Ad Koets

Summary

Affiliation: Utrecht University
Country: The Netherlands

Publications

  1. ncbi request reprint Heat-shock protein-specific T-cell responses in various stages of bovine paratuberculosis
    A P Koets
    Department of Immunology, Institute of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    Vet Immunol Immunopathol 70:105-15. 1999
  2. pmc Differential changes in heat shock protein-, lipoarabinomannan-, and purified protein derivative-specific immunoglobulin G1 and G2 isotype responses during bovine Mycobacterium avium subsp. paratuberculosis infection
    A P Koets
    Department of Immunology, Institute of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Infect Immun 69:1492-8. 2001
  3. pmc Progressive bovine paratuberculosis is associated with local loss of CD4(+) T cells, increased frequency of gamma delta T cells, and related changes in T-cell function
    Ad Koets
    Immunology Division, Department of Infectious Diseases and Immunology, Utrecht University, Utrecht, The Netherlands
    Infect Immun 70:3856-64. 2002
  4. ncbi request reprint Mycobacterial 70 kD heat-shock protein is an effective subunit vaccine against bovine paratuberculosis
    Ad Koets
    Department of Farm Animal Health, P O Box 80 165, Faculty of Veterinary Medicine, Utrecht University, 3508 TD Utrecht, The Netherlands
    Vaccine 24:2550-9. 2006
  5. ncbi request reprint Genetic variation of susceptibility to Mycobacterium avium subsp. paratuberculosis infection in dairy cattle
    A P Koets
    Institute of Infectious Diseases and Immunology, Department of Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    J Dairy Sci 83:2702-8. 2000
  6. doi request reprint Hsp70 vaccination-induced antibodies recognize B cell epitopes in the cell wall of Mycobacterium avium subspecies paratuberculosis
    Wiebren Santema
    Immunology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, P O Box 80165, 3508 TD Utrecht, The Netherlands
    Vaccine 29:1364-73. 2011
  7. doi request reprint Heat shock protein 70 subunit vaccination against bovine paratuberculosis does not interfere with current immunodiagnostic assays for bovine tuberculosis
    Wiebren Santema
    Department of Infectious Diseases and Immunology, Immunology Division, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Vaccine 27:2312-9. 2009
  8. doi request reprint Searching for proteins of Mycobacterium avium subspecies paratuberculosis with diagnostic potential by comparative qualitative proteomic analysis of mycobacterial tuberculins
    Wiebren Santema
    Department of Infectious Diseases and Immunology, Immunology Division, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Vet Microbiol 138:191-6. 2009
  9. pmc Postexposure subunit vaccination against chronic enteric mycobacterial infection in a natural host
    Wiebren Santema
    Epidemiology Division, Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Infect Immun 81:1990-5. 2013
  10. doi request reprint Immune response of cattle immunized with a conjugate of the glycolipid glucose monomycolate and protein
    Thi Kim Anh Nguyen
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584CL, Utrecht, The Netherlands
    Vet Immunol Immunopathol 142:265-70. 2011

Detail Information

Publications19

  1. ncbi request reprint Heat-shock protein-specific T-cell responses in various stages of bovine paratuberculosis
    A P Koets
    Department of Immunology, Institute of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    Vet Immunol Immunopathol 70:105-15. 1999
    ..Furthermore, this study shows that HSP70, being a well-defined antigen in comparison with PPD antigens, can be used to monitor cell-mediated immune responses in studies regarding the immunopathogenesis of bovine paratuberculosis...
  2. pmc Differential changes in heat shock protein-, lipoarabinomannan-, and purified protein derivative-specific immunoglobulin G1 and G2 isotype responses during bovine Mycobacterium avium subsp. paratuberculosis infection
    A P Koets
    Department of Immunology, Institute of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Infect Immun 69:1492-8. 2001
    ....
  3. pmc Progressive bovine paratuberculosis is associated with local loss of CD4(+) T cells, increased frequency of gamma delta T cells, and related changes in T-cell function
    Ad Koets
    Immunology Division, Department of Infectious Diseases and Immunology, Utrecht University, Utrecht, The Netherlands
    Infect Immun 70:3856-64. 2002
    ....
  4. ncbi request reprint Mycobacterial 70 kD heat-shock protein is an effective subunit vaccine against bovine paratuberculosis
    Ad Koets
    Department of Farm Animal Health, P O Box 80 165, Faculty of Veterinary Medicine, Utrecht University, 3508 TD Utrecht, The Netherlands
    Vaccine 24:2550-9. 2006
    ....
  5. ncbi request reprint Genetic variation of susceptibility to Mycobacterium avium subsp. paratuberculosis infection in dairy cattle
    A P Koets
    Institute of Infectious Diseases and Immunology, Department of Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    J Dairy Sci 83:2702-8. 2000
    ..Because the economic impact of the disease is substantial, the development and application of genetic tools, along with other control methods, could be instrumental in the eradication of paratuberculosis...
  6. doi request reprint Hsp70 vaccination-induced antibodies recognize B cell epitopes in the cell wall of Mycobacterium avium subspecies paratuberculosis
    Wiebren Santema
    Immunology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, P O Box 80165, 3508 TD Utrecht, The Netherlands
    Vaccine 29:1364-73. 2011
    ..These results indicate that vaccination-induced antibodies can bind intact bacteria and have the potential to contribute to the protective effect of Hsp70/DDA subunit vaccination against bovine paratuberculosis...
  7. doi request reprint Heat shock protein 70 subunit vaccination against bovine paratuberculosis does not interfere with current immunodiagnostic assays for bovine tuberculosis
    Wiebren Santema
    Department of Infectious Diseases and Immunology, Immunology Division, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Vaccine 27:2312-9. 2009
    ..In conclusion, the Hsp70/DDA subunit vaccine may contribute to paratuberculosis control strategies, without compromising diagnosis of bovine tuberculosis or paratuberculosis...
  8. doi request reprint Searching for proteins of Mycobacterium avium subspecies paratuberculosis with diagnostic potential by comparative qualitative proteomic analysis of mycobacterial tuberculins
    Wiebren Santema
    Department of Infectious Diseases and Immunology, Immunology Division, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Vet Microbiol 138:191-6. 2009
    ....
  9. pmc Postexposure subunit vaccination against chronic enteric mycobacterial infection in a natural host
    Wiebren Santema
    Epidemiology Division, Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Infect Immun 81:1990-5. 2013
    ..Targeted therapeutic postexposure vaccination complementary to selective use of antibiotics could be an effective approach for control of chronic mycobacterial infections...
  10. doi request reprint Immune response of cattle immunized with a conjugate of the glycolipid glucose monomycolate and protein
    Thi Kim Anh Nguyen
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584CL, Utrecht, The Netherlands
    Vet Immunol Immunopathol 142:265-70. 2011
    ..In conclusion, the generation of isotype-switched anti lipid antibodies appears to require more than providing peptide epitopes for T helper cells to support glycolipid specific B cells in antibody production...
  11. doi request reprint γδ T cell homing to skin and migration to skin-draining lymph nodes is CCR7 independent
    Manouk Vrieling
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584 CL, Utrecht, The Netherlands
    J Immunol 188:578-84. 2012
    ..Our findings suggest that γδ T cell skin egress and migration into the peripheral lymphatics is CCR7-independent and possibly mediated by CD62L expression...
  12. doi request reprint Bovine paratuberculosis: recent advances in vaccine development
    Wiebren Santema
    Department of Infectious Diseases and Immunology, Immunology Division, Utrecht University, Utrecht, The Netherlands
    Vet Q 31:183-91. 2011
    ..This review provides a brief overview of the microbiology, epidemiology and immunology of bovine paratuberculosis, and focuses on recent advances in the development of vaccines against paratuberculosis...
  13. ncbi request reprint Immunopotentiating heat shock proteins: negotiators between innate danger and control of autoimmunity
    Willem van Eden
    Division of Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 2584CL, Utrecht, The Netherlands
    Vaccine 21:897-901. 2003
    ....
  14. ncbi request reprint Intra-uterine transmission of paratuberculosis (Johne's disease) in farmed red deer
    H C J van Kooten
    Department of Farm Animal Health, Faculty of Veterinary Medicine, University of Utrecht, Yalelaan 1, De Uithof, 3584 CL Utrecht, Netherlands
    N Z Vet J 54:16-20. 2006
    ..To determine whether intra-uterine transmission of paratuberculosis (Johne's disease) occurs in farmed red deer (Cervus elaphus) in New Zealand...
  15. ncbi request reprint Postweaning growth check in pigs is markedly reduced by intermittent suckling and extended lactation
    M Berkeveld
    Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 7, 3584 CL Utrecht, The Netherlands
    J Anim Sci 85:258-66. 2007
    ..Because the IS6 regimen did not prevent the growth check after the onset of IS and is rather laborious, we suggest that IS12 might be preferable for a practical implementation of IS...
  16. ncbi request reprint Mycobacterium avium ssp. paratuberculosis recombinant heat shock protein 70 interaction with different bovine antigen-presenting cells
    M F M Langelaar
    Department of Infectious Diseases and Immunology, Utrecht University, Utrecht, Netherlands
    Scand J Immunol 61:242-50. 2005
    ..These data suggest that rHsp70-based vaccines may be useful for the successful immunization of cattle...
  17. ncbi request reprint Intermittent suckling during an extended lactation period: effects on piglet behavior
    M Berkeveld
    Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 7, 3584 CL Utrecht, The Netherlands
    J Anim Sci 85:3415-24. 2007
    ..001) and aggressive (P = 0.004) behavior compared with pre-weaning values. Intermittent suckling may contribute to adaptation to the postweaning state by stimulating eating behavior, without causing obvious behavioral distress...
  18. ncbi request reprint Influence of 17beta-oestradiol, nortestosterone and dexamethasone on the adaptive immune response in veal calves
    S W F Eisenberg
    Department of Farm Animal Health, Faculty of Veterinary Medicine, University of Utrecht, 3583 CL, Utrecht, The Netherlands
    Res Vet Sci 84:199-205. 2008
    ....
  19. ncbi request reprint How does Mycobacterium avium subsp. paratuberculosis resist intracellular degradation?
    M Z Tessema
    Department of Pathology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    Vet Q 23:153-62. 2001
    ..Current understanding about the survival strategies of M. a. paratuberculosis and its implications in the epidemiology, diagnosis, and control of the disease are discussed...