Research Topics

Genomes and Genes


Björn P Meij


Affiliation: Utrecht University
Country: The Netherlands


  1. Olthof M, Lu L, Tryfonidou M, Loozen L, Pouran B, Yaszemski M, et al. The osteoinductive effect of controlled BMP-2 release is location-dependent. Tissue Eng Part A. 2018;: pubmed publisher
    ..Additionally, more bone formation in OPF-BP compared to ACS at both application sites emphasizes the role of biomaterials as a scaffold to achieve proper bone tissue formation. ..
  2. de Vries S, Doeselaar M, Meij B, Tryfonidou M, Ito K. Notochordal cell matrix as a therapeutic agent for intervertebral disc regeneration. Tissue Eng Part A. 2018;: pubmed publisher
    ..Therefore NCM has potential in a regenerative therapy for disc degeneration, and warrants additional in vivo studies. ..
  3. Del Magno S, Grinwis G, Voorhout G, Meij B. Dynamic computed tomography of the pituitary gland using a single slice scanner in dogs with pituitary-dependent hypercortisolism. Res Vet Sci. 2016;107:42-49 pubmed publisher
    ..However, based on this study, the aim of surgery in dogs with pituitary-dependent hypercortisolism remains total adenohypophysectomy, and when the neurophypophysis is recognized, it may be left in situ. ..
  4. Tellegen A, Willems N, Tryfonidou M, Meij B. Pedicle screw-rod fixation: a feasible treatment for dogs with severe degenerative lumbosacral stenosis. BMC Vet Res. 2015;11:299 pubmed publisher
    ..Pedicle screw-rod fixation alone does not result in interbody vertebral bone fusion between L7 and S1. ..
  5. Bach F, Zhang Y, Miranda Bedate A, Verdonschot L, Bergknut N, Creemers L, et al. Increased caveolin-1 in intervertebral disc degeneration facilitates repair. Arthritis Res Ther. 2016;18:59 pubmed publisher
    ..Further studies are needed to investigate how caveolin-1 modifies other signaling pathways and facilitates IVD repair. ..
  6. Teunissen M, Van der Veen A, Smit T, Tryfonidou M, Meij B. Effect of a titanium cage as a stand-alone device on biomechanical stability in the lumbosacral spine of canine cadavers. Vet J. 2017;220:17-23 pubmed publisher
    ..From a biomechanical point of view, the use of a stand-alone intervertebral cage is a potential alternative to dorsal fixation of the lumbosacral junction, since it increases spinal stability and restores disc height. ..
  7. Arkesteijn I, Smolders L, Spillekom S, Riemers F, Potier E, Meij B, et al. Effect of coculturing canine notochordal, nucleus pulposus and mesenchymal stromal cells for intervertebral disc regeneration. Arthritis Res Ther. 2015;17:60 pubmed publisher
    ..In this respect, NC-conditioned medium may be better than coculture for future studies of the regenerative potential of NCs. ..
  8. Willems N, Yang H, Langelaan M, Tellegen A, Grinwis G, Kranenburg H, et al. Biocompatibility and intradiscal application of a thermoreversible celecoxib-loaded poly-N-isopropylacrylamide MgFe-layered double hydroxide hydrogel in a canine model. Arthritis Res Ther. 2015;17:214 pubmed publisher
  9. request reprint
    Meij B, Suwankong N, van der Veen A, Hazewinkel H. Biomechanical flexion-extension forces in normal canine lumbosacral cadaver specimens before and after dorsal laminectomy-discectomy and pedicle screw-rod fixation. Vet Surg. 2007;36:742-51 pubmed
    ..Dorsal laminectomy and partial discectomy does not lead to significant spinal instability. Pedicle screw-rod fixation of L7 and S1 may be used to stabilize an unstable L7-S1 junction in dogs with degenerative lumbosacral stenosis. ..

More Information


  1. Meij B, Bergknut N. Degenerative lumbosacral stenosis in dogs. Vet Clin North Am Small Anim Pract. 2010;40:983-1009 pubmed publisher
    ..New insight into the biomechanics and pathobiology of DLSS and developments in minimally invasive surgical techniques will influence treatment options in the near future. ..
  2. Willems N, Bach F, Plomp S, Van Rijen M, Wolfswinkel J, Grinwis G, et al. Intradiscal application of rhBMP-7 does not induce regeneration in a canine model of spontaneous intervertebral disc degeneration. Arthritis Res Ther. 2015;17:137 pubmed publisher
  3. Olthof M, Tryfonidou M, Liu X, Pouran B, Meij B, Dhert W, et al. Phosphate functional groups improve OPF osteoconduction and BMP-2 osteoinductive efficacy. Tissue Eng Part A. 2017;: pubmed publisher
    ..Therefore, functionalizing hydrogels with phosphate groups by crosslinking monomers into the hydrogel matrix could provide a valuable method for improving polymer characteristics and hold great promise for bone tissue engineering. ..
  4. Smolders L, Meij B, Onis D, Riemers F, Bergknut N, Wubbolts R, et al. Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies. Arthritis Res Ther. 2013;15:R23 pubmed publisher
    ..Therefore, Caveolin-1 may be regarded an exciting target for developing strategies for IVD regeneration. ..