Sebastiaan J Vastert
Affiliation: University Medical Center Utrecht
Country: The Netherlands
- Systemic JIA: new developments in the understanding of the pathophysiology and therapySebastiaan J Vastert
Department of Pediatric Immunology Wilhelmina Children s Hospital, University Medical Center Utrecht, Lundlaan 6, 3584 EA, Utrecht, The Netherlands
Best Pract Res Clin Rheumatol 23:655-64. 2009..These therapies might also change the long-term outcome of this disease. However, controlled trials set up in international collaboration are needed to determine the optimal treatment strategies for all sJIA patients...
- Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritisSebastiaan J Vastert
Department of Paediatric Immunology, Wilhelmina Children s Hospital, University Medical Centre Utrecht, Lundlaan 6, 3584 EA Utrecht, The Netherlands
Rheumatology (Oxford) 49:441-9. 2010..Interestingly, SoJIA patients display decreased levels of perforin in NK cells and diminished NK cell function as well. Here, we analysed PRF1 and its putative promoter in SoJIA patients with or without a history of MAS...
- Defective phosphorylation of interleukin-18 receptor beta causes impaired natural killer cell function in systemic-onset juvenile idiopathic arthritisWilco de Jager
Department of Pediatrics, Centre for Cellular and Molecular Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands
Arthritis Rheum 60:2782-93. 2009..Since IL-18 can drive NK cell function, we examined how the high plasma levels of this cytokine are related to the documented NK cell failure in these patients...
- FOXP3+ CD4+ Tregs lose suppressive potential but remain anergic during transient inflammation in humanAlvin W L Schadenberg
Department of Pediatric Immunology, Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
Eur J Immunol 41:1132-42. 2011..These data show that inflammation inhibits Treg function through soluble factors present in plasma. These results underscore the functional role of FOXP3(+) Tregs during inflammation in vivo...
- Development of inflammatory bowel disease in patients with juvenile idiopathic arthritis treated with etanerceptTrudy D van Dijken
Department of Pediatric Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands
J Rheumatol 38:1441-6. 2011..We give the clinical characteristics of the IBD in patients with JIA using etanercept...