Jacob A S Vorstman

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. doi request reprint Using genetic findings in autism for the development of new pharmaceutical compounds
    Jacob A S Vorstman
    Department of Psychiatry, Brain Center Rudolf Magnus, A001 468, University Medical Center Utrecht, Heidelberglaan 100, 3485 CX, Utrecht, The Netherlands
    Psychopharmacology (Berl) 231:1063-78. 2014
  2. doi request reprint Genetic causes of developmental disorders
    Jacob A S Vorstman
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Curr Opin Neurol 26:128-36. 2013
  3. doi request reprint No evidence that common genetic risk variation is shared between schizophrenia and autism
    Jacob A S Vorstman
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 162:55-60. 2013
  4. doi request reprint Expression of autism spectrum and schizophrenia in patients with a 22q11.2 deletion
    Jacob A S Vorstman
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Schizophr Res 143:55-9. 2013
  5. ncbi request reprint Identification of novel autism candidate regions through analysis of reported cytogenetic abnormalities associated with autism
    J A S Vorstman
    Department of Child and Adolescent Psychiatry, University Medical Centre Utrecht, Afd K and J Psychiatrie, Heidelberglaan 100, Huispost A01 468, 3584 CX Utrecht, The Netherlands
    Mol Psychiatry 11:1, 18-28. 2006
  6. pmc A double hit implicates DIAPH3 as an autism risk gene
    J A S Vorstman
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Mol Psychiatry 16:442-51. 2011
  7. pmc Association of the PIK4CA schizophrenia-susceptibility gene in adults with the 22q11.2 deletion syndrome
    Jacob A S Vorstman
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 150:430-3. 2009
  8. ncbi request reprint The 22q11.2 deletion in children: high rate of autistic disorders and early onset of psychotic symptoms
    Jacob A S Vorstman
    Department of Child and Adolescent Psychiatry, University Medical Centre, Utrecht, The Netherlands
    J Am Acad Child Adolesc Psychiatry 45:1104-13. 2006
  9. pmc Proline affects brain function in 22q11DS children with the low activity COMT 158 allele
    Jacob A S Vorstman
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Neuropsychopharmacology 34:739-46. 2009
  10. pmc Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis
    Eske M Derks
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
    PLoS ONE 7:e37852. 2012

Detail Information

Publications18

  1. doi request reprint Using genetic findings in autism for the development of new pharmaceutical compounds
    Jacob A S Vorstman
    Department of Psychiatry, Brain Center Rudolf Magnus, A001 468, University Medical Center Utrecht, Heidelberglaan 100, 3485 CX, Utrecht, The Netherlands
    Psychopharmacology (Berl) 231:1063-78. 2014
    ..A primary value of genetic research is enhancing our insight into the biology of autism through the study of identified autism risk genes...
  2. doi request reprint Genetic causes of developmental disorders
    Jacob A S Vorstman
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Curr Opin Neurol 26:128-36. 2013
    ..Here, we review these findings and discuss possible implications for our current understanding of the cause of developmental disorders...
  3. doi request reprint No evidence that common genetic risk variation is shared between schizophrenia and autism
    Jacob A S Vorstman
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 162:55-60. 2013
    ..These findings provide important novel insights into shared and distinct elements of the genetic architecture of autism and schizophrenia...
  4. doi request reprint Expression of autism spectrum and schizophrenia in patients with a 22q11.2 deletion
    Jacob A S Vorstman
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Schizophr Res 143:55-9. 2013
    ..Alternatively, seemingly different disorders could represent the same phenotype observed at different developmental stages or the same underlying pathogenesis with different phenotypic expressions...
  5. ncbi request reprint Identification of novel autism candidate regions through analysis of reported cytogenetic abnormalities associated with autism
    J A S Vorstman
    Department of Child and Adolescent Psychiatry, University Medical Centre Utrecht, Afd K and J Psychiatrie, Heidelberglaan 100, Huispost A01 468, 3584 CX Utrecht, The Netherlands
    Mol Psychiatry 11:1, 18-28. 2006
    ..3, 17p11.2, 18q21.1, 18q23, 22q11.2, 22q13.3 and Xp22.2-p22.3...
  6. pmc A double hit implicates DIAPH3 as an autism risk gene
    J A S Vorstman
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Mol Psychiatry 16:442-51. 2011
    ....
  7. pmc Association of the PIK4CA schizophrenia-susceptibility gene in adults with the 22q11.2 deletion syndrome
    Jacob A S Vorstman
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 150:430-3. 2009
    ..Second, the results of this study indicate that variation at PIK4CA may be a relevant factor influencing the risk of schizophrenia in individuals with 22q11DS...
  8. ncbi request reprint The 22q11.2 deletion in children: high rate of autistic disorders and early onset of psychotic symptoms
    Jacob A S Vorstman
    Department of Child and Adolescent Psychiatry, University Medical Centre, Utrecht, The Netherlands
    J Am Acad Child Adolesc Psychiatry 45:1104-13. 2006
    ..To examine psychopathology and influence of intelligence level on psychiatric symptoms in children with the 22q11.2 deletion syndrome (22q11DS)...
  9. pmc Proline affects brain function in 22q11DS children with the low activity COMT 158 allele
    Jacob A S Vorstman
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Neuropsychopharmacology 34:739-46. 2009
    ..22q11DS patients with low dopamine catabolic capacity are therefore especially vulnerable to this functional disruption...
  10. pmc Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis
    Eske M Derks
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
    PLoS ONE 7:e37852. 2012
    ..This does not necessarily imply that a genetic basis is nonexistent, but does suggest that it is distinct from the polygenic risk score for schizophrenia...
  11. pmc Prevalence of 22q11.2 deletions in 311 Dutch patients with schizophrenia
    Mechteld L C Hoogendoorn
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Schizophr Res 98:84-8. 2008
    ..The prevalence of 22q11.2DS in schizophrenia patients is lower than the frequently reported prevalence of 2% or more...
  12. doi request reprint Cognitive development in children with 22q11.2 deletion syndrome
    Sasja N Duijff
    Department of Paediatric Psychology, University Medical Centre Utrecht, The Netherlands
    Br J Psychiatry 200:462-8. 2012
    ..2 deletion syndrome. If confirmed longitudinally, this could indicate that one or more genes within 22q11.2 are involved in cognitive decline...
  13. doi request reprint Cognitive and behavioral trajectories in 22q11DS from childhood into adolescence: a prospective 6-year follow-up study
    Sasja N Duijff
    Department of Pediatric Psychology, Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
    Res Dev Disabil 34:2937-45. 2013
    ..It can be concluded that children with 22q11DS follow a unique developmental trajectory. Cognitive deterioration is severe in some but does not appear to predict behavioral problems in early adolescence...
  14. pmc Gene-network analysis identifies susceptibility genes related to glycobiology in autism
    Bert van der Zwaag
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 4:e5324. 2009
    ..Our findings suggest that the occurrence of genomic gains and losses of genes associated with glycobiology are important contributors to the development of ASD...
  15. pmc Social Responsiveness Scale-aided analysis of the clinical impact of copy number variations in autism
    Emma van Daalen
    Department of Child and Adolescent Psychiatry, University Medical Centre, Utrecht, The Netherlands
    Neurogenetics 12:315-23. 2011
    ..Our study extends the scope of genome-wide CNV profiling beyond de novo CNVs in sporadic patients and may aid in uncovering missing heritability in genome-wide screening studies of complex psychiatric disorders...
  16. pmc Genome-wide analysis shows increased frequency of copy number variation deletions in Dutch schizophrenia patients
    Jacobine E Buizer-Voskamp
    Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 70:655-62. 2011
    ....
  17. pmc Proline and COMT status affect visual connectivity in children with 22q11.2 deletion syndrome
    Maurice J C M Magnée
    Rudolf Magnus Institute of Neuroscience, Department of Child and Adolescent Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 6:e25882. 2011
    ..Therefore, 22q11DS may represent a unique model to understand the neurobiology of visual processing deficits related with ASD and psychosis...
  18. doi request reprint Increased paternal age and the influence on burden of genomic copy number variation in the general population
    Jacobine E Buizer-Voskamp
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Hum Genet 132:443-50. 2013
    ..While it remains possible that local genomic effects may exist for specific phenotypes, this study indicates that global CNV burden and increased father's age may be independent disease risk factors...