Johanna Westra

Summary

Affiliation: University Medical Center Groningen
Country: The Netherlands

Publications

  1. ncbi request reprint Hypoxia-inducible factor-1 as regulator of angiogenesis in rheumatoid arthritis - therapeutic implications
    Johanna Westra
    Department of Rheumatology and Clinical Immunology, Medical Biology Section, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Curr Med Chem 17:254-63. 2010
  2. doi request reprint Role for CaMKII inhibition in rheumatoid arthritis: effects on HIF-1-induced VEGF production by rheumatoid synovial fibroblasts
    Johanna Westra
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands
    Ann N Y Acad Sci 1173:706-11. 2009
  3. pmc Expression and regulation of HIF-1alpha in macrophages under inflammatory conditions; significant reduction of VEGF by CaMKII inhibitor
    Johanna Westra
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands
    BMC Musculoskelet Disord 11:61. 2010
  4. ncbi request reprint Regulation of cytokine-induced HIF-1alpha expression in rheumatoid synovial fibroblasts
    Johanna Westra
    Department of Rheumatology and Clinical Immunology, University Medical Center, Groningen, The Netherlands
    Ann N Y Acad Sci 1108:340-8. 2007
  5. ncbi request reprint p38 mitogen-activated protein kinase (MAPK) in rheumatoid arthritis
    J Westra
    Department of Rheumatology, University Medical Center Groningen, P O Box 30001, 9700 RB Groningen, The Netherlands
    Mini Rev Med Chem 6:867-74. 2006
  6. pmc Differential influence of p38 mitogen activated protein kinase (MAPK) inhibition on acute phase protein synthesis in human hepatoma cell lines
    J Westra
    Department of Rheumatology, University Medical Centre Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Ann Rheum Dis 65:929-35. 2006
  7. doi request reprint Angiopoietin-2 is highly correlated with inflammation and disease activity in recent-onset rheumatoid arthritis and could be predictive for cardiovascular disease
    Johanna Westra
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Rheumatology (Oxford) 50:665-73. 2011
  8. pmc Strong inhibition of TNF-alpha production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ 67657, a p38 mitogen-activated protein kinase (MAPK) inhibitor
    Johanna Westra
    Department of Rheumatology, University Hospital Groningen, Groningen, The Netherlands
    Arthritis Res Ther 6:R384-92. 2004
  9. ncbi request reprint Differential effects of NF-{kappa}B and p38 MAPK inhibitors and combinations thereof on TNF-{alpha}- and IL-1{beta}-induced proinflammatory status of endothelial cells in vitro
    Joanna M Kuldo
    University Medical Center Groningen, Department of Pathology, Medical Biology Section, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Am J Physiol Cell Physiol 289:C1229-39. 2005
  10. doi request reprint Cell-mediated immune responses to influenza vaccination in Wegener's granulomatosis
    Albert Holvast
    Department of Rheumatology and Clinical Immunology, University Medical Centre Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Ann Rheum Dis 69:924-7. 2010

Detail Information

Publications38

  1. ncbi request reprint Hypoxia-inducible factor-1 as regulator of angiogenesis in rheumatoid arthritis - therapeutic implications
    Johanna Westra
    Department of Rheumatology and Clinical Immunology, Medical Biology Section, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Curr Med Chem 17:254-63. 2010
    ..This review will concisely summarize the general knowledge on the molecular control of gene expression by HIF-1, its involvement in RA, and potential for therapeutic intervention at the level of HIF-1 activity...
  2. doi request reprint Role for CaMKII inhibition in rheumatoid arthritis: effects on HIF-1-induced VEGF production by rheumatoid synovial fibroblasts
    Johanna Westra
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands
    Ann N Y Acad Sci 1173:706-11. 2009
    ..The present study was designed to investigate the effects of a novel CaMKII inhibitor SMP-114, which was effective in a collagen-induced arthritis model in rats, on rheumatoid synovial fibroblasts...
  3. pmc Expression and regulation of HIF-1alpha in macrophages under inflammatory conditions; significant reduction of VEGF by CaMKII inhibitor
    Johanna Westra
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands
    BMC Musculoskelet Disord 11:61. 2010
    ..We investigated the effects of CaMKII-inhibitors amongst other kinase inhibitors, on HIF-1 alpha expression and downstream production of pro-angiogenic factors in macrophages...
  4. ncbi request reprint Regulation of cytokine-induced HIF-1alpha expression in rheumatoid synovial fibroblasts
    Johanna Westra
    Department of Rheumatology and Clinical Immunology, University Medical Center, Groningen, The Netherlands
    Ann N Y Acad Sci 1108:340-8. 2007
    ..Both the ERK pathway and the PI3K pathway are involved in the cytokine-induced HIF-1alpha expression in RSF and in the expression of proangiogenic factors...
  5. ncbi request reprint p38 mitogen-activated protein kinase (MAPK) in rheumatoid arthritis
    J Westra
    Department of Rheumatology, University Medical Center Groningen, P O Box 30001, 9700 RB Groningen, The Netherlands
    Mini Rev Med Chem 6:867-74. 2006
    ..In this review new insights such as non-stressful activation of p38 MAPK, and the role of p38 MAPK in regulation of NF-kappaB recruitment are also discussed...
  6. pmc Differential influence of p38 mitogen activated protein kinase (MAPK) inhibition on acute phase protein synthesis in human hepatoma cell lines
    J Westra
    Department of Rheumatology, University Medical Centre Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Ann Rheum Dis 65:929-35. 2006
    ..p38 MAPK inhibitors, especially, have been developed and are now in phase II clinical trials for rheumatoid arthritis (RA)...
  7. doi request reprint Angiopoietin-2 is highly correlated with inflammation and disease activity in recent-onset rheumatoid arthritis and could be predictive for cardiovascular disease
    Johanna Westra
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Rheumatology (Oxford) 50:665-73. 2011
    ....
  8. pmc Strong inhibition of TNF-alpha production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ 67657, a p38 mitogen-activated protein kinase (MAPK) inhibitor
    Johanna Westra
    Department of Rheumatology, University Hospital Groningen, Groningen, The Netherlands
    Arthritis Res Ther 6:R384-92. 2004
    ..The results presented here may have important implications for the treatment of rheumatoid arthritis...
  9. ncbi request reprint Differential effects of NF-{kappa}B and p38 MAPK inhibitors and combinations thereof on TNF-{alpha}- and IL-1{beta}-induced proinflammatory status of endothelial cells in vitro
    Joanna M Kuldo
    University Medical Center Groningen, Department of Pathology, Medical Biology Section, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Am J Physiol Cell Physiol 289:C1229-39. 2005
    ..Application of combinations of drugs that affect multiple targets in activated endothelial cells may therefore be considered as a potential new therapeutic strategy to inhibit inflammatory disease activity...
  10. doi request reprint Cell-mediated immune responses to influenza vaccination in Wegener's granulomatosis
    Albert Holvast
    Department of Rheumatology and Clinical Immunology, University Medical Centre Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Ann Rheum Dis 69:924-7. 2010
    ..In Wegener's granulomatosis (WG), antibody responses to influenza vaccination appear to be similar to those in healthy controls, but cell-mediated responses have not been studied...
  11. doi request reprint Humoral responses after influenza vaccination are severely reduced in patients with rheumatoid arthritis treated with rituximab
    Sander Van Assen
    Department of Internal Medicine, Division of Infectious Diseases, University Medical Center Groningen, Groningen, The Netherlands
    Arthritis Rheum 62:75-81. 2010
    ..We also undertook to assess the safety of influenza vaccination and the effects of previous influenza vaccination...
  12. doi request reprint Effect of a second, booster, influenza vaccination on antibody responses in quiescent systemic lupus erythematosus: an open, prospective, controlled study
    Albert Holvast
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Rheumatology (Oxford) 48:1294-9. 2009
    ..In SLE, a decreased antibody response on influenza vaccination has been reported. In this study, we assessed whether a booster vaccination could improve antibody responses, as determined by seroprotection rates, in SLE patients...
  13. ncbi request reprint Chemokine production and E-selectin expression in activated endothelial cells are inhibited by p38 MAPK (mitogen activated protein kinase) inhibitor RWJ 67657
    Johanna Westra
    Department of Rheumatology, University Medical Centre Groningen, The Netherlands
    Int Immunopharmacol 5:1259-69. 2005
    ..Treatment with RWJ 67657 could lead to reduced leukocyte infiltration by the reduction of E-selectin expression and chemokine production...
  14. doi request reprint Patients with humoral primary immunodeficiency do not develop protective anti-influenza antibody titers after vaccination with trivalent subunit influenza vaccine
    Sander Van Assen
    Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Clin Immunol 136:228-35. 2010
    ..Previous vaccination in patients and treatment with IVIg did not result in a higher rate of postvaccination titer > or =40. In conclusion, patients with hPID show hardly any humoral response following influenza vaccination...
  15. pmc Decreased CXCR1 and CXCR2 expression on neutrophils in anti-neutrophil cytoplasmic autoantibody-associated vasculitides potentially increases neutrophil adhesion and impairs migration
    Nan Hu
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, PO Box 30, 001, 9700 RB, Groningen, The Netherlands
    Arthritis Res Ther 13:R201. 2011
    ..We speculate that down-regulated expression of CXCR1/2 retains neutrophils within the vessel wall and, consequently, leads to vessel damage...
  16. doi request reprint Cell-mediated immune responses to inactivated trivalent influenza-vaccination are decreased in patients with common variable immunodeficiency
    Sander Van Assen
    Department of Internal Medicine, Division of Infectious Diseases, University Medical Center Groningen, The Netherlands
    Clin Immunol 141:161-8. 2011
    ..Concluding, CMI responses following influenza vaccination are hampered in CVID-patients compared to HC. Additional protective strategies against influenza other than vaccination are warranted...
  17. pmc Effects of RWJ 67657, a p38 mitogen activated protein kinase (MAPK) inhibitor, on the production of inflammatory mediators by rheumatoid synovial fibroblasts
    J Westra
    Department of Rheumatology, University Hospital Groningen, PO Box 30 001, 9700 RB Groningen, Netherlands
    Ann Rheum Dis 63:1453-9. 2004
    ..To investigate the effect of the p38 mitogen activated protein kinase (MAPK) inhibitor RWJ 67657 on inflammatory mediator production by rheumatoid synovial fibroblasts (RSF)...
  18. pmc Advanced glycation endproducts are increased in rheumatoid arthritis patients with controlled disease
    Lodewijk de Groot
    Department of Rheumatology and Clinical Immunology, University Medical Centre, University of Groningen, Groningen, The Netherlands
    Arthritis Res Ther 13:R205. 2011
    ....
  19. pmc Increase in IL-21 producing T-cells in patients with systemic lupus erythematosus
    Sebastian Dolff
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Arthritis Res Ther 13:R157. 2011
    ..The novel cytokine interleukin-21 (IL-21) is suggested to be crucial for triggering T-cell responses towards IL-17 producing cells. Thus, we aimed to investigate the ability of T-cells to produce IL-21 and IL-17 in SLE patients...
  20. doi request reprint Targeted folate receptor β fluorescence imaging as a measure of inflammation to estimate vulnerability within human atherosclerotic carotid plaque
    Nynke A Jager
    Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Nucl Med 53:1222-9. 2012
    ..By conjugating the ligand folate with a fluorescent contrast agent, fluorescein isothiocyanate (FITC), we aimed to explore the potential role of FR-β fluorescence imaging in the distinction of vulnerable sites from more stable regions...
  21. doi request reprint Macrophage folate receptor-β (FR-β) expression in auto-immune inflammatory rheumatic diseases: a forthcoming marker for cardiovascular risk?
    Nynke A Jager
    Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, PB 30 001, 9700 RB, Groningen, The Netherlands
    Autoimmun Rev 11:621-6. 2012
    ..Therefore, expression of FR-β on activated macrophages holds a promising potential for early diagnosis and better analysis of optimal treatment regiments of vascular diseases in association with systemic diseases...
  22. doi request reprint Dysregulated neutrophil--endothelial interaction in antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides: implications for pathogenesis and disease intervention
    Nan Hu
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Autoimmun Rev 10:536-43. 2011
    ..In addition, potential elements for disease intervention based on this process are discussed...
  23. pmc High mobility group box 1 (HMGB1) and anti-HMGB1 antibodies and their relation to disease characteristics in systemic lupus erythematosus
    Deena A Abdulahad
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Arthritis Res Ther 13:R71. 2011
    ..In this study we determined levels of HMGB1 and anti-HMGB1 in SLE patients in comparison to healthy controls (HC) and analysed their relation with disease activity...
  24. ncbi request reprint Serum matrix metalloproteinase 3 levels during treatment with sulfasalazine or combination of methotrexate and sulfasalazine in patients with early rheumatoid arthritis
    Marcel D Posthumus
    Department of Rheumatology, University Hospital Groningen, The Netherlands
    J Rheumatol 29:883-9. 2002
    ..To determine the effects of treatment with sulfasalazine (SSZ) or the combination of methotrexate (MTX) and SSZ on serum matrix metalloproteinase 3 (MMP-3) levels in patients with early rheumatoid arthritis (RA)...
  25. doi request reprint Inhibition of high-mobility group box 1 as therapeutic option in autoimmune disease: lessons from animal models
    Fleur Schaper
    Department of Rheumatology and Clinical Immunology, Medical Biology Section, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Curr Opin Rheumatol 25:254-9. 2013
    ..This review will focus on the modulation of HMGB1 in animal models of (auto)immune diseases...
  26. ncbi request reprint Hypoxia inducible factor-1-alpha (HIF-1alpha) is related to both angiogenesis and inflammation in rheumatoid arthritis
    E Brouwer
    Department of Rheumatology and Clinical Immunology, University Medical Centre Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Clin Exp Rheumatol 27:945-51. 2009
    ....
  27. doi request reprint HMGB1 in systemic lupus Erythematosus: Its role in cutaneous lesions development
    D A Abdulahad
    Department of Rheumatology and Clinical Immunology, University Medical Center, University of Groningen, The Netherlands
    Autoimmun Rev 9:661-5. 2010
    ..In this review the general characteristics and activities of HMGB1 are highlighted and its role in SLE will be discussed with special attention to its involvement in the pathogenesis of skin lesions...
  28. doi request reprint Lessons to be learned from periodontitis
    Koen M J Janssen
    Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Curr Opin Rheumatol 25:241-7. 2013
    ..Emphasis is paid to the potential role of the periodontal pathogen Porphyromonas gingivalis in the etiopathogenesis of both periodontitis and RA, in particular by post-translational modification of arginine into citrulline...
  29. doi request reprint The periodontium of periodontitis patients contains citrullinated proteins which may play a role in ACPA (anti-citrullinated protein antibody) formation
    Willem Nesse
    Department of Oral and Maxillofacial Surgery, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands
    J Clin Periodontol 39:599-607. 2012
    ..To determine the presence and location (stroma versus epithelium) of citrullinated proteins in periodontitis tissue as compared to non-periodontitis tissue and synovial tissue of RA patients...
  30. pmc CCR5Δ32 genotype leads to a Th2 type directed immune response in ESRD patients
    Friso L H Muntinghe
    Internal Medicine, Vasculair Medicine, University Medical Center Groningen, Groningen, The Netherlands
    PLoS ONE 7:e31257. 2012
    ..So, in the present study we determined the Th1-Th2 type directed immune response in ESRD patients carrying and not carrying the CCR5Δ32 genetic variant after stimulation...
  31. ncbi request reprint AGE and their receptor RAGE in systemic autoimmune diseases: an inflammation propagating factor contributing to accelerated atherosclerosis
    Hans L A Nienhuis
    Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Autoimmunity 42:302-4. 2009
    ..The AGE-RAGE interaction might act as a pro-inflammatory loop in these patients, contributing to chronic low grade inflammation rendering these individuals susceptible for development of accelerated atherosclerosis...
  32. doi request reprint Studies of cell-mediated immune responses to influenza vaccination in systemic lupus erythematosus
    Albert Holvast
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Arthritis Rheum 60:2438-47. 2009
    ..This study was therefore undertaken to assess cell-mediated responses to influenza vaccination in patients with SLE...
  33. doi request reprint Autoantibodies against glomerular endothelial cells in anti-neutrophil cytoplasmic autoantibody-associated systemic vasculitis
    Nan Hu
    Departments of Rheumatology and Clinical Immunology, University Medical Center Groningen, The Netherlands
    Nephrology (Carlton) 14:11-5. 2009
    ..Therefore, we investigated AECA prevalence using a human glomerular endothelial cell line compared with primary human umbilical vein endothelial cells, which have frequently been used for AECA detection...
  34. doi request reprint Membrane-bound proteinase 3 and its receptors: relevance for the pathogenesis of Wegener's Granulomatosis
    Nan Hu
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands
    Autoimmun Rev 8:510-4. 2009
    ..This review gives updated information on the mechanism of mPR3 expression and the relevance of colocalization of mPR3 with other molecules on the neutrophil membrane for the pathophysiological events occurring in WG...
  35. ncbi request reprint Serum matrix metalloproteinase 3 levels in comparison to C-reactive protein in periods with and without progression of radiological damage in patients with early rheumatoid arthritis
    M D Posthumus
    Department of Rheumatology, University Hospital Groningen, The Netherlands
    Clin Exp Rheumatol 21:465-72. 2003
    ..To evaluate serum matrix metalloproteinase 3 (MMP-3) levels in comparison to C-reactive protein (CRP) in periods with and without progression of radiological damage in patients with early rheumatoid arthritis (RA)...
  36. doi request reprint Coexpression of CD177 and membrane proteinase 3 on neutrophils in antineutrophil cytoplasmic autoantibody-associated systemic vasculitis: anti-proteinase 3-mediated neutrophil activation is independent of the role of CD177-expressing neutrophils
    N Hu
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands
    Arthritis Rheum 60:1548-57. 2009
    ....
  37. ncbi request reprint Constitutive NF-kappaB DNA-binding activity in AML is frequently mediated by a Ras/PI3-K/PKB-dependent pathway
    K U Birkenkamp
    Division of Hematology, Department of Medicine, University of Groningen, The Netherlands
    Leukemia 18:103-12. 2004
    ..The present study demonstrates that Ras activation is an important pathway for triggering the NF-kappaB pathway in AML cells...
  38. ncbi request reprint Serum matrix metalloproteinase 3 in early rheumatoid arthritis is correlated with disease activity and radiological progression
    M D Posthumus
    Department of Rheumatology, University Hospital Groningen, Groningen, The Netherlands
    J Rheumatol 27:2761-8. 2000
    ..To analyze the clinical significance of serial measurements of serum matrix metalloproteinase 3 (MMP-3) levels in relation to markers of disease activity and radiological progression in early rheumatoid arthritis (RA)...