P J Voshol

Summary

Affiliation: University of Groningen
Country: The Netherlands

Publications

  1. ncbi Reduced plasma cholesterol and increased fecal sterol loss in multidrug resistance gene 2 P-glycoprotein-deficient mice
    P J Voshol
    Groningen Institute for Drug Studies, Laboratory of Nutrition and Metabolism, University Hospital Groningen, Groningen, The Netherlands
    Gastroenterology 114:1024-34. 1998
  2. ncbi Postprandial chylomicron formation and fat absorption in multidrug resistance gene 2 P-glycoprotein-deficient mice
    P J Voshol
    Groningen Institute for Drug Studies, Center for Liver, Digestive, and Metabolic Diseases, University Hospital Groningen, Groningen, The Netherlands
    Gastroenterology 118:173-82. 2000
  3. ncbi Dietary cholesterol does not normalize low plasma cholesterol levels but induces hyperbilirubinemia and hypercholanemia in Mdr2 P-glycoprotein-deficient mice
    P J Voshol
    Groningen University Institute for Drug Exploration, Center for Liver, Digestive and Metabolic Diseases, Department of Pediatrics, University Hospital Groningen, The Netherlands
    J Hepatol 34:202-9. 2001
  4. ncbi Biliary phospholipid secretion is not required for intestinal absorption and plasma status of linoleic acid in mice
    D M Minich
    Groningen Institute for Drug Studies, Center for Liver, Digestive and Metabolic Diseases, University Hospital Groningen, Groningen, The Netherlands
    Biochim Biophys Acta 1441:14-22. 1999
  5. ncbi Down-regulation of intestinal scavenger receptor class B, type I (SR-BI) expression in rodents under conditions of deficient bile delivery to the intestine
    P J Voshol
    Groningen University Institute for Drug Exploration, Center for Liver, Digestive and Metabolic Diseases, University Hospital Groningen, Hanzeplein 1, NL 9713 GZ Groningen, The Netherlands
    Biochem J 356:317-25. 2001
  6. ncbi Apolipoprotein E participates in the regulation of very low density lipoprotein-triglyceride secretion by the liver
    A R Mensenkamp
    Groningen Institute for Drug Studies, University Hospital Groningen, 9713 GZ Groningen
    J Biol Chem 274:35711-8. 1999
  7. ncbi Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice
    E Korsheninnikova
    Department of Molecular Cell Biology, Leiden University Medical Centre, Postzone S1 P, Postbus 9600, 2300 RC, Leiden, The Netherlands
    Diabetologia 49:3049-57. 2006
  8. ncbi High fat diet induced hepatic insulin resistance is not related to changes in hypothalamic mRNA expression of NPY, AgRP, POMC and CART in mice
    A C Heijboer
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Peptides 26:2554-8. 2005
  9. ncbi Intracerebroventricular administration of melanotan II increases insulin sensitivity of glucose disposal in mice
    A C Heijboer
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Diabetologia 48:1621-6. 2005
  10. ncbi Hepatic steatosis: a mediator of the metabolic syndrome. Lessons from animal models
    M den Boer
    TNO Prevention and Health, Gaubius Laboratory Leiden, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 24:644-9. 2004

Collaborators

Detail Information

Publications13

  1. ncbi Reduced plasma cholesterol and increased fecal sterol loss in multidrug resistance gene 2 P-glycoprotein-deficient mice
    P J Voshol
    Groningen Institute for Drug Studies, Laboratory of Nutrition and Metabolism, University Hospital Groningen, Groningen, The Netherlands
    Gastroenterology 114:1024-34. 1998
    ..The aim of this study was to evaluate the importance of the biliary pathway in cholesterol homeostasis by determining the effects of mdr2 Pgp deficiency on hepatic and plasma lipid levels and cholesterol kinetics in chow-fed mice...
  2. ncbi Postprandial chylomicron formation and fat absorption in multidrug resistance gene 2 P-glycoprotein-deficient mice
    P J Voshol
    Groningen Institute for Drug Studies, Center for Liver, Digestive, and Metabolic Diseases, University Hospital Groningen, Groningen, The Netherlands
    Gastroenterology 118:173-82. 2000
    ..Mdr2((-/-)) mice do not secrete phospholipids and cholesterol into bile, and bile salt secretion is not impaired. Mdr2((+/-)) mice show only impaired (-40%) phospholipid secretion...
  3. ncbi Dietary cholesterol does not normalize low plasma cholesterol levels but induces hyperbilirubinemia and hypercholanemia in Mdr2 P-glycoprotein-deficient mice
    P J Voshol
    Groningen University Institute for Drug Exploration, Center for Liver, Digestive and Metabolic Diseases, Department of Pediatrics, University Hospital Groningen, The Netherlands
    J Hepatol 34:202-9. 2001
    ..Induction of hyperbilirubinemia and hypercholanemia by dietary cholesterol in Mdr2(-/-) mice delineates the important role of biliary lipid secretion in normal hepatic functioning...
  4. ncbi Biliary phospholipid secretion is not required for intestinal absorption and plasma status of linoleic acid in mice
    D M Minich
    Groningen Institute for Drug Studies, Center for Liver, Digestive and Metabolic Diseases, University Hospital Groningen, Groningen, The Netherlands
    Biochim Biophys Acta 1441:14-22. 1999
    ..Present data indicate that biliary phospholipids are involved in the rate of appearance in plasma of enterally administered linoleic acid, but are not required for net intestinal absorption or plasma status of linoleic acid...
  5. ncbi Down-regulation of intestinal scavenger receptor class B, type I (SR-BI) expression in rodents under conditions of deficient bile delivery to the intestine
    P J Voshol
    Groningen University Institute for Drug Exploration, Center for Liver, Digestive and Metabolic Diseases, University Hospital Groningen, Hanzeplein 1, NL 9713 GZ Groningen, The Netherlands
    Biochem J 356:317-25. 2001
    ..Factors associated with cholestasis appear to be involved in transcriptional control of intestinal SR-BI expression. The role of SR-BI in the cholesterol-absorption process remains to be defined...
  6. ncbi Apolipoprotein E participates in the regulation of very low density lipoprotein-triglyceride secretion by the liver
    A R Mensenkamp
    Groningen Institute for Drug Studies, University Hospital Groningen, 9713 GZ Groningen
    J Biol Chem 274:35711-8. 1999
    ..These findings indicate a regulatory role of apoE in hepatic VLDL-triglyceride secretion, independent from its role in lipoprotein clearance...
  7. ncbi Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice
    E Korsheninnikova
    Department of Molecular Cell Biology, Leiden University Medical Centre, Postzone S1 P, Postbus 9600, 2300 RC, Leiden, The Netherlands
    Diabetologia 49:3049-57. 2006
    ..We examined activation of mTOR-signalling in relation to insulin resistance and hepatic steatosis in mice...
  8. ncbi High fat diet induced hepatic insulin resistance is not related to changes in hypothalamic mRNA expression of NPY, AgRP, POMC and CART in mice
    A C Heijboer
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Peptides 26:2554-8. 2005
    ..Therefore, a major physiological role of these neuroendocrine factors in the induction of hepatic insulin resistance during a high fat diet seems less likely...
  9. ncbi Intracerebroventricular administration of melanotan II increases insulin sensitivity of glucose disposal in mice
    A C Heijboer
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Diabetologia 48:1621-6. 2005
    ..The present study was conducted to evaluate the effects of central administration of melanotan II (MTII), a melanocortin-3/4 receptor agonist, on hepatic and whole-body insulin sensitivity, independent of food intake and body weight...
  10. ncbi Hepatic steatosis: a mediator of the metabolic syndrome. Lessons from animal models
    M den Boer
    TNO Prevention and Health, Gaubius Laboratory Leiden, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 24:644-9. 2004
    ..Therefore, the liver participates passively and actively in the metabolic derangements of the metabolic syndrome. We speculate that similar mechanisms may also be involved in human pathophysiology...
  11. ncbi Protection from obesity and insulin resistance in mice overexpressing human apolipoprotein C1
    M C Jong
    TNO Prevention and Health, Gaubius Laboratory, Leiden, The Netherlands
    Diabetes 50:2779-85. 2001
    ..In conclusion, a marked reduction in the uptake of fatty acids into adipocytes may underlie the protection from obesity and insulin resistance in transgenic mice overexpressing human APOC1...
  12. ncbi In muscle-specific lipoprotein lipase-overexpressing mice, muscle triglyceride content is increased without inhibition of insulin-stimulated whole-body and muscle-specific glucose uptake
    P J Voshol
    TNO Prevention and Health, Division VBO, Leiden, The Netherlands
    Diabetes 50:2585-90. 2001
    ....
  13. ncbi Dynamics of insulin signalling in liver during hyperinsulinemic euglycaemic clamp conditions in vivo and the effects of high-fat feeding in male mice
    E Korsheninnikova
    Departments of Molecular Cell Biology, Leiden University Medical Centre, Leiden, The Netherlands
    Arch Physiol Biochem 113:173-85. 2007
    ..A sustained increased phosphorylation of the serine/threonine kinases p70S6kinase and Jun N-terminal kinase in the absence of insulin may underlie the abrogated phosphorylation of the IRS proteins and their downstream targets...