan 16, 3583 CA Utrecht, The Netherlands
Eur Respir J 27:1217-22. 2006..36). In contrast with previous findings in Asian populations, the current authors were not able to confirm the beneficial effect of angiotensin-converting enzyme inhibitors on pneumonia risk in a general, essentially white population... - Statin treatment and reduced risk of pneumonia in patients with diabetesE M W van de Garde
Utrecht Institute for Pharmaceutical Sciences UIPS, Department of Pharmacoepidemiology and Pharmacotherapy, Sorbonnelaan 16, 3583 CA Utrecht, The Netherlands
Thorax 61:957-61. 2006..Because of an increased risk of pneumonia in patients with diabetes, we assessed the effects of statin use on the occurrence of pneumonia in adult diabetic patients... - Angiotensin-converting enzyme inhibitor use and protection against pneumonia in patients with diabetesEwoudt M W van de Garde
Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht The Netherlands
J Hypertens 25:235-9. 2007..Because of the high risk of pneumonia in patients with diabetes, we aimed to assess the effect of angiotensin-converting enzyme (ACE) inhibitor use on the occurrence of pneumonia in a general population of patients with diabetes... - Prior outpatient antibacterial therapy as prognostic factor for mortality in hospitalized pneumonia patientsEwoudt M W van de Garde
Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Sorbonnelaan 16, 3584 CA Utrecht, and Department of Clinical Pharmacy, St Antonius Hospital, Nieuwegein, The Netherlands
Respir Med 100:1342-8. 2006..To assess whether prior outpatient treatment is associated with outcome in patients hospitalized for community-acquired pneumonia (CAP)... - Difference in risks of allergic reaction to sulfonamide drugs based on chemical structureB Marianne Verdel
Utrecht Institute for Pharmaceutical Sciences UIPS, Faculty of Science, Utrecht University, Netherlands
Ann Pharmacother 40:1040-6. 2006..The chemical structure of sulfonamide antibiotics and sulfonamide nonantibiotics can affect the potential for adverse reactions... - Increased bleeding risk with concurrent use of selective serotonin reuptake inhibitors and coumarinsTom Schalekamp
Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands
Arch Intern Med 168:180-5. 2008.... - Discontinuation of statins among patients with type 2 diabetesE J F Lamberts
Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
Diabetes Metab Res Rev 28:241-5. 2012.... - Influence of antidepressants on glycaemic control in patients with diabetes mellitusM J Knol
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
Pharmacoepidemiol Drug Saf 17:577-86. 2008..Anecdotal evidence suggests that antidepressants (ADs) may complicate glycaemic control. The objective of this longitudinal study was to investigate the influence of ADs on glycaemic control within diabetes patients... - Risk of drug-induced photosensitivity: focus on spectroscopic and molecular characteristicsB M Verdel
Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences UIPS, Faculty of Science, Utrecht University, Utrecht, The Netherlands
Pharmacoepidemiol Drug Saf 18:602-9. 2009..Drug-induced photosensitivity is difficult to predict and remains a challenge for both the dermatological clinical practice and pharmacovigilance... - Drug-induced thrombocytopenia: a population studyMaarten J Ten Berg
Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands
Drug Saf 29:713-21. 2006..Future studies including more patients and with laboratory data should confirm our findings before drawing definite conclusions... - Is aspirin useful in patients on lithium? A pharmacoepidemiological study related to bipolar disorderPieter Stolk
Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands
Prostaglandins Leukot Essent Fatty Acids 82:9-14. 2010..We hypothesized that other agents that target the brain AA cascade, nonsteroidal anti-inflammatory drugs (NSAIDs) and glucocorticoids, also would ameliorate BD symptoms... - Antipsychotic drug use and risk of pneumonia in elderly peopleWilma Knol
Department of Geriatrics, University Medical Center Utrecht, Utrecht, The Netherlands
J Am Geriatr Soc 56:661-6. 2008..To investigate the association between antipsychotic drug use and risk of pneumonia in elderly people... - Effects of glucocorticoids on the neutrophil count: a cohort study among hospitalized patientsKarin J Velthove
Faculty of Science, Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, P O BOX 80082, 3508 TB Utrecht, The Netherlands
Pulm Pharmacol Ther 23:129-34. 2010..The objective of this study was to investigate the effect of systemic glucocorticoids on the absolute neutrophil count in hospitalized patients... - Risk of aplastic anemia in patients using antiepileptic drugsKim B Handoko
Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands
Epilepsia 47:1232-6. 2006..8 years. CONCLUSIONS: This study indicates that use of AEDs, in particular CBZ and VPA, is associated with a ninefold increased risk of aplastic anemia. Physicians should be alert to the possibility of AED-associated aplastic anemia... - Drug-related nephrotoxic and ototoxic reactions : a link through a predictive mechanistic commonalityBertha Maria Verdel
Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences UIPS, Faculty of Science, Utrecht University, Utrecht, The Netherlands
Drug Saf 31:877-84. 2008..It has been suggested that drugs that influence the transport of sodium and/or potassium change ionic homeostasis in the inner ear and, hence, induce functional disturbances such as hearing loss, tinnitus and vertigo... - Medication changes prior to hospitalization for obstructive lung disease: a case-crossover studyKarin J Velthove
Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, The Netherlands
Ann Pharmacother 44:267-73. 2010..Hospitalizations have always been seen as a solid outcome parameter in pharmacoepidemiology. However, the period leading to hospitalization and prehospital management of the patient are equally important... - Measuring exacerbations in obstructive lung diseaseKarin J Velthove
Division of Pharmacoepidemiology and Pharmacotherapy, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands
Pharmacoepidemiol Drug Saf 19:367-74. 2010..The aim of this study was to quantify the incidence of different exacerbation markers in obstructive lung disease and to identify predictors for these exacerbation markers... - Association between hospitalization and discontinuity of medication therapy used in the community setting in the NetherlandsRutger Stuffken
Division of Pharmacoepidemiology and Pharmacotherapy, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, NetherlandsNetherlands
Ann Pharmacother 42:933-9. 2008..Hospitalization may put patients at increased risk of discontinuity of medication use... - Identification of exacerbations in obstructive lung disease through biomarkersKarin J Velthove
Faculty of Science, Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands
Biomarkers 14:523-8. 2009..In conclusion, neutrophil and eosinophil counts seem to be useful biomarkers for identifying exacerbations in pharmacoepidemiological studies on obstructive lung disease... - Construction of drug treatment episodes from drug-dispensing histories is influenced by the gap lengthHelga Gardarsdottir
Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CA Utrecht, The Netherlands
J Clin Epidemiol 63:422-7. 2010..We investigated how different methods used to construct antidepressant treatment episodes influence their median estimated length... - Society already achieves economic benefits from generic substitution but fails to do the same for therapeutic substitutionPearl D Gumbs
Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, Utrecht, The Netherlands
Br J Clin Pharmacol 64:680-5. 2007..To assess the potential annual savings due to generic and therapeutic substitution of statin therapy for the general Dutch population, taking the patients medical history into account... - Evaluation of risk profiles for gastrointestinal and cardiovascular adverse effects in nonselective NSAID and COX-2 inhibitor users: a cohort study using pharmacy dispensing data in The NetherlandsDeborah Layton
Drug Safety Research Unit, Blundell Lane, Southampton, Hampshire, England
Drug Saf 31:143-58. 2008..The channelling paradox may exist for cyclo-oxygenase (COX)-2 selective inhibitors ('coxibs') instead of traditional nonselective NSAIDs in relation to both gastrointestinal (GI) and cardiovascular (CV) safety...