T Pattij

Summary

Affiliation: Utrecht University
Country: The Netherlands

Publications

  1. ncbi request reprint Effects of drug discrimination history on anti-punishment properties of chlordiazepoxide in rats
    T Pattij
    Department of Psychopharmacology, Faculty of Pharmacy, Utrecht University, Sorbonnelaan 16, 3584 CA, Utrecht, Netherlands
    Pharmacol Biochem Behav 67:621-7. 2000
  2. ncbi request reprint Autonomic changes associated with enhanced anxiety in 5-HT(1A) receptor knockout mice
    Tommy Pattij
    Department of Psychopharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Neuropsychopharmacology 27:380-90. 2002
  3. ncbi request reprint GABA(A)-benzodiazepine receptor complex sensitivity in 5-HT(1A) receptor knockout mice on a 129/Sv background
    Tommy Pattij
    Department of Psychopharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, 3584 CA, Utrecht, Netherlands
    Eur J Pharmacol 447:67-74. 2002
  4. ncbi request reprint Stress-induced hyperthermia in the 5-HT(1A) receptor knockout mouse is normal
    T Pattij
    Department of Psychopharmacology, Faculty of Pharmacy, Utrecht University, Utrecht, The Netherlands
    Biol Psychiatry 49:569-74. 2001
  5. ncbi request reprint The 5-HT(1A) receptor knockout mouse and anxiety
    B Olivier
    Department of Psychopharmacology, Faculty of Pharmacy, Utrecht University, Sorbonnelaan 16, 3584CA Utrecht, The Netherlands
    Behav Pharmacol 12:439-50. 2001
  6. ncbi request reprint 5-HT1B receptor knockout, but not 5-HT1A receptor knockout mice, show reduced startle reactivity and footshock-induced sensitization, as measured with the acoustic startle response
    A Dirks
    Department of Psychopharmacology, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
    Behav Brain Res 118:169-78. 2001
  7. ncbi request reprint Psychopharmacology of male rat sexual behavior: modeling human sexual dysfunctions?
    B Olivier
    Department of Psychopharmacology, Utrecht Institute for Pharmaceutical Sciences and Rudolf Magnus Institute of Neuroscience, Utrecht University, Utrecht, The Netherlands
    Int J Impot Res 18:S14-23. 2006
  8. ncbi request reprint Effects of chronic treatment with fluvoxamine and paroxetine during adolescence on serotonin-related behavior in adult male rats
    Trynke R de Jong
    Department of Anatomy, Radboud University Nijmegen Medical Centre, Intern Mail Nr 230 Postbus 9101 6500 HB, Nijmegen, The Netherlands
    Eur Neuropsychopharmacol 16:39-48. 2006
  9. ncbi request reprint Individual differences in male rat ejaculatory behaviour: searching for models to study ejaculation disorders
    Tommy Pattij
    Department of Anatomy, University Medical Center St Radboud, Nijmegen, The Netherlands
    Eur J Neurosci 22:724-34. 2005
  10. ncbi request reprint Impulsive choice and impulsive action predict vulnerability to distinct stages of nicotine seeking in rats
    Leontien Diergaarde
    Center for Neurogenomics and Cognitive Research, Department of Anatomy and Neurosciences, VU Medical Center, Amsterdam, The Netherlands
    Biol Psychiatry 63:301-8. 2008

Detail Information

Publications20

  1. ncbi request reprint Effects of drug discrimination history on anti-punishment properties of chlordiazepoxide in rats
    T Pattij
    Department of Psychopharmacology, Faculty of Pharmacy, Utrecht University, Sorbonnelaan 16, 3584 CA, Utrecht, Netherlands
    Pharmacol Biochem Behav 67:621-7. 2000
    ..The data indicate that rats can be reliably trained and tested in drug discrimination and conflict procedures within a single session and that CDP's discriminative stimulus does not alter its anti-conflict effects...
  2. ncbi request reprint Autonomic changes associated with enhanced anxiety in 5-HT(1A) receptor knockout mice
    Tommy Pattij
    Department of Psychopharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Neuropsychopharmacology 27:380-90. 2002
    ..The present findings show that 5-HT(1A) receptor KO mice display a more "anxious-like" phenotype not only at a behavioral, but also at autonomic levels...
  3. ncbi request reprint GABA(A)-benzodiazepine receptor complex sensitivity in 5-HT(1A) receptor knockout mice on a 129/Sv background
    Tommy Pattij
    Department of Psychopharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, 3584 CA, Utrecht, Netherlands
    Eur J Pharmacol 447:67-74. 2002
    ..The anxious phenotype of 1AKO mice seems to occur independent of the GABA(A)-benzodiazepine receptor complex functioning...
  4. ncbi request reprint Stress-induced hyperthermia in the 5-HT(1A) receptor knockout mouse is normal
    T Pattij
    Department of Psychopharmacology, Faculty of Pharmacy, Utrecht University, Utrecht, The Netherlands
    Biol Psychiatry 49:569-74. 2001
    ..Moreover, on pharmacologic challenges with the 5-HT(1A) receptor agonist flesinoxan we expected an absence of the functional response in knockout mice relative to wild type mice...
  5. ncbi request reprint The 5-HT(1A) receptor knockout mouse and anxiety
    B Olivier
    Department of Psychopharmacology, Faculty of Pharmacy, Utrecht University, Sorbonnelaan 16, 3584CA Utrecht, The Netherlands
    Behav Pharmacol 12:439-50. 2001
    ..Depending on the genetic background, this null mutation may be associated with changes in GABA(A)-ergic neurotransmission. It is as yet unclear which mechanisms are involved in this intriguing differentiation...
  6. ncbi request reprint 5-HT1B receptor knockout, but not 5-HT1A receptor knockout mice, show reduced startle reactivity and footshock-induced sensitization, as measured with the acoustic startle response
    A Dirks
    Department of Psychopharmacology, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
    Behav Brain Res 118:169-78. 2001
    ..Furthermore, it is concluded that the hyperreactivity in 1BKO mice cannot be generalized to all stimuli, including the startling stimuli used in this study, but is probably restricted to mild environmental stimuli only...
  7. ncbi request reprint Psychopharmacology of male rat sexual behavior: modeling human sexual dysfunctions?
    B Olivier
    Department of Psychopharmacology, Utrecht Institute for Pharmaceutical Sciences and Rudolf Magnus Institute of Neuroscience, Utrecht University, Utrecht, The Netherlands
    Int J Impot Res 18:S14-23. 2006
    ..These preclinical studies and models contribute to a better understanding of the neurobiology of ejaculation and boost the development of novel drug targets to treat ejaculatory disorders such as premature and retarded ejaculation...
  8. ncbi request reprint Effects of chronic treatment with fluvoxamine and paroxetine during adolescence on serotonin-related behavior in adult male rats
    Trynke R de Jong
    Department of Anatomy, Radboud University Nijmegen Medical Centre, Intern Mail Nr 230 Postbus 9101 6500 HB, Nijmegen, The Netherlands
    Eur Neuropsychopharmacol 16:39-48. 2006
    ..No differences between the groups were found in the other tests. Apparently, chronic treatment with SSRIs during adolescence may cause mild changes in adult behavior...
  9. ncbi request reprint Individual differences in male rat ejaculatory behaviour: searching for models to study ejaculation disorders
    Tommy Pattij
    Department of Anatomy, University Medical Center St Radboud, Nijmegen, The Netherlands
    Eur J Neurosci 22:724-34. 2005
    ..Further exploring the neurobiological mechanisms underlying these differences may be a promising approach to gain insights into the aetiology of sexual dysfunctions such as premature, retarded or an-ejaculation...
  10. ncbi request reprint Impulsive choice and impulsive action predict vulnerability to distinct stages of nicotine seeking in rats
    Leontien Diergaarde
    Center for Neurogenomics and Cognitive Research, Department of Anatomy and Neurosciences, VU Medical Center, Amsterdam, The Netherlands
    Biol Psychiatry 63:301-8. 2008
    ..Although heavy smoking has been associated with impulsivity in humans, it is not clear whether poor impulse control represents a risk factor in the etiology of nicotine dependence...
  11. ncbi request reprint Operant learning and differential-reinforcement-of-low-rate 36-s responding in 5-HT1A and 5-HT1B receptor knockout mice
    Tommy Pattij
    Department of Anatomy, University Medical Center St Radboud, Geert Grooteplein 21, 6525 EZ Nijmegen, The Netherlands
    Behav Brain Res 141:137-45. 2003
    ..In contrast, 5-HT(1A) receptors appear to be involved in facilitation of autoshaping, but their role in impulsivity and prefrontal cortex-dependent learning and memory appears to be limited...
  12. ncbi request reprint 5-HT1A receptor knockout mice and mice overexpressing corticotropin-releasing hormone in models of anxiety
    Lucianne Groenink
    Department of Psychopharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, The Netherlands
    Eur J Pharmacol 463:185-97. 2003
    ..Rather than studying the direct consequences of alterations in the targeted gene, 1AKO and CRH-OE mice seem very valuable to study compensatory processes that seem to have taken place in reaction to life-long changes in gene expression...
  13. ncbi request reprint Stress-induced hyperthermia and anxiety: pharmacological validation
    Berend Olivier
    Department of Psychopharmacology, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, The Netherlands
    Eur J Pharmacol 463:117-32. 2003
    ....
  14. ncbi request reprint GABAA-benzodiazepine receptor complex ligands and stress-induced hyperthermia in singly housed mice
    Berend Olivier
    Department of Psychopharmacology, Faculty of Pharmacy, Utrecht University, Sorbonnelaan 16, 3584CA Utrecht, The Netherlands
    Pharmacol Biochem Behav 72:179-88. 2002
    ..The singly housed SIH is proposed as a simple and reliable screen for detecting anxiety-like properties of drugs that is valid in every mouse strain tested so far...
  15. ncbi request reprint Activation of the brain 5-HT2C receptors causes hypolocomotion without anxiogenic-like cardiovascular adjustments in mice
    Oliver Stiedl
    Center for Neurogenomics and Cognitive Research CNCR and Institute of Neurosciences INW, Vrije Universiteit Amsterdam, The Netherlands
    Neuropharmacology 52:949-57. 2007
    ..In summary, in view of lack of autonomic effects, and the lack of hypoactivity upon forebrain stimulation, the hypolocomotion induced by systemic mCPP cannot be explained by an enhanced anxiety-like state...
  16. pmc Effects of the cannabinoid CB1 receptor antagonist rimonabant on distinct measures of impulsive behavior in rats
    Tommy Pattij
    Department of Anatomy and Neurosciences, Research Institute Neurosciences Vrije Universiteit, Center for Neurogenomics and Cognitive Research, VU Medical Center, Van der Boechorststraat 7, Amsterdam, 1081 BT, The Netherlands
    Psychopharmacology (Berl) 193:85-96. 2007
    ..Pathological impulsivity is a prominent feature in several psychiatric disorders, but detailed understanding of the specific neuronal processes underlying impulsive behavior is as yet lacking...
  17. ncbi request reprint Involvement of dopamine D1 and D2 receptors in the nucleus accumbens core and shell in inhibitory response control
    Tommy Pattij
    Department of Anatomy and Neurosciences, Research Institute Neurosciences Vrije Universiteit, Center for Neurogenomics and Cognitive Research, VU Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    Psychopharmacology (Berl) 191:587-98. 2007
    ..Impaired inhibitory control over behavior is a key feature in various psychiatric disorders, and recent studies indicated an important role for dopamine D(1) and D(2) receptors and the nucleus accumbens (Acb) in this respect...
  18. ncbi request reprint Citalopram combined with WAY 100635 inhibits ejaculation and ejaculation-related Fos immunoreactivity
    Trynke R de Jong
    Department of Anatomy, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Eur J Pharmacol 509:49-59. 2005
    ..Citalopram reduced Fos-immunoreactivity in the arcuate hypothalamic nucleus, an area that might link serotonergic neurotransmission to ejaculation...
  19. ncbi request reprint Impulsive-like behavior in differential-reinforcement-of-low-rate 36 s responding in mice depends on training history
    Tommy Pattij
    Department of Anatomy, University Medical Center St Radboud, Geert Grooteplein 21, 6525 EZ Nijmegen, The Netherlands
    Neurosci Lett 354:169-71. 2004
    ..Taken together, the present data suggest that impulsive-like responding in the DRL 36 s procedure in mice depends on prior behavioral history...
  20. ncbi request reprint Serotonin transporter deficiency in rats improves inhibitory control but not behavioural flexibility
    Judith R Homberg
    Hubrecht Institute, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Eur J Neurosci 26:2066-73. 2007
    ....