Johanna Fink-Gremmels

Summary

Affiliation: Utrecht University
Country: The Netherlands

Publications

  1. doi request reprint Mycotoxins in cattle feeds and carry-over to dairy milk: a review
    Johanna Fink-Gremmels
    Faculty of Veterinary Medicine, Division of Veterinary Pharmacology, Pharmacy and Toxicology, Utrecht University, Utrecht, The Netherlands
    Food Addit Contam Part A Chem Anal Control Expo Risk Assess 25:172-80. 2008
  2. pmc In vitro evaluation of defined oligosaccharide fractions in an equine model of inflammation
    Johannes Cornelis Vendrig
    Department of Veterinary Pharmacology, Pharmacotherapy and Toxicology, Faculty of Veterinary Medicine, Utrecht University, P, O, box 80152, 3508, TD Utrecht, The Netherlands
    BMC Vet Res 9:147. 2013
  3. doi request reprint Implications of hepatic cytochrome P450-related biotransformation processes in veterinary sciences
    Johanna Fink-Gremmels
    Utrecht University, Faculty of Veterinary Medicine, Div Veterinary Pharmacology, Pharmacy and Toxicology, Yalelaan 104, PO Box 80 152, 3508 TD Utrecht, The Netherlands
    Eur J Pharmacol 585:502-9. 2008
  4. doi request reprint The role of mycotoxins in the health and performance of dairy cows
    J Fink-Gremmels
    Utrecht University, Faculty of Veterinary Medicine, Division of Veterinary Pharmacology, Pharmacy and Toxicology, Yalelaan 104, 3508 TD, Utrecht, The Netherlands
    Vet J 176:84-92. 2008
  5. doi request reprint Defense mechanisms against toxic phytochemicals in the diet of domestic animals
    Johanna Fink-Gremmels
    Faculty of Veterinary Medicine, Division of Veterinary Pharmacology, Pharmacy and Toxicology, Utrecht University, Yalelaan, 3584 CM Utrecht, The Netherlands
    Mol Nutr Food Res 54:249-58. 2010
  6. ncbi request reprint The role of alveolar macrophages in the pathogenesis of recurrent airway obstruction in horses
    Tamarinde T J M Laan
    Department of Equine Science, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    J Vet Intern Med 20:167-74. 2006
  7. doi request reprint Deoxynivalenol-induced cytotoxicity, cytokines and related genes in unstimulated or lipopolysaccharide stimulated primary porcine macrophages
    Susanne Doll
    Department of Equine Science, Utrecht University, The Netherlands
    Toxicol Lett 184:97-106. 2009
  8. ncbi request reprint The anti-inflammatory effects of IV administered clenbuterol in horses with recurrent airway obstruction
    Tamarinde T J M Laan
    Department of Equine Science, Faculty of Veterinary Medicine, Utrecht University, P O Box 80152, 3508 TD Utrecht, The Netherlands
    Vet J 171:429-37. 2006
  9. doi request reprint Interactions of deoxynivalenol and lipopolysaccharides on cytotoxicity protein synthesis and metabolism of DON in porcine hepatocytes and Kupffer cell enriched hepatocyte cultures
    Susanne Doll
    Division of Veterinary Pharmacology, Pharmacy and Toxicology, Department of Equine Science, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    Toxicol Lett 189:121-9. 2009
  10. pmc In vitro assessment of adsorbents aiming to prevent deoxynivalenol and zearalenone mycotoxicoses
    Monica Sabater-Vilar
    Department of Veterinary, Pharmacology, Pharmacy and Toxicology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 104, P O Box 80 152, 3508, TD Utrecht, The Netherlands
    Mycopathologia 163:81-90. 2007

Collaborators

Detail Information

Publications30

  1. doi request reprint Mycotoxins in cattle feeds and carry-over to dairy milk: a review
    Johanna Fink-Gremmels
    Faculty of Veterinary Medicine, Division of Veterinary Pharmacology, Pharmacy and Toxicology, Utrecht University, Utrecht, The Netherlands
    Food Addit Contam Part A Chem Anal Control Expo Risk Assess 25:172-80. 2008
    ..The rate of absorption determines not only the internal dose and risk for adverse health effects, but also the excretion of mycotoxins and the biologically active metabolites into milk...
  2. pmc In vitro evaluation of defined oligosaccharide fractions in an equine model of inflammation
    Johannes Cornelis Vendrig
    Department of Veterinary Pharmacology, Pharmacotherapy and Toxicology, Faculty of Veterinary Medicine, Utrecht University, P, O, box 80152, 3508, TD Utrecht, The Netherlands
    BMC Vet Res 9:147. 2013
    ..Acquired data were analysed in a Bayesian hierarchical linear regression model, accounting for variation between horses...
  3. doi request reprint Implications of hepatic cytochrome P450-related biotransformation processes in veterinary sciences
    Johanna Fink-Gremmels
    Utrecht University, Faculty of Veterinary Medicine, Div Veterinary Pharmacology, Pharmacy and Toxicology, Yalelaan 104, PO Box 80 152, 3508 TD Utrecht, The Netherlands
    Eur J Pharmacol 585:502-9. 2008
    ....
  4. doi request reprint The role of mycotoxins in the health and performance of dairy cows
    J Fink-Gremmels
    Utrecht University, Faculty of Veterinary Medicine, Division of Veterinary Pharmacology, Pharmacy and Toxicology, Yalelaan 104, 3508 TD, Utrecht, The Netherlands
    Vet J 176:84-92. 2008
    ..Due to a pre-existing negative energy balance, cows in the transition period are considered to be particularly sensitive to the exposure to feeds contaminated with moulds, fungal spores and mycotoxins...
  5. doi request reprint Defense mechanisms against toxic phytochemicals in the diet of domestic animals
    Johanna Fink-Gremmels
    Faculty of Veterinary Medicine, Division of Veterinary Pharmacology, Pharmacy and Toxicology, Utrecht University, Yalelaan, 3584 CM Utrecht, The Netherlands
    Mol Nutr Food Res 54:249-58. 2010
    ..Moreover, mechanistic data related to tissue disposition and excretion pathways of PSMs for example into milk, could substantially support the assessment of the risks for consumers of foods derived from PSM-exposed animals...
  6. ncbi request reprint The role of alveolar macrophages in the pathogenesis of recurrent airway obstruction in horses
    Tamarinde T J M Laan
    Department of Equine Science, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    J Vet Intern Med 20:167-74. 2006
    ..These data suggest that the differences between susceptible and nonsusceptible horses to RAO are not only dependent on adaptive immunity but also start with an innate immune response...
  7. doi request reprint Deoxynivalenol-induced cytotoxicity, cytokines and related genes in unstimulated or lipopolysaccharide stimulated primary porcine macrophages
    Susanne Doll
    Department of Equine Science, Utrecht University, The Netherlands
    Toxicol Lett 184:97-106. 2009
    ..The results of the present investigation suggest a contribution of cytokines, especially TNF-alpha and IL-1beta, induced by DON in porcine macrophages to the effects observed in vivo...
  8. ncbi request reprint The anti-inflammatory effects of IV administered clenbuterol in horses with recurrent airway obstruction
    Tamarinde T J M Laan
    Department of Equine Science, Faculty of Veterinary Medicine, Utrecht University, P O Box 80152, 3508 TD Utrecht, The Netherlands
    Vet J 171:429-37. 2006
    ..This anti-inflammatory activity of CB is of additive value to its currently recognised use in equine RAO...
  9. doi request reprint Interactions of deoxynivalenol and lipopolysaccharides on cytotoxicity protein synthesis and metabolism of DON in porcine hepatocytes and Kupffer cell enriched hepatocyte cultures
    Susanne Doll
    Division of Veterinary Pharmacology, Pharmacy and Toxicology, Department of Equine Science, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    Toxicol Lett 189:121-9. 2009
    ..Glucuronidation rate, as well as total DON recovery, decreased with increasing concentrations of DON, giving rise to assumptions on the formation of undetected metabolites...
  10. pmc In vitro assessment of adsorbents aiming to prevent deoxynivalenol and zearalenone mycotoxicoses
    Monica Sabater-Vilar
    Department of Veterinary, Pharmacology, Pharmacy and Toxicology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 104, P O Box 80 152, 3508, TD Utrecht, The Netherlands
    Mycopathologia 163:81-90. 2007
    ....
  11. doi request reprint Transgenerational toxicity of Zearalenone in pigs
    Eric J Schoevers
    Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 104, 3584 CM, Utrecht, The Netherlands
    Reprod Toxicol 34:110-9. 2012
    ..In conclusion, ZEN reduced the quantity of healthy follicles, which may lead to premature oocyte depletion in adulthood...
  12. ncbi request reprint Exposure of oocytes to the Fusarium toxins zearalenone and deoxynivalenol causes aneuploidy and abnormal embryo development in pigs
    Hassan Malekinejad
    Department of Veterinary Pharmacology, Utrecht University, 3584 CM Utrecht, The Netherlands
    Biol Reprod 77:840-7. 2007
    ..It is concluded that ZEA and DON can lead to abnormal spindle formation, leading to less fertile oocytes and embryos with abnormal ploidy, and that the effects of ZEA and DON are not synergistic...
  13. ncbi request reprint Ketamine inhibits LPS-induced tumour necrosis factor-alpha and interleukin-6 in an equine macrophage cell line
    Daniëlle P K Lankveld
    Section Anaesthesiology and Intensive Care, Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 12, 3584 CM, Utrecht, The Netherlands
    Vet Res 36:257-62. 2005
    ..The results demonstrate a cytokine-modulating activity of ketamine in an equine cell line, suggesting a beneficial role for ketamine in the treatment of equine endotoxaemia...
  14. ncbi request reprint Evaluation of cytokine production by equine alveolar macrophages exposed to lipopolysaccharide, Aspergillus fumigatus, and a suspension of hay dust
    Tamarinde T J M Laan
    Department of Equine Science, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 12 16, 3508 TD Utrecht, The Netherlands
    Am J Vet Res 66:1584-9. 2005
    ..To evaluate cytokine production by equine alveolar macrophages after exposure to lipopolysaccharide (LPS), Aspergillus fumigatus, and hay dust, and determine the effect of clenbuterol on the cytokine response...
  15. doi request reprint Implications of ABC transporters on the disposition of typical veterinary medicinal products
    Jan A Schrickx
    Utrecht University, Faculty of Veterinary Medicine, Veterinary Pharmacology, Pharmacy and Toxicology, Yalelaan 104, 3584 CM Utrecht, Netherlands
    Eur J Pharmacol 585:510-9. 2008
    ....
  16. ncbi request reprint Generation and characterisation of an equine macrophage cell line (e-CAS cells) derived from equine bone marrow cells
    Arno H Werners
    Department of Veterinary Pharmacology, Pharmacy and Toxicology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 16, 3584 CM, Utrecht, The Netherlands
    Vet Immunol Immunopathol 97:65-76. 2004
    ..These data show that the established cell line (e-CAS) shows the characteristics of equine macrophages and may, therefore, prove to be a unique in vitro model for studying the cellular biology of equine inflammation...
  17. doi request reprint Interactions of deoxynivalenol and lipopolysaccharides on cytokine excretion and mRNA expression in porcine hepatocytes and Kupffer cell enriched hepatocyte cultures
    Susanne Doll
    Division of Veterinary Pharmacology, Pharmacy and Toxicology, Department of Equine Science, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    Toxicol Lett 190:96-105. 2009
    ....
  18. ncbi request reprint Patulin produced by an Aspergillus clavatus isolated from feed containing malting residues associated with a lethal neurotoxicosis in cattle
    Monica Sabater-Vilar
    Department of Veterinary Pharmacology, Pharmacy and Toxicology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 16 3508 TD, Utrecht, The Netherlands
    Mycopathologia 158:419-26. 2004
    ..The isolated fungus appeared to produce patulin in culture medium. Traces of patulin were also detected in the fodder. These findings and their possible role in the intoxication are discussed...
  19. ncbi request reprint Inhibition of aflatoxin B1 mutagenicity by cyclopiazonic acid in the presence of human liver preparations
    Monica Sabater Vilar
    Department of Veterinary, Pharmacology, Pharmacy and Toxicology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 16, P O Box 80 152, 3508 TD Utrecht, Netherlands
    Toxicol Lett 143:291-9. 2003
    ..These findings might be of relevance to the epidemiology of food-borne mycotoxicosis as similar molar ratios to those investigated here have been reported in food commodities...
  20. doi request reprint Intestinal barrier function in neonatal foals: options for improvement
    Johannes C Vendrig
    Department of Veterinary Pharmacology, Pharmacotherapy and Toxicology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 104, 3584 CM Utrecht, The Netherlands
    Vet J 193:32-7. 2012
    ..This class of compounds forms a source for new dietary formulas that may orchestrate gut colonisation by the commensal flora in the early phase of life and so reduce the risks of inflammation and pathogen invasion...
  21. ncbi request reprint Bioactivation of zearalenone by porcine hepatic biotransformation
    Hassan Malekinejad
    Department of Veterinary Pharmacology, Pharmacy and Toxicology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 16, 3508 TD Utrecht, The Netherlands
    Vet Res 36:799-810. 2005
    ..The bioactivation of ZEA into the more active alpha-zearalenol seems to provide a possible explanation for the observed high sensitivity of pigs towards feeding-stuffs contaminated with the mycotoxin...
  22. ncbi request reprint Tissue distribution of ochratoxin A as determined by HPLC and ELISA and histopathological effects in chickens
    Krisztina Biró
    Department of Veterinary Pharacology, Pharmacy and Toxicology, Faculty of Veterinary Medicine, University of Utrecht, Yalelaan 16, P O Box 80152, 3508 TD Utrecht, The Netherlands
    Avian Pathol 31:141-8. 2002
    ..The findings indicate that the dose applied causes subclinical tissue lesions and measurable tissue residues...
  23. ncbi request reprint Effects of antitussive agents administered before bronchoalveolar lavage in horses
    Cornélie M Westermann
    Department of Equine Science, Faculty of Veterinary Medicine, Utrecht University, PO Box 80152, 3508 TD, Utrecht, The Netherlands
    Am J Vet Res 66:1420-4. 2005
    ..To determine whether treatment of horses with antitussive agents before bronchoalveolar lavage (BAL) reduces the frequency and intensity of the cough reflex during BAL...
  24. pmc Integration of pharmacokinetic and pharmacodynamic indices of marbofloxacin in turkeys
    Aneliya Milanova Haritova
    Utrecht University, Faculty of Veterinary Medicine, Department of Pharmacology, Pharmacy, and Toxicology, Yalelaan 16 De Uithof, P O Box 80152, 3508 TD Utrecht, The Netherlands
    Antimicrob Agents Chemother 50:3779-85. 2006
    ..In conclusion, the results of the present study provide the rationale for an optimal dose regimen for marbofloxacin in turkeys and hence should form the basis for dose selection in forthcoming clinical trials...
  25. ncbi request reprint Modulation of the cytokine responses in equine macrophages following TACE-inhibition
    Joris J Wijnker
    Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 12, 3584 CM Utrecht, The Netherlands
    Vet Immunol Immunopathol 99:237-43. 2004
    ..These results suggest that equine TNF-alpha, like its human homologue, is released from its membrane-bound position by TACE...
  26. ncbi request reprint Genotoxicity assessment of five tremorgenic mycotoxins (fumitremorgen B, paxilline, penitrem A, verruculogen, and verrucosidin) produced by molds isolated from fermented meats
    Monica Sabater-Vilar
    Department of Veterinary Pharmacology, Pharmacy and Toxicology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 16, P O Box 80 152, 3508 TD Utrecht, The Netherlands
    J Food Prot 66:2123-9. 2003
    ..The use of fungal starter cultures to avoid tremorgen contamination in fermented meats is recommended...
  27. ncbi request reprint Functional studies on the activity of efflux transporters in an ex vivo model with chicken splenocytes and evaluation of selected fluoroquinolones in this model
    Aneliya Milanova Haritova
    Department of Pharmacology, Veterinary Physiology and Physiological Chemistry, Faculty of Veterinary Medicine, Trakia University, 6000 Stara Zagora, Bulgaria
    Biochem Pharmacol 73:752-9. 2007
    ..None of these fluoroquinolones significantly inhibit P-gp function at concentrations up to 50 microM, with exception of danofloxacin and danofloxacin mesylate that were found to reduce Rh-123 efflux by approximately 15%...
  28. ncbi request reprint A pharmacokinetic model to document the actual disposition of topical ivermectin in cattle
    Céline M Laffont
    UMR 181 de Physiopathologie et Toxicologie Expérimentales INRA ENVT, Ecole Nationale Veterinaire de Toulouse, 23 Chemin des Capelles, 31076 Toulouse cedex 03, France
    Vet Res 34:445-60. 2003
    ..More importantly, the simulations revealed that non-treated cattle could get easily contaminated by allo-licking, raising the public health problem of unexpected drug residues in edible tissues...
  29. ncbi request reprint Evaluation of spermatological parameters in ochratoxin A--challenged boars
    Krisztina Biró
    Department and Clinic of Obstetrics and Reproduction, Faculty of Veterinary Science, Szt István University, P O Box 2, H 1400 Budapest, Hungary
    Theriogenology 60:199-207. 2003
    ..Further research is required to elucidate the possibility of a direct or indirect interaction between the toxin and germ cells (spermatogonia)...
  30. ncbi request reprint Beta-lyase-dependent attenuation of cisplatin-mediated toxicity by selenocysteine Se-conjugates in renal tubular cell lines
    Martijn Rooseboom
    Leiden Amsterdam Center for Drug Research, Division of Molecular Toxicology, Department of Pharmacochemistry, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands
    J Pharmacol Exp Ther 301:884-92. 2002
    ..The precise molecular mechanism by which selenols, generated by beta-lyase, provide protection against cisplatin-induced cytotoxicity, however, remains to be established...