P G Volders

Summary

Affiliation: University Hospital Maastricht
Country: The Netherlands

Publications

  1. ncbi request reprint Repolarizing K+ currents ITO1 and IKs are larger in right than left canine ventricular midmyocardium
    P G Volders
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands
    Circulation 99:206-10. 1999
  2. ncbi request reprint Downregulation of delayed rectifier K(+) currents in dogs with chronic complete atrioventricular block and acquired torsades de pointes
    P G Volders
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands
    Circulation 100:2455-61. 1999
  3. ncbi request reprint Wide QRS complex tachycardia with negative precordial concordance: always a ventricular origin?
    Paul G A Volders
    Department of Cardiology, Academic Hospital Maastricht, Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands
    J Cardiovasc Electrophysiol 14:109-11. 2003
  4. ncbi request reprint Probing the contribution of IKs to canine ventricular repolarization: key role for beta-adrenergic receptor stimulation
    Paul G A Volders
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Academic Hospital Maastricht, PO Box 5800, 6202 AZ, Maastricht, Netherlands
    Circulation 107:2753-60. 2003
  5. doi request reprint I(Ks) restricts excessive beat-to-beat variability of repolarization during beta-adrenergic receptor stimulation
    Daniel M Johnson
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, PO Box 5800, 6202 AZ, Maastricht, The Netherlands
    J Mol Cell Cardiol 48:122-30. 2010
  6. pmc Accumulation of slowly activating delayed rectifier potassium current (IKs) in canine ventricular myocytes
    Milan Stengl
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Academic Hospital Maastricht, The Netherlands
    J Physiol 551:777-86. 2003
  7. ncbi request reprint Temporal patterns of electrical remodeling in canine ventricular hypertrophy: focus on IKs downregulation and blunted beta-adrenergic activation
    Milan Stengl
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University and Academic Hospital Maastricht, PO Box 5800, 6202 AZ, Maastricht, The Netherlands
    Cardiovasc Res 72:90-100. 2006
  8. ncbi request reprint Increased short-term variability of repolarization predicts d-sotalol-induced torsades de pointes in dogs
    Morten B Thomsen
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, Netherlands
    Circulation 110:2453-9. 2004
  9. ncbi request reprint Electrophysiological safety of sertindole in dogs with normal and remodeled hearts
    Morten B Thomsen
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Academic Hospital Maastricht, P O Box 5800, NL 6202 AZ, Maastricht, The Netherlands
    J Pharmacol Exp Ther 307:776-84. 2003
  10. ncbi request reprint Serial left-ventricular biopsy sampling using a minimally invasive trans-thoracic approach in adult dogs
    Dirk W Donker
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Academic Hospital Maastricht and Maastricht University, P O Box 5800, 6202 AZ, Maastricht, The Netherlands
    Pflugers Arch 454:1043-51. 2007

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Repolarizing K+ currents ITO1 and IKs are larger in right than left canine ventricular midmyocardium
    P G Volders
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands
    Circulation 99:206-10. 1999
    ..We examined transient outward (ITO1), delayed (IKs and IKr), and inward rectifier K+ currents (IK1) in relation to action potential characteristics of RV and LV midmyocardial (M) cells of the same adult canine hearts...
  2. ncbi request reprint Downregulation of delayed rectifier K(+) currents in dogs with chronic complete atrioventricular block and acquired torsades de pointes
    P G Volders
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands
    Circulation 100:2455-61. 1999
    ..We examined whether K(+)-current alterations contribute to these proarrhythmic responses in an animal model of TdP: the dog with chronic complete atrioventricular block (AVB) and biventricular hypertrophy...
  3. ncbi request reprint Wide QRS complex tachycardia with negative precordial concordance: always a ventricular origin?
    Paul G A Volders
    Department of Cardiology, Academic Hospital Maastricht, Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands
    J Cardiovasc Electrophysiol 14:109-11. 2003
  4. ncbi request reprint Probing the contribution of IKs to canine ventricular repolarization: key role for beta-adrenergic receptor stimulation
    Paul G A Volders
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Academic Hospital Maastricht, PO Box 5800, 6202 AZ, Maastricht, Netherlands
    Circulation 107:2753-60. 2003
    ..In large mammals and humans, the contribution of IKs to ventricular repolarization is still incompletely understood...
  5. doi request reprint I(Ks) restricts excessive beat-to-beat variability of repolarization during beta-adrenergic receptor stimulation
    Daniel M Johnson
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, PO Box 5800, 6202 AZ, Maastricht, The Netherlands
    J Mol Cell Cardiol 48:122-30. 2010
    ..Loss of I(Ks) plus overriding of Ca(2+)-dependent membrane currents, including inward Na(+)-Ca(2)(+) exchange current, conspire to proarrhythmic BVR under these conditions...
  6. pmc Accumulation of slowly activating delayed rectifier potassium current (IKs) in canine ventricular myocytes
    Milan Stengl
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Academic Hospital Maastricht, The Netherlands
    J Physiol 551:777-86. 2003
    ..Block of IKs, however, led to a reverse rate-dependent prolongation of APD indicating that IKs does not have a dominant role at short cycle lengths...
  7. ncbi request reprint Temporal patterns of electrical remodeling in canine ventricular hypertrophy: focus on IKs downregulation and blunted beta-adrenergic activation
    Milan Stengl
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University and Academic Hospital Maastricht, PO Box 5800, 6202 AZ, Maastricht, The Netherlands
    Cardiovasc Res 72:90-100. 2006
    ....
  8. ncbi request reprint Increased short-term variability of repolarization predicts d-sotalol-induced torsades de pointes in dogs
    Morten B Thomsen
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, Netherlands
    Circulation 110:2453-9. 2004
    ..The predictive value of different repolarization parameters, including beat-to-beat variability of repolarization (BVR), was compared in this serial investigation in dogs with chronic AV block...
  9. ncbi request reprint Electrophysiological safety of sertindole in dogs with normal and remodeled hearts
    Morten B Thomsen
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Academic Hospital Maastricht, P O Box 5800, NL 6202 AZ, Maastricht, The Netherlands
    J Pharmacol Exp Ther 307:776-84. 2003
    ..v. doses sertindole can pose a serious proarrhythmic risk when electrical remodeling of the ventricles is present. At clinically relevant doses, however, sertindole does not cause TdP in anesthetized dogs with normal or remodeled hearts...
  10. ncbi request reprint Serial left-ventricular biopsy sampling using a minimally invasive trans-thoracic approach in adult dogs
    Dirk W Donker
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Academic Hospital Maastricht and Maastricht University, P O Box 5800, 6202 AZ, Maastricht, The Netherlands
    Pflugers Arch 454:1043-51. 2007
    ..The technique is safe and has no long-term effects on cardiac function or structure...
  11. pmc Subepicardial phase 0 block and discontinuous transmural conduction underlie right precordial ST-segment elevation by a SCN5A loss-of-function mutation
    Marketa Bebarova
    Dept of Cardiology, Cardiovascular Research Institute Maastricht, Academic Hospital Maastricht, 6202 AZ, Maastricht, The Netherlands
    Am J Physiol Heart Circ Physiol 295:H48-58. 2008
    ..The late slow-upstroke action potentials at the subepicardium produce T-wave inversion in the computed ECG waveform, in line with the clinical ECG...
  12. ncbi request reprint Impact of acute and enduring volume overload on mechanotransduction and cytoskeletal integrity of canine left ventricular myocardium
    Dirk W Donker
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Academic Hospital Maastricht, 6202 AZ Maastricht, The Netherlands
    Am J Physiol Heart Circ Physiol 292:H2324-32. 2007
    ..Subsequent cytoskeletal reorganization coincides with the upregulation of melusin, P-Akt, P-GSK3beta, and MLP, indicating a strong drive to compensated hypertrophy...
  13. ncbi request reprint Mapping a novel locus for familial atrial fibrillation on chromosome 10p11-q21
    Paul G A Volders
    Department of Cardiology, Academic Hospital Maastricht, Maastricht, The Netherlands
    Heart Rhythm 4:469-75. 2007
    ..2 million Americans. Recently, several chromosomal loci and genes have been found to be associated with familial AF. However, in most other AF cases, the genetic basis is still poorly understood...
  14. ncbi request reprint Increased Na+ concentration and altered Na/K pump activity in hypertrophied canine ventricular cells
    Fons Verdonck
    Interdisciplinary Research Center, University of Leuven Campus Kortrijk, E Sabbelaan 53, B 8500, Kortrijk, Belgium
    Cardiovasc Res 57:1035-43. 2003
    ..To investigate whether hypertrophy in the dog with chronic atrioventricular block (CAVB) alters [Na+]i and Na/K-pump function of ventricular myocytes...
  15. ncbi request reprint In vivo mechanisms precipitating torsades de pointes in a canine model of drug-induced long-QT1 syndrome
    David J Gallacher
    Center of Excellence for Cardiovascular Safety Research, Johnson and Johnson Pharmaceutical Research and Development, Beerse, Belgium
    Cardiovasc Res 76:247-56. 2007
    ..An in vivo model of long-QT1 (LQT1) syndrome and TdP in a species with I(Ks) characteristics relevant to man is lacking. We investigated the in vivo mechanisms of TdP in a novel canine model of drug-induced LQT1 syndrome...
  16. pmc Window Ca2+ current and its modulation by Ca2+ release in hypertrophied cardiac myocytes from dogs with chronic atrioventricular block
    Gudrun Antoons
    Laboratory of Experimental Cardiology, University of Leuven, Leuven, Belgium
    J Physiol 579:147-60. 2007
    ..In conclusion, in cAVB, the larger window current, its rightward shift and enhanced dynamic modulation by SR Ca2+ release may contribute to an increased incidence of EADs in cAVB under beta-adrenergic stimulation...
  17. ncbi request reprint Atrial-specific drug AVE0118 is free of torsades de pointes in anesthetized dogs with chronic complete atrioventricular block
    Avram Oros
    Department of Medical Physiology, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands
    Heart Rhythm 3:1339-45. 2006
    ..This finding suggests that AVE0118 may be devoid of proarrhythmic side effects. Experimentally, AVE0118 has been antiarrhythmic against some specific ventricular arrhythmias...
  18. ncbi request reprint Beat-to-Beat variability of repolarization determines proarrhythmic outcome in dogs susceptible to drug-induced torsades de pointes
    Morten B Thomsen
    Department of Medical Physiology, Heart Lung Center Utrecht, University Medical Center Utrecht, Utrecht, The Netherlands
    J Am Coll Cardiol 48:1268-76. 2006
    ..We investigated whether increasing or decreasing beat-to-beat variability of repolarization (BVR) would change drug-induced proarrhythmic outcome accordingly...
  19. ncbi request reprint Spatial and temporal inhomogeneities during Ca2+ release from the sarcoplasmic reticulum in pig ventricular myocytes
    Frank R Heinzel
    Laboratory of Experimental Cardiology, University of Leuven, Leuven, Belgium
    Circ Res 91:1023-30. 2002
    ..This lower number of functional couplons contributes to a slower overall rate of rise of [Ca2+]i...
  20. ncbi request reprint Sudden cardiac death in dogs with remodeled hearts is associated with larger beat-to-beat variability of repolarization
    Morten B Thomsen
    Department of Medical Physiology, Heart Lung Centre Utrecht, Yalelaan 50, NL 3584 CM Utrecht, The Netherlands
    Basic Res Cardiol 100:279-87. 2005
    ..Cardiac electrical remodeling after AVB is associated with an increase in beat-to-beat variability of repolarization. Chronic AVB dogs displaying further elevated variability of repolarization are prone to arrhythmia-related SCD...
  21. ncbi request reprint Increased phospholamban phosphorylation limits the force-frequency response in the MLP-/- mouse with heart failure
    Gudrun Antoons
    Laboratory of Experimental Cardiology, University of Leuven, Campus Gasthuisberg O N 704, Herestraat 49, B 3000 Leuven, Belgium
    J Mol Cell Cardiol 40:350-60. 2006
    ..This represents a novel paradigm for altered Ca(2+) handling in heart failure, underscoring the importance of phosphorylation pathways...