B M Gadella


Affiliation: Utrecht University
Country: The Netherlands


  1. Ferraz M, Henning H, Costa P, Malda J, Melchels F, Wubbolts R, et al. Improved bovine embryo production in an oviduct-on-a-chip system: prevention of poly-spermic fertilization and parthenogenic activation. Lab Chip. 2017;17:905-916 pubmed publisher
  2. Ferraz M, Rho H, Hemerich D, Henning H, van Tol H, Hölker M, et al. An oviduct-on-a-chip provides an enhanced in vitro environment for zygote genome reprogramming. Nat Commun. 2018;9:4934 pubmed publisher
  3. Gadella B. Sperm membrane physiology and relevance for fertilization. Anim Reprod Sci. 2008;107:229-36 pubmed publisher
    ..This paper emphasizes biochemical models for membrane surface modelling and their potential involvement for remodelling the sperm surface in the above described processes. ..
  4. Lolicato F, Brouwers J, de Lest C, Wubbolts R, Aardema H, Priore P, et al. The cumulus cell layer protects the bovine maturing oocyte against fatty acid-induced lipotoxicity. Biol Reprod. 2015;92:16 pubmed publisher
    ..We suggest that this protective function of the cumulus cell layers is important for the developmental competence of the oocyte. The relevance of our findings for assisted reproduction technologies is discussed. ..
  5. Brogan P, Beitsma M, Henning H, Gadella B, Stout T. Liquid storage of equine semen: Assessing the effect of d-penicillamine on longevity of ejaculated and epididymal stallion sperm. Anim Reprod Sci. 2015;159:155-62 pubmed publisher
    ..The negative effect on motility of epididymal sperm may reflect differences in (membrane) physiology of spermatozoa that have not been exposed to seminal plasma. ..
  6. Gadella B, Boerke A. An update on post-ejaculatory remodeling of the sperm surface before mammalian fertilization. Theriogenology. 2016;85:113-24 pubmed publisher
    ..A concise overview in the current understanding of the process of capacitation and the sperm surface changes is provided. The gaps in knowledge of these prefertilization processes are critically discussed. ..
  7. van Gestel R, Brouwers J, Ultee A, Helms J, Gadella B. Ultrastructure and lipid composition of detergent-resistant membranes derived from mammalian sperm and two types of epithelial cells. Cell Tissue Res. 2016;363:129-45 pubmed publisher
    ..For this special issue, the relevance of our findings is discussed in a sperm physiological context. ..
  8. Gadella B, Tsai P, Boerke A, Brewis I. Sperm head membrane reorganisation during capacitation. Int J Dev Biol. 2008;52:473-80 pubmed publisher
    ..In this review, we cover the latest insights about sperm lipid raft research and discuss how sperm lipid raft dynamics may relate to sperm-zona binding and the zona-induced acrosome reaction...
  9. Gadella B. The assembly of a zona pellucida binding protein complex in sperm. Reprod Domest Anim. 2008;43 Suppl 5:12-9 pubmed publisher
    ..The relevance for this to predict and identify the proteins involved in sperm zona binding in vivo is discussed...

More Information


  1. Gadella B, Evans J. Membrane fusions during mammalian fertilization. Adv Exp Med Biol. 2011;713:65-80 pubmed publisher
    ..In addition, there is a block at the level of the oolemma (also known as the membrane block to polyspermy). ..
  2. Gadella B. Dynamic regulation of sperm interactions with the zona pellucida prior to and after fertilisation. Reprod Fertil Dev. 2012;25:26-37 pubmed publisher
    ..The current understanding of sperm interactions with the cumulus and ZP layers surrounding the oocyte is reviewed with a special emphasis on the lack of comparative knowledge on this topic in humans, as well as in most farm mammals. ..
  3. Boerke A, van der Lit J, Lolicato F, Stout T, Helms J, Gadella B. Removal of GPI-anchored membrane proteins causes clustering of lipid microdomains in the apical head area of porcine sperm. Theriogenology. 2014;81:613-24 pubmed publisher
    ..In full capacitating conditions (i.e., the presence of bicarbonate and albumin), PIPLC treatment caused sperm deterioration. The possible role of GPI-APs removal from the sperm surface during sperm capacitation is discussed. ..
  4. Ferraz M, Henning H, Stout T, Vos P, Gadella B. Designing 3-Dimensional In Vitro Oviduct Culture Systems to Study Mammalian Fertilization and Embryo Production. Ann Biomed Eng. 2017;45:1731-1744 pubmed publisher
    ..The increased possibilities and concomitant challenges when trying to more closely investigate oviduct physiology, gamete activation, fertilization and embryo production are discussed. ..