Research Topics
| P G VoldersSummaryAffiliation: University Hospital Maastricht Country: The Netherlands Publications
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Detail Information
Publications
Repolarizing K+ currents ITO1 and IKs are larger in right than left canine ventricular midmyocardiumP G Volders
Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands
Circulation 99:206-10. 1999..We examined transient outward (ITO1), delayed (IKs and IKr), and inward rectifier K+ currents (IK1) in relation to action potential characteristics of RV and LV midmyocardial (M) cells of the same adult canine hearts...- Downregulation of delayed rectifier K(+) currents in dogs with chronic complete atrioventricular block and acquired torsades de pointesP G Volders
Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands
Circulation 100:2455-61. 1999..We examined whether K(+)-current alterations contribute to these proarrhythmic responses in an animal model of TdP: the dog with chronic complete atrioventricular block (AVB) and biventricular hypertrophy... - Wide QRS complex tachycardia with negative precordial concordance: always a ventricular origin?Paul G A Volders
Department of Cardiology, Academic Hospital Maastricht, Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands
J Cardiovasc Electrophysiol 14:109-11. 2003 - Probing the contribution of IKs to canine ventricular repolarization: key role for beta-adrenergic receptor stimulationPaul G A Volders
Department of Cardiology, Cardiovascular Research Institute Maastricht, Academic Hospital Maastricht, PO Box 5800, 6202 AZ, Maastricht, Netherlands
Circulation 107:2753-60. 2003..In large mammals and humans, the contribution of IKs to ventricular repolarization is still incompletely understood... 
I(Ks) restricts excessive beat-to-beat variability of repolarization during beta-adrenergic receptor stimulationDaniel M Johnson
Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, PO Box 5800, 6202 AZ, Maastricht, The Netherlands
J Mol Cell Cardiol 48:122-30. 2010..Loss of I(Ks) plus overriding of Ca(2+)-dependent membrane currents, including inward Na(+)-Ca(2)(+) exchange current, conspire to proarrhythmic BVR under these conditions...
Accumulation of slowly activating delayed rectifier potassium current (IKs) in canine ventricular myocytesMilan Stengl
Department of Cardiology, Cardiovascular Research Institute Maastricht, Academic Hospital Maastricht, The Netherlands
J Physiol 551:777-86. 2003..Block of IKs, however, led to a reverse rate-dependent prolongation of APD indicating that IKs does not have a dominant role at short cycle lengths...- Temporal patterns of electrical remodeling in canine ventricular hypertrophy: focus on IKs downregulation and blunted beta-adrenergic activationMilan Stengl
Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University and Academic Hospital Maastricht, PO Box 5800, 6202 AZ, Maastricht, The Netherlands
Cardiovasc Res 72:90-100. 2006..Provocation testing with isoproterenol identifies repolarization instability based on acquired channelopathy... - Increased short-term variability of repolarization predicts d-sotalol-induced torsades de pointes in dogsMorten B Thomsen
Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, Netherlands
Circulation 110:2453-9. 2004..CONCLUSIONS: Proarrhythmia is not related to differences in prolongation of repolarization but corresponds to BVR, here quantified as STV of the left ventricle. STV could be a new parameter to predict drug-induced TdP in patients... - Electrophysiological safety of sertindole in dogs with normal and remodeled heartsMorten B Thomsen
Department of Cardiology, Cardiovascular Research Institute Maastricht, Academic Hospital Maastricht, P.O. Box 5800, NL 6202 AZ, Maastricht, The Netherlands
J Pharmacol Exp Ther 307:776-84. 2003..v. doses sertindole can pose a serious proarrhythmic risk when electrical remodeling of the ventricles is present. At clinically relevant doses, however, sertindole does not cause TdP in anesthetized dogs with normal or remodeled hearts... - Serial left-ventricular biopsy sampling using a minimally invasive trans-thoracic approach in adult dogsDirk W Donker
Department of Cardiology, Cardiovascular Research Institute Maastricht, Academic Hospital Maastricht and Maastricht University, P O Box 5800, 6202 AZ, Maastricht, The Netherlands
Pflugers Arch 454:1043-51. 2007..The technique is safe and has no long-term effects on cardiac function or structure... - Subepicardial phase 0 block and discontinuous transmural conduction underlie right precordial ST-segment elevation by a SCN5A loss-of-function mutationMarketa Bebarova
Dept of Cardiology, Cardiovascular Research Institute Maastricht, Academic Hospital Maastricht, 6202 AZ, Maastricht, The Netherlands
Am J Physiol Heart Circ Physiol 295:H48-58. 2008..The late slow-upstroke action potentials at the subepicardium produce T-wave inversion in the computed ECG waveform, in line with the clinical ECG... - Impact of acute and enduring volume overload on mechanotransduction and cytoskeletal integrity of canine left ventricular myocardiumDirk W Donker
Department of Cardiology, Cardiovascular Research Institute Maastricht, Academic Hospital Maastricht, 6202 AZ Maastricht, The Netherlands
Am J Physiol Heart Circ Physiol 292:H2324-32. 2007..Subsequent cytoskeletal reorganization coincides with the upregulation of melusin, P-Akt, P-GSK3beta, and MLP, indicating a strong drive to compensated hypertrophy... - Mapping a novel locus for familial atrial fibrillation on chromosome 10p11-q21Paul G A Volders
Department of Cardiology, Academic Hospital Maastricht, Maastricht, The Netherlands
Heart Rhythm 4:469-75. 2007..2 million Americans. Recently, several chromosomal loci and genes have been found to be associated with familial AF. However, in most other AF cases, the genetic basis is still poorly understood... - Increased Na+ concentration and altered Na/K pump activity in hypertrophied canine ventricular cellsFons Verdonck
Interdisciplinary Research Center, University of Leuven Campus Kortrijk, E Sabbelaan 53, B 8500, Kortrijk, Belgium
Cardiovasc Res 57:1035-43. 2003..To investigate whether hypertrophy in the dog with chronic atrioventricular block (CAVB) alters [Na+]i and Na/K-pump function of ventricular myocytes... - In vivo mechanisms precipitating torsades de pointes in a canine model of drug-induced long-QT1 syndromeDavid J Gallacher
Center of Excellence for Cardiovascular Safety Research, Johnson and Johnson Pharmaceutical Research and Development, Beerse, Belgium
Cardiovasc Res 76:247-56. 2007..An in vivo model of long-QT1 (LQT1) syndrome and TdP in a species with I(Ks) characteristics relevant to man is lacking. We investigated the in vivo mechanisms of TdP in a novel canine model of drug-induced LQT1 syndrome... - Window Ca2+ current and its modulation by Ca2+ release in hypertrophied cardiac myocytes from dogs with chronic atrioventricular blockGudrun Antoons
Laboratory of Experimental Cardiology, University of Leuven, Leuven, Belgium
J Physiol 579:147-60. 2007..In conclusion, in cAVB, the larger window current, its rightward shift and enhanced dynamic modulation by SR Ca2+ release may contribute to an increased incidence of EADs in cAVB under beta-adrenergic stimulation... - Atrial-specific drug AVE0118 is free of torsades de pointes in anesthetized dogs with chronic complete atrioventricular blockAvram Oros
Department of Medical Physiology, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands
Heart Rhythm 3:1339-45. 2006..This finding suggests that AVE0118 may be devoid of proarrhythmic side effects. Experimentally, AVE0118 has been antiarrhythmic against some specific ventricular arrhythmias... - Beat-to-Beat variability of repolarization determines proarrhythmic outcome in dogs susceptible to drug-induced torsades de pointesMorten B Thomsen
Department of Medical Physiology, Heart Lung Center Utrecht, University Medical Center Utrecht, Utrecht, The Netherlands
J Am Coll Cardiol 48:1268-76. 2006..The BVR is superior to QT interval prolongation in the prediction and prevention of drug-induced TdP in this experimental model... - Spatial and temporal inhomogeneities during Ca2+ release from the sarcoplasmic reticulum in pig ventricular myocytesFrank R Heinzel
Laboratory of Experimental Cardiology, University of Leuven, Leuven, Belgium
Circ Res 91:1023-30. 2002..This lower number of functional couplons contributes to a slower overall rate of rise of [Ca2+]i... - Sudden cardiac death in dogs with remodeled hearts is associated with larger beat-to-beat variability of repolarizationMorten B Thomsen
Department of Medical Physiology, Heart Lung Centre Utrecht, Yalelaan 50, NL-3584 CM Utrecht, The Netherlands
Basic Res Cardiol 100:279-87. 2005..Cardiac electrical remodeling after AVB is associated with an increase in beat-to-beat variability of repolarization. Chronic AVB dogs displaying further elevated variability of repolarization are prone to arrhythmia-related SCD... - Increased phospholamban phosphorylation limits the force-frequency response in the MLP-/- mouse with heart failureGudrun Antoons
Laboratory of Experimental Cardiology, University of Leuven, Campus Gasthuisberg O N 704, Herestraat 49, B 3000 Leuven, Belgium
J Mol Cell Cardiol 40:350-60. 2006..This represents a novel paradigm for altered Ca(2+) handling in heart failure, underscoring the importance of phosphorylation pathways...