Joost B Beltman

Summary

Affiliation: Utrecht University
Country: The Netherlands

Publications

  1. pmc Chemotactic migration of T cells towards dendritic cells promotes the detection of rare antigens
    Renske M A Vroomans
    Theoretical Biology, Utrecht University, Utrecht, The Netherlands
    PLoS Comput Biol 8:e1002763. 2012
  2. pmc Towards estimating the true duration of dendritic cell interactions with T cells
    Joost B Beltman
    Theoretical Biology, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    J Immunol Methods 347:54-69. 2009
  3. ncbi request reprint Analysing immune cell migration
    Joost B Beltman
    Theoretical Biology, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Nat Rev Immunol 9:789-98. 2009
  4. pmc B cells within germinal centers migrate preferentially from dark to light zone
    Joost B Beltman
    Theoretical Biology, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Proc Natl Acad Sci U S A 108:8755-60. 2011
  5. ncbi request reprint Spatial modelling of brief and long interactions between T cells and dendritic cells
    Joost B Beltman
    Theoretical Biology, Utrecht University, Padualaan 8, CH 3584 Utrecht, The Netherlands
    Immunol Cell Biol 85:306-14. 2007
  6. pmc Lymph node topology dictates T cell migration behavior
    Joost B Beltman
    Theoretical Biology, Utrecht University, 3584 CH Utrecht, Netherlands
    J Exp Med 204:771-80. 2007
  7. ncbi request reprint Random migration and signal integration promote rapid and robust T cell recruitment
    Johannes Textor
    Theoretical Biology and Bioinformatics, Utrecht University, Utrecht, The Netherlands
    PLoS Comput Biol 10:e1003752. 2014
  8. pmc A general functional response of cytotoxic T lymphocyte-mediated killing of target cells
    Saikrishna Gadhamsetty
    Theoretical Biology and Bioinformatics, Utrecht University, Utrecht, The Netherlands Electronic address
    Biophys J 106:1780-91. 2014
  9. ncbi request reprint MHC polymorphism under host-pathogen coevolution
    Jose A M Borghans
    Theoretical Biology, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Immunogenetics 55:732-9. 2004

Detail Information

Publications9

  1. pmc Chemotactic migration of T cells towards dendritic cells promotes the detection of rare antigens
    Renske M A Vroomans
    Theoretical Biology, Utrecht University, Utrecht, The Netherlands
    PLoS Comput Biol 8:e1002763. 2012
    ..Moreover, the chemotaxis-driven migration still roughly appears as a random walk, hence fine-tuned analysis of cell tracks will be required to detect chemotaxis within microscopy data...
  2. pmc Towards estimating the true duration of dendritic cell interactions with T cells
    Joost B Beltman
    Theoretical Biology, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    J Immunol Methods 347:54-69. 2009
    ..We discuss in detail how future experiments can be optimized such that MPM contact data will be minimally affected by these factors...
  3. ncbi request reprint Analysing immune cell migration
    Joost B Beltman
    Theoretical Biology, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Nat Rev Immunol 9:789-98. 2009
    ..We propose how these errors can be recognized and corrected, and suggest ways to prevent the data analysis itself leading to biased results...
  4. pmc B cells within germinal centers migrate preferentially from dark to light zone
    Joost B Beltman
    Theoretical Biology, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Proc Natl Acad Sci U S A 108:8755-60. 2011
    ..This is consistent with experimental observations, and we show that at the observed cellular motility such a time course cannot be explained without the small preferential migration from DZ to LZ...
  5. ncbi request reprint Spatial modelling of brief and long interactions between T cells and dendritic cells
    Joost B Beltman
    Theoretical Biology, Utrecht University, Padualaan 8, CH 3584 Utrecht, The Netherlands
    Immunol Cell Biol 85:306-14. 2007
    ..Finally, by performing long simulations (after prior fitting to short time scale data) we are able to provide an estimate of the average contact duration between T cells and DCs...
  6. pmc Lymph node topology dictates T cell migration behavior
    Joost B Beltman
    Theoretical Biology, Utrecht University, 3584 CH Utrecht, Netherlands
    J Exp Med 204:771-80. 2007
    ..We present experimental evidence for the presence of such turbulent streams in LNs. Finally, the model allows us to estimate the scanning rates of DCs (2,000 different T cells per hour) and T cells (100 different DCs per hour)...
  7. ncbi request reprint Random migration and signal integration promote rapid and robust T cell recruitment
    Johannes Textor
    Theoretical Biology and Bioinformatics, Utrecht University, Utrecht, The Netherlands
    PLoS Comput Biol 10:e1003752. 2014
    ..Thus, the combination of two-scale stochastic migration and signal integration is an efficient and robust strategy for T cell immune surveillance. ..
  8. pmc A general functional response of cytotoxic T lymphocyte-mediated killing of target cells
    Saikrishna Gadhamsetty
    Theoretical Biology and Bioinformatics, Utrecht University, Utrecht, The Netherlands Electronic address
    Biophys J 106:1780-91. 2014
    ..For the other cases, a biological interpretation of the parameters is still possible. Our results imply that this DS function can be used as a tool to predict the cellular interactions in cytotoxicity data. ..
  9. ncbi request reprint MHC polymorphism under host-pathogen coevolution
    Jose A M Borghans
    Theoretical Biology, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Immunogenetics 55:732-9. 2004
    ..Provided that the host population is sufficiently large, a large set of MHC alleles can persist over many host generations under host-pathogen coevolution, despite the fact that allele frequencies continuously change...