B Daan Westenbrink

Summary

Affiliation: University Medical Center Groningen
Country: The Netherlands

Publications

  1. ncbi request reprint Anaemia in chronic heart failure is not only related to impaired renal perfusion and blunted erythropoietin production, but to fluid retention as well
    B Daan Westenbrink
    Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Eur Heart J 28:166-71. 2007
  2. doi request reprint Vascular endothelial growth factor is crucial for erythropoietin-induced improvement of cardiac function in heart failure
    B Daan Westenbrink
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, Hanzeplein 1, PO Box 30001, Groningen 9700 RB, The Netherlands
    Cardiovasc Res 87:30-9. 2010
  3. doi request reprint Sustained postoperative anaemia is associated with an impaired outcome after coronary artery bypass graft surgery: insights from the IMAGINE trial
    B Daan Westenbrink
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, Hanzeplein 1, P O Box 30001, Groningen 9700 RB, The Netherlands
    Heart 97:1590-6. 2011
  4. ncbi request reprint Erythropoietin improves cardiac function through endothelial progenitor cell and vascular endothelial growth factor mediated neovascularization
    B Daan Westenbrink
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, Hanzeplein 1, PO Box 30001, 9700 RB Groningen, The Netherlands
    Eur Heart J 28:2018-27. 2007
  5. ncbi request reprint Therapeutic potential of erythropoietin in cardiovascular disease: erythropoiesis and beyond
    B Daan Westenbrink
    University Medical Center Groningen, Hanzeplein 1, P O Box 30001, 9700 RB Groningen, The Netherlands
    Curr Heart Fail Rep 4:127-33. 2007
  6. doi request reprint Bone marrow dysfunction in chronic heart failure patients
    B Daan Westenbrink
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, Hanzeplein 1, PO Box 30001, Groningen 9700 RB, The Netherlands
    Eur J Heart Fail 12:676-84. 2010
  7. doi request reprint Erythropoietin stimulates normal endothelial progenitor cell-mediated endothelial turnover, but attributes to neovascularization only in the presence of local ischemia
    B Daan Westenbrink
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, Hanzeplein 1, P O Box 30001, 9700 RB Groningen, The Netherlands
    Cardiovasc Drugs Ther 22:265-74. 2008
  8. doi request reprint Anemia in chronic heart failure: etiology and treatment options
    B Daan Westenbrink
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Curr Opin Cardiol 23:141-7. 2008
  9. ncbi request reprint Low-dose erythropoietin improves cardiac function in experimental heart failure without increasing haematocrit
    Erik Lipsic
    Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Eur J Heart Fail 10:22-9. 2008
  10. doi request reprint Differential associations between renal function and "modifiable" risk factors in patients with chronic heart failure
    Tom D J Smilde
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Clin Res Cardiol 98:121-9. 2009

Detail Information

Publications19

  1. ncbi request reprint Anaemia in chronic heart failure is not only related to impaired renal perfusion and blunted erythropoietin production, but to fluid retention as well
    B Daan Westenbrink
    Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Eur Heart J 28:166-71. 2007
    ..The present study aims to investigate the relation between anaemia, renal perfusion, erythropoietin production, and fluid retention in CHF patients...
  2. doi request reprint Vascular endothelial growth factor is crucial for erythropoietin-induced improvement of cardiac function in heart failure
    B Daan Westenbrink
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, Hanzeplein 1, PO Box 30001, Groningen 9700 RB, The Netherlands
    Cardiovasc Res 87:30-9. 2010
    ..We intended to delineate the mechanisms of erythropoietin (EPO)-induced cardiac vascular endothelial growth factor (VEGF) production and to establish if VEGF is crucial for EPO-induced improvement of cardiac performance...
  3. doi request reprint Sustained postoperative anaemia is associated with an impaired outcome after coronary artery bypass graft surgery: insights from the IMAGINE trial
    B Daan Westenbrink
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, Hanzeplein 1, P O Box 30001, Groningen 9700 RB, The Netherlands
    Heart 97:1590-6. 2011
    ..To investigate the association between sustained postoperative anaemia and outcome after coronary artery bypass graft (CABG) surgery...
  4. ncbi request reprint Erythropoietin improves cardiac function through endothelial progenitor cell and vascular endothelial growth factor mediated neovascularization
    B Daan Westenbrink
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, Hanzeplein 1, PO Box 30001, 9700 RB Groningen, The Netherlands
    Eur Heart J 28:2018-27. 2007
    ..We studied the effects of EPO on homing and incorporation of endothelial progenitor cells (EPC) into the myocardial microvasculature and myocardial expression of angiogenic factors...
  5. ncbi request reprint Therapeutic potential of erythropoietin in cardiovascular disease: erythropoiesis and beyond
    B Daan Westenbrink
    University Medical Center Groningen, Hanzeplein 1, P O Box 30001, 9700 RB Groningen, The Netherlands
    Curr Heart Fail Rep 4:127-33. 2007
    ..EPO exhibits a vast array of beneficial effects in cardiovascular disease. In addition to the correction of anemia in CHF, rhEPO might benefit patients with cardiovascular disease...
  6. doi request reprint Bone marrow dysfunction in chronic heart failure patients
    B Daan Westenbrink
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, Hanzeplein 1, PO Box 30001, Groningen 9700 RB, The Netherlands
    Eur J Heart Fail 12:676-84. 2010
    ..To investigate whether chronic heart failure (CHF) is associated with a general dysfunction of the haematopoietic compartment...
  7. doi request reprint Erythropoietin stimulates normal endothelial progenitor cell-mediated endothelial turnover, but attributes to neovascularization only in the presence of local ischemia
    B Daan Westenbrink
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, Hanzeplein 1, P O Box 30001, 9700 RB Groningen, The Netherlands
    Cardiovasc Drugs Ther 22:265-74. 2008
    ..We aimed to evaluate whether ischemia is required for erythropoietin (EPO) induced stimulation of endothelial progenitor cells (EPCs) and their related effects on endothelial and cardiac function...
  8. doi request reprint Anemia in chronic heart failure: etiology and treatment options
    B Daan Westenbrink
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Curr Opin Cardiol 23:141-7. 2008
    ..The review will describe current advances in the understanding of the pathophysiology of anemia and the potential therapeutic effects of recombinant human erythropoietin...
  9. ncbi request reprint Low-dose erythropoietin improves cardiac function in experimental heart failure without increasing haematocrit
    Erik Lipsic
    Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Eur J Heart Fail 10:22-9. 2008
    ..However, the increased haematocrit associated with EPO treatment might exert concomitant deleterious effects...
  10. doi request reprint Differential associations between renal function and "modifiable" risk factors in patients with chronic heart failure
    Tom D J Smilde
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Clin Res Cardiol 98:121-9. 2009
    ..Our aim was to determine different pathophysiologic markers that are associated with reduced renal function in CHF...
  11. pmc Tubular damage in chronic systolic heart failure is associated with reduced survival independent of glomerular filtration rate
    Kevin Damman
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Heart 96:1297-302. 2010
    ..The prognostic impact of reduced glomerular filtration rate (GFR) in chronic heart failure (CHF) is increasingly recognised, but little is known about tubular damage in these patients...
  12. ncbi request reprint Levels of hematopoiesis inhibitor N-acetyl-seryl-aspartyl-lysyl-proline partially explain the occurrence of anemia in heart failure
    Peter van der Meer
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Circulation 112:1743-7. 2005
    ..The aim of the present study was to determine possible mechanisms linking anemia to renin-angiotensin system activity in CHF patients...
  13. doi request reprint Erythropoietin in cardiac disease: new features of an old drug
    Willem Peter T Ruifrok
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur J Pharmacol 585:270-7. 2008
    ....
  14. ncbi request reprint A single bolus of a long-acting erythropoietin analogue darbepoetin alfa in patients with acute myocardial infarction: a randomized feasibility and safety study
    Erik Lipsic
    Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Cardiovasc Drugs Ther 20:135-41. 2006
    ..The present study evaluated the safety and tolerability of EPO treatment in non-anemic patients with acute myocardial infarction (MI)...
  15. doi request reprint Erythropoietin levels in heart failure after an acute myocardial infarction: determinants, prognostic value, and the effects of captopril versus losartan
    Anne M S Belonje
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Am Heart J 157:91-6. 2009
    ..In patients with chronic heart failure, erythropoietin (Epo) levels are increased and related to a poor prognosis. Furthermore, Epo levels in these patients show a weak correlation with hemoglobin levels...
  16. doi request reprint Anaemia is associated with shorter leucocyte telomere length in patients with chronic heart failure
    Liza S M Wong
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, The Netherlands
    Eur J Heart Fail 12:348-53. 2010
    ..We hypothesize that short telomere length contributes to the susceptibility to develop anaemia in patients with CHF...
  17. doi request reprint Suicidal erythrocyte death, eryptosis, as a novel mechanism in heart failure-associated anaemia
    Hasan Mahmud
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9713 GZ, The Netherlands
    Cardiovasc Res 98:37-46. 2013
    ..Excessive eryptosis may lead to anaemia. We aimed to study the role of eryptosis in heart failure (HF)-associated anaemia...
  18. ncbi request reprint Heart failure highlights in 2011
    B Daan Westenbrink
    Department of Cardiology, University Medical Center Groningen, 9700 RB Groningen, The Netherlands
    Eur J Heart Fail 14:1090-6. 2012
    ..All research areas are addressed, including experimental studies, biomarkers, clinical trials, arrhythmias, and new insights into the role of device therapy...
  19. ncbi request reprint Can critically short telomeres cause functional exhaustion of progenitor cells in postinfarction heart failure?
    Hisko Oeseburg
    J Am Coll Cardiol 50:1911-2; author reply 1912-3. 2007