P C Souverein

Summary

Affiliation: Utrecht University
Country: The Netherlands

Publications

  1. pmc Use of beta-blockers and the risk of hip/femur fracture in the United Kingdom and The Netherlands
    F De Vries
    Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Universiteit Utrecht, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
    Calcif Tissue Int 80:69-75. 2007
  2. pmc Linking community pharmacy dispensing data to prescribing data of general practitioners
    Stefan R Florentinus
    Department of Pharmacoepidemiology and Pharmacotherapy, Institute for Pharmaceutical Sciences, Utrecht University, Faculty of Pharmaceutical Sciences, Utrecht, The Netherlands
    BMC Med Inform Decis Mak 6:18. 2006
  3. ncbi request reprint Evaluating adverse cardiovascular effects of drug treatment for benign prostatic hyperplasia (BPH): methodological considerations
    P C Souverein
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht, The Netherlands
    J Clin Epidemiol 54:518-24. 2001
  4. ncbi request reprint Use of antiepileptic drugs and risk of fractures: case-control study among patients with epilepsy
    P C Souverein
    Department of Pharmacoepidemiology and Pharmacotherapy, Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Neurology 66:1318-24. 2006
  5. ncbi request reprint Treatment of benign prostatic hyperplasia and occurrence of prostatic surgery and acute urinary retention: a population-based cohort study in the Netherlands
    P C Souverein
    Department Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands
    Eur Urol 47:505-10. 2005
  6. ncbi request reprint Incidence of fractures among epilepsy patients: a population-based retrospective cohort study in the General Practice Research Database
    Patrick C Souverein
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Epilepsia 46:304-10. 2005
  7. pmc Use of oral glucocorticoids and risk of cardiovascular and cerebrovascular disease in a population based case-control study
    P C Souverein
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, PO Box 80082, 3508 TB Utrecht, The Netherlands
    Heart 90:859-65. 2004
  8. ncbi request reprint Use of alpha-blockers and the risk of hip/femur fractures
    P C Souverein
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands
    J Intern Med 254:548-54. 2003
  9. ncbi request reprint Drug treatment of benign prostatic hyperplasia and hospital admission for BPH-related surgery
    P C Souverein
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, P O BOX 80082, 3508 TB, Utrecht, The Netherlands
    Eur Urol 43:528-34. 2003
  10. ncbi request reprint Study of the association between ischemic heart disease and use of alpha-blockers and finasteride indicated for the treatment of benign prostatic hyperplasia
    P C Souverein
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, PO Box 80082, 3508 TB, Utrecht, The Netherlands
    Eur Urol 42:254-61. 2002

Collaborators

Detail Information

Publications41

  1. pmc Use of beta-blockers and the risk of hip/femur fracture in the United Kingdom and The Netherlands
    F De Vries
    Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Universiteit Utrecht, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
    Calcif Tissue Int 80:69-75. 2007
    ....
  2. pmc Linking community pharmacy dispensing data to prescribing data of general practitioners
    Stefan R Florentinus
    Department of Pharmacoepidemiology and Pharmacotherapy, Institute for Pharmaceutical Sciences, Utrecht University, Faculty of Pharmaceutical Sciences, Utrecht, The Netherlands
    BMC Med Inform Decis Mak 6:18. 2006
    ..However, most of these databases consist either of prescribing, dispensing or administrative data and therefore lack insight in the interaction between the several health professionals around the patient...
  3. ncbi request reprint Evaluating adverse cardiovascular effects of drug treatment for benign prostatic hyperplasia (BPH): methodological considerations
    P C Souverein
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht, The Netherlands
    J Clin Epidemiol 54:518-24. 2001
    ..This question is an important challenge to observational research and once again stresses the need for control of possible biases in choosing an appropriate study design...
  4. ncbi request reprint Use of antiepileptic drugs and risk of fractures: case-control study among patients with epilepsy
    P C Souverein
    Department of Pharmacoepidemiology and Pharmacotherapy, Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Neurology 66:1318-24. 2006
    ..To study the association between use of antiepileptic drugs (AEDs) and risk of fractures...
  5. ncbi request reprint Treatment of benign prostatic hyperplasia and occurrence of prostatic surgery and acute urinary retention: a population-based cohort study in the Netherlands
    P C Souverein
    Department Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands
    Eur Urol 47:505-10. 2005
    ..We sought to expand on data of an earlier pharmacy-based study by obtaining more information on BPH disease parameters by using a Dutch GP-based research database...
  6. ncbi request reprint Incidence of fractures among epilepsy patients: a population-based retrospective cohort study in the General Practice Research Database
    Patrick C Souverein
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Epilepsia 46:304-10. 2005
    ..To compare the incidence of various fractures in a cohort of patients with epilepsy with a reference cohort of patients not having epilepsy...
  7. pmc Use of oral glucocorticoids and risk of cardiovascular and cerebrovascular disease in a population based case-control study
    P C Souverein
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, PO Box 80082, 3508 TB Utrecht, The Netherlands
    Heart 90:859-65. 2004
    ..To assess whether use of oral glucocorticoids is associated with cardiovascular and cerebrovascular morbidity...
  8. ncbi request reprint Use of alpha-blockers and the risk of hip/femur fractures
    P C Souverein
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands
    J Intern Med 254:548-54. 2003
    ..To study the association between use of alpha-blockers and risk of hip/femur fractures...
  9. ncbi request reprint Drug treatment of benign prostatic hyperplasia and hospital admission for BPH-related surgery
    P C Souverein
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, P O BOX 80082, 3508 TB, Utrecht, The Netherlands
    Eur Urol 43:528-34. 2003
    ..To investigate whether there is a difference in the risk of progressing to BPH-related prostatic surgery between patients using alpha-blockers and patients using the 5-alpha-reductase inhibitors (5-ARIs)...
  10. ncbi request reprint Study of the association between ischemic heart disease and use of alpha-blockers and finasteride indicated for the treatment of benign prostatic hyperplasia
    P C Souverein
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, PO Box 80082, 3508 TB, Utrecht, The Netherlands
    Eur Urol 42:254-61. 2002
    ....
  11. ncbi request reprint Incidence and determinants of sildenafil (dis)continuation: the Dutch cohort of sildenafil users
    P C Souverein
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht, The Netherlands
    Int J Impot Res 14:259-65. 2002
    ....
  12. ncbi request reprint The Dutch cohort of sildenafil users: baseline characteristics
    P C Souverein
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands
    BJU Int 87:648-53. 2001
    ..To identify a Dutch cohort of sildenafil users and describe their baseline characteristics...
  13. doi request reprint Changes in outpatient lithium treatment in the Netherlands during 1996-2005
    I Wilting
    Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Faculty of Science, Utrecht, The Netherlands
    J Affect Disord 111:94-9. 2008
    ..The objectives of the present study were to investigate in outpatients in the Netherlands between 1996 and 2005, changes in 1) the incidence and prevalence of lithium use and 2) lithium use patterns (discontinuation, add-on, and switch)...
  14. ncbi request reprint Effect of oral antiplatelet agents on major bleeding in users of coumarins
    Tom Schalekamp
    Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    Thromb Haemost 100:1076-83. 2008
    ..Concurrent use of clopidogrel or dipyridamole and coumarins is probably not safer than concurrent use of aspirin and coumarins...
  15. ncbi request reprint Changes in medication associated with epilepsy-related hospitalisation: a case-crossover study
    Kim B Handoko
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands
    Pharmacoepidemiol Drug Saf 16:189-96. 2007
    ..To assess the association between changes in medication and epilepsy-related hospitalisation...
  16. doi request reprint Use of serotonergic drugs and the risk of bleeding
    B M Verdel
    Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    Clin Pharmacol Ther 89:89-96. 2011
    ..The association between antipsychotic drugs and gastrointestinal bleeding may warrant further research, in view of the fact that this association was rather unexpected...
  17. ncbi request reprint The association between exposure to COX-2 inhibitors and schizophrenia deterioration. A nested case-control study
    P Stolk
    Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands
    Pharmacopsychiatry 40:111-5. 2007
    ..COX-2 inhibitors (COX-2i) have been reported to have beneficial effects on schizophrenia. This observational study assesses the association between exposure to COX-2i or/and NSAIDs and schizophrenia deterioration...
  18. pmc Dopaminergic drugs and the risk of hip or femur fracture: a population-based case-control study
    M E L Arbouw
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Universiteit Utrecht, P O BOX 80082, 3508 TB, Utrecht, The Netherlands
    Osteoporos Int 22:2197-204. 2011
    ..Concomitant use of antidepressants further increased this risk. Fracture risk assessment may be warranted in elderly users of dopaminergic drugs...
  19. ncbi request reprint Angiotensin-converting enzyme inhibitor use and pneumonia risk in a general population
    E M W van de Garde
    Dept of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute of Pharmaceutical Sciences UIPS, Sorbonnelaan 16, 3583 CA Utrecht, The Netherlands
    Eur Respir J 27:1217-22. 2006
    ..36). In contrast with previous findings in Asian populations, the current authors were not able to confirm the beneficial effect of angiotensin-converting enzyme inhibitors on pneumonia risk in a general, essentially white population...
  20. pmc Statin treatment and reduced risk of pneumonia in patients with diabetes
    E M W van de Garde
    Utrecht Institute for Pharmaceutical Sciences UIPS, Department of Pharmacoepidemiology and Pharmacotherapy, Sorbonnelaan 16, 3583 CA Utrecht, The Netherlands
    Thorax 61:957-61. 2006
    ..Because of an increased risk of pneumonia in patients with diabetes, we assessed the effects of statin use on the occurrence of pneumonia in adult diabetic patients...
  21. ncbi request reprint Angiotensin-converting enzyme inhibitor use and protection against pneumonia in patients with diabetes
    Ewoudt M W van de Garde
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht The Netherlands
    J Hypertens 25:235-9. 2007
    ..Because of the high risk of pneumonia in patients with diabetes, we aimed to assess the effect of angiotensin-converting enzyme (ACE) inhibitor use on the occurrence of pneumonia in a general population of patients with diabetes...
  22. ncbi request reprint Prior outpatient antibacterial therapy as prognostic factor for mortality in hospitalized pneumonia patients
    Ewoudt M W van de Garde
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Sorbonnelaan 16, 3584 CA Utrecht, and Department of Clinical Pharmacy, St Antonius Hospital, Nieuwegein, The Netherlands
    Respir Med 100:1342-8. 2006
    ..To assess whether prior outpatient treatment is associated with outcome in patients hospitalized for community-acquired pneumonia (CAP)...
  23. ncbi request reprint Difference in risks of allergic reaction to sulfonamide drugs based on chemical structure
    B Marianne Verdel
    Utrecht Institute for Pharmaceutical Sciences UIPS, Faculty of Science, Utrecht University, Netherlands
    Ann Pharmacother 40:1040-6. 2006
    ..The chemical structure of sulfonamide antibiotics and sulfonamide nonantibiotics can affect the potential for adverse reactions...
  24. doi request reprint Increased bleeding risk with concurrent use of selective serotonin reuptake inhibitors and coumarins
    Tom Schalekamp
    Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    Arch Intern Med 168:180-5. 2008
    ....
  25. doi request reprint Discontinuation of statins among patients with type 2 diabetes
    E J F Lamberts
    Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Diabetes Metab Res Rev 28:241-5. 2012
    ....
  26. doi request reprint Influence of antidepressants on glycaemic control in patients with diabetes mellitus
    M J Knol
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Pharmacoepidemiol Drug Saf 17:577-86. 2008
    ..Anecdotal evidence suggests that antidepressants (ADs) may complicate glycaemic control. The objective of this longitudinal study was to investigate the influence of ADs on glycaemic control within diabetes patients...
  27. ncbi request reprint Risk of drug-induced photosensitivity: focus on spectroscopic and molecular characteristics
    B M Verdel
    Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences UIPS, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    Pharmacoepidemiol Drug Saf 18:602-9. 2009
    ..Drug-induced photosensitivity is difficult to predict and remains a challenge for both the dermatological clinical practice and pharmacovigilance...
  28. doi request reprint Antipsychotic drug use and risk of pneumonia in elderly people
    Wilma Knol
    Department of Geriatrics, University Medical Center Utrecht, Utrecht, The Netherlands
    J Am Geriatr Soc 56:661-6. 2008
    ..To investigate the association between antipsychotic drug use and risk of pneumonia in elderly people...
  29. ncbi request reprint Drug-induced thrombocytopenia: a population study
    Maarten J Ten Berg
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands
    Drug Saf 29:713-21. 2006
    ..This study aims to quantify the risk for thrombocytopenia following exposure to drugs that are most often reported to cause thrombocytopenia in the general population...
  30. pmc Is aspirin useful in patients on lithium? A pharmacoepidemiological study related to bipolar disorder
    Pieter Stolk
    Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands
    Prostaglandins Leukot Essent Fatty Acids 82:9-14. 2010
    ..We hypothesized that other agents that target the brain AA cascade, nonsteroidal anti-inflammatory drugs (NSAIDs) and glucocorticoids, also would ameliorate BD symptoms...
  31. ncbi request reprint Risk of aplastic anemia in patients using antiepileptic drugs
    Kim B Handoko
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands
    Epilepsia 47:1232-6. 2006
    ..To assess the association between exposure to antiepileptic drugs (AEDs) and the occurrence of aplastic anemia...
  32. doi request reprint Medication changes prior to hospitalization for obstructive lung disease: a case-crossover study
    Karin J Velthove
    Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, The Netherlands
    Ann Pharmacother 44:267-73. 2010
    ..Hospitalizations have always been seen as a solid outcome parameter in pharmacoepidemiology. However, the period leading to hospitalization and prehospital management of the patient are equally important...
  33. doi request reprint Effects of glucocorticoids on the neutrophil count: a cohort study among hospitalized patients
    Karin J Velthove
    Faculty of Science, Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, P O BOX 80082, 3508 TB Utrecht, The Netherlands
    Pulm Pharmacol Ther 23:129-34. 2010
    ..The objective of this study was to investigate the effect of systemic glucocorticoids on the absolute neutrophil count in hospitalized patients...
  34. ncbi request reprint Drug-related nephrotoxic and ototoxic reactions : a link through a predictive mechanistic commonality
    Bertha Maria Verdel
    Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences UIPS, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    Drug Saf 31:877-84. 2008
    ..It has been suggested that drugs that influence the transport of sodium and/or potassium change ionic homeostasis in the inner ear and, hence, induce functional disturbances such as hearing loss, tinnitus and vertigo...
  35. ncbi request reprint Antidepressant prescribing in five European countries: application of common definitions to assess the prevalence, clinical observations, and methodological implications
    V Abbing-Karahagopian
    Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht University, P O Box 80 082, Utrecht, The Netherlands
    Eur J Clin Pharmacol 70:849-57. 2014
    ..The aim of this study was to describe the time trends in antidepressant prescribing in the last decade and the variation in the prevalence, calculated in a uniform manner, in seven European electronic healthcare databases...
  36. doi request reprint Identification of exacerbations in obstructive lung disease through biomarkers
    Karin J Velthove
    Faculty of Science, Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands
    Biomarkers 14:523-8. 2009
    ..In conclusion, neutrophil and eosinophil counts seem to be useful biomarkers for identifying exacerbations in pharmacoepidemiological studies on obstructive lung disease...
  37. ncbi request reprint Association between hospitalization and discontinuity of medication therapy used in the community setting in the Netherlands
    Rutger Stuffken
    Division of Pharmacoepidemiology and Pharmacotherapy, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, NetherlandsNetherlands
    Ann Pharmacother 42:933-9. 2008
    ..Hospitalization may put patients at increased risk of discontinuity of medication use...
  38. doi request reprint Measuring exacerbations in obstructive lung disease
    Karin J Velthove
    Division of Pharmacoepidemiology and Pharmacotherapy, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands
    Pharmacoepidemiol Drug Saf 19:367-74. 2010
    ..The aim of this study was to quantify the incidence of different exacerbation markers in obstructive lung disease and to identify predictors for these exacerbation markers...
  39. doi request reprint Construction of drug treatment episodes from drug-dispensing histories is influenced by the gap length
    Helga Gardarsdottir
    Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CA Utrecht, The Netherlands
    J Clin Epidemiol 63:422-7. 2010
    ..We investigated how different methods used to construct antidepressant treatment episodes influence their median estimated length...
  40. pmc Society already achieves economic benefits from generic substitution but fails to do the same for therapeutic substitution
    Pearl D Gumbs
    Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, Utrecht, The Netherlands
    Br J Clin Pharmacol 64:680-5. 2007
    ..To assess the potential annual savings due to generic and therapeutic substitution of statin therapy for the general Dutch population, taking the patients medical history into account...
  41. ncbi request reprint Evaluation of risk profiles for gastrointestinal and cardiovascular adverse effects in nonselective NSAID and COX-2 inhibitor users: a cohort study using pharmacy dispensing data in The Netherlands
    Deborah Layton
    Drug Safety Research Unit, Blundell Lane, Southampton, Hampshire, England
    Drug Saf 31:143-58. 2008
    ..The channelling paradox may exist for cyclo-oxygenase (COX)-2 selective inhibitors ('coxibs') instead of traditional nonselective NSAIDs in relation to both gastrointestinal (GI) and cardiovascular (CV) safety...