Marcel M Verbeek

Summary

Affiliation: University Medical Centre Nijmegen
Country: The Netherlands

Publications

  1. pmc Agrin is a major heparan sulfate proteoglycan accumulating in Alzheimer's disease brain
    M M Verbeek
    Department of Pathology, University Hospital Nijmegen, Nijmegen, The Netherlands
    Am J Pathol 155:2115-25. 1999
  2. ncbi Amyloid-beta-induced degeneration of human brain pericytes is dependent on the apolipoprotein E genotype
    M M Verbeek
    Department of Pathology, University Hospital Nijmegen, The Netherlands
    Ann N Y Acad Sci 903:187-99. 2000
  3. ncbi Accumulation of the amyloid-beta precursor protein in multivesicular body-like organelles
    Marcel M Verbeek
    Department of Neurology, University Medical Center Nijmegen, The Netherlands
    J Histochem Cytochem 50:681-90. 2002
  4. doi Apolipoprotein E protects cultured pericytes and astrocytes from D-Abeta(1-40)-mediated cell death
    Ilona B Bruinsma
    Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands
    Brain Res 1315:169-80. 2010
  5. ncbi Apolipoprotein E genotype regulates amyloid-beta cytotoxicity
    Micha M M Wilhelmus
    Department of Neurology, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands
    J Neurosci 25:3621-7. 2005
  6. ncbi Insulin inhibits amyloid beta-induced cell death in cultured human brain pericytes
    Annemieke A M Rensink
    Department of Neurology, University Medical Centre Nijmegen, The Netherlands
    Neurobiol Aging 25:93-103. 2004
  7. pmc Cerebrospinal fluid amyloid beta(40) is decreased in cerebral amyloid angiopathy
    Marcel M Verbeek
    Department of Neurology, Radboud University Nijmegen Medical Center, Donders Center for Brain, Cognition and Behavior, Nijmegen, The Netherlands
    Ann Neurol 66:245-9. 2009
  8. ncbi Small heat shock protein HspB8: its distribution in Alzheimer's disease brains and its inhibition of amyloid-beta protein aggregation and cerebrovascular amyloid-beta toxicity
    Micha M M Wilhelmus
    Department of Neurology and Alzheimer Centre, 830 LKN, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500, Nijmegen, The Netherlands
    Acta Neuropathol 111:139-49. 2006
  9. ncbi Amyloid beta induces cellular relocalization and production of agrin and glypican-1
    Nienke M Timmer
    Department of Neurology, Laboratory of Pediatrics and Neurology, Donders Centre for Brain, Cognition and Behaviour, Alzheimer Centre Nijmegen, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Brain Res 1260:38-46. 2009
  10. ncbi Diagnostic accuracy of ELISA and xMAP technology for analysis of amyloid beta(42) and tau proteins
    Thierry S M Reijn
    Department of Neurology, Alzheimer Centre Nijmegen, Laboratory of Pediatrics and Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Chem 53:859-65. 2007

Collaborators

Detail Information

Publications64

  1. pmc Agrin is a major heparan sulfate proteoglycan accumulating in Alzheimer's disease brain
    M M Verbeek
    Department of Pathology, University Hospital Nijmegen, Nijmegen, The Netherlands
    Am J Pathol 155:2115-25. 1999
    ....
  2. ncbi Amyloid-beta-induced degeneration of human brain pericytes is dependent on the apolipoprotein E genotype
    M M Verbeek
    Department of Pathology, University Hospital Nijmegen, The Netherlands
    Ann N Y Acad Sci 903:187-99. 2000
    ..The results of this study are in line with the observations that inheritance of the ApoE epsilon 4 allele increases the risk of developing Alzheimer's disease, and that the ApoE epsilon 2 allele has a relatively protective effect...
  3. ncbi Accumulation of the amyloid-beta precursor protein in multivesicular body-like organelles
    Marcel M Verbeek
    Department of Neurology, University Medical Center Nijmegen, The Netherlands
    J Histochem Cytochem 50:681-90. 2002
    ..Accumulation of the APP in this organelle is reflected by its reduced secretion from the cell...
  4. doi Apolipoprotein E protects cultured pericytes and astrocytes from D-Abeta(1-40)-mediated cell death
    Ilona B Bruinsma
    Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands
    Brain Res 1315:169-80. 2010
    ..Furthermore, since apoE production in pericytes is genotype dependent, this may contribute to the apoE genotype-dependent development of CAA in vivo...
  5. ncbi Apolipoprotein E genotype regulates amyloid-beta cytotoxicity
    Micha M M Wilhelmus
    Department of Neurology, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands
    J Neurosci 25:3621-7. 2005
    ....
  6. ncbi Insulin inhibits amyloid beta-induced cell death in cultured human brain pericytes
    Annemieke A M Rensink
    Department of Neurology, University Medical Centre Nijmegen, The Netherlands
    Neurobiol Aging 25:93-103. 2004
    ..Our data indicate that the formation of a fibril network is essential for Abeta-induced cell death in HBP. Additionally, insulin may be involved in the regulation of Abeta fibrillization in AD...
  7. pmc Cerebrospinal fluid amyloid beta(40) is decreased in cerebral amyloid angiopathy
    Marcel M Verbeek
    Department of Neurology, Radboud University Nijmegen Medical Center, Donders Center for Brain, Cognition and Behavior, Nijmegen, The Netherlands
    Ann Neurol 66:245-9. 2009
    ....
  8. ncbi Small heat shock protein HspB8: its distribution in Alzheimer's disease brains and its inhibition of amyloid-beta protein aggregation and cerebrovascular amyloid-beta toxicity
    Micha M M Wilhelmus
    Department of Neurology and Alzheimer Centre, 830 LKN, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500, Nijmegen, The Netherlands
    Acta Neuropathol 111:139-49. 2006
    ..We conclude that HspB8 might play an important role in regulating Abeta aggregation and, therefore, the development of classic SPs in AD and CAA in HCHWA-D...
  9. ncbi Amyloid beta induces cellular relocalization and production of agrin and glypican-1
    Nienke M Timmer
    Department of Neurology, Laboratory of Pediatrics and Neurology, Donders Centre for Brain, Cognition and Behaviour, Alzheimer Centre Nijmegen, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Brain Res 1260:38-46. 2009
    ..We conclude that Abeta can modulate the cellular expression of agrin and glypican-1, which may contribute to the accumulation of these HSPG in AD lesions...
  10. ncbi Diagnostic accuracy of ELISA and xMAP technology for analysis of amyloid beta(42) and tau proteins
    Thierry S M Reijn
    Department of Neurology, Alzheimer Centre Nijmegen, Laboratory of Pediatrics and Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Chem 53:859-65. 2007
    ..Recently, the xMAP technology has been introduced as an alternative to ELISA for measurement of these markers...
  11. ncbi Cerebral amyloid angiopathy with severe secondary vascular pathology: a histopathological study
    Jack van Horssen
    Department of Pathology, University Medical Center, Nijmegen, The Netherlands
    Dement Geriatr Cogn Disord 20:321-30. 2005
    ..The functional impact of CAA and CAA-related secondary vascular changes on cognitive performance warrants further exploration...
  12. doi Hourly variability of cerebrospinal fluid biomarkers in Alzheimer's disease subjects and healthy older volunteers
    Diane Slats
    Department of Geriatric Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neurobiol Aging 33:831.e1-9. 2012
    ..Furthermore, continuous sampling of CSF proved to be a useful and robust method, which may also be used to investigate AD pathogenesis and to evaluate pharmacotherapeutic interventions...
  13. doi Aggregation and cytotoxic properties towards cultured cerebrovascular cells of Dutch-mutated Abeta40 (DAbeta(1-40)) are modulated by sulfate moieties of heparin
    Nienke M Timmer
    Radboud University Nijmegen Medical Centre, Department of Neurology, Department of Laboratory Medicine, Donders Centre for Brain, Cognition and Behavior, Alzheimer Centre Nijmegen, Nijmegen, The Netherlands
    Neurosci Res 66:380-9. 2010
    ..We conclude that sulfate moieties within GAGs, like heparin and HS, have an important role in Abeta aggregation in CAA and in Abeta-mediated toxicity of cerebrovascular cells...
  14. doi Sulfation of heparan sulfate associated with amyloid-beta plaques in patients with Alzheimer's disease
    Ilona B Bruinsma
    Department of Neurology and Alzheimer Centre, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Acta Neuropathol 119:211-20. 2010
    ....
  15. ncbi Collagen XVIII: a novel heparan sulfate proteoglycan associated with vascular amyloid depositions and senile plaques in Alzheimer's disease brains
    Jack van Horssen
    Department of Pathology, University Medical Center, Nijmegen, The Netherlands
    Brain Pathol 12:456-62. 2002
    ....
  16. ncbi Inhibition of amyloid-beta-induced cell death in human brain pericytes in vitro
    Annemieke A M Rensink
    Department of Neurology, University Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    Brain Res 952:111-21. 2002
    ..Inhibition of fibril formation at the cell surface could be an important factor in therapy aimed at reducing cerebral amyloid angiopathy...
  17. doi Cerebrospinal fluid analysis in the workup of GLUT1 deficiency syndrome: a systematic review
    Wilhelmina G Leen
    Department of Neurology, Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands
    JAMA Neurol 70:1440-4. 2013
    ..Reports of patients with apparently normal CSF glucose levels, however, have raised the question whether CSF analysis is a reliable screening tool for GLUT1 deficiency syndrome...
  18. ncbi Child neurology: differential diagnosis of a low CSF glucose in children and young adults
    Wilhelmina G Leen
    From the Department of Neurology W G L, B G E, M M V and Department of Pediatric Neurology M A W, Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands Department of Pediatrics C J d W, Genetics E J K, and Laboratory Medicine M M V, R A W, Radboud University Medical Centre, Nijmegen, the Netherlands and Department of Pediatrics and Pediatric Neurology J K, Children s Hospital, Aschaffenburg, Germany
    Neurology 81:e178-81. 2013
    ..We present a practical overview on the differential diagnosis of a low CSF glucose and stress the importance of recognizing a low CSF glucose as the diagnostic marker for GLUT1 deficiency syndrome, a treatable neurometabolic disorder. ..
  19. ncbi Expression of the cytokine leukemia inhibitory factor and pro-apoptotic insulin-like growth factor binding protein-3 in Alzheimer's disease
    Annemieke A M Rensink
    Department of Pathology, University Medical Center Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Acta Neuropathol 104:525-33. 2002
    ..IGFBP-3 is known to inhibit cell proliferation and induce apoptosis and may therefore contribute to neuronal degeneration in AD...
  20. doi CSF tau, Aβ42, and MHPG differentiate dementia with Lewy bodies from Alzheimer's disease
    Marjolein B Aerts
    Radboud University Nijmegen Medical Centre, Department of Neurology and Parkinson Center Nijmegen, Nijmegen, The Netherlands
    J Alzheimers Dis 27:377-84. 2011
    ....
  21. doi CSF neurofilament proteins levels are elevated in sporadic Creutzfeldt-Jakob disease
    Jeroen J J van Eijk
    Department of Neurology, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Alzheimer Centre Nijmegen, The Netherlands
    J Alzheimers Dis 21:569-76. 2010
    ..Prospective studies are needed to determine whether NFL and NFHp35 may be additional tools in the differential diagnosis of rapidly progressive dementias...
  22. ncbi Addition of MHPG to Alzheimer's disease biomarkers improves differentiation of dementia with Lewy bodies from Alzheimer's disease but not other dementias
    Megan K Herbert
    Department of Neurology, Radboud University Medical Centre, and Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands Radboud Alzheimer Centre, Nijmegen, The Netherlands Department of Laboratory Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
    Alzheimers Dement 10:448-455.e2. 2014
    ....
  23. ncbi Heparan sulphate proteoglycans in Alzheimer's disease and amyloid-related disorders
    Jack van Horssen
    Department of Pathology, University Medical Center, Nijmegen, Netherlands
    Lancet Neurol 2:482-92. 2003
    ....
  24. ncbi Current state and future directions of neurochemical biomarkers for Alzheimer's disease
    Danielle de Jong
    Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Clin Chem Lab Med 45:1421-34. 2007
    ..g., multiplex analysis of biomarkers, proteomics), to the discovery of novel, potential biomarkers (e.g., amyloid beta oligomers, isoprostanes), and to the extension of this research towards identification of biomarkers in plasma...
  25. ncbi Expression pattern of apoptosis-related markers in Huntington's disease
    Jose C Vis
    Department of Neurology 321, University Medical Centre Nijmegen, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Acta Neuropathol 109:321-8. 2005
    ....
  26. doi MicroRNAs in Alzheimer's disease: differential expression in hippocampus and cell-free cerebrospinal fluid
    Mareike Muller
    Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Centre, Nijmegen, The Netherlands Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Centre, Nijmegen, The Netherlands
    Neurobiol Aging 35:152-8. 2014
    ..In conclusion, the abnormal expression of several miRNAs in hippocampus of intermediate- and late-stage AD patients suggests their involvement in AD pathogenesis, and low levels of miR-146a in CSF were associated with AD. ..
  27. doi A prediction model to calculate probability of Alzheimer's disease using cerebrospinal fluid biomarkers
    Petra E Spies
    Department of Geriatric Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Alzheimers Dement 9:262-8. 2013
    ..We aimed to develop a prediction model based on cerebrospinal fluid (CSF) biomarkers, that would yield a single estimate representing the probability that dementia in a memory clinic patient is due to Alzheimer's disease (AD)...
  28. doi Amyloid-β oligomer detection by ELISA in cerebrospinal fluid and brain tissue
    Kim A Bruggink
    Department of Neurology, Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands
    Anal Biochem 433:112-20. 2013
    ..Our data suggest that levels of small oligomers might not be suitable as biomarkers for AD. In addition, we demonstrate the importance of avoiding HAMA interference in assays to quantify Aβ oligomers in human body fluids...
  29. ncbi Reviewing reasons for the decreased CSF Abeta42 concentration in Alzheimer disease
    Petra E Spies
    Department of Geriatric Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Front Biosci (Landmark Ed) 17:2024-34. 2012
    ..Evidence for other possibilities such as a decreased production of Abeta42, an increased proteolytic breakdown or microglial uptake of Abeta42, or an increased clearance of Abeta42 to the blood, is - at best - scarce or even absent...
  30. pmc Cerebrospinal fluid glucose and lactate: age-specific reference values and implications for clinical practice
    Wilhelmina G Leen
    Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, The Netherlands
    PLoS ONE 7:e42745. 2012
    ..Furthermore, hypoglycemia was associated with an increased CSF/plasma glucose ratio, whereas hyperglycemia did not affect the CSF/plasma glucose ratio...
  31. doi Inhibition of α-synuclein aggregation by small heat shock proteins
    Ilona B Bruinsma
    Department of Neurology and Alzheimer Centre, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Proteins 79:2956-67. 2011
    ..In conclusion, sHsps may regulate α-syn aggregation and, therefore, optimization of the interaction between sHsps and α-syn may be an interesting target for therapeutic intervention in the pathogenesis of α-synucleinopathies...
  32. ncbi Cerebrospinal fluid amyloid beta42/phosphorylated tau ratio discriminates between Alzheimer's disease and vascular dementia
    Danielle de Jong
    Department of Neurology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    J Gerontol A Biol Sci Med Sci 61:755-8. 2006
    ....
  33. doi Optimisation of the quantification of glutamine synthetase and myelin basic protein in cerebrospinal fluid by a combined acidification and neutralisation protocol
    Megan K Herbert
    Radboud University Nijmegen Medical Centre, Department of Neurology, Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Alzheimer Centre Nijmegen, Nijmegen, The Netherlands
    J Immunol Methods 381:1-8. 2012
    ..Based on our results, we suggest including the AFBN protocol in the evaluation of new biomarker development protocols to avoid confounders such as CSF pH or epitope-masking of the target protein...
  34. ncbi Absence of heparan sulfate proteoglycans in Lewy bodies and Lewy neurites in Parkinson's disease brains
    Jack van Horssen
    Department of Pathology, University Medical Center, Nijmegen, The Netherlands
    J Alzheimers Dis 6:469-74. 2004
    ....
  35. doi CSF levels of DJ-1 and tau distinguish MSA patients from PD patients and controls
    Megan K Herbert
    Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands Department of Laboratory Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
    Parkinsonism Relat Disord 20:112-5. 2014
    ..92). Our results highlight the potential benefits of a combination of DJ-1 and total tau as biomarkers for differential diagnosis of MSA and PD...
  36. doi CSF studies facilitate DNA diagnosis in familial Alzheimer's disease due to a presenilin-1 mutation
    Susanne T de Bot
    Department of Neurology, Donders Centre for Brain Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Alzheimers Dis 17:53-7. 2009
    ..A causative p.L424R PSEN1 mutation was subsequently identified...
  37. ncbi Movement disorders in GLUT1 deficiency syndrome respond to the modified Atkins diet
    Wilhelmina G Leen
    Department of Neurology, Radboud University Medical Centre, Donders Institute for Brain, Cognition, and Behaviour, Nijmegen, The Netherlands
    Mov Disord 28:1439-42. 2013
    ..First-choice treatment is a ketogenic diet, but compliance is poor. We have investigated the effect of the modified Atkins diet as an alternative treatment for movement disorders in GLUT1DS...
  38. doi Diagnosis of progressive supranuclear palsy: can measurement of tau forms help?
    H Bea Kuiperij
    Department of Neurology, Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Alzheimer Centre Nijmegen, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Neurobiol Aging 33:204.e17-8. 2012
    ..We conclude that more sensitive techniques are needed to measure tau forms in CSF...
  39. doi TDP-43 plasma levels are higher in amyotrophic lateral sclerosis
    Esther Verstraete
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Amyotroph Lateral Scler 13:446-51. 2012
    ..In conclusion, our data indicate that TDP-43 plasma levels may have potential as a marker for ALS. A genotype-phenotype relationship could not, however, be established in this cohort...
  40. doi CSF α-synuclein concentrations do not fluctuate over hours and are not correlated to amyloid β in humans
    Petra E Spies
    Department of Geriatric Medicine, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, and Alzheimer Centre, Nijmegen, The Netherlands
    Neurosci Lett 504:336-8. 2011
    ..Furthermore, we did not find evidence for an interaction between amyloid β and α-synuclein concentrations in CSF...
  41. ncbi Creatine protects against 3-nitropropionic acid-induced cell death in murine corticostriatal slice cultures
    Jose C Vis
    Department of Neurology, University Medical Centre Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Brain Res 1024:16-24. 2004
    ....
  42. ncbi The diagnostic value of CSF amyloid-β(43) in differentiation of dementia syndromes
    Kim A Bruggink
    Department of Neurology, 830 LGEM, Radboud University Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Curr Alzheimer Res 10:1034-40. 2013
    ..In conclusion, quantification of Aβ43 in CSF does not add novel diagnostic information to the differential diagnosis of AD compared to existing biomarkers. ..
  43. ncbi Accumulation of heparan sulfate proteoglycans in cerebellar senile plaques
    Jack van Horssen
    Department of Pathology, University Medical Center, Nijmegen, The Netherlands
    Neurobiol Aging 23:537-45. 2002
    ....
  44. doi Linkage analysis for plasma amyloid beta levels in persons with hypertension implicates Aβ-40 levels to presenilin 2
    Carla A Ibrahim-Verbaas
    Department of Neurology, Erasmus University Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Hum Genet 131:1869-76. 2012
    ..1 × 10(-3) for rs2514299). This linkage study of plasma concentrations of Aβ40 and Aβ42 yielded two suggestive regions, of which one points toward a known locus for familial AD...
  45. doi Reciprocal interactions between sleep, circadian rhythms and Alzheimer's disease: focus on the role of hypocretin and melatonin
    Diane Slats
    Radboud University Nijmegen Medical Centre, Department of Geriatric Medicine, The Netherlands
    Ageing Res Rev 12:188-200. 2013
    ....
  46. doi Methods for analysis of amyloid-β aggregates
    Kim A Bruggink
    Radboud University Nijmegen Medical Centre, Department of Neurology, Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Alzheimer Centre Nijmegen, Nijmegen, The Netherlands
    J Alzheimers Dis 28:735-58. 2012
    ..In this review, we provide an overview and discussion of the most important techniques used for these aims. Often a combination of techniques will be appropriate to obtain the most optimal information...
  47. ncbi CSF protein profiling using Multiplex Immuno-assay: A potential new diagnostic tool for leptomeningeal metastases
    Dieta Brandsma
    Department of Neurology, G03 228, University Medical Center Utrecht, PO Box 85500, 3584 Utrecht, CX, The Netherlands
    J Neurol 253:1177-84. 2006
    ..More sensitive tools are needed to diagnose LM. We measured a profile of proteins involved in adhesion and inflammation in the CSF of LM and control patients and determined their potential diagnostic value for LM...
  48. doi Cerebrospinal fluid alpha-synuclein does not discriminate between dementia disorders
    Petra E Spies
    Department of Geriatric Medicine, Radboud University Nijmegen Medical Centre, Donders Centre for Neuroscience, Nijmegen, The Netherlands
    J Alzheimers Dis 16:363-9. 2009
    ..We conclude that in clinically diagnosed patients, alpha-synuclein does not appear to be a useful biomarker for the differentiation between DLB and other types of dementia...
  49. doi CSF neurofilament protein analysis in the differential diagnosis of ALS
    Thierry S Reijn
    Dept of Neurology, Radboud University Nijmegen Medical Centre, 830 LKN, 9101, 6500 HB, Nijmegen, The Netherlands
    J Neurol 256:615-9. 2009
    ..Cerebrospinal fluid (CSF) biomarkers have been studied to differentiate between patients with ALS and neurological controls, but not in comparison to clinically more relevant disorders mimicking ALS...
  50. ncbi CSF neurofilament light chain and tau differentiate multiple system atrophy from Parkinson's disease
    W Farid Abdo
    Department of Neurology, Radboud University, Nijmegen Medical Centre, The Netherlands
    Neurobiol Aging 28:742-7. 2007
    ..In early disease stages it can be clinically difficult to differentiate idiopathic Parkinson's disease (IPD) from patients with multiple system atrophy predominated by parkinsonism (MSA-P)...
  51. doi Enoxaparin treatment administered at both early and late stages of amyloid β deposition improves cognition of APPswe/PS1dE9 mice with differential effects on brain Aβ levels
    Nienke M Timmer
    Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Alzheimer Centre Nijmegen, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neurobiol Dis 40:340-7. 2010
    ..In any case, our study suggests that enoxaparin treatment has potential as a therapeutic agent for Alzheimer's disease...
  52. ncbi Pathogenesis of cerebral amyloid angiopathy
    Annemieke A M Rensink
    Department of Neurology, Laboratory of Pediatrics and Neurology, University Medical Center, 319, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Brain Res Brain Res Rev 43:207-23. 2003
    ....
  53. doi Do amyloid β-associated factors co-deposit with Aβ in mouse models for Alzheimer's disease?
    Nienke M Timmer
    Department of Neurology, Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Alzheimer Centre Nijmegen, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Alzheimers Dis 22:345-55. 2010
    ..In this review, the co-deposition of factors known to associate with human Aβ deposits is summarized for several different AD mouse models...
  54. doi Autoantibodies to cytosolic 5'-nucleotidase 1A in inclusion body myositis
    Helma Pluk
    Department of Biomolecular Chemistry, Institute for Molecules and Materials and Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, The Netherlands
    Ann Neurol 73:397-407. 2013
    ..We used human skeletal muscle extracts as a source of antigens to detect autoantibodies in sIBM and to characterize the corresponding antigen...
  55. pmc The paradox of hyperdopaminuria in aromatic L-amino Acid deficiency explained
    Tessa Wassenberg
    Department of Neurology, Radboud University Nijmegen Medical Centre, Donders Centre for Brain, Cognition and Behaviour, Nijmegen, The Netherlands
    JIMD Rep 4:39-45. 2012
    ....
  56. doi Glucose transporter-1 deficiency syndrome: the expanding clinical and genetic spectrum of a treatable disorder
    Wilhelmina G Leen
    Department of Neurology, Radboud University Nijmegen Medical Centre, 935 Neurology, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Brain 133:655-70. 2010
    ..Our study demonstrates that a lumbar puncture provides the diagnostic clue to glucose transporter-1 deficiency syndrome and can thereby dramatically reduce diagnostic delay to allow early start of the ketogenic diet...
  57. ncbi Cerebral level of vGlut1 is increased and level of glycine is decreased in TgSwDI mice
    Nienke M Timmer
    Department of Neurology, Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Center, Nijmegen, The Netherlands
    J Alzheimers Dis 39:89-101. 2014
    ..Although there are some discrepancies between our results and those found in AD patients, our results suggest that several components of the glutamatergic system might serve as meaningful markers to monitor the progression of AD. ..
  58. ncbi Comparison of methods for the detection of oligoclonal IgG bands in cerebrospinal fluid and serum: results of the Dutch Quality Control survey
    Marcel M Verbeek
    Department of Neurology, University Medical Center, 6500 HB Nijmegen, The Netherlands
    Clin Chem 48:1578-80. 2002
  59. doi CSF hypocretin-1 levels are normal in patients with amyotrophic lateral sclerosis
    Frank G van Rooij
    Radboud University Nijmegen, Donders Centre for Neuroscience, Medical Centre, Department of Neurology, Nijmegen, The Netherlands
    Amyotroph Lateral Scler 10:487-9. 2009
    ..We conclude that it is unlikely that the hypocretin system is involved in the degenerative process of ALS...
  60. ncbi Rituximab and intravenous immunoglobulins for relapsing postinfectious opsoclonus-myoclonus syndrome
    Wilhelmina G Leen
    Department of Pediatric Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Pediatr Neurol 39:213-7. 2008
    ..Treatment with rituximab in combination with intravenous immunoglobulin, however, resulted in significant longterm clinical improvement...
  61. ncbi MALDI-TOF mass spectrometry analysis of cerebrospinal fluid tryptic peptide profiles to diagnose leptomeningeal metastases in patients with breast cancer
    Lennard J Dekker
    Laboratory of Neuro Oncology, Department of Neurology, Dr Molewaterplein 40, 3015 GD, Erasmus MC, Rotterdam, The Netherlands
    Mol Cell Proteomics 4:1341-9. 2005
    ..The same method can be used to develop diagnostic assays for other neurological disorders...
  62. doi A de novo p.Asp18Asn mutation in TREX1 in a patient with Aicardi-Goutières syndrome
    Charlotte A Haaxma
    Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Am J Med Genet A 152:2612-7. 2010
    ..This report serves to enhance awareness of de novo heterozygous mutations underlying Aicardi-Goutières syndrome-with a concomitant low risk of recurrence...
  63. pmc Cerebral microvascular amyloid beta protein deposition induces vascular degeneration and neuroinflammation in transgenic mice expressing human vasculotropic mutant amyloid beta precursor protein
    Jianting Miao
    Department of Medicine, HSC, Stony Brook University, Stony Brook, NY 11794 8153, USA
    Am J Pathol 167:505-15. 2005
    ..Together, these studies identify the Tg-SwDI mouse as a unique model to investigate selective accumulation of cerebral microvascular amyloid and the associated neuroinflammation...
  64. pmc Lipoprotein receptor-related protein-1 mediates amyloid-beta-mediated cell death of cerebrovascular cells
    Micha M M Wilhelmus
    Department of Neurology and Alzheimer Center, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Am J Pathol 171:1989-99. 2007
    ..Although perivascular cells may adapt their A beta internalization capacity to the levels of A beta present, saturated LRP-1/LDLR-mediated uptake of A beta results in degeneration of perivascular cells...