O H Klungel

Summary

Affiliation: Utrecht University
Country: The Netherlands

Publications

  1. ncbi request reprint Excess stroke among hypertensive men and women attributable to undertreatment of hypertension
    O H Klungel
    Department of Pharmacoepidemiology and Pharmacotherapy, Faculty of Pharmacy, University of Utrecht, The Netherlands
    Stroke 30:1312-8. 1999
  2. ncbi request reprint Methods to assess intended effects of drug treatment in observational studies are reviewed
    Olaf H Klungel
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute of Pharmaceutical Sciences UIPS, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
    J Clin Epidemiol 57:1223-31. 2004
  3. ncbi request reprint Lipid-lowering drug use and cardiovascular events after myocardial infarction
    Olaf H Klungel
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
    Ann Pharmacother 36:751-7. 2002
  4. doi request reprint Perceived diabetes status is independently associated with glucose monitoring behaviour among type 2 diabetes mellitus patients
    Olaf H Klungel
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, P O BOX 80082, 3508 TB Utrecht, The Netherlands
    Prim Care Diabetes 2:25-30. 2008
  5. ncbi request reprint Antihypertensive drug therapies and the risk of ischemic stroke
    O H Klungel
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute of Pharmaceutical Sciences, Sorbonnelann 16, 3584 CA Utrecht, The Netherlands
    Arch Intern Med 161:37-43. 2001
  6. ncbi request reprint Estimating the prevalence of hypertension corrected for the effect of within-person variability in blood pressure
    O H Klungel
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, 3584 CA, Utrecht, The Netherlands
    J Clin Epidemiol 53:1158-63. 2000
  7. ncbi request reprint Sex differences in the medication choice for hypertension in general practice. A study with written case simulations
    O H Klungel
    Department of Pharmacoepidemiology and Pharmacotherapy, Faculty of Pharmacy, Universiteit Utrecht, The Netherlands
    Pharm World Sci 22:140-6. 2000
  8. ncbi request reprint Control of blood pressure and risk of stroke among pharmacologically treated hypertensive patients
    O H Klungel
    Department of Epidemiology, Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, USA
    Stroke 31:420-4. 2000
  9. ncbi request reprint The association between antihypertensive drug therapies and plasma lipid levels in the general population
    A H Maitland-van der Zee
    Utrecht Institute for Pharmaceutical Sciences (UIPS, Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht University, Utrecht, The Netherlands
    J Hum Hypertens 15:701-5. 2001
  10. ncbi request reprint Is drug treatment of hypertension in clinical practice as effective as in randomized controlled trials with regard to the reduction of the incidence of stroke?
    O H Klungel
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, P O BOX 80082, 3508 TB Utrecht, The Netherlands
    Epidemiology 12:339-44. 2001

Detail Information

Publications91

  1. ncbi request reprint Excess stroke among hypertensive men and women attributable to undertreatment of hypertension
    O H Klungel
    Department of Pharmacoepidemiology and Pharmacotherapy, Faculty of Pharmacy, University of Utrecht, The Netherlands
    Stroke 30:1312-8. 1999
    ..The aim of our study was to investigate the consequences of undertreatment of hypertension for women and men in terms of stroke occurrence...
  2. ncbi request reprint Methods to assess intended effects of drug treatment in observational studies are reviewed
    Olaf H Klungel
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute of Pharmaceutical Sciences UIPS, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
    J Clin Epidemiol 57:1223-31. 2004
    ..To review methods that seek to adjust for confounding in observational studies when assessing intended drug effects...
  3. ncbi request reprint Lipid-lowering drug use and cardiovascular events after myocardial infarction
    Olaf H Klungel
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
    Ann Pharmacother 36:751-7. 2002
    ....
  4. doi request reprint Perceived diabetes status is independently associated with glucose monitoring behaviour among type 2 diabetes mellitus patients
    Olaf H Klungel
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, P O BOX 80082, 3508 TB Utrecht, The Netherlands
    Prim Care Diabetes 2:25-30. 2008
    ..To investigate if patients' perceptions of their diabetes status is related to blood glucose self-monitoring (SMBG) behaviour, independent of self-reported disease severity...
  5. ncbi request reprint Antihypertensive drug therapies and the risk of ischemic stroke
    O H Klungel
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute of Pharmaceutical Sciences, Sorbonnelann 16, 3584 CA Utrecht, The Netherlands
    Arch Intern Med 161:37-43. 2001
    ..The relative effectiveness of various antihypertensive drugs with regard to the reduction of stroke incidence remains uncertain...
  6. ncbi request reprint Estimating the prevalence of hypertension corrected for the effect of within-person variability in blood pressure
    O H Klungel
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, 3584 CA, Utrecht, The Netherlands
    J Clin Epidemiol 53:1158-63. 2000
    ..1-8.4% overestimation). When repeated measurements of blood pressure are not available in a population study for a sample of that same study, it is advisable to use data from another study to correct for WPV...
  7. ncbi request reprint Sex differences in the medication choice for hypertension in general practice. A study with written case simulations
    O H Klungel
    Department of Pharmacoepidemiology and Pharmacotherapy, Faculty of Pharmacy, Universiteit Utrecht, The Netherlands
    Pharm World Sci 22:140-6. 2000
    ..These considerations may also play a role in the sex difference in the choice of calcium antagonists and angiotensin converting enzyme inhibitors and require further investigation...
  8. ncbi request reprint Control of blood pressure and risk of stroke among pharmacologically treated hypertensive patients
    O H Klungel
    Department of Epidemiology, Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, USA
    Stroke 31:420-4. 2000
    ..We estimated the proportion of strokes occurring among treated hypertensive patients that may be attributable to uncontrolled blood pressure...
  9. ncbi request reprint The association between antihypertensive drug therapies and plasma lipid levels in the general population
    A H Maitland-van der Zee
    Utrecht Institute for Pharmaceutical Sciences (UIPS, Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht University, Utrecht, The Netherlands
    J Hum Hypertens 15:701-5. 2001
    ..The combination of a diuretic and a beta-blocker was associated with a worse lipid profile...
  10. ncbi request reprint Is drug treatment of hypertension in clinical practice as effective as in randomized controlled trials with regard to the reduction of the incidence of stroke?
    O H Klungel
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, P O BOX 80082, 3508 TB Utrecht, The Netherlands
    Epidemiology 12:339-44. 2001
    ..The relative risk reduction that we found was similar to those found in randomized controlled trials...
  11. doi request reprint Genetic variation in the renin-angiotensin system modifies the beneficial effects of ACE inhibitors on the risk of diabetes mellitus among hypertensives
    O Bozkurt
    Faculty of Science, Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    J Hum Hypertens 22:774-80. 2008
    ....
  12. ncbi request reprint Cardiovascular drug use and hospitalizations attributable to type 2 diabetes
    J A Erkens
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht University, Utrecht, The Netherlands
    Diabetes Care 24:1428-32. 2001
    ..To investigate cardiovascular drug use and hospitalizations attributable to type 2 diabetes from 1 year before until 6 years after the start of oral antidiabetic therapy...
  13. ncbi request reprint Influence of correction for within-person variability in blood pressure on the prevalence, awareness, treatment, and control of hypertension
    O H Klungel
    Department of Pharmacoepidemiology and Pharmacotherapy, Faculty of Pharmacy, Utrecht University, The Netherlands
    Am J Hypertens 13:88-91. 2000
    ..It may be advisable to perform a correction for within-person variability to obtain valid prevalence estimates in surveys that only take one or two measurements of blood pressure...
  14. pmc Pharmacogenetic interactions of three candidate gene polymorphisms with ACE-inhibitors or beta-blockers and the risk of atherosclerosis
    H Schelleman
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Br J Clin Pharmacol 64:57-66. 2007
    ....
  15. doi request reprint Added value of pharmacogenetic testing in predicting statin response: results from the REGRESS trial
    F H van der Baan
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Pharmacogenomics J 13:318-24. 2013
    ..The added value of genetic factors over non-genetic variables is for the greater part produced by gene-gene interactions. This underlines the importance to examine gene-gene interactions in future (pharmaco)genetic research. ..
  16. ncbi request reprint Drug-Induced lipid changes: a review of the unintended effects of some commonly used drugs on serum lipid levels
    A K Mantel-Teeuwisse
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, The Netherlands
    Drug Saf 24:443-56. 2001
    ..In cases of extreme hyperlipidaemia, medication use should be reassessed...
  17. pmc Determinants of DNA yield and purity collected with buccal cell samples
    D B M A van Wieren-de Wijer
    Department of Pharmacoepidemiology and Pharmacotherapy, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, P O BOX 80082, 3508 TB, Utrecht, The Netherlands
    Eur J Epidemiol 24:677-82. 2009
    ..95). One technician obtained significantly lower DNA yields. Older age was associated with lower DNA purity. In conclusion, DNA yield from buccal swabs was higher in men and DNA purity was associated with age and the use of diuretics...
  18. doi request reprint Comparison of various measures for assessing medication refill adherence using prescription data
    N M Vink
    Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Pharmacoepidemiol Drug Saf 18:159-65. 2009
    ..Few studies have made direct comparisons, and little is known about the accuracy of these measures in patients on a multiple-drug regimen...
  19. ncbi request reprint Prognostic factors of early metastasis and mortality in dogs with appendicular osteosarcoma after receiving surgery: an individual patient data meta-analysis
    A F Schmidt
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, P O Box 85500, 3508 GA Utrecht, the Netherlands Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, P O BOX 80082, 3508 TB Utrecht, The Netherlands Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 7, Utrecht 3584 CL, The Netherlands Electronic address
    Prev Vet Med 112:414-22. 2013
    ..Age was a prognostic factor for mortality but not for metastasis. ..
  20. pmc Undertreatment of hypercholesterolaemia: a population-based study
    A K Mantel-Teeuwisse
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands
    Br J Clin Pharmacol 55:389-97. 2003
    ....
  21. ncbi request reprint Comparison of different methods to estimate prevalence of drug use by using pharmacy records
    A K Mantel-Teeuwisse
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, P O BOX 80082, 3508 TB, Utrecht, The Netherlands
    J Clin Epidemiol 54:1181-6. 2001
    ..However, defined daily doses should not be used to estimate (point) prevalences of drug use because this measure is significantly influenced by prescribed dosage regimens...
  22. ncbi request reprint Cholesteryl ester transfer protein polymorphisms, statin use, and their impact on cholesterol levels and cardiovascular events
    M Leusink
    1 Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands 2 Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Clin Pharmacol Ther 95:314-20. 2014
    ..Focusing on functional CETP variants, we showed that in carriers of the rs3764261 T variant, HDLc increased more during statin treatment, and protection against MI by statins appeared to be reduced as compared with those in noncarriers. ..
  23. ncbi request reprint Prevalence and determinants of undertreatment of hypertension in the Netherlands
    H Schelleman
    Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands
    J Hum Hypertens 18:317-24. 2004
    ..Therefore, the detection and control of hypertension in the Netherlands needs to improve. Several groups of hypertensives were identified that need additional care and attention...
  24. ncbi request reprint Application of routine electronic health record databases for pharmacogenetic research
    A Yasmina
    Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands Department of Pharmacology and Therapeutics, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin, Indonesia
    J Intern Med 275:590-604. 2014
    ..It also summarizes the potential of linking pharmacoepidemiology and pharmacogenetics (along with its strengths and limitations) and provides examples of pharmacogenetic studies utilizing electronic health record databases. ..
  25. doi request reprint The patterns of anticoagulation control and the risk of stroke, bleeding and mortality in patients with non-valvular atrial fibrillation
    H A VAN DEN Ham
    Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    J Thromb Haemost 11:107-15. 2013
    ..Anticoagulation control is often summarized using the percentage of time spent in a therapeutic range (TTR). This method does not describe the timing and severity of fluctuations in the International Normalised Ratio (INR)...
  26. ncbi request reprint Use of fluorquinolones is associated with a reduced risk of coronary heart disease in diabetes mellitus type 2 patients
    J A Erkens
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands
    Eur Heart J 23:1575-9. 2002
    ..The aim of the present study was to investigate whether use of specific antibiotic drugs decreases the risk of coronary heart disease in diabetes mellitus type 2 patients...
  27. ncbi request reprint Costs and effects of combining stenting and abciximab (ReoPro) in daily practice
    J E Zwart-van Rijkom
    Utrecht University, Department of Pharmaco epidemiology and Pharmacotherapy, Utrecht, The Netherlands
    Int J Cardiol 77:299-303. 2001
    ..We conducted a study in daily clinical practice comparing stented and non-stented patients undergoing coronary angioplasty with abciximab administration. Furthermore, we compare our results with the findings of the EPISTENT trial...
  28. doi request reprint Interpretation and inference in noninferiority randomized controlled trials in drug research
    G Wangge
    Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, The Netherlands
    Clin Pharmacol Ther 88:420-3. 2010
    ..On the basis of our review of 232 trials, we conclude that the interpretation and inference of NI trials are complicated, partly because of the incompleteness of the information...
  29. doi request reprint Use of statins is associated with an increased risk of rheumatoid arthritis
    H J I de Jong
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Ann Rheum Dis 71:648-54. 2012
    ..The authors studied whether statin use was associated with an increased risk of developing RA by conducting a case-control study using the Netherlands Information Network of General Practice database...
  30. pmc Potential impact of benzodiazepine use on the rate of hip fractures in five large European countries and the United States
    T P Khong
    Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, Universiteitsweg 99, Utrecht, The Netherlands
    Calcif Tissue Int 91:24-31. 2012
    ..8 % and 8.2 %. During the next phase of the IMI-PROTECT study, a comparison with individual patient data will show whether this approach is valid...
  31. ncbi request reprint An epidemiological approach to assess the economic burden of NSAID-induced gastrointestinal events in The Netherlands
    R M Herings
    PHARMO Institute, Utrecht, The Netherlands
    Pharmacoeconomics 19:655-65. 2001
    ..To use the population attributable risk (PAR) to estimate the treatment costs resulting from nonsteroidal anti-inflammatory drug (NSAID)-induced gastrointestinal (GI) morbidity...
  32. pmc Society already achieves economic benefits from generic substitution but fails to do the same for therapeutic substitution
    Pearl D Gumbs
    Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, Utrecht, The Netherlands
    Br J Clin Pharmacol 64:680-5. 2007
    ..To assess the potential annual savings due to generic and therapeutic substitution of statin therapy for the general Dutch population, taking the patients medical history into account...
  33. ncbi request reprint The effectiveness of hydroxy-methylglutaryl coenzyme A reductase inhibitors (statins) in the elderly is not influenced by apolipoprotein E genotype
    Anke Hilse Maitland-van der Zee
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute of Pharmaceutical Sciences UIPS, Utrecht University, Utrecht, The Netherlands
    Pharmacogenetics 12:647-53. 2002
    ..The protective effect of statins on total mortality was not statistically significant, but did not seem to differ between subjects with different apoE genotypes...
  34. ncbi request reprint Differences in the association between structural factors and diabetes self-monitoring support
    Michiel J Storimans
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 26, Utrecht, The Netherlands
    Pharm World Sci 29:676-82. 2007
    ..To determine if the association between the level of community pharmacy diabetes services and six of its reported determinants is influenced by the definition of these services...
  35. ncbi request reprint Depressive symptoms in subjects with diagnosed and undiagnosed type 2 diabetes
    Mirjam J Knol
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands
    Psychosom Med 69:300-5. 2007
    ..To investigate if disturbed glucose homeostasis or known diagnosis of diabetes was associated with depressive symptoms. The reason for the increased prevalence of depression in patients with Type 2 diabetes mellitus (DM2) is unknown...
  36. ncbi request reprint Effects of the renin-angiotensin system genes and salt sensitivity genes on blood pressure and atherosclerosis in the total population and patients with type 2 diabetes
    Mojgan Yazdanpanah
    Genetic Epidemiology Unit, Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Diabetes 56:1905-12. 2007
    ..04 mm, P = 0.02). We found that among type 2 diabetic patients, mean systolic blood pressure, pulse pressure, and risk of hypertension increased with the number of risk genotypes for the RAS genes and the salt sensitivity genes...
  37. ncbi request reprint Epistatic effect of cholesteryl ester transfer protein and hepatic lipase on serum high-density lipoprotein cholesterol levels
    Aaron Isaacs
    Genetic Epidemiology Unit, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 92:2680-7. 2007
    ..The objectives of the current study were to characterize the effect of the hepatic lipase variant, and its interaction with the CETP variant, in terms of cholesterol levels, atherosclerosis, and risk of myocardial infarction (MI)...
  38. ncbi request reprint Angiotensinogen M235T polymorphism and the risk of myocardial infarction and stroke among hypertensive patients on ACE-inhibitors or beta-blockers
    Hedi Schelleman
    Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands
    Eur J Hum Genet 15:478-84. 2007
    ..ACE-inhibitor users with at least one copy of the 235T-allele of the AGT gene might have an increased risk of MI and stroke...
  39. ncbi request reprint Myopathy due to statin/fibrate use in the Netherlands
    Aukje K Mantel-Teeuwisse
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands
    Ann Pharmacother 36:1957-60. 2002
    ..To estimate the number of expected cases of myopathy based on the prevalence of lipid-lowering drug use, and to compare this number with the observed number of cases of myopathy due to lipid-lowering drug use in the Netherlands...
  40. ncbi request reprint The cholesteryl ester transfer protein I405V polymorphism is associated with increased high-density lipoprotein levels and decreased risk of myocardial infarction: the Rotterdam Study
    Aaron Isaacs
    Genetic Epidemiology Unit, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Cardiovasc Prev Rehabil 14:419-21. 2007
    ..The effect of the cholesteryl ester transfer protein (CETP) I405V polymorphism on lipid levels, atherosclerosis and myocardial infarction (MI) was examined in 6421 participants from the Rotterdam Study...
  41. ncbi request reprint Rates and determinants of reinitiating antihypertensive therapy after prolonged stoppage: a population-based study
    Boris L G Van Wijk
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    J Hypertens 25:689-97. 2007
    ..To assess patterns of restarting antihypertensive drugs after a prolonged period of discontinuation...
  42. pmc Absence of an interaction between the angiotensin-converting enzyme insertion-deletion polymorphism and pravastatin on cardiovascular disease in high-risk hypertensive patients: the Genetics of Hypertension-Associated Treatment (GenHAT) study
    Anke Hilse Maitland-van der Zee
    School of Public Health, University of Texas Health Science Center at Houston, 1200 Hermann Pressler, Houston TX, USA
    Am Heart J 153:54-8. 2007
    ....
  43. ncbi request reprint Comparing treatment effects after adjustment with multivariable Cox proportional hazards regression and propensity score methods
    Edwin P Martens
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Pharmacoepidemiol Drug Saf 17:1-8. 2008
    ..To compare adjusted effects of drug treatment for hypertension on the risk of stroke from propensity score (PS) methods with a multivariable Cox proportional hazards (Cox PH) regression in an observational study with censored data...
  44. ncbi request reprint Pharmacogenetics of glucose-lowering drug treatment: a systematic review
    Ozlem Bozkurt
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Mol Diagn Ther 11:291-302. 2007
    ..Future studies with adequate sample sizes in which several SNPs in multiple candidate genes are genotyped in patients with diabetes should provide reliable information on genetic variants and response to glucose-lowering drugs...
  45. ncbi request reprint The effect of discontinuation of antihypertensives on the risk of acute myocardial infarction and stroke
    Nancy S Breekveldt-Postma
    PHARMO Institute, Utrecht, The Netherlands
    Curr Med Res Opin 24:121-7. 2008
    ..The present study investigates the effect of early treatment discontinuation with antihypertensive drugs on the risk of acute myocardial infarction (AMI) or stroke in daily clinical practice...
  46. pmc Time trends in lipid lowering drug use in The Netherlands. Has the backlog of candidates for treatment been eliminated?
    Aukje K Mantel-Teeuwisse
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Br J Clin Pharmacol 53:379-85. 2002
    ..To assess time trends in lipid lowering drug use in The Netherlands...
  47. ncbi request reprint Genetic polymorphisms: importance for response to HMG-CoA reductase inhibitors
    Anke Hilse Maitland-van der Zee
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute of Pharmaceutical Sciences UIPS, Utrecht University, Sorbonnelaan 16, P O BOX 80082, The Netherlands
    Atherosclerosis 163:213-22. 2002
    ..Determining the genotype will not deny therapy to a subject, but will help in deciding the therapy that will suit the patient best...
  48. ncbi request reprint Quality of hypertension treatment and risk of stroke in the general population
    Olaf H Klungel
    J Hypertens 20:1949-50. 2002
  49. ncbi request reprint Rate and determinants of 10-year persistence with antihypertensive drugs
    Boris Lg Van Wijk
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, The Netherlands
    J Hypertens 23:2101-7. 2005
    ..To assess the proportion of patients starting with antihypertensive drug treatment who continued treatment for at least 10 years...
  50. ncbi request reprint Effectiveness of statins in the reduction of the risk of myocardial infarction is modified by the GNB3 C825T variant
    Bas J M Peters
    Division of Pharmacoepidemiology and Pharmacotherapy, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    Pharmacogenet Genomics 18:631-6. 2008
    ..Therefore, we assessed whether the effectiveness of statins in reducing the risk of MI was modified by the GNB3 C825T polymorphism...
  51. doi request reprint Systematic differences in treatment effect estimates between propensity score methods and logistic regression
    Edwin P Martens
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute of Pharmaceutical Sciences UIPS, Utrecht University, Utrecht, The Netherlands
    Int J Epidemiol 37:1142-7. 2008
    ..From literature reviews it has been concluded that treatment effect estimates from both methods are quite similar. With this study we will show that there are systematic differences which can be substantial...
  52. ncbi request reprint Effect of persistent use of antihypertensives on blood pressure goal attainment
    Nancy S Breekveldt-Postma
    PHARMO Institute, Utrecht, The Netherlands
    Curr Med Res Opin 24:1025-31. 2008
    ..The present study investigates the relationship between persistence with antihypertensive drugs (AHT) and blood pressure (BP) goal attainment in daily clinical practice...
  53. doi request reprint The association between antidepressant use and hypoglycaemia in diabetic patients: a nested case-control study
    Hieronymus J Derijks
    Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences UIPS, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    Pharmacoepidemiol Drug Saf 17:336-44. 2008
    ..We have carried out a nested case-control study among diabetic patients to assess the risk of hypoglycaemia requiring hospitalisation associated with the use of antidepressants...
  54. doi request reprint Increased bleeding risk with concurrent use of selective serotonin reuptake inhibitors and coumarins
    Tom Schalekamp
    Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    Arch Intern Med 168:180-5. 2008
    ....
  55. pmc A cross-national study of the persistence of antihypertensive medication use in the elderly
    Boris L G Van Wijk
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands b l g
    J Hypertens 26:145-53. 2008
    ..The aim of this study was to describe and compare patterns of use of antihypertensive drugs in a population of elderly patients in the United States (Pennsylvania), Canada (British Columbia) and the Netherlands...
  56. ncbi request reprint Adherence to evidence-based statin guidelines reduces the risk of hospitalizations for acute myocardial infarction by 40%: a cohort study
    Fernie J A Penning-van Beest
    PHARMO Institute, PO Box 85222, 3508 AE Utrecht, The Netherlands
    Eur Heart J 28:154-9. 2007
    ..To investigate the 'real world' effectiveness of robust statin therapy, focusing on the effect of dose and early treatment discontinuation on the risk of hospitalization for acute myocardial infarction (AMI)...
  57. ncbi request reprint Drug costs associated with non-adherence to cholesterol management guidelines for primary prevention of cardiovascular disease in an elderly population: the Rotterdam study
    Pearl D Gumbs
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceuticals Sciences UIPS, Utrecht University, Utrecht, The Netherlands
    Drugs Aging 23:733-41. 2006
    ..However, several studies have established both undertreatment and non-guidelines-indicated treatment with statins, suggesting a suboptimal use of resources...
  58. ncbi request reprint A comparison of two multiple-characteristic decision-making models for the comparison of antihypertensive drug classes: Simple Additive Weighting (SAW) and Technique for Order Preference by Similarity to an Ideal Solution (TOPSIS)
    Boris L G Van Wijk
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands
    Am J Cardiovasc Drugs 6:251-8. 2006
    ....
  59. ncbi request reprint A multilocus approach to the antihypertensive pharmacogenetics of hydrochlorothiazide
    Anke Hilse Maitland-van der Zee
    Human Genetics Center, University of Texas Health Science Center, Houston, TX 77030, USA
    Pharmacogenet Genomics 15:287-93. 2005
    ..To assess the influence of variations in multiple candidate genes on inter-individual variation in diastolic blood pressure (DBP) response to hydrochlorothiazide...
  60. ncbi request reprint Adherence to and dosing of beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitors in the general population differs according to apolipoprotein E-genotypes
    Anke Hilse Maitland-van der Zee
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, Utrecht, The Netherlands
    Pharmacogenetics 13:219-23. 2003
    ..18 (CI 1.01-10.03) in men. The apoE genotype is associated with discontinuation of statins. This suggests that subjects who are genetically prone to develop hypercholesterolemia show the highest risk of discontinuation of treatment...
  61. ncbi request reprint Should rosuvastatin be withdrawn from the market?
    Stefan R Florentinus
    Lancet 364:1577; author reply 1578-9. 2004
  62. ncbi request reprint Geographic region influences pharmacy's dispensing of blood glucose test strips
    Michiel J Storimans
    Ann Pharmacother 38:1751-2. 2004
  63. pmc Recent trends in (under)treatment of hypercholesterolaemia in the Netherlands
    Aukje K Mantel-Teeuwisse
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, Utrecht, The Netherlands
    Br J Clin Pharmacol 58:310-6. 2004
    ..To assess recent trends in undertreatment of hypercholesterolaemia (1998-2002)...
  64. ncbi request reprint The association between compliance with antihypertensive drugs and modification of antihypertensive drug regimen
    Boris L G Van Wijk
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute of Pharmaceutical Sciences, Utrecht, The Netherlands
    J Hypertens 22:1831-7. 2004
    ..The objective of this study was to assess the association between non-compliance and change in medication regimen...
  65. ncbi request reprint Drug-gene interactions between genetic polymorphisms and antihypertensive therapy
    Hedi Schelleman
    Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands
    Drugs 64:1801-16. 2004
    ..Unfortunately, the quality of these studies is quite variable. Given the methodological problems, the results from the candidate gene studies are still inconclusive and further research is necessary...
  66. ncbi request reprint Statins are less effective in common daily practice among patients with hypercholesterolemia: the REALITY-PHARMO study
    Wim G Goettsch
    PHARMO Institute, Utrecht, The Netherlands
    Curr Med Res Opin 20:1025-33. 2004
    ..To study the use and effectiveness of lipid-lowering drugs with respect to lowering of cholesterol levels in routine daily practice...
  67. ncbi request reprint Effectiveness of HMG-CoA reductase inhibitors is modified by the ACE insertion deletion polymorphism
    Anke Hilse Maitland-van der Zee
    Atherosclerosis 175:377-9. 2004
  68. ncbi request reprint Pharmacoeconomic evaluation of testing for angiotensin-converting enzyme genotype before starting beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitor therapy in men
    Anke Hilse Maitland-van der Zee
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University Utrecht, The Netherlands
    Pharmacogenetics 14:53-60. 2004
    ..If other studies confirm that men with the DD genotype do not benefit from treatment with statins, screening for ACE genotype in men most likely will be a cost-effective strategy before initiating statin therapy...
  69. ncbi request reprint Failure to continue lipid-lowering drug use following the withdrawal of cerivastatin
    Aukje K Mantel-Teeuwisse
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Drug Saf 27:63-70. 2004
    ..Persistence with lipid-lowering drug use is important in order for patients to gain full treatment benefit. The withdrawal of cerivastatin from the market may have affected persistence due to the fear of serious adverse effects...
  70. ncbi request reprint Antihypertensive drug therapy and the risk of lower extremity amputations in pharmacologically treated type 2 diabetes patients
    Joelle A Erkens
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands
    Pharmacoepidemiol Drug Saf 13:139-46. 2004
    ..The objective of this study was to determine the association between different antihypertensive drug therapies and lower extremity amputations (LEAs) in type 2 diabetes patients...
  71. ncbi request reprint Comparison of two methodologies to analyze exposure to statins in an observational study on effectiveness
    Anke Hilse Maitland-van der Zee
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute of Pharmaceutical Sciences UIPS, Utrecht University, Sorbonnelaan 16, P O BOX 80082, 3508 TB, The Netherlands
    J Clin Epidemiol 57:237-42. 2004
    ..To obtain valid results, the definition of exposure in an observational study is critical. The objective of our study was to compare different exposure definitions for assessing the effectiveness of statins...
  72. pmc Suboptimal choices and dosing of statins at start of therapy
    Aukje K Mantel-Teeuwisse
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, Utrecht, The Netherlands
    Br J Clin Pharmacol 60:83-9. 2005
    ..To assess dosing and determinants of the choice of statins among starters of statins...
  73. ncbi request reprint Demographic, environmental, and genetic predictors of metabolic side effects of hydrochlorothiazide treatment in hypertensive subjects
    Anke Hilse Maitland-van der Zee
    Human Genetics Center, University of Texas Health Science Centre, Houston, TX 77030, USA
    Am J Hypertens 18:1077-83. 2005
    ..The aim of this study was to characterize interindividual variation in glucose and lipid responses to hydrochlorothiazide and to identify demographic, environmental, and genetic predictors associated with this variation...
  74. ncbi request reprint Dispensing glucose test materials in Dutch community pharmacies
    Michiel J Storimans
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute of Pharmaceutical Sciences, Utrecht, The Netherlands
    Pharm World Sci 26:52-5. 2004
    ..To assess the proportion of diabetic patients who collect self-monitoring equipment for glucose testing in Dutch community pharmacies...
  75. ncbi request reprint CYP2C9 genotyping in acenocoumarol treatment: is it a cost-effective addition to international normalized ratio monitoring?
    Tom Schalekamp
    Department of Pharmacoepidemiology and Pharmacotherapy, University Institute of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Clin Pharmacol Ther 79:511-20. 2006
  76. ncbi request reprint The influence of the alpha-adducin G460W polymorphism and angiotensinogen M235T polymorphism on antihypertensive medication and blood pressure
    Hedi Schelleman
    Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands
    Eur J Hum Genet 14:860-6. 2006
    ..33 mmHg (95% CI:-9.66 to 5.01). The G460W polymorphism and the M235T polymorphism did not modify the difference in blood pressure levels among subjects who used diuretics, beta-blockers, calcium antagonists, or ACE inhibitors...
  77. ncbi request reprint Regional influences on the dispensing of glucose test strips in Dutch community pharmacies
    Michiel J Storimans
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, P O BOX 80082, 3508 TB, Utrecht, The Netherlands
    Pharm World Sci 28:26-32. 2006
    ..Pharmacy practice guidelines promote the role of community pharmacies in self-monitoring of blood glucose. However, variations between Dutch pharmacies exist in the proportion of patients to whom test strips are dispensed...
  78. pmc Prescribing behaviour according to Dutch and European guidelines on the management of hypercholesterolaemia (1992-1999)
    Aukje K Mantel-Teeuwisse
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, Utrecht, The Netherlands
    Br J Clin Pharmacol 61:592-600. 2006
    ..The success of the full implementation of a new guideline may depend on the observed discrepancy between daily medical practice developed before the release of the guideline and new treatment recommendations issued by the guideline...
  79. ncbi request reprint Initial non-compliance with antihypertensive monotherapy is followed by complete discontinuation of antihypertensive therapy
    Boris L G Van Wijk
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands
    Pharmacoepidemiol Drug Saf 15:587-93. 2006
    ..The objective of our study was to assess the association between non-compliance and discontinuation in patients who started using antihypertensive monotherapy...
  80. ncbi request reprint Drug-gene interaction between the insertion/deletion polymorphism of the angiotensin-converting enzyme gene and antihypertensive therapy
    Hedi Schelleman
    Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, Netherlands
    Ann Pharmacother 40:212-8. 2006
    ..There are some indications that the angiotensin-converting enzyme (ACE) gene modifies the response to antihypertensive drugs, but the results have been inconclusive...
  81. ncbi request reprint Refill persistence with chronic medication assessed from a pharmacy database was influenced by method of calculation
    Boris L G Van Wijk
    Department of Pharmacoepidemiology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
    J Clin Epidemiol 59:11-7. 2006
    ..In literature, different methods of calculating persistence are used. In this study, the effect of using these different methods on persistence and the association of patients characteristics and persistence are assessed...
  82. ncbi request reprint Generic substitution of antihypertensive drugs: does it affect adherence?
    Boris L G Van Wijk
    Department of Pharmacoepidemiology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Ann Pharmacother 40:15-20. 2006
    ..However, pharmacists and physicians often find that patients and brand-name manufacturers have doubt about the equivalence of the substituted drug. This may be reflected by decreased adherence to therapy...
  83. ncbi request reprint Collaborative services among community pharmacies for patients with diabetes
    Michiel J Storimans
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences and Scientific Institute Dutch Pharmacists, Utrecht, Netherlands
    Ann Pharmacother 39:1647-53. 2005
    ..Still, the importance of local agreements on the division of roles with, for example, local general practitioners or diabetes nurses, is less clear...
  84. ncbi request reprint Differences in antihypertensive drug persistence associated with drug class and gender: a PHARMO study
    Joelle A Erkens
    PHARMO Institute for Drug Outcomes Research, Utrecht, The Netherlands
    Pharmacoepidemiol Drug Saf 14:795-803. 2005
    ..The objective of the study is to investigate factors related to treatment persistence among users of antihypertensive (AHT) drugs in daily practice...
  85. ncbi request reprint Refill compliance in type 2 diabetes mellitus: a predictor of switching to insulin therapy?
    José A Spoelstra
    Julius Center for General Practice and Patient Oriented Research, University Medical Center Utrecht, HP D01 335, PO Box 85500, 3508 GA Utrecht, Netherlands
    Pharmacoepidemiol Drug Saf 12:121-7. 2003
    ..To assess whether switching to insulin therapy in patients with type 2 diabetes mellitus is associated with medication refill compliance of oral hypoglycemic agents...
  86. ncbi request reprint Economic evaluations of cholesterol-lowering drugs: a critical and systematic review
    Pearl D Gumbs
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceuticals Sciences UIPS, Utrecht University, Utrecht, The Netherlands
    Pharmacoeconomics 25:187-99. 2007
    ..In general, piggy-back evaluations tended to score higher on quality and may therefore be more valuable in decision making...
  87. ncbi request reprint Conditioning on the propensity score can result in biased estimation of common measures of treatment effect: a Monte Carlo study (p n/a) by Peter C. Austin, Paul Grootendorst, Sharon-Lise T. Normand, Geoffrey M. Anderson, Statistics in Medicine, Published
    Edwin P Martens
    Stat Med 26:3208-10; author reply 3210-2. 2007
  88. ncbi request reprint Effectiveness of interventions by community pharmacists to improve patient adherence to chronic medication: a systematic review
    Boris Lg Van Wijk
    Department of Pharmacoepidemiology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, Utrecht, Netherlands
    Ann Pharmacother 39:319-28. 2005
    ..To systematically review the impact of interventions by community pharmacists on patients' adherence with chronic medication...
  89. ncbi request reprint Instrumental variables: application and limitations
    Edwin P Martens
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute of Pharmaceutical Sciences UIPS, Utrecht University, Utrecht, The Netherlands
    Epidemiology 17:260-7. 2006
    ..We conclude that instrumental variables can be useful in case of moderate confounding but are less useful when strong confounding exists, because strong instruments cannot be found and assumptions will be easily violated...
  90. ncbi request reprint Pharmacogenetics in health-care practice
    der Zee Anke Hilse Maitland-van
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Pharm World Sci 26:253-5. 2004
  91. ncbi request reprint Cardiovascular drug use and differences in the incidence of cardiovascular mortality in elderly Serbian men
    Paul Hommerson
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, P O BOX 80082, 3508 TB Utrecht, The Netherlands
    Pharm World Sci 27:124-8. 2005
    ..To assess whether the difference in risk of cardiovascular mortality between urban and rural areas of Serbia could be explained by differences in the use of cardiovascular medication...