P J Voshol
Affiliation: University of Groningen
Country: The Netherlands
- Reduced plasma cholesterol and increased fecal sterol loss in multidrug resistance gene 2 P-glycoprotein-deficient miceP J Voshol
Groningen Institute for Drug Studies, Laboratory of Nutrition and Metabolism, University Hospital Groningen, Groningen, The Netherlands
Gastroenterology 114:1024-34. 1998..The aim of this study was to evaluate the importance of the biliary pathway in cholesterol homeostasis by determining the effects of mdr2 Pgp deficiency on hepatic and plasma lipid levels and cholesterol kinetics in chow-fed mice...
- Postprandial chylomicron formation and fat absorption in multidrug resistance gene 2 P-glycoprotein-deficient miceP J Voshol
Groningen Institute for Drug Studies, Center for Liver, Digestive, and Metabolic Diseases, University Hospital Groningen, Groningen, The Netherlands
Gastroenterology 118:173-82. 2000..Mdr2((-/-)) mice do not secrete phospholipids and cholesterol into bile, and bile salt secretion is not impaired. Mdr2((+/-)) mice show only impaired (-40%) phospholipid secretion...
- Dietary cholesterol does not normalize low plasma cholesterol levels but induces hyperbilirubinemia and hypercholanemia in Mdr2 P-glycoprotein-deficient miceP J Voshol
Groningen University Institute for Drug Exploration, Center for Liver, Digestive and Metabolic Diseases, Department of Pediatrics, University Hospital Groningen, The Netherlands
J Hepatol 34:202-9. 2001..Induction of hyperbilirubinemia and hypercholanemia by dietary cholesterol in Mdr2(-/-) mice delineates the important role of biliary lipid secretion in normal hepatic functioning...
- Biliary phospholipid secretion is not required for intestinal absorption and plasma status of linoleic acid in miceD M Minich
Groningen Institute for Drug Studies, Center for Liver, Digestive and Metabolic Diseases, University Hospital Groningen, Groningen, The Netherlands
Biochim Biophys Acta 1441:14-22. 1999..Present data indicate that biliary phospholipids are involved in the rate of appearance in plasma of enterally administered linoleic acid, but are not required for net intestinal absorption or plasma status of linoleic acid...
- Down-regulation of intestinal scavenger receptor class B, type I (SR-BI) expression in rodents under conditions of deficient bile delivery to the intestineP J Voshol
Groningen University Institute for Drug Exploration, Center for Liver, Digestive and Metabolic Diseases, University Hospital Groningen, Hanzeplein 1, NL 9713 GZ Groningen, The Netherlands
Biochem J 356:317-25. 2001..Factors associated with cholestasis appear to be involved in transcriptional control of intestinal SR-BI expression. The role of SR-BI in the cholesterol-absorption process remains to be defined...
- Apolipoprotein E participates in the regulation of very low density lipoprotein-triglyceride secretion by the liverA R Mensenkamp
Groningen Institute for Drug Studies, University Hospital Groningen, 9713 GZ Groningen
J Biol Chem 274:35711-8. 1999..These findings indicate a regulatory role of apoE in hepatic VLDL-triglyceride secretion, independent from its role in lipoprotein clearance...
- Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in miceE Korsheninnikova
Department of Molecular Cell Biology, Leiden University Medical Centre, Postzone S1 P, Postbus 9600, 2300 RC, Leiden, The Netherlands
Diabetologia 49:3049-57. 2006..We examined activation of mTOR-signalling in relation to insulin resistance and hepatic steatosis in mice...
- High fat diet induced hepatic insulin resistance is not related to changes in hypothalamic mRNA expression of NPY, AgRP, POMC and CART in miceA C Heijboer
Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
Peptides 26:2554-8. 2005..Therefore, a major physiological role of these neuroendocrine factors in the induction of hepatic insulin resistance during a high fat diet seems less likely...
- Intracerebroventricular administration of melanotan II increases insulin sensitivity of glucose disposal in miceA C Heijboer
Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
Diabetologia 48:1621-6. 2005..The present study was conducted to evaluate the effects of central administration of melanotan II (MTII), a melanocortin-3/4 receptor agonist, on hepatic and whole-body insulin sensitivity, independent of food intake and body weight...
- Hepatic steatosis: a mediator of the metabolic syndrome. Lessons from animal modelsM den Boer
TNO Prevention and Health, Gaubius Laboratory Leiden, Leiden, The Netherlands
Arterioscler Thromb Vasc Biol 24:644-9. 2004..Therefore, the liver participates passively and actively in the metabolic derangements of the metabolic syndrome. We speculate that similar mechanisms may also be involved in human pathophysiology...
- Protection from obesity and insulin resistance in mice overexpressing human apolipoprotein C1M C Jong
TNO Prevention and Health, Gaubius Laboratory, Leiden, The Netherlands
Diabetes 50:2779-85. 2001..In conclusion, a marked reduction in the uptake of fatty acids into adipocytes may underlie the protection from obesity and insulin resistance in transgenic mice overexpressing human APOC1...
- In muscle-specific lipoprotein lipase-overexpressing mice, muscle triglyceride content is increased without inhibition of insulin-stimulated whole-body and muscle-specific glucose uptakeP J Voshol
TNO Prevention and Health, Division VBO, Leiden, The Netherlands
Diabetes 50:2585-90. 2001....
- Dynamics of insulin signalling in liver during hyperinsulinemic euglycaemic clamp conditions in vivo and the effects of high-fat feeding in male miceE Korsheninnikova
Departments of Molecular Cell Biology, Leiden University Medical Centre, Leiden, The Netherlands
Arch Physiol Biochem 113:173-85. 2007..A sustained increased phosphorylation of the serine/threonine kinases p70S6kinase and Jun N-terminal kinase in the absence of insulin may underlie the abrogated phosphorylation of the IRS proteins and their downstream targets...