Affiliation: Utrecht University
Country: The Netherlands
Olthof M, Kempen D, Liu X, Dadsetan M, Tryfonidou M, Yaszemski M, et al
. Effect of biomaterial electrical charge on in vivo bone formation. Tissue Eng Part A. 2019;: pubmed publisher
..Overall, this study clearly shows that negative charge enhances bone formation compared to neutral and positive charge in OPF composites. ..
de Windt T, Niemansburg S, Vonk L, van Delden J, Roes K, Dhert W, et al
. Ethics in musculoskeletal regenerative medicine; guidance in choosing the appropriate comparator in clinical trials. Osteoarthritis Cartilage. 2019;27:34-40 pubmed publisher
..The latter may be compared to 'standard of care'. From a scientific perspective, choosing the correct comparator based on ethical guidelines is a step forward in the success of musculoskeletal RM. ..
Olthof M, Lu L, Tryfonidou M, Loozen L, Pouran B, Yaszemski M, et al
. The osteoinductive effect of controlled BMP-2 release is location-dependent. Tissue Eng Part A. 2018;: pubmed publisher
..Additionally, more bone formation in OPF-BP compared to ACS at both application sites emphasizes the role of biomaterials as a scaffold to achieve proper bone tissue formation. ..
Olthof M, Tryfonidou M, Dadsetan M, Dhert W, Yaszemski M, Kempen D, et al
. In Vitro and In Vivo Correlation of BMP-2 Release Profiles from Complex Delivery Vehicles. Tissue Eng Part C Methods. 2018;: pubmed publisher
..Altogether, these results imply that more sophisticated in vitro systems should be used in bone regeneration to accurately discriminate and predict in vivo BMP-2 release from different complex delivery vehicles. ..
Croes M, Ã–ner F, van Neerven D, Sabir E, Kruyt M, Blokhuis T, et al
. Proinflammatory T cells and IL-17 stimulate osteoblast differentiation. Bone. 2016;84:262-270 pubmed publisher
..From all T cells, the proinflammatory T cells, including the T helper 17 cells, are most stimulatory for osteogenesis. ..
Krouwels A, Melchels F, Van Rijen M, Oner F, Dhert W, Tryfonidou M, et al
. Comparing Hydrogels for Human Nucleus Pulposus Regeneration: Role of Osmolarity During Expansion. Tissue Eng Part C Methods. 2018;24:222-232 pubmed publisher
..Although culture in SF medium reduces the amount of proteoglycans produced during redifferentiation culture, isolating and expanding the cells in high osmolarity medium can largely compensate for this loss. ..
Olthof M, Tryfonidou M, Liu X, Pouran B, Meij B, Dhert W, et al
. Phosphate functional groups improve OPF osteoconduction and BMP-2 osteoinductive efficacy. Tissue Eng Part A. 2017;: pubmed publisher
..Therefore, functionalizing hydrogels with phosphate groups by crosslinking monomers into the hydrogel matrix could provide a valuable method for improving polymer characteristics and hold great promise for bone tissue engineering. ..