Herman G M Westenberg

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. ncbi A double-blind placebo-controlled study of controlled release fluvoxamine for the treatment of generalized social anxiety disorder
    Herman G M Westenberg
    Department of Biological Psychiatry, University Hospital Utrecht, The Netherlands
    J Clin Psychopharmacol 24:49-55. 2004
  2. ncbi Overview of panic and social anxiety disorders
    Herman G M Westenberg
    Department of Psychiatry, University Medical Centre, Utrecht, The Netherlands
    J Clin Psychiatry 65:22-6. 2004
  3. ncbi Role of extracellular serotonin levels in the effect of 5-HT1B receptor blockade
    Lotte De Groote
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Psychopharmacology (Berl) 167:153-8. 2003
  4. doi Quetiapine augments the effect of citalopram in non-refractory obsessive-compulsive disorder: a randomized, double-blind, placebo-controlled study of 76 patients
    Nienke C C Vulink
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 70:1001-8. 2009
  5. ncbi Effects of quetiapine on cognitive functioning in obsessive-compulsive disorder
    Femke de Geus
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Int Clin Psychopharmacol 22:77-84. 2007
  6. doi Neuropsychological performance is related to current social and occupational functioning in veterans with posttraumatic stress disorder
    Elbert Geuze
    Research Centre Military Mental Health, Ministry of Defense, Utrecht, The Netherlands
    Depress Anxiety 26:7-15. 2009
  7. ncbi Role of 5-HT1B receptors in the regulation of extracellular serotonin and dopamine in the dorsal striatum of mice
    Lotte De Groote
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Eur J Pharmacol 476:71-7. 2003
  8. ncbi Prediction of response to paroxetine and venlafaxine by serotonin-related genes in obsessive-compulsive disorder in a randomized, double-blind trial
    Damiaan Denys
    Department of Psychiatry, The Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 68:747-53. 2007
  9. ncbi Extracellular serotonin in the prefrontal cortex is limited through terminal 5-HT(1B) autoreceptors: a microdialysis study in knockout mice
    Lotte De Groote
    Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Psychopharmacology (Berl) 162:419-24. 2002
  10. doi Catechol-O-methyltranferase gene expression is associated with response to citalopram in obsessive-compulsive disorder
    Nienke C C Vulink
    Department of Psychiatry, AMC, University of Amsterdam, Amsterdam, The Netherlands
    Int J Psychiatry Clin Pract 16:277-83. 2012

Collaborators

Detail Information

Publications64

  1. ncbi A double-blind placebo-controlled study of controlled release fluvoxamine for the treatment of generalized social anxiety disorder
    Herman G M Westenberg
    Department of Biological Psychiatry, University Hospital Utrecht, The Netherlands
    J Clin Psychopharmacol 24:49-55. 2004
    ..In summary, fluvoxamine CR is an efficacious, safe, and well-tolerated treatment of generalized social anxiety disorder...
  2. ncbi Overview of panic and social anxiety disorders
    Herman G M Westenberg
    Department of Psychiatry, University Medical Centre, Utrecht, The Netherlands
    J Clin Psychiatry 65:22-6. 2004
    ..Panic and social anxiety disorders are often comorbid with other psychiatric disorders. Medication treatment and/or cognitive-behavioral therapy might need to be continued over the long term to prevent relapse...
  3. ncbi Role of extracellular serotonin levels in the effect of 5-HT1B receptor blockade
    Lotte De Groote
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Psychopharmacology (Berl) 167:153-8. 2003
    ....
  4. doi Quetiapine augments the effect of citalopram in non-refractory obsessive-compulsive disorder: a randomized, double-blind, placebo-controlled study of 76 patients
    Nienke C C Vulink
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 70:1001-8. 2009
    ..To assess the efficacy of quetiapine addition to citalopram in treatment-naive or medication-free obsessive-compulsive disorder (OCD) patients...
  5. ncbi Effects of quetiapine on cognitive functioning in obsessive-compulsive disorder
    Femke de Geus
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Int Clin Psychopharmacol 22:77-84. 2007
    ..It is proposed that this failure may be caused by attention difficulties owing to somnolence...
  6. doi Neuropsychological performance is related to current social and occupational functioning in veterans with posttraumatic stress disorder
    Elbert Geuze
    Research Centre Military Mental Health, Ministry of Defense, Utrecht, The Netherlands
    Depress Anxiety 26:7-15. 2009
    ..However, most of these studies had several methodological disadvantages. None of these studies assessed parameters related to social or occupational functioning...
  7. ncbi Role of 5-HT1B receptors in the regulation of extracellular serotonin and dopamine in the dorsal striatum of mice
    Lotte De Groote
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Eur J Pharmacol 476:71-7. 2003
    ..In addition, the results in 5-HT1B knockout mice do not support a role of 5-HT1B heteroreceptors in the striatum on dopamine outflow in this brain area of mice...
  8. ncbi Prediction of response to paroxetine and venlafaxine by serotonin-related genes in obsessive-compulsive disorder in a randomized, double-blind trial
    Damiaan Denys
    Department of Psychiatry, The Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 68:747-53. 2007
    ..The purpose of the present study was to determine whether polymorphisms of the serotonin transporter (5-HTT), 5-HT1B, and 5-HT2A receptor genes affect the efficacy of SRI treatment in OCD...
  9. ncbi Extracellular serotonin in the prefrontal cortex is limited through terminal 5-HT(1B) autoreceptors: a microdialysis study in knockout mice
    Lotte De Groote
    Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Psychopharmacology (Berl) 162:419-24. 2002
    ..Serotonin (5-HT) autoreceptors regulate extracellular 5-HT levels and have been suggested to limit the effects of acute treatment with selective serotonin reuptake inhibitors (SSRIs)...
  10. doi Catechol-O-methyltranferase gene expression is associated with response to citalopram in obsessive-compulsive disorder
    Nienke C C Vulink
    Department of Psychiatry, AMC, University of Amsterdam, Amsterdam, The Netherlands
    Int J Psychiatry Clin Pract 16:277-83. 2012
    ..To determine whether polymorphisms of the dopamine D(2) receptor (DRD2) and catechol-O-methyl-transferase (COMT) receptor genes affect the efficacy of quetiapine addition to citalopram in patients with OCD...
  11. ncbi An evaluation of the effect of NAS-181, a new selective 5-HT(1B) receptor antagonist, on extracellular 5-HT levels in rat frontal cortex
    Lotte De Groote
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Naunyn Schmiedebergs Arch Pharmacol 367:89-94. 2003
    ..In the absence of fluvoxamine, GR127935, SB224289 and NAS-181 all reduced 5-HT levels, suggesting partial agonistic properties of these compounds. In conclusion, the results show that NAS-181 is a potent 5-HT(1B) receptor antagonist...
  12. ncbi Long-term behavioral changes after cessation of chronic antidepressant treatment in olfactory bulbectomized rats
    Megan E Breuer
    Utrecht University, Utrecht Institute for Pharmaceutical Sciences, Department of Psychopharmacology, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 61:990-5. 2007
    ..Moreover, depression-like behavior after OBX can be reversed with antidepressant drugs. However, the lasting effects of these antidepressant drugs on behavior after cessation of treatment have never been studied...
  13. pmc Impaired neuroendocrine and immune response to acute stress in medication-naive patients with a first episode of psychosis
    Janine A E M van Venrooij
    The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Schizophr Bull 38:272-9. 2012
    ..These findings indicate that impairments in stress processing are associated with the endophenotype of psychosis and are not a result of illness progression or antipsychotic medication...
  14. ncbi Female hormones affect symptom severity in obsessive-compulsive disorder
    Nienke C C Vulink
    The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Int Clin Psychopharmacol 21:171-5. 2006
    ..Because reproductive cycle events influence the symptom severity of OCD, the menstrual cycle should be taken into account when assessing the severity of OCD symptoms during pharmacological studies...
  15. ncbi A double-blind, randomized, placebo-controlled trial of quetiapine addition in patients with obsessive-compulsive disorder refractory to serotonin reuptake inhibitors
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 65:1040-8. 2004
    ..This study was conducted to evaluate the efficacy and tolerability of quetiapine in addition to an SRI for treatment-refractory patients with OCD...
  16. ncbi Permanent deficits in serotonergic functioning of olfactory bulbectomized rats: an in vivo microdialysis study
    Hiske M van der Stelt
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, The Netherlands
    Biol Psychiatry 57:1061-7. 2005
    ..The present study describes the effects of olfactory bulbectomy on functioning of the serotonergic system...
  17. ncbi A double-blind switch study of paroxetine and venlafaxine in obsessive-compulsive disorder
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 65:37-43. 2004
    ..However, no controlled research has been published yet that prospectively examined the effects of changing SRIs. This article describes the first double-blind switch study of 2 SRIs in patients with OCD...
  18. ncbi Use of factor analysis to detect potential phenotypes in obsessive-compulsive disorder
    Damiaan Denys
    Department of Psychiatry, University Medical Center, HP B 01 206, PO Box 85500, GA Utrecht 3508, The Netherlands
    Psychiatry Res 128:273-80. 2004
    ..We observed significant differences in sex distribution, age of onset, Y-BOCS scores and familial prevalence of OCD in relation to the symptom dimensions. These findings provide further evidence for distinct clinical phenotypes in OCD...
  19. ncbi Behavior therapy augments response of patients with obsessive-compulsive disorder responding to drug treatment
    Nienke H Tenneij
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 66:1169-75. 2005
    ..The objective of this study was to examine whether addition of behavior therapy would augment treatment outcome in these patients...
  20. ncbi Spatial working memory in obsessive-compulsive disorder improves with clinical response: A functional MRI study
    Nic J A van der Wee
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 X Utrecht, The Netherlands
    Eur Neuropsychopharmacol 17:16-23. 2007
    ..Our preliminary findings suggests that spatial working memory deficits in OCD and their functional anatomical correlates, as assessed with a spatial n-back task, are, at least to some extent, state dependent...
  21. doi Paroxetine augmentation in patients with generalised social anxiety disorder, non-responsive to mirtazapine or placebo
    Sara I J Schutters
    Department of Psychiatry, University Medical Centre Utrecht, The Netherlands
    Hum Psychopharmacol 26:72-6. 2011
    ..The aim of the study was to investigate if combination of mirtazapine with paroxetine causes a greater therapeutic effect and less sexual side effects than paroxetine monotherapy in social anxiety disorder (SAD)...
  22. doi Disgust affects TNF-alpha, IL-6 and noradrenalin levels in patients with obsessive-compulsive disorder
    Sjoerd B A H A Fluitman
    The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Psychoneuroendocrinology 35:906-11. 2010
    ..In conclusion, our data suggests that symptom provocation in OCD patients with contamination fear is accompanied by alterations in the immune and neuroendocrine systems but does not affect cortisol levels...
  23. ncbi A double blind comparison of venlafaxine and paroxetine in obsessive-compulsive disorder
    Damiaan Denys
    Department of Psychiatry, University Medical Center B 01 206, PO Box 85500, 3508 GA Utrecht, The Netherlands
    J Clin Psychopharmacol 23:568-75. 2003
    ..These results show that venlafaxine was equally effective to paroxetine in treating patients with OCD. Venlafaxine may be a useful therapy for obsessive-compulsive patients, but is not superior to SSRIs...
  24. doi Thinner prefrontal cortex in veterans with posttraumatic stress disorder
    Elbert Geuze
    Research Centre, Military Mental Healthcare, Ministry of Defence, Utrecht, The Netherlands
    Neuroimage 41:675-81. 2008
    ..Cortical thickness correlated with memory measures in the veterans without PTSD, but not in the veterans with PTSD. Cortical thinning in these regions may thus correspond to functional abnormalities observed in patients with PTSD...
  25. ncbi The role of dopamine in obsessive-compulsive disorder: preclinical and clinical evidence
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 65:11-7. 2004
    ..In this review, the preclinical and clinical evidence on the role of dopamine in OCD is summarized...
  26. doi Sympathetic activity and hypothalamo-pituitary-adrenal axis activity during sleep in post-traumatic stress disorder: a study assessing polysomnography with simultaneous blood sampling
    Saskia van Liempt
    Research Center Military Mental Health Care, Utrecht, The Netherlands
    Psychoneuroendocrinology 38:155-65. 2013
    ..According to polysomnography (PSG), only minor changes in sleep architecture were described. This warrants alternative methods for assessing sleep regulation in PTSD...
  27. ncbi Mirtazapine in generalized social anxiety disorder: a randomized, double-blind, placebo-controlled study
    Sara I J Schutters
    Department of Psychiatry, University Medical Centre Utrecht, The Netherlands
    Int Clin Psychopharmacol 25:302-4. 2010
    ..5 +/- 16.9 and 11.2 +/- 17.8 respectively, and on the number of responders, 13 and 13%, respectively. In conclusion, mirtazapine (30-45 mg/day) failed to be effective in the generalized social anxiety disorder...
  28. ncbi Effects of paroxetine and venlafaxine on immune parameters in patients with obsessive compulsive disorder
    Damiaan Denys
    Department of Psychiatry, UMC, Rudolf Magnus Institute of Neuroscience, B 01 206, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Psychoneuroendocrinology 31:355-60. 2006
    ..This study was carried out to investigate whether treatment with paroxetine and venlafaxine modifies the immune function in OCD and whether this modification is related to treatment outcome...
  29. ncbi Association between serotonergic candidate genes and specific phenotypes of obsessive compulsive disorder
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry University Medical Center Utrecht, Utrecht, The Netherlands
    J Affect Disord 91:39-44. 2006
    ..The purpose of the present study was to investigate the role of the serotonin transporter (5-HTT) and serotonin 5-HT1B and 5-HT2A receptor genes in OCD...
  30. ncbi Synergistic dopamine increase in the rat prefrontal cortex with the combination of quetiapine and fluvoxamine
    Damiaan Denys
    Department of Psychiatry, The Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Psychopharmacology (Berl) 176:195-203. 2004
    ....
  31. ncbi Assessment of DSM-IV personality disorders in obsessive-compulsive disorder: comparison of clinical diagnosis, self-report questionnaire, and semi-structured interview
    Nienke H Tenney
    Department of Psychiatry, University Medical Center, Utrecht, The Netherlands
    J Pers Disord 17:550-61. 2003
    ..However, there was generally low correspondence regarding which patient had which personality disorder. Results concerning the relation of external variables were the most promising for the structured clinical interview...
  32. ncbi Bupropion for patients with obsessive-compulsive disorder: an open-label, fixed-dose study
    Nienke C C Vulink
    Department of Psychiatry, University Medical Center Utrecht, The Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands
    J Clin Psychiatry 66:228-30. 2005
    ..In the present study, we examined the efficacy of bupropion for patients with obsessive-compulsive disorder (OCD)...
  33. doi Wireless implantable micro-stimulation device for high frequency bilateral deep brain stimulation in freely moving mice
    Ria de Haas
    Department of Psychiatry, UMC Utrecht, Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands
    J Neurosci Methods 209:113-9. 2012
    ..This newly designed device can now be used in the highly needed DBS behavioral studies in mice, to further investigate the underlying mechanisms of DBS in behavioral animal models for psychiatric disorders...
  34. ncbi Emerging skin-picking behaviour after serotonin reuptake inhibitor-treatment in patients with obsessive-compulsive disorder: possible mechanisms and implications for clinical care
    Damiaan Denys
    Department of Psychiatry, University Medical Centre, Utrecht, The Netherlands
    J Psychopharmacol 17:127-9. 2003
    ..Two case reports are presented demonstrating that SSRI-treatment may induce or aggravate pathological skin-picking behaviour. Possible mechanisms of SSRI-induced pathological skin-picking and implications for clinical care are discussed...
  35. ncbi Sexual pleasure in women with obsessive-compulsive disorder?
    Nienke C C Vulink
    The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht UMCU, B 01 206, P O Box 85500, 3508 GA Utrecht, The Netherlands
    J Affect Disord 91:19-25. 2006
    ..This study compared subjective appreciation of sexuality and sexual functioning between OCD patients and healthy subjects and controlled for the influence of medication or OCD subtypes on sexual functioning and satisfaction...
  36. ncbi Effects of dietary tryptophan variations on extracellular serotonin in the dorsal hippocampus of rats
    Hiske M van der Stelt
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Huispostnr A01 126, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Psychopharmacology (Berl) 172:137-44. 2004
    ..Moreover, there is circumstantial evidence suggesting that plasma tryptophan (TRP) levels can predict response to SSRIs. These findings suggest that dietary TRP variations may affect the efficacy of SSRI in major depression...
  37. ncbi Symptom dimensions in obsessive-compulsive disorder: factor analysis on a clinician-rated scale and a self-report measure
    Damiaan Denys
    Department of Psychiatry, University Medical Centre, Utrecht, The Netherlands
    Psychopathology 37:181-9. 2004
    ..This means that the use of both clinician-administered and self-report measures is recommended, so that the entire spectrum of symptoms is represented...
  38. ncbi Pharmacotherapy for disordered sleep in post-traumatic stress disorder: a systematic review
    Saskia van Liempt
    Department of Military Psychiatry, Central Military Hospital, Utrecht, The Netherlands
    Int Clin Psychopharmacol 21:193-202. 2006
    ..Some recent studies show promising results, especially for alpha1-adrenoceptor and 5-HT2 receptor antagonists. However, randomized controlled trials with larger populations need to be conducted...
  39. ncbi Attention and cognition in patients with obsessive-compulsive disorder
    Femke de Geus
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Psychiatry Clin Neurosci 61:45-53. 2007
    ..The results show that patients with OCD have cognitive deficits. The authors hypothesize that these deficits may be interpreted by attentional deficits caused by a dysfunctional anterior cingulate cortex...
  40. ncbi Precuneal activity during encoding in veterans with posttraumatic stress disorder
    Elbert Geuze
    Department of Military Psychiatry, Central Military Hospital, Ministry of Defense, Utrecht, The Netherlands
    Prog Brain Res 167:293-7. 2008
    ..The precuneus was less activated in veterans with PTSD, which correlated significantly with the severity of PTSD. Like fronto-temporal regions the precuneus is differentially activated during memory formation in veterans with PTSD...
  41. doi Electroconvulsive therapy has acute immunological and neuroendocrine effects in patients with major depressive disorder
    Sjoerd B A H A Fluitman
    The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    J Affect Disord 131:388-92. 2011
    ..Major depressive disorder is associated with alterations in the neuroendocrine as well as immune system. Few studies examined the impact of electroconvulsive therapy (ECT) on these systems in patients with major depressive disorder (MDD)...
  42. doi Compulsivity in mouse strains homologous with chromosomes 7p and 15q linked to obsessive-compulsive disorder
    Martien J H Kas
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 153:252-9. 2010
    ..Genetic fine mapping of compulsivity in mice provides new opportunities to reveal mechanisms underlying this significant psychiatric trait...
  43. ncbi Decreased thalamic blood flow in obsessive-compulsive disorder patients responding to fluvoxamine
    Kamini L Ho Pian
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Psychiatry Res 138:89-97. 2005
    ..Pre-treatment cerebellar and whole brain HMPAO uptake was significantly higher in responders to treatment compared with non-responders. We suggest that the thalamus plays a central role in the response to drug treatment...
  44. ncbi Behavioural effects of rapid intravenous administration of meta-chlorophenylpiperazine in patients with panic disorder and controls
    Nic J A van der Wee
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur Neuropsychopharmacol 14:413-7. 2004
    ..Our data suggests that the behavioural effects of rapid intravenous administration of 0.1 mg/kg of m-CPP in patients with PD indeed show a unique combination of high sensitivity and selectivity...
  45. doi Behavioral pattern analysis and dopamine release in quinpirole-induced repetitive behavior in rats
    Ria de Haas
    Department of Psychiatry, UMC Utrecht, Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands
    J Psychopharmacol 25:1712-9. 2011
    ..These findings suggest that quinpirole-induced behavior mimics only part of the compulsive behavior as shown in OCD patients...
  46. ncbi Effect of a pharmacological intervention on quality of life in patients with obsessive-compulsive disorder
    Nienke H Tenney
    Department of Psychiatry, University Medical Centre, Utrecht, The Netherlands
    Int Clin Psychopharmacol 18:29-33. 2003
    ..Furthermore, neither improvement in symptoms, nor baseline self-directedness, was associated with the improvement in QoL...
  47. ncbi Low level of dopaminergic D2 receptor binding in obsessive-compulsive disorder
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 55:1041-5. 2004
    ..Despite growing evidence for involvement of the dopaminergic system in obsessive-compulsive disorder (OCD), the functional anatomy of the dopaminergic system in the basal ganglia has been investigated sparsely...
  48. ncbi The influence of amphetamine on language activation: an fMRI study
    Iris E C Sommer
    Rudolf Magnus Institute of Neuroscience Psychiatry Department, University Medical Center Utrecht, Heidelberglaan 100, 3584CX, Utrecht, The Netherlands
    Psychopharmacology (Berl) 183:387-93. 2006
    ..In humans, cerebral dopamine neurotransmission is also correlated to motor dominance. Since language dominance is related to motor dominance, amphetamine might also affect cerebral dominance for language...
  49. ncbi Glutamate and anxiety
    Veerle Bergink
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, B01 206, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Eur Neuropsychopharmacol 14:175-83. 2004
    ..It can be expected that selective modulators of glutamate activity will be of great clinical significance for the treatment of anxiety disorders...
  50. pmc Deep brain stimulation reveals a dissociation of consummatory and motivated behaviour in the medial and lateral nucleus accumbens shell of the rat
    Geoffrey Van der Plasse
    Department Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    PLoS ONE 7:e33455. 2012
    ..As such, these findings provide important leads for the possible future application of DBS as a treatment for eating disorders such as anorexia nervosa...
  51. ncbi Signaling pathways involved in Ca2+- and Pb2+-induced vesicular catecholamine release from rat PC12 cells
    Remco H S Westerink
    Institute for Risk Assessment Sciences, Utrecht University, PO Box 80176, 3508 TD, Utrecht, The Netherlands
    Brain Res 957:25-36. 2002
    ..It is concluded that Ca(2+)-evoked exocytosis is modulated mainly by PKC and calcineurin, whereas Pb(2+)-evoked exocytosis is mainly modulated by CaM kinase II...
  52. ncbi Autonomic and neuroendocrine responses to a psychosocial stressor in adults with autistic spectrum disorder
    Lucres M C Jansen
    Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
    J Autism Dev Disord 36:891-9. 2006
    ..However, in contrast to previous findings in low functioning autistic children, ASD adults showed increased basal oxytocin levels, which may be related to developmental factors...
  53. ncbi The effects of selective serotonin reuptake inhibitors on extracellular 5-HT levels in the hippocampus of 5-HT(1B) receptor knockout mice
    Lotte De Groote
    Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Eur J Pharmacol 439:93-100. 2002
    ..In addition, the different dose-response to fluvoxamine suggests that 5-HT(1B) knockout mice have possible adaptations of 5-HT transporters in order to compensate for the loss of the terminal 5-HT(1B) autoreceptor...
  54. ncbi Social anxiety disorder and generalized anxiety disorder: serotonergic and dopaminergic neurocircuitry
    Dan J Stein
    Medical Research Council Unit on Anxiety Disorders, The University of Stellenbosch, Tygerberg, Cape Town, South Africa
    J Clin Psychiatry 63:12-9. 2002
    ..Future work will undoubtedly clarify how genetic and environmental factors interact to fashion the neurocircuitry that mediates anxiety symptoms...
  55. ncbi Fluvoxamine CR in the long-term treatment of social anxiety disorder: the 12- to 24-week extension phase of a multicentre, randomized, placebo-controlled trial
    Dan J Stein
    MRC Unit on Anxiety Disorders, University of Stellenbosch, Cape Town, South Africa, and University of Florida, Gainesville, FL, USA
    Int J Neuropsychopharmacol 6:317-23. 2003
    ....
  56. ncbi Metabotropic glutamate II receptor agonists in panic disorder: a double blind clinical trial with LY354740
    Veerle Bergink
    Erasmus MC U M C, Rotterdam, The Netherlands
    Int Clin Psychopharmacol 20:291-3. 2005
    ..Because preclinical data collectively indicate anxiolytic properties of mGlu type 2 receptor agonists, clinical studies with other agents are warranted...
  57. ncbi Axis I and II comorbidity in a large sample of patients with obsessive-compulsive disorder
    Damiaan Denys
    University Medical Center B 01 206, P O Box 85500, 3508 GA Utrecht, The Netherlands
    J Affect Disord 80:155-62. 2004
    ....
  58. ncbi Neural correlates of associative learning and memory in veterans with posttraumatic stress disorder
    Elbert Geuze
    Research Centre Military Mental Health, Ministry of Defense, PO Box 90 000, 3509AA Utrecht, The Netherlands
    J Psychiatr Res 42:659-69. 2008
    ..Deficits in memory performance in PTSD appear to be related to altered activity in fronto-temporal areas during both the encoding and retrieval phase of memory processing...
  59. ncbi Altered pain processing in veterans with posttraumatic stress disorder
    Elbert Geuze
    Department of Military Psychiatry, Central Military Hospital, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Arch Gen Psychiatry 64:76-85. 2007
    ..Several brain areas related to pain processing are implicated in PTSD. To our knowledge, no functional imaging study has discussed whether patients with PTSD experience and process pain in a different way than control subjects...
  60. ncbi Reduced sensitivity in the recognition of anger and disgust in social anxiety disorder
    Barbara Montagne
    Utrech University and Radboud University Centre, Nijmegen, The Netherlands
    Cogn Neuropsychiatry 11:389-401. 2006
    ..It is well documented that in different psychiatric disorders (e.g., depression, schizophrenia) patients may show an altered processing of emotions. However, in generalised social anxiety, emotion recognition has not been studied...
  61. ncbi Efficacy of quetiapine in generalized social anxiety disorder: results from an open-label study
    Sara I J Schutters
    J Clin Psychiatry 66:540-2. 2005
  62. ncbi Obsessive-compulsive disorder revisited from a treatment perspective
    Herman G M Westenberg
    Department of Psychiatry University Medical Center Utrecht, The Netherlands
    Psychiatr Danub 19:375-7. 2007
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    ....
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