Herman G M Westenberg

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. ncbi Recent advances in understanding and treating social anxiety disorder
    Herman G M Westenberg
    Section Psychiatric Phenotypes of Biological Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
    CNS Spectr 14:24-33. 2009
  2. ncbi Role of extracellular serotonin levels in the effect of 5-HT1B receptor blockade
    Lotte De Groote
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Psychopharmacology (Berl) 167:153-8. 2003
  3. ncbi Effects of quetiapine on cognitive functioning in obsessive-compulsive disorder
    Femke de Geus
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Int Clin Psychopharmacol 22:77-84. 2007
  4. ncbi Extracellular serotonin in the prefrontal cortex is limited through terminal 5-HT(1B) autoreceptors: a microdialysis study in knockout mice
    Lotte De Groote
    Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Psychopharmacology (Berl) 162:419-24. 2002
  5. ncbi Role of 5-HT1B receptors in the regulation of extracellular serotonin and dopamine in the dorsal striatum of mice
    Lotte De Groote
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Eur J Pharmacol 476:71-7. 2003
  6. ncbi Prediction of response to paroxetine and venlafaxine by serotonin-related genes in obsessive-compulsive disorder in a randomized, double-blind trial
    Damiaan Denys
    Department of Psychiatry, The Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 68:747-53. 2007
  7. doi Quetiapine augments the effect of citalopram in non-refractory obsessive-compulsive disorder: a randomized, double-blind, placebo-controlled study of 76 patients
    Nienke C C Vulink
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 70:1001-8. 2009
  8. ncbi An evaluation of the effect of NAS-181, a new selective 5-HT(1B) receptor antagonist, on extracellular 5-HT levels in rat frontal cortex
    Lotte De Groote
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Naunyn Schmiedebergs Arch Pharmacol 367:89-94. 2003
  9. ncbi Long-term behavioral changes after cessation of chronic antidepressant treatment in olfactory bulbectomized rats
    Megan E Breuer
    Utrecht University, Utrecht Institute for Pharmaceutical Sciences, Department of Psychopharmacology, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 61:990-5. 2007
  10. pmc Impaired neuroendocrine and immune response to acute stress in medication-naive patients with a first episode of psychosis
    Janine A E M van Venrooij
    The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Schizophr Bull 38:272-9. 2012

Collaborators

Detail Information

Publications45

  1. ncbi Recent advances in understanding and treating social anxiety disorder
    Herman G M Westenberg
    Section Psychiatric Phenotypes of Biological Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
    CNS Spectr 14:24-33. 2009
    ....
  2. ncbi Role of extracellular serotonin levels in the effect of 5-HT1B receptor blockade
    Lotte De Groote
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Psychopharmacology (Berl) 167:153-8. 2003
    ....
  3. ncbi Effects of quetiapine on cognitive functioning in obsessive-compulsive disorder
    Femke de Geus
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Int Clin Psychopharmacol 22:77-84. 2007
    ..It is proposed that this failure may be caused by attention difficulties owing to somnolence...
  4. ncbi Extracellular serotonin in the prefrontal cortex is limited through terminal 5-HT(1B) autoreceptors: a microdialysis study in knockout mice
    Lotte De Groote
    Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Psychopharmacology (Berl) 162:419-24. 2002
    ..Serotonin (5-HT) autoreceptors regulate extracellular 5-HT levels and have been suggested to limit the effects of acute treatment with selective serotonin reuptake inhibitors (SSRIs)...
  5. ncbi Role of 5-HT1B receptors in the regulation of extracellular serotonin and dopamine in the dorsal striatum of mice
    Lotte De Groote
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Eur J Pharmacol 476:71-7. 2003
    ..In addition, the results in 5-HT1B knockout mice do not support a role of 5-HT1B heteroreceptors in the striatum on dopamine outflow in this brain area of mice...
  6. ncbi Prediction of response to paroxetine and venlafaxine by serotonin-related genes in obsessive-compulsive disorder in a randomized, double-blind trial
    Damiaan Denys
    Department of Psychiatry, The Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 68:747-53. 2007
    ..The purpose of the present study was to determine whether polymorphisms of the serotonin transporter (5-HTT), 5-HT1B, and 5-HT2A receptor genes affect the efficacy of SRI treatment in OCD...
  7. doi Quetiapine augments the effect of citalopram in non-refractory obsessive-compulsive disorder: a randomized, double-blind, placebo-controlled study of 76 patients
    Nienke C C Vulink
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 70:1001-8. 2009
    ..To assess the efficacy of quetiapine addition to citalopram in treatment-naive or medication-free obsessive-compulsive disorder (OCD) patients...
  8. ncbi An evaluation of the effect of NAS-181, a new selective 5-HT(1B) receptor antagonist, on extracellular 5-HT levels in rat frontal cortex
    Lotte De Groote
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Naunyn Schmiedebergs Arch Pharmacol 367:89-94. 2003
    ..In the absence of fluvoxamine, GR127935, SB224289 and NAS-181 all reduced 5-HT levels, suggesting partial agonistic properties of these compounds. In conclusion, the results show that NAS-181 is a potent 5-HT(1B) receptor antagonist...
  9. ncbi Long-term behavioral changes after cessation of chronic antidepressant treatment in olfactory bulbectomized rats
    Megan E Breuer
    Utrecht University, Utrecht Institute for Pharmaceutical Sciences, Department of Psychopharmacology, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 61:990-5. 2007
    ..Moreover, depression-like behavior after OBX can be reversed with antidepressant drugs. However, the lasting effects of these antidepressant drugs on behavior after cessation of treatment have never been studied...
  10. pmc Impaired neuroendocrine and immune response to acute stress in medication-naive patients with a first episode of psychosis
    Janine A E M van Venrooij
    The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Schizophr Bull 38:272-9. 2012
    ..These findings indicate that impairments in stress processing are associated with the endophenotype of psychosis and are not a result of illness progression or antipsychotic medication...
  11. ncbi Permanent deficits in serotonergic functioning of olfactory bulbectomized rats: an in vivo microdialysis study
    Hiske M van der Stelt
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, The Netherlands
    Biol Psychiatry 57:1061-7. 2005
    ..The present study describes the effects of olfactory bulbectomy on functioning of the serotonergic system...
  12. ncbi Neonatal basolateral amygdala lesions affect monoamine and cannabinoid brain systems in adult rats
    Hans Bouwmeester
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Centre Utrecht, Utrecht University, The Netherlands
    Int J Neuropsychopharmacol 10:727-39. 2007
    ....
  13. ncbi Spatial working memory in obsessive-compulsive disorder improves with clinical response: A functional MRI study
    Nic J A van der Wee
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 X Utrecht, The Netherlands
    Eur Neuropsychopharmacol 17:16-23. 2007
    ..Our preliminary findings suggests that spatial working memory deficits in OCD and their functional anatomical correlates, as assessed with a spatial n-back task, are, at least to some extent, state dependent...
  14. ncbi A double-blind, randomized, placebo-controlled trial of quetiapine addition in patients with obsessive-compulsive disorder refractory to serotonin reuptake inhibitors
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 65:1040-8. 2004
    ..This study was conducted to evaluate the efficacy and tolerability of quetiapine in addition to an SRI for treatment-refractory patients with OCD...
  15. doi Disgust affects TNF-alpha, IL-6 and noradrenalin levels in patients with obsessive-compulsive disorder
    Sjoerd B A H A Fluitman
    The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Psychoneuroendocrinology 35:906-11. 2010
    ..In conclusion, our data suggests that symptom provocation in OCD patients with contamination fear is accompanied by alterations in the immune and neuroendocrine systems but does not affect cortisol levels...
  16. ncbi The role of dopamine in obsessive-compulsive disorder: preclinical and clinical evidence
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 65:11-7. 2004
    ..In this review, the preclinical and clinical evidence on the role of dopamine in OCD is summarized...
  17. ncbi Behavior therapy augments response of patients with obsessive-compulsive disorder responding to drug treatment
    Nienke H Tenneij
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 66:1169-75. 2005
    ..The objective of this study was to examine whether addition of behavior therapy would augment treatment outcome in these patients...
  18. ncbi Female hormones affect symptom severity in obsessive-compulsive disorder
    Nienke C C Vulink
    The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Int Clin Psychopharmacol 21:171-5. 2006
    ..Because reproductive cycle events influence the symptom severity of OCD, the menstrual cycle should be taken into account when assessing the severity of OCD symptoms during pharmacological studies...
  19. ncbi Synergistic dopamine increase in the rat prefrontal cortex with the combination of quetiapine and fluvoxamine
    Damiaan Denys
    Department of Psychiatry, The Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Psychopharmacology (Berl) 176:195-203. 2004
    ....
  20. doi Marked inbred mouse strain difference in the expression of quinpirole induced compulsive like behavior based on behavioral pattern analysis
    Ria de Haas
    Department of Neuroscience and Pharmacology, UMC Utrecht, Rudolf Magnus Institute of Neuroscience, The Netherlands
    Eur Neuropsychopharmacol 22:657-63. 2012
    ..This phenotype resembles that of OCD rituals in patients and indicates that this strain is very interesting to further validate for studying neurobiological mechanisms of compulsive behavior...
  21. ncbi Effects of paroxetine and venlafaxine on immune parameters in patients with obsessive compulsive disorder
    Damiaan Denys
    Department of Psychiatry, UMC, Rudolf Magnus Institute of Neuroscience, B 01 206, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Psychoneuroendocrinology 31:355-60. 2006
    ..This study was carried out to investigate whether treatment with paroxetine and venlafaxine modifies the immune function in OCD and whether this modification is related to treatment outcome...
  22. doi Wireless implantable micro-stimulation device for high frequency bilateral deep brain stimulation in freely moving mice
    Ria de Haas
    Department of Psychiatry, UMC Utrecht, Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands
    J Neurosci Methods 209:113-9. 2012
    ..This newly designed device can now be used in the highly needed DBS behavioral studies in mice, to further investigate the underlying mechanisms of DBS in behavioral animal models for psychiatric disorders...
  23. ncbi Association between serotonergic candidate genes and specific phenotypes of obsessive compulsive disorder
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry University Medical Center Utrecht, Utrecht, The Netherlands
    J Affect Disord 91:39-44. 2006
    ..The purpose of the present study was to investigate the role of the serotonin transporter (5-HTT) and serotonin 5-HT1B and 5-HT2A receptor genes in OCD...
  24. ncbi Effects of dietary tryptophan variations on extracellular serotonin in the dorsal hippocampus of rats
    Hiske M van der Stelt
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Huispostnr A01 126, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Psychopharmacology (Berl) 172:137-44. 2004
    ..Moreover, there is circumstantial evidence suggesting that plasma tryptophan (TRP) levels can predict response to SSRIs. These findings suggest that dietary TRP variations may affect the efficacy of SSRI in major depression...
  25. ncbi Bupropion for patients with obsessive-compulsive disorder: an open-label, fixed-dose study
    Nienke C C Vulink
    Department of Psychiatry, University Medical Center Utrecht, The Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands
    J Clin Psychiatry 66:228-30. 2005
    ..In the present study, we examined the efficacy of bupropion for patients with obsessive-compulsive disorder (OCD)...
  26. ncbi Attention and cognition in patients with obsessive-compulsive disorder
    Femke de Geus
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Psychiatry Clin Neurosci 61:45-53. 2007
    ..The results show that patients with OCD have cognitive deficits. The authors hypothesize that these deficits may be interpreted by attentional deficits caused by a dysfunctional anterior cingulate cortex...
  27. doi Electroconvulsive therapy has acute immunological and neuroendocrine effects in patients with major depressive disorder
    Sjoerd B A H A Fluitman
    The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    J Affect Disord 131:388-92. 2011
    ..Major depressive disorder is associated with alterations in the neuroendocrine as well as immune system. Few studies examined the impact of electroconvulsive therapy (ECT) on these systems in patients with major depressive disorder (MDD)...
  28. doi Compulsivity in mouse strains homologous with chromosomes 7p and 15q linked to obsessive-compulsive disorder
    Martien J H Kas
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 153:252-9. 2010
    ..Genetic fine mapping of compulsivity in mice provides new opportunities to reveal mechanisms underlying this significant psychiatric trait...
  29. ncbi Behavioural effects of rapid intravenous administration of meta-chlorophenylpiperazine in patients with panic disorder and controls
    Nic J A van der Wee
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur Neuropsychopharmacol 14:413-7. 2004
    ..Our data suggests that the behavioural effects of rapid intravenous administration of 0.1 mg/kg of m-CPP in patients with PD indeed show a unique combination of high sensitivity and selectivity...
  30. ncbi Decreased thalamic blood flow in obsessive-compulsive disorder patients responding to fluvoxamine
    Kamini L Ho Pian
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Psychiatry Res 138:89-97. 2005
    ..Pre-treatment cerebellar and whole brain HMPAO uptake was significantly higher in responders to treatment compared with non-responders. We suggest that the thalamus plays a central role in the response to drug treatment...
  31. ncbi Altered pain processing in veterans with posttraumatic stress disorder
    Elbert Geuze
    Department of Military Psychiatry, Central Military Hospital, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Arch Gen Psychiatry 64:76-85. 2007
    ..Several brain areas related to pain processing are implicated in PTSD. To our knowledge, no functional imaging study has discussed whether patients with PTSD experience and process pain in a different way than control subjects...
  32. ncbi Neural correlates of associative learning and memory in veterans with posttraumatic stress disorder
    Elbert Geuze
    Research Centre Military Mental Health, Ministry of Defense, PO Box 90 000, 3509AA Utrecht, The Netherlands
    J Psychiatr Res 42:659-69. 2008
    ..Deficits in memory performance in PTSD appear to be related to altered activity in fronto-temporal areas during both the encoding and retrieval phase of memory processing...
  33. ncbi Precuneal activity during encoding in veterans with posttraumatic stress disorder
    Elbert Geuze
    Department of Military Psychiatry, Central Military Hospital, Ministry of Defense, Utrecht, The Netherlands
    Prog Brain Res 167:293-7. 2008
    ..The precuneus was less activated in veterans with PTSD, which correlated significantly with the severity of PTSD. Like fronto-temporal regions the precuneus is differentially activated during memory formation in veterans with PTSD...
  34. doi Neuropsychological performance is related to current social and occupational functioning in veterans with posttraumatic stress disorder
    Elbert Geuze
    Research Centre Military Mental Health, Ministry of Defense, Utrecht, The Netherlands
    Depress Anxiety 26:7-15. 2009
    ..However, most of these studies had several methodological disadvantages. None of these studies assessed parameters related to social or occupational functioning...
  35. doi Thinner prefrontal cortex in veterans with posttraumatic stress disorder
    Elbert Geuze
    Research Centre, Military Mental Healthcare, Ministry of Defence, Utrecht, The Netherlands
    Neuroimage 41:675-81. 2008
    ..Cortical thickness correlated with memory measures in the veterans without PTSD, but not in the veterans with PTSD. Cortical thinning in these regions may thus correspond to functional abnormalities observed in patients with PTSD...
  36. doi Behavioral pattern analysis and dopamine release in quinpirole-induced repetitive behavior in rats
    Ria de Haas
    Department of Psychiatry, UMC Utrecht, Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands
    J Psychopharmacol 25:1712-9. 2011
    ..These findings suggest that quinpirole-induced behavior mimics only part of the compulsive behavior as shown in OCD patients...
  37. ncbi Serotonergic functioning in children with oppositional defiant disorder: a sumatriptan challenge study
    Heddeke Snoek
    Department of Child and Adolescent Psychiatry, B01 201, University Medical Center Utrecht, PO Box 85500, Utrecht 3508 GA, The Netherlands
    Biol Psychiatry 51:319-25. 2002
    ..The aim of the present study was to investigate 5-HT(1B/1D) receptor functioning in normal intelligent hospitalized children with oppositional defiant disorder (ODD)...
  38. ncbi The influence of amphetamine on language activation: an fMRI study
    Iris E C Sommer
    Rudolf Magnus Institute of Neuroscience Psychiatry Department, University Medical Center Utrecht, Heidelberglaan 100, 3584CX, Utrecht, The Netherlands
    Psychopharmacology (Berl) 183:387-93. 2006
    ..In humans, cerebral dopamine neurotransmission is also correlated to motor dominance. Since language dominance is related to motor dominance, amphetamine might also affect cerebral dominance for language...
  39. ncbi Low level of dopaminergic D2 receptor binding in obsessive-compulsive disorder
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 55:1041-5. 2004
    ..Despite growing evidence for involvement of the dopaminergic system in obsessive-compulsive disorder (OCD), the functional anatomy of the dopaminergic system in the basal ganglia has been investigated sparsely...
  40. ncbi Autonomic and neuroendocrine responses to a psychosocial stressor in adults with autistic spectrum disorder
    Lucres M C Jansen
    Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
    J Autism Dev Disord 36:891-9. 2006
    ..However, in contrast to previous findings in low functioning autistic children, ASD adults showed increased basal oxytocin levels, which may be related to developmental factors...
  41. doi Sympathetic activity and hypothalamo-pituitary-adrenal axis activity during sleep in post-traumatic stress disorder: a study assessing polysomnography with simultaneous blood sampling
    Saskia van Liempt
    Research Center Military Mental Health Care, Utrecht, The Netherlands
    Psychoneuroendocrinology 38:155-65. 2013
    ..According to polysomnography (PSG), only minor changes in sleep architecture were described. This warrants alternative methods for assessing sleep regulation in PTSD...
  42. pmc Deep brain stimulation reveals a dissociation of consummatory and motivated behaviour in the medial and lateral nucleus accumbens shell of the rat
    Geoffrey Van der Plasse
    Department Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    PLoS ONE 7:e33455. 2012
    ..As such, these findings provide important leads for the possible future application of DBS as a treatment for eating disorders such as anorexia nervosa...
  43. ncbi A double-blind switch study of paroxetine and venlafaxine in obsessive-compulsive disorder
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 65:37-43. 2004
    ..However, no controlled research has been published yet that prospectively examined the effects of changing SRIs. This article describes the first double-blind switch study of 2 SRIs in patients with OCD...
  44. ncbi Glutamate and anxiety
    Veerle Bergink
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, B01 206, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Eur Neuropsychopharmacol 14:175-83. 2004
    ..It can be expected that selective modulators of glutamate activity will be of great clinical significance for the treatment of anxiety disorders...
  45. ncbi The effects of selective serotonin reuptake inhibitors on extracellular 5-HT levels in the hippocampus of 5-HT(1B) receptor knockout mice
    Lotte De Groote
    Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Eur J Pharmacol 439:93-100. 2002
    ..In addition, the different dose-response to fluvoxamine suggests that 5-HT(1B) knockout mice have possible adaptations of 5-HT transporters in order to compensate for the loss of the terminal 5-HT(1B) autoreceptor...