Esther F A Brandon

Summary

Affiliation: Utrecht University
Country: The Netherlands

Publications

  1. ncbi request reprint An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons
    Esther F A Brandon
    Division of Drug Toxicology, Department of Biomedical Analysis, Faculty of Pharmaceutical Sciences, Utrecht University, The Netherlands
    Toxicol Appl Pharmacol 189:233-46. 2003
  2. ncbi request reprint In vitro characterization of the biotransformation of thiocoraline, a novel marine anti-cancer drug
    Esther F A Brandon
    Faculty of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Invest New Drugs 22:241-51. 2004
  3. ncbi request reprint In vitro characterization of the human biotransformation pathways of aplidine, a novel marine anti-cancer drug
    Esther F A Brandon
    Department of Pharmaceutical Sciences, Section of Biomedical Analysis, Division of Drug Toxicology, Utrecht University, Utrecht, The Netherlands
    Invest New Drugs 25:9-19. 2007
  4. ncbi request reprint In vitro characterization of the human biotransformation and CYP reaction phenotype of ET-743 (Yondelis, Trabectidin), a novel marine anti-cancer drug
    Esther F A Brandon
    Faculty of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Invest New Drugs 24:3-14. 2006
  5. ncbi request reprint In-vitro cytotoxicity of ET-743 (Trabectedin, Yondelis), a marine anti-cancer drug, in the Hep G2 cell line: influence of cytochrome P450 and phase II inhibition, and cytochrome P450 induction
    Esther F A Brandon
    Division of Drug Toxicology, Department of Biomedical Analysis, Faculty of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Anticancer Drugs 16:935-43. 2005
  6. ncbi request reprint Validation of in vitro cell models used in drug metabolism and transport studies; genotyping of cytochrome P450, phase II enzymes and drug transporter polymorphisms in the human hepatoma (HepG2), ovarian carcinoma (IGROV-1) and colon carcinoma (CaCo-2, LS
    Esther F A Brandon
    Department of Biomedical Analysis, Section of Drug Toxicology, Faculty of Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
    Toxicol Appl Pharmacol 211:1-10. 2006
  7. ncbi request reprint Structure elucidation of aplidine metabolites formed in vitro by human liver microsomes using triple quadrupole mass spectrometry
    Esther F A Brandon
    Utrecht University, Faculty of Pharmaceutical Sciences, Department of Biomedical Analysis, Division of Drug Toxicology, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
    J Mass Spectrom 40:821-31. 2005

Detail Information

Publications7

  1. ncbi request reprint An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons
    Esther F A Brandon
    Division of Drug Toxicology, Department of Biomedical Analysis, Faculty of Pharmaceutical Sciences, Utrecht University, The Netherlands
    Toxicol Appl Pharmacol 189:233-46. 2003
    ..This review describes the practical aspects of selected in vitro human liver models with comparisons between the methods...
  2. ncbi request reprint In vitro characterization of the biotransformation of thiocoraline, a novel marine anti-cancer drug
    Esther F A Brandon
    Faculty of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Invest New Drugs 22:241-51. 2004
    ..These results provide evidence that human CYP3A4 plays a major role in the metabolism of thiocoraline in vitro and that the metabolites formed by CYP are conjugated by the phase II enzymes UGT, ST and GST...
  3. ncbi request reprint In vitro characterization of the human biotransformation pathways of aplidine, a novel marine anti-cancer drug
    Esther F A Brandon
    Department of Pharmaceutical Sciences, Section of Biomedical Analysis, Division of Drug Toxicology, Utrecht University, Utrecht, The Netherlands
    Invest New Drugs 25:9-19. 2007
    ..Further, the metabolites formed by CYPs can be conjugated by UGT, SULT and GST. These findings could help interpret the in vivo pharmacokinetics of aplidine...
  4. ncbi request reprint In vitro characterization of the human biotransformation and CYP reaction phenotype of ET-743 (Yondelis, Trabectidin), a novel marine anti-cancer drug
    Esther F A Brandon
    Faculty of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Invest New Drugs 24:3-14. 2006
    ..Furthermore, ET-743 is conjugated by UGT and GST. This information could be important for interpretation of the pharmacokinetic data of clinical trials and prediction of drug-drug interactions...
  5. ncbi request reprint In-vitro cytotoxicity of ET-743 (Trabectedin, Yondelis), a marine anti-cancer drug, in the Hep G2 cell line: influence of cytochrome P450 and phase II inhibition, and cytochrome P450 induction
    Esther F A Brandon
    Division of Drug Toxicology, Department of Biomedical Analysis, Faculty of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Anticancer Drugs 16:935-43. 2005
    ..These findings indicate that combination therapy of ET-743 with CYP inhibitors, e.g. other anti-cancer drugs, could lead to changes in the hepatotoxicity of ET-743 and are therefore of clinical importance...
  6. ncbi request reprint Validation of in vitro cell models used in drug metabolism and transport studies; genotyping of cytochrome P450, phase II enzymes and drug transporter polymorphisms in the human hepatoma (HepG2), ovarian carcinoma (IGROV-1) and colon carcinoma (CaCo-2, LS
    Esther F A Brandon
    Department of Biomedical Analysis, Section of Drug Toxicology, Faculty of Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
    Toxicol Appl Pharmacol 211:1-10. 2006
    ..However, this characterization will be an aid in the interpretation of the results of biotransformation and transport studies using these in vitro cell models...
  7. ncbi request reprint Structure elucidation of aplidine metabolites formed in vitro by human liver microsomes using triple quadrupole mass spectrometry
    Esther F A Brandon
    Utrecht University, Faculty of Pharmaceutical Sciences, Department of Biomedical Analysis, Division of Drug Toxicology, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
    J Mass Spectrom 40:821-31. 2005
    ..The identification of these metabolites formed in vitro may greatly aid the elucidation of the metabolic pathways of aplidine in humans...