Aletta D Kraneveld

Summary

Affiliation: Utrecht University
Country: The Netherlands

Publications

  1. doi request reprint The two faces of mast cells in food allergy and allergic asthma: the possible concept of Yin Yang
    Aletta D Kraneveld
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    Biochim Biophys Acta 1822:93-9. 2012
  2. ncbi request reprint Neuro-immune interactions in inflammatory bowel disease and irritable bowel syndrome: future therapeutic targets
    Aletta D Kraneveld
    Division Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands
    Eur J Pharmacol 585:361-74. 2008
  3. ncbi request reprint Beneficial effect of tachykinin NK1 receptor antagonism in the development of hapten-induced colitis in mice
    Anneke Rijnierse
    Division of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Eur J Pharmacol 548:150-7. 2006
  4. pmc Cigarette smoke-induced collagen destruction; key to chronic neutrophilic airway inflammation?
    Saskia A Overbeek
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    PLoS ONE 8:e55612. 2013
  5. doi request reprint Chemo-attractant N-acetyl proline-glycine-proline induces CD11b/CD18-dependent neutrophil adhesion
    Saskia A Overbeek
    Division of Pharmacology, Utrecht University, Utrecht, The Netherlands
    Biochim Biophys Acta 1830:2188-93. 2013
  6. doi request reprint The combination of Bifidobacterium breve with non-digestible oligosaccharides suppresses airway inflammation in a murine model for chronic asthma
    Seil Sagar
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands Danone Research, Centre for Specialised Nutrition, Wageningen, The Netherlands Electronic address
    Biochim Biophys Acta 1842:573-83. 2014
  7. doi request reprint CXCR2 antagonists block the N-Ac-PGP-induced neutrophil influx in the airways of mice, but not the production of the chemokine CXCL1
    Saskia Braber
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    Eur J Pharmacol 668:443-9. 2011
  8. pmc Cigarette smoke-induced lung emphysema in mice is associated with prolyl endopeptidase, an enzyme involved in collagen breakdown
    Saskia Braber
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht Univ, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 300:L255-65. 2011
  9. ncbi request reprint An association between neutrophils and immunoglobulin free light chains in the pathogenesis of chronic obstructive pulmonary disease
    Saskia Braber
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, The Netherlands
    Am J Respir Crit Care Med 185:817-24. 2012
  10. ncbi request reprint The tachykinin NK1 receptor is crucial for the development of non-atopic airway inflammation and hyperresponsiveness
    Hanneke P M van der Kleij
    Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands
    Eur J Pharmacol 476:249-55. 2003

Collaborators

Detail Information

Publications51

  1. doi request reprint The two faces of mast cells in food allergy and allergic asthma: the possible concept of Yin Yang
    Aletta D Kraneveld
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    Biochim Biophys Acta 1822:93-9. 2012
    ..Therefore, mast cells can be regarded as 'Ying Yan' modulators in allergic responses in intestinal tract and airways. This article is part of a Special Issue entitled: Mast Cells in Inflammation...
  2. ncbi request reprint Neuro-immune interactions in inflammatory bowel disease and irritable bowel syndrome: future therapeutic targets
    Aletta D Kraneveld
    Division Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands
    Eur J Pharmacol 585:361-74. 2008
    ..Investigations of receptor-mediated and intracellular signal pathways in neuro-immune interactions might help to develop more effective therapeutic approaches for chronic inflammatory intestinal diseases...
  3. ncbi request reprint Beneficial effect of tachykinin NK1 receptor antagonism in the development of hapten-induced colitis in mice
    Anneke Rijnierse
    Division of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Eur J Pharmacol 548:150-7. 2006
    ....
  4. pmc Cigarette smoke-induced collagen destruction; key to chronic neutrophilic airway inflammation?
    Saskia A Overbeek
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    PLoS ONE 8:e55612. 2013
    ..Here we investigated whether cigarette smoke extract (CSE) stimulates human PMNs to breakdown whole matrix collagen leading to the generation of the chemotactic collagen fragment N-ac-PGP...
  5. doi request reprint Chemo-attractant N-acetyl proline-glycine-proline induces CD11b/CD18-dependent neutrophil adhesion
    Saskia A Overbeek
    Division of Pharmacology, Utrecht University, Utrecht, The Netherlands
    Biochim Biophys Acta 1830:2188-93. 2013
    ..In the current study, we investigate whether N-ac-PGP influences β(2)-integrin activation and function in neutrophilic firm adhesion to endothelium...
  6. doi request reprint The combination of Bifidobacterium breve with non-digestible oligosaccharides suppresses airway inflammation in a murine model for chronic asthma
    Seil Sagar
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands Danone Research, Centre for Specialised Nutrition, Wageningen, The Netherlands Electronic address
    Biochim Biophys Acta 1842:573-83. 2014
    ....
  7. doi request reprint CXCR2 antagonists block the N-Ac-PGP-induced neutrophil influx in the airways of mice, but not the production of the chemokine CXCL1
    Saskia Braber
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    Eur J Pharmacol 668:443-9. 2011
    ....
  8. pmc Cigarette smoke-induced lung emphysema in mice is associated with prolyl endopeptidase, an enzyme involved in collagen breakdown
    Saskia Braber
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht Univ, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 300:L255-65. 2011
    ..Together with MMPs, PE may play an important role in the formation of PGP and thus in the pathophysiology of lung emphysema...
  9. ncbi request reprint An association between neutrophils and immunoglobulin free light chains in the pathogenesis of chronic obstructive pulmonary disease
    Saskia Braber
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, The Netherlands
    Am J Respir Crit Care Med 185:817-24. 2012
    ..Interestingly, immunoglobulin free light chains (IgLC) are able to prolong the life of neutrophils; therefore, IgLC may contribute to the chronic state of inflammation...
  10. ncbi request reprint The tachykinin NK1 receptor is crucial for the development of non-atopic airway inflammation and hyperresponsiveness
    Hanneke P M van der Kleij
    Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands
    Eur J Pharmacol 476:249-55. 2003
    ..In conclusion, distal from mast cell activation, the tachykinin NK1 receptor is crucial for the infiltration of pulmonary neutrophils and the development of tracheal hyperreactivity in non-atopic asthma...
  11. ncbi request reprint Ig-free light chains play a crucial role in murine mast cell-dependent colitis and are associated with human inflammatory bowel diseases
    Anneke Rijnierse
    Division of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    J Immunol 185:653-9. 2010
    ..Our data suggest that IgLCs may play a role in the pathogenesis of IBD, which provides novel therapeutic means to prevent or ameliorate the adverse gastrointestinal manifestations of IBD...
  12. ncbi request reprint Key role for mast cells in nonatopic asthma
    Aletta D Kraneveld
    Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    J Immunol 169:2044-53. 2002
    ..Our findings show that mast cells play a key role in the regulation of pulmonary hypersensitivity responses in this murine model for nonatopic asthma...
  13. doi request reprint Transcriptional modulation of pattern recognition receptors in acute colitis in mice
    Bin Zheng
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, The Netherlands
    Biochim Biophys Acta 1832:2162-72. 2013
    ..This study provides an extensive expression survey of PRRs along the colon during the acute colitis and shows that the induced inflammation is characterized by a Th1- and IL-17 mediated cytokine response. ..
  14. pmc Collagen degradation and neutrophilic infiltration: a vicious circle in inflammatory bowel disease
    Pim J Koelink
    Division of Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Gut 63:578-87. 2014
    ..PGP is derived from collagen by the combined action of matrix metalloproteinase (MMP) 8 and/or MMP9 and prolyl endopeptidase (PE). We investigated the role of PGP in inflammatory bowel disease (IBD)...
  15. pmc Elicitation of allergic asthma by immunoglobulin free light chains
    Aletta D Kraneveld
    Department of Pharmacology and Pathophysiology, Faculty of Pharmaceutical Sciences, Utrecht University, 3508 TB Utrecht, The Netherlands
    Proc Natl Acad Sci U S A 102:1578-83. 2005
    ..In addition, the ability to inhibit pharmacologically LC-induced mast cell activation provides a therapeutic means to prevent or ameliorate the adverse bronchopulmonary manifestations of this incapacitating disorder...
  16. ncbi request reprint Murine model for non-IgE-mediated asthma
    Hanneke P M van der Kleij
    Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Inflammation 28:115-25. 2004
    ..These characteristics bear marked similarity with those observed in non-atopic asthmatic patients. Therefore, this model can be used to further study the mechanisms potentially responsible for the development of non-IgE-mediated asthma...
  17. ncbi request reprint TNF-alpha is crucial for the development of mast cell-dependent colitis in mice
    Anneke Rijnierse
    Division of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands
    Am J Physiol Gastrointest Liver Physiol 291:G969-76. 2006
    ..These findings suggest that TNF-alpha can play an instrumental role in causing inflammatory responses in the present murine model for IBD downstream from mast cell activation...
  18. doi request reprint Targeting chemokine receptors in chronic inflammatory diseases: an extensive review
    Pim J Koelink
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Sciences, Utrecht University, Utrecht, The Netherlands
    Pharmacol Ther 133:1-18. 2012
    ....
  19. pmc Bifidobacterium breve and Lactobacillus rhamnosus treatment is as effective as budesonide at reducing inflammation in a murine model for chronic asthma
    Seil Sagar
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands
    Respir Res 15:46. 2014
    ....
  20. doi request reprint Immunoglobulinfree light chains reduce in an antigen-specific manner the rate of rise of action potentials of mouse non-nociceptive dorsal root ganglion neurons
    Anneke Rijnierse
    Division of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands Electronic address
    J Neuroimmunol 264:14-23. 2013
    ..We suggest that antigen-specific activation of IgLC-sensitized non-nociceptive DRG neurons may contribute to immunological hypersensitivity responses and neuroinflammation. ..
  21. doi request reprint Immunoglobulin-free light chains mediate antigen-specific responses of murine dorsal root ganglion neurons
    Anneke Rijnierse
    Division of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    J Neuroimmunol 208:80-6. 2009
    ..These results show that IgLC and IgE can mediate antigen-specific responses in murine neurons. Our findings present a novel way of antigen-specific neuronal activation...
  22. pmc Inflammatory changes in the airways of mice caused by cigarette smoke exposure are only partially reversed after smoking cessation
    Saskia Braber
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    Respir Res 11:99. 2010
    ..To the best of our knowledge, this is the first reported in vivo study in which cytokine profiles were determined after cessation of cigarette smoke exposure...
  23. ncbi request reprint Mast cells and nerves tickle in the tummy: implications for inflammatory bowel disease and irritable bowel syndrome
    Anneke Rijnierse
    Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands
    Pharmacol Ther 116:207-35. 2007
    ..In this review the focus lies on studies appointed to the direct interaction between mast cells and nerves in IBD, IBS, and animal models for these disorders so far...
  24. pmc Cigarette smoke induces β2-integrin-dependent neutrophil migration across human endothelium
    Saskia A Overbeek
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    Respir Res 12:75. 2011
    ..The aim of this study was to investigate the effect of cigarette smoke on neutrophil migration and on β2-integrin activation and function in neutrophilic transmigration through endothelium...
  25. ncbi request reprint Intestinal epithelium-derived galectin-9 is involved in the immunomodulating effects of nondigestible oligosaccharides
    Sander de Kivit
    Division of Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    J Innate Immun 5:625-38. 2013
    ..Our findings show that galectin-9 secreted by IEC apically exposed to TLR9 ligand in the presence of scGOS/lcFOS is involved in Th1 and Treg polarization and may be a promising target to prevent or treat allergic disease. ..
  26. doi request reprint Intestinal inflammation in a murine model of autism spectrum disorders
    Caroline G M de Theije
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands Electronic address
    Brain Behav Immun 37:240-7. 2014
    ....
  27. pmc New perspective on dextran sodium sulfate colitis: antigen-specific T cell development during intestinal inflammation
    Mary E Morgan
    Division of Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    PLoS ONE 8:e69936. 2013
    ..This gives added depth and utility to the DSS model as well as a way to track T cells that are primed against luminal antigens. ..
  28. doi request reprint Autistic-like behavioural and neurochemical changes in a mouse model of food allergy
    Caroline G M de Theije
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands Electronic address
    Behav Brain Res 261:265-74. 2014
    ..Together with a genetic predisposition and multiple environmental factors, these effects of allergic immune activation may exacerbate behavioural abnormalities in patients with ASD. ..
  29. doi request reprint Lipopolysaccharide increases degradation of central monoamines: an in vivo microdialysis study in the nucleus accumbens and medial prefrontal cortex of mice
    Floor van Heesch
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, Faculty of Science, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands Electronic address
    Eur J Pharmacol 725:55-63. 2014
    ..In conclusion, the present findings suggest that peripheral LPS increases DAT activity in the nucleus accumbens and increases NET and SERT activity in the medial prefrontal cortex of mice...
  30. ncbi request reprint Critical role for mast cells in the pathogenesis of 2,4-dinitrobenzene-induced murine colonic hypersensitivity reaction
    Anneke Rijnierse
    Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands
    J Immunol 176:4375-84. 2006
    ..This study demonstrates the importance of mast cells in the development of clinical symptoms and inflammation in the presented murine model for IBD...
  31. pmc N-acetylated Proline-Glycine-Proline induced G-protein dependent chemotaxis of neutrophils is independent of CXCL8 release
    Saskia A Overbeek
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    Eur J Pharmacol 668:428-34. 2011
    ..In vivo, this may lead in the long term to a self-maintaining situation enhanced by both N-ac-PGP and CXCL8, leading to a further increase in neutrophil infiltration and chronic inflammation...
  32. ncbi request reprint The neuro-immune axis: prospect for novel treatments for mental disorders
    Aletta D Kraneveld
    Division of Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Basic Clin Pharmacol Toxicol 114:128-36. 2014
    ..Pharmacologically bioactive molecules as well as medical nutrition targeting the (gut)-immune-brain axis could be such an approach. ..
  33. doi request reprint Systemic tumor necrosis factor-alpha decreases brain stimulation reward and increases metabolites of serotonin and dopamine in the nucleus accumbens of mice
    Floor van Heesch
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences UIPS, Faculty of Science, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands
    Behav Brain Res 253:191-5. 2013
    ..However, more research is needed to understand the precise molecular mechanisms by which TNF-α increases transporter activity and anhedonia. ..
  34. pmc Bifidobacterium breve Attenuates Murine Dextran Sodium Sulfate-Induced Colitis and Increases Regulatory T Cell Responses
    Bin Zheng
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Science, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    PLoS ONE 9:e95441. 2014
    ..In vivo B. breve intervention ameliorates DSS-induced colitis symptoms and this protective effect may mediated by its effects on the T-cell composition. ..
  35. pmc Differential regulation of inflammation and immunity in mild and severe experimental asthma
    Seil Sagar
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    Mediators Inflamm 2013:808470. 2013
    ..This preclinical data may help in directing clinical research towards a better understanding and therapy in mild and severe asthmatic patients...
  36. pmc Effect of cigarette smoke extract on dendritic cells and their impact on T-cell proliferation
    Esmaeil Mortaz
    Division of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    PLoS ONE 4:e4946. 2009
    ..The cigarette smoke-induced release of CCL3 and CXCL2 by DCs may contribute to the influx of CD8(+)T cells and neutrophils into the airways, respectively...
  37. pmc Cigarette smoke attenuates the production of cytokines by human plasmacytoid dendritic cells and enhances the release of IL-8 in response to TLR-9 stimulation
    Esmaeil Mortaz
    Division of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Respir Res 10:47. 2009
    ....
  38. doi request reprint Dual role of Toll-like receptors in asthma and chronic obstructive pulmonary disease
    Gillina F G Bezemer
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    Pharmacol Rev 64:337-58. 2012
    ..Because of a possible dual role of TLRs in airway diseases with shared symptoms and risk factors but different immunological mechanisms, caution should be taken while designing pulmonary TLR-based therapies...
  39. ncbi request reprint Functional expression of neurokinin 1 receptors on mast cells induced by IL-4 and stem cell factor
    Hanneke P M van der Kleij
    Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    J Immunol 171:2074-9. 2003
    ..In conclusion, BMMC were shown to express NK(1) receptors upon IL-4/SCF coculture. This expression of NK(1) receptors has been demonstrated to be of functional relevance and leads to an increase in the sensitivity of BMMC to substance P...
  40. ncbi request reprint Food allergy and food-based therapies in neurodevelopmental disorders
    Caroline G M de Theije
    Division of Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Pediatr Allergy Immunol 25:218-26. 2014
    ..Furthermore, opportunities for nutritional interventions in neurodevelopmental disorders are provided. ..
  41. doi request reprint Neuroprotective and cognitive enhancing effects of a multi-targeted food intervention in an animal model of neurodegeneration and depression
    Yuliya E Borre
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands Rudolf Magnus Institute of Neuroscience, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands Electronic address
    Neuropharmacology 79:738-49. 2014
    ..This proof-of-concept study suggests that a diet, which simultaneously targets multiple disease etiologies, can prevent/impede the development of a neurodegenerative and depressive disorders and the concomitant cognitive deficits. ..
  42. ncbi request reprint Immunoglobulin-free light chains elicit immediate hypersensitivity-like responses
    Frank A Redegeld
    Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Nat Med 8:694-701. 2002
    ..IgLCs may therefore be a novel factor in the humoral immune response to antigen exposure. Our findings open new avenues in investigating the pathogenesis of autoimmune diseases and their treatments...
  43. pmc Extracellular vesicles modulate host-microbe responses by altering TLR2 activity and phagocytosis
    Jeroen van Bergenhenegouwen
    Nutricia Research, Utrecht, The Netherlands Department of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    PLoS ONE 9:e89121. 2014
    ..EVs can be found in any tissue or bodily fluid, therefore insights into EV-microbe interactions are important in understanding the mechanism of action of potential probiotics and gut immune homeostasis...
  44. doi request reprint Lipopolysaccharide-induced anhedonia is abolished in male serotonin transporter knockout rats: an intracranial self-stimulation study
    Floor van Heesch
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Faculty of Science, Universiteitsweg 99, Utrecht, The Netherlands
    Brain Behav Immun 29:98-103. 2013
    ..Therefore, it is concluded that an intact SERT function is needed for pro-inflammatory cytokine-induced anhedonia and weight loss in rats...
  45. pmc Cigarette smoke regulates the expression of TLR4 and IL-8 production by human macrophages
    Hadi Sarir
    Division of Pharmacology and Pathophysiology, Departement of Pharmaceutical Sciences, Faculty of Sciences, Utrecht University, The Netherlands
    J Inflamm (Lond) 6:12. 2009
    ..Cigarette smoke contains high concentration of oxidants which can stimulate immune cells to produce reactive oxygen species, cytokines and chemokines...
  46. doi request reprint Altered gut microbiota and activity in a murine model of autism spectrum disorders
    Caroline G M de Theije
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    Brain Behav Immun 37:197-206. 2014
    ..These results open new avenues in the scientific trajectory of managing neurodevelopmental disorders by gut microbiome modulation. ..
  47. doi request reprint New endogenous CXC chemokine ligands as potential targets in lung emphysema
    Gert Folkerts
    Division of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, 3508 TB Utrecht, The Netherlands
    Trends Pharmacol Sci 29:181-5. 2008
    ..In this opinion article we will present a new hypothesis through which the chronicity and remodeling of tissue of several inflammatory diseases could be explained...
  48. ncbi request reprint Mast cell-derived TNF-alpha primes sensory nerve endings in a pulmonary hypersensitivity reaction
    Anneke H van Houwelingen
    Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3508 TB Utrecht, The Netherlands
    J Immunol 168:5297-302. 2002
    ....
  49. doi request reprint Pathways underlying the gut-to-brain connection in autism spectrum disorders as future targets for disease management
    Caroline G M de Theije
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    Eur J Pharmacol 668:S70-80. 2011
    ..This review focuses on the importance of (allergic) gastrointestinal problems in ASD. We provide an overview of the possible gut-to-brain pathways and discuss opportunities for pharmaceutical and/or nutritional approaches for therapy...
  50. doi request reprint Glycan recognition at the interface of the intestinal immune system: target for immune modulation via dietary components
    Sander de Kivit
    Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Eur J Pharmacol 668:S124-32. 2011
    ..Insight in the recognition of glycans in the intestinal tract may open new avenues for the treatment of intestinal inflammatory diseases by either nutritional concepts or pharmacological intervention...
  51. ncbi request reprint A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation
    Nathaniel M Weathington
    Department of Physiology and Biophysics, University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, Alabama 35294, USA
    Nat Med 12:317-23. 2006
    ..Thus, PGP's activity links degradation of ECM with neutrophil recruitment in airway inflammation, and PGP may be a biomarker and therapeutic target for neutrophilic inflammatory diseases...