Research Topics
| B H WolffenbuttelSummaryAffiliation: University Hospital Maastricht Country: The Netherlands Publications
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Detail Information
Publications
Comparison of different insulin regimens in elderly patients with NIDDMB H Wolffenbuttel
Department of Internal Medicine, University Hospital Maastricht, The Netherlands
Diabetes Care 19:1326-32. 1996....
[Postprandial glucose peaks in the pathogenesis of cardiovascular disease in diabetes mellitus; implications for metabolic control]B H R Wolffenbuttel
Academisch Ziekenhuis, Afd Endocrinologie, Postbus 5800, 6202 AZ Maastricht
Ned Tijdschr Geneeskd 146:654-8. 2002..People suffering from diabetes are best advised to direct their self control also at the bloodglucose level 1.5-2 h after a meal...
[Disorders of lipid metabolism in 3 patients with diabetes mellitus type 2]B H Wolffenbuttel
Academisch Ziekenhuis, Afd Endocrinologie, Postbus 5800, 6202 AZ Maastrict
Ned Tijdschr Geneeskd 145:761-5. 2001....
RosiglitazoneB H Wolffenbuttel
Dept of Endocrinology and Metabolism, University Hospital Maastricht, P O Box 5800, NL 6202 AZ Maastricht, The Netherlands
Expert Opin Pharmacother 2:467-78. 2001..Additional studies will also explore its long-term effects in sparing beta-cell function and reducing diabetes-related complications and atherosclerosis...
Addition of low-dose rosiglitazone to sulphonylurea therapy improves glycaemic control in Type 2 diabetic patientsB H Wolffenbuttel
University Hospital Maastricht, The Netherlands
Diabet Med 17:40-7. 2000..This study was designed to test the efficacy and safety of low-dose rosiglitazone, a potent, insulin-sensitizing thiazolidinedione, in combination with sulphonylurea in Type 2 diabetic patients...
Repaglinide--a new compound for the treatment of patients with type 2 diabetesB H Wolffenbuttel
Dept of Endocrinology and Metabolism, University Hospital Maastricht, The Netherlands
Neth J Med 55:229-34. 1999..Although the overall incidence of hypoglycaemia was similar during use of repaglinide and of sulphonylurea, fewer serious hypoglycaemic episodes were observed in repaglinide-treated patients...
[Glycemic regulation and management of essential hypertension in diabetics with type 2 diabetes mellitus; the 'United Kingdom prospective diabetes study' of diabetic complications]B H Wolffenbuttel
Afd Endocrinologie, Academisch Ziekenhuis Maastricht
Ned Tijdschr Geneeskd 143:1197-201. 1999..Non of the antihypertensive drugs used (an ACE inhibitor and a beta-blocking agent) offered any advantages over the other...
A 1-year multicenter randomized double-blind comparison of repaglinide and glyburide for the treatment of type 2 diabetes. Dutch and German Repaglinide Study GroupB H Wolffenbuttel
Department of Endocrinology, University Hospital Maastricht, The Netherlands
Diabetes Care 22:463-7. 1999..This multicenter study was designed to compare the efficacy and safety of this drug with glyburide in a 1-year randomized double-blind study of outpatients with type 2 diabetes...
Beneficial gamma-knife radiosurgery in a patient with Nelson's syndromeB H Wolffenbuttel
Department of Endocrinology, University Hospital Maastricht, The Netherlands
Clin Neurol Neurosurg 100:60-3. 1998..It is concluded that gamma-knife radiosurgery may be a good alternative for patients with Nelson's syndrome who have rapidly recurring disease...
Prognostic factors for successful insulin therapy in subjects with type 2 diabetesB H Wolffenbuttel
Department of Endocrinology and Metabolism, University Hospital Maastricht, The Netherlands
Neth J Med 54:63-9. 1999..To assess which factors influence or predict the efficacy of insulin therapy in subjects with type 2 diabetes, who were poorly controlled despite maximal doses of oral glucose lowering agents...
Efficacy and safety of a new cholesterol synthesis inhibitor, atorvastatin, in comparison with simvastatin and pravastatin, in subjects with hypercholesterolemiaB H Wolffenbuttel
Department of Endocrinology and Metabolism, University Hospital Maastricht, Netherlands
Neth J Med 52:131-7. 1998..In a 16-week, multicenter, randomized, open-label cross-over study we compared the efficacy and safety of the new compound atorvastatin for reducing LDL-cholesterol with simvastatin or pravastatin...
Effect of atorvastatin on LDL oxidation and antioxidants in normocholesterolemic type 2 diabetic patientsW A Oranje
Department of Endocrinology and Metabolism, University Hospital Maastricht, Maastricht, The Netherlands
Clin Chim Acta 311:91-4. 2001..Oxidative stress in diabetes increases lipid peroxidation, which stimulates the development of atherosclerosis...
Arteriolar reactivity in conscious diabetic rats: influence of aminoguanidine treatmentF R Crijns
Department of Endocrinology and Metabolism, Cardiovascular Research Institute, University Hospital Maastricht, The Netherlands
Diabetes 47:918-23. 1998..05 vs. untreated control rats). These data indicate that 6 weeks of experimental diabetes is associated with a decreased endothelium-dependent and -independent vasodilatation. AG treatment had no beneficial effect on this disturbance...
Lipid peroxidation in type 2 diabetes: relationship with macrovascular disease?W A Oranje
Dept of Endocrinology and Metabolism, University Hospital Maastricht, The Netherlands
Neth J Med 53:61-8. 1998..Macrovascular disease is the leading cause of death in diabetes. The increased risk of atherosclerosis in diabetes may be partly explained by increased lipid peroxidation...
Mechanical properties of mesenteric arteries in diabetic rats: consequences of outward remodelingF R Crijns
Department of Endocrinology and Metabolism, Cardiovascular Research Institute Maastricht, University Hospital Maastricht, 6202 AZ Maastricht, The Netherlands
Am J Physiol 276:H1672-7. 1999..These results indicate that mesenteric small arteries of diabetic rats display eutrophic outward remodeling associated with increased wall tension and circumferential wall stress...
Effects of acarbose (Glucobay) in persons with type 1 diabetes: a multicentre studyJ P Sels
Department of Endocrinology and Metabolism, University Hospital Maastricht, The Netherlands
Diabetes Res Clin Pract 41:139-45. 1998..We conclude that acarbose up to 3 x 100 mg/day can be a valuable adjunct to insulin in improving metabolic control in persons with type 1 diabetes...
Miglitol, a new alpha-glucosidase inhibitorJ P Sels
Department of Endocrinology, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
Expert Opin Pharmacother 1:149-56. 1999..More long-term data are needed to fully assess to the clinical use of miglitol in these patients...
Pitfall of the accessory spleenJ P Sels
Department of Endocrinology, University Hospital Maastricht, P O Box 5800, 6202 AZ, Maastricht, The Netherlands
Neth J Med 56:153-8. 2000..The insulinoma was identified as such during laparotomy, whereas additional jodo-cholesterol scintigraphy revealed the real nature of the lesion in the patient with Cushing's syndrome. Both patients were operated successfully...
Clinical experience with Sandostatin LAR in patients with acromegalyC A Heijckmann
Department of Endocrinology, University Hospital Maastricht, P.O. Box 5800, NL-6202 AZ Maastricht, The Netherlands
Neth J Med 59:286-91. 2001..In six patients, the dose had to be increased to 30-40 mg monthly because the IGF-1 levels still remained elevated. Sandostatin LAR may be considered a great improvement for the treatment of patients with (symptomatic) acromegaly...
Cytochrome P450, peroxisome proliferation, and cytoplasmic fatty acid-binding protein content in liver, heart and kidney of the diabetic ratW Engels
Department of Internal Medicine, Maastricht University, The Netherlands
Mol Cell Biochem 192:53-61. 1999..Consequently, it is not likely that dicarboxylic acids are involved in the induction of peroxisome proliferation in the heart...
CETP inhibition in cardiovascular risk management: a critical appraisalR P F Dullaart
University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Eur J Clin Invest 37:90-8. 2007..We propose that low HDL cholesterol in the context of high triglycerides, such as found in type 2 diabetes mellitus, could become an important indication area for this new class of drugs...
Preoperative pharmacological management of phaeochromocytomaA N A van der Horst-Schrivers
Department of Endocrinology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
Neth J Med 64:290-5. 2006..We reviewed the relevant literature on this subject. In addition, we compared the several preoperative treatment protocols of the eight university medical centres in the Netherlands...
Time course of specific AGEs during optimised glycaemic control in type 2 diabetesC J A L Mentink
Department of Human Biology, Faculty of Health Sciences, Maastricht University, Maastricht, The Netherlands
Neth J Med 64:10-6. 2006..This suggests that these specific AGEs are influenced by other factors in addition to overall glycaemia, such as oxidative stress...
Elevated plasma phospholipid transfer protein activity is a determinant of carotid intima-media thickness in type 2 diabetes mellitusR De Vries
Department of Endocrinology, University Medical Center Groningen, University of Groningen, P O Box 30 001, RB 9700 Groningen, The Netherlands
Diabetologia 49:398-404. 2006..We analysed the relationship between carotid artery intima-media thickness (IMT), an established marker of atherosclerosis, and PLTP activity in diabetic patients and control subjects...
[Missed hyperinsulinaemia in a patient with an insulinoma]R S M E Wouters
afd Interne Geneeskunde, Scheper Ziekenhuis, Boermarkeweg 60, 7824 AA Emmen
Ned Tijdschr Geneeskd 149:944-6. 2005..Therefore new normative values are needed for the newer insulin assays when diagnosing an insulin-producing islet cell tumour. Pro-insulin and C-peptide assays may play a useful role in this...
Do diabetologists recognise self-management problems in their patients?J C Keers
Northern Centre for Healthcare Research, P O Box 196, Groningen 9700 AD, The Netherlands
Diabetes Res Clin Pract 66:157-61. 2004..The aim of this study was to determine whether diabetologists recognise patients' needs for additional intensive multidisciplinary care due to glycaemic and diabetes-related psychosocial difficulties...
Hypoglycaemia with insulin aspart: a double-blind, randomised, crossover trial in subjects with Type 1 diabetesS R Heller
Northern General Hospital, Sheffield S5 7AU, UK
Diabet Med 21:769-75. 2004....
Effects of androgenic-anabolic steroids on apolipoproteins and lipoprotein (a)F Hartgens
Netherlands Centre for Doping Affairs, Capelle aan den IJssel, The Netherlands
Br J Sports Med 38:253-9. 2004....
Resource consumption and costs in Dutch patients with type 2 diabetes mellitus. Results from 29 general practicesW K Redekop
Institute for Medical Technology Assessment iMTA, Erasmus University Rotterdam, Rotterdam, The Netherlands
Diabet Med 19:246-53. 2002....
[The prevalence of the metabolic syndrome in the Netherlands: increased risk of cardiovascular diseases and diabetes mellitus type 2 in one quarter of persons under 60]M B Bos
Rijksinstituut voor Volksgezondheid en Milieu, Centrum voor Voeding en Gezondheid, Bilthoven
Ned Tijdschr Geneeskd 151:2382-8. 2007..To estimate the prevalence of the metabolic syndrome in the Netherlands in two populations in the age category 28-59 years and to compare this with the prevalence of hypercholesterolaemia in these populations...
