Affiliation: Utrecht University
Country: The Netherlands
- FGF2 signaling is required for the development of neuronal circuits regulating blood pressureRosanna Dono
Department of Developmental Biology, Faculty of Biology, Utrecht University, Utrecht, The Netherlands
Circ Res 90:E5-E10. 2002..The full text of this article is available at http://www.circresaha.org...
- Fibroblast growth factors as regulators of central nervous system development and functionRosanna Dono
Faculty of Biology, Department of Developmental Biology, Utrecht University, NL 3584CH Utrecht, The Netherlands
Am J Physiol Regul Integr Comp Physiol 284:R867-81. 2003..Finally, I will focus on the function of FGF signaling in the adult brain and in regulating maintenance and repair of damaged neural tissues...
- Glypican 4 modulates FGF signalling and regulates dorsoventral forebrain patterning in Xenopus embryosAntonella Galli
Department of Developmental Biology, Faculty of Biology, Utrecht University, Padualaan 8, NL 3584CH Utrecht, The Netherlands
Development 130:4919-29. 2003..We propose that GPC4 regulates dorsoventral forebrain patterning by positive modulation of FGF signalling...
- Liver regeneration in FGF-2-deficient mice: VEGF acts as potential functional substitute for FGF-2Jörg Sturm
Chirurgische Klinik, Universitatsklinikum Mannheim, Germany
Liver Int 24:161-8. 2004..The aim of the study was to evaluate this role in a FGF-2 knockout mouse model...
- Reduced mobility of fibroblast growth factor (FGF)-deficient myoblasts might contribute to dystrophic changes in the musculature of FGF2/FGF6/mdx triple-mutant micePetra Neuhaus
Institute of Physiological Chemistry, University of Halle Wittenberg, 06097 Halle, Germany
Mol Cell Biol 23:6037-48. 2003..We propose that FGFs are critical components of the muscle regeneration machinery that enhance skeletal muscle regeneration, probably by stimulation of muscle stem cell migration...
- Functions of fibroblast growth factor (FGF)-2 and FGF-5 in astroglial differentiation and blood-brain barrier permeability: evidence from mouse mutantsBernhard Reuss
Department of Neuroanatomy, IZN, University of Heidelberg, 69120 Heidelberg, Germany
J Neurosci 23:6404-12. 2003..The observed defect in astroglial differentiation is accompanied by a defect in BBB function arguing for an indirect or direct role of FGFs in the regulation of BBB permeability in vivo...
- Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expressionAimee Zuniga
Developmental Genetics, Department of Clinical Biological Sciences, University of Basel Medical School, CH 4056 Basel, Switzerland
Genes Dev 18:1553-64. 2004..Our studies reveal the large genomic landscape harboring this GCR, which is required for tissue-specific coexpression of two structurally and functionally unrelated genes...
- Enlarged infarct volume and loss of BDNF mRNA induction following brain ischemia in mice lacking FGF-2Irina Kiprianova
Interdisciplinary Center for Neurosciences, Department of Neuroanatomy, University of Heidelberg, D 69120 Heidelberg, Germany
Exp Neurol 189:252-60. 2004..Together, our data provide the first evidence that endogenous FGF-2 is important in coping with ischemic brain damage suggesting fgf2 as one crucial target gene for new therapeutic strategies in brain ischemia...
- Impaired myocardial capillarogenesis and increased adaptive capillary growth in FGF2-deficient miceKerstin Amann
Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
Lab Invest 86:45-53. 2006..These data demonstrate that two intact Fgf2 genes are necessary for normal capillary development after birth, whereas FGF2 seems to be dispensable for adaptive myocardial capillary growth in the adult mouse...
- Glypicans are differentially expressed during patterning and neurogenesis of early mouse brainGuillaume Luxardi
IBDML CNRS UMR 6216, INSERM UMR623, Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
Biochem Biophys Res Commun 352:55-60. 2007..The novel expression sites of glypicans shown here contribute to the identification of signalling molecules involved in brain patterning...
- Met acts on Mdm2 via mTOR to signal cell survival during developmentAnice Moumen
Developmental Biology Institute of Marseille Luminy IBDML CNRS INSERM Université de la Méditerrannée, Campus de Luminy Case 907, 13288 Marseille Cedex 09, France
Development 134:1443-51. 2007..Our studies identify a novel mechanism for Met-triggered cell survival during embryogenesis, involving translational regulation of Mdm2 by mTOR. Moreover, they reinforce mTOR as a potential drug target in cancer...