Louk J M J Vanderschuren

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. ncbi Behavioral and neural mechanisms of compulsive drug seeking
    Louk J M J Vanderschuren
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, The Netherlands
    Eur J Pharmacol 526:77-88. 2005
  2. ncbi Involvement of the dorsal striatum in cue-controlled cocaine seeking
    Louk J M J Vanderschuren
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 25:8665-70. 2005
  3. ncbi Drug seeking becomes compulsive after prolonged cocaine self-administration
    Louk J M J Vanderschuren
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Science 305:1017-9. 2004
  4. ncbi Endocannabinoids in amygdala and nucleus accumbens mediate social play reward in adolescent rats
    Viviana Trezza
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands
    J Neurosci 32:14899-908. 2012
  5. ncbi Cannabinoid and opioid modulation of social play behavior in adolescent rats: differential behavioral mechanisms
    Viviana Trezza
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur Neuropsychopharmacol 18:519-30. 2008
  6. ncbi Prosocial effects of nicotine and ethanol in adolescent rats through partially dissociable neurobehavioral mechanisms
    Viviana Trezza
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Neuropsychopharmacology 34:2560-73. 2009
  7. ncbi Distinct contributions of dopamine in the dorsolateral striatum and nucleus accumbens shell to the reinforcing properties of cocaine
    Maartje M J Veeneman
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Neuropsychopharmacology 37:487-98. 2012
  8. ncbi Nucleus accumbens μ-opioid receptors mediate social reward
    Viviana Trezza
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands
    J Neurosci 31:6362-70. 2011
  9. ncbi Methylphenidate disrupts social play behavior in adolescent rats
    Louk J M J Vanderschuren
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Neuropsychopharmacology 33:2946-56. 2008
  10. ncbi Impaired neurocognitive functions affect social learning processes in oppositional defiant disorder and conduct disorder: implications for interventions
    Walter Matthys
    Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Heidelberglaan, Utrecht, The Netherlands
    Clin Child Fam Psychol Rev 15:234-46. 2012

Research Grants

  1. Social play behavior in periadolescent rats in relation to later drug abuse
    LOUK VANDERSCHUREN; Fiscal Year: 2007

Collaborators

Detail Information

Publications31

  1. ncbi Behavioral and neural mechanisms of compulsive drug seeking
    Louk J M J Vanderschuren
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, The Netherlands
    Eur J Pharmacol 526:77-88. 2005
    ..Furthermore, we will try to put these studies in a theoretical perspective, and discuss the hypothesized underlying neural and behavioral mechanisms...
  2. ncbi Involvement of the dorsal striatum in cue-controlled cocaine seeking
    Louk J M J Vanderschuren
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 25:8665-70. 2005
    ..In addition, given the importance of the dorsal striatum in stimulus-response habit learning, these data suggest that the habitual or compulsive quality of persistent drug seeking depends on dorsal striatal mechanisms...
  3. ncbi Drug seeking becomes compulsive after prolonged cocaine self-administration
    Louk J M J Vanderschuren
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Science 305:1017-9. 2004
    ....
  4. ncbi Endocannabinoids in amygdala and nucleus accumbens mediate social play reward in adolescent rats
    Viviana Trezza
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands
    J Neurosci 32:14899-908. 2012
    ....
  5. ncbi Cannabinoid and opioid modulation of social play behavior in adolescent rats: differential behavioral mechanisms
    Viviana Trezza
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur Neuropsychopharmacol 18:519-30. 2008
    ....
  6. ncbi Prosocial effects of nicotine and ethanol in adolescent rats through partially dissociable neurobehavioral mechanisms
    Viviana Trezza
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Neuropsychopharmacology 34:2560-73. 2009
    ..Furthermore, the stimulating effects of nicotine and ethanol on social play behavior are independent of their anxiolytic-like properties...
  7. ncbi Distinct contributions of dopamine in the dorsolateral striatum and nucleus accumbens shell to the reinforcing properties of cocaine
    Maartje M J Veeneman
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Neuropsychopharmacology 37:487-98. 2012
    ..We suggest that the DLS and the NAcc shell mediate somewhat distinct facets of the reinforcing properties of cocaine, related to its rewarding and motivational aspects, respectively...
  8. ncbi Nucleus accumbens μ-opioid receptors mediate social reward
    Viviana Trezza
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands
    J Neurosci 31:6362-70. 2011
    ..Altered NAc μ-opioid receptor function may underlie social impairments in psychiatric disorders such as autism, schizophrenia, or personality disorders...
  9. ncbi Methylphenidate disrupts social play behavior in adolescent rats
    Louk J M J Vanderschuren
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Neuropsychopharmacology 33:2946-56. 2008
    ..However, given the importance of social play for development, these findings may also indicate an adverse side effect of methylphenidate...
  10. ncbi Impaired neurocognitive functions affect social learning processes in oppositional defiant disorder and conduct disorder: implications for interventions
    Walter Matthys
    Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Heidelberglaan, Utrecht, The Netherlands
    Clin Child Fam Psychol Rev 15:234-46. 2012
    ....
  11. ncbi Divergent effects of anandamide transporter inhibitors with different target selectivity on social play behavior in adolescent rats
    Viviana Trezza
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    J Pharmacol Exp Ther 328:343-50. 2009
    ..Furthermore, these results suggest that off-target effects may be responsible for some of the conflicting effects of anandamide transporter inhibitors on behavior...
  12. ncbi Amygdala 14-3-3ζ as a novel modulator of escalating alcohol intake in mice
    Heidi M B Lesscher
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 7:e37999. 2012
    ..This study identifies amygdala 14-3-3ζ as a novel key modulator that is engaged during escalation of alcohol use...
  13. ncbi The pleasures of play: pharmacological insights into social reward mechanisms
    Viviana Trezza
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Trends Pharmacol Sci 31:463-9. 2010
    ..This provides a framework to understand how the brain processes social emotions, to make young individuals enjoy social play...
  14. ncbi Conditioned place preference induced by social play behavior: parametrics, extinction, reinstatement and disruption by methylphenidate
    Viviana Trezza
    Rudolf Magnus Institute of Neuroscience, Dept of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur Neuropsychopharmacol 19:659-69. 2009
    ..social play is likely to be the most rewarding aspect of social interaction in adolescent rats; 5. social context influences the subjective effects of methylphenidate...
  15. ncbi Dissociable effects of monoamine reuptake inhibitors on distinct forms of impulsive behavior in rats
    Petra J J Baarendse
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, UMC Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Psychopharmacology (Berl) 219:313-26. 2012
    ..However, impulsive behavior is behaviorally and neurally heterogeneous, and several caveats remain in our understanding of the role of monoamines in impulse control...
  16. ncbi Evaluating the rewarding nature of social interactions in laboratory animals
    Viviana Trezza
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands
    Dev Cogn Neurosci 1:444-58. 2011
    ..Last, we discuss how animal models contributed to our understanding of social reward mechanisms and its psychological components throughout development...
  17. ncbi Deep brain stimulation reveals a dissociation of consummatory and motivated behaviour in the medial and lateral nucleus accumbens shell of the rat
    Geoffrey Van der Plasse
    Department Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    PLoS ONE 7:e33455. 2012
    ..As such, these findings provide important leads for the possible future application of DBS as a treatment for eating disorders such as anorexia nervosa...
  18. ncbi Olanzapine and sibutramine have opposing effects on the motivation for palatable food
    Esther M van der Zwaal
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
    Behav Pharmacol 23:198-204. 2012
    ..Moreover, the ability of sibutramine to reduce this motivation for palatable food may play an important role in the efficacy of sibutramine as an add-on treatment to counteract olanzapine-induced weight gain...
  19. ncbi The neurobiology of oppositional defiant disorder and conduct disorder: altered functioning in three mental domains
    Walter Matthys
    University Medical Center Utrecht, B01 324, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Dev Psychopathol 25:193-207. 2013
    ....
  20. ncbi Inflexible and indifferent alcohol drinking in male mice
    Heidi M B Lesscher
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, The Netherlands
    Alcohol Clin Exp Res 34:1219-25. 2010
    ....
  21. ncbi Simultaneous blockade of dopamine and noradrenaline reuptake promotes disadvantageous decision making in a rat gambling task
    Petra J J Baarendse
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Psychopharmacology (Berl) 225:719-31. 2013
    ..Moreover, impulsivity has been associated with aberrant decision making, but the underlying mechanisms are incompletely understood...
  22. ncbi Cannabis and the developing brain: insights from behavior
    Viviana Trezza
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Pharmacol 585:441-52. 2008
    ....
  23. ncbi Risky decision making in substance dependent adolescents with a disruptive behavior disorder
    Dennis J L G Schutter
    Department of Experimental Psychology, Utrecht University, Heidelberglaan 2, 3584 CS, Utrecht, The Netherlands
    J Abnorm Child Psychol 39:333-9. 2011
    ..Healthy controls and DBD-SD did not differ on risky decision making. These results suggest that risky decision making is a vulnerability factor for the development of SD in a subgroup of adolescents with DBD without ADHD...
  24. ncbi Bidirectional cannabinoid modulation of social behavior in adolescent rats
    Viviana Trezza
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Psychopharmacology (Berl) 197:217-27. 2008
    ..Marijuana use in adolescents is a highly social activity, and interacting endocannabinoid and opioid systems may modulate social reward. However, cannabinoid exposure has been reported to reduce social behavior...
  25. ncbi Putting a spin on the dorsal-ventral divide of the striatum
    Pieter Voorn
    Department of Anatomy, Research Institute Neurosciences, VU University Medical Center, MF-G-102, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Trends Neurosci 27:468-74. 2004
    ..Therefore, this review presents a synthesis between the dorsal-ventral distinction and the more mediolateral-oriented functional striatal gradient...
  26. ncbi Critical involvement of dopaminergic neurotransmission in impulsive decision making
    Marcel M van Gaalen
    Department of Medical Pharmacology, Research Institute Neurosciences Vrije Universiteit, Center for Neurogenomics and Cognitive Research, Free University Medical Center, Amsterdam, The Netherlands
    Biol Psychiatry 60:66-73. 2006
    ..Commonly prescribed for this condition, amphetamine (Adderall), reduces impulsive decision making; however, the neuropharmacologic mechanism of this effect of amphetamine is unclear...
  27. ncbi Behavioral disinhibition requires dopamine receptor activation
    Marcel M van Gaalen
    Department of Anatomy and Neurosciences, Research Institute Neurosciences Vrije Universiteit, Center for Neurogenomics and Cognitive Research (CNCR, VU Medical Center, Amsterdam, The Netherlands
    Psychopharmacology (Berl) 187:73-85. 2006
    ..In addition, dopamine D1 and D2 receptors play important, but perhaps distinct roles, in inhibitory control of behavior...
  28. ncbi On the role of noradrenaline in psychostimulant-induced psychomotor activity and sensitization
    Louk J M J Vanderschuren
    Drug Abuse Program, Department of Medical Pharmacology, Research Institute Neurosciences VU, VU Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Psychopharmacology (Berl) 169:176-85. 2003
    ....
  29. ncbi Psychostimulant-induced behavioral sensitization depends on nicotinic receptor activation
    Anton N M Schoffelmeer
    Drug Abuse Program, Research Institute Neurosciences Vrije Universiteit, Department of Medical Pharmacology, Vrije Universiteit Medical Center, 1081 BT Amsterdam, The Netherlands
    J Neurosci 22:3269-76. 2002
    ..These data indicate that nicotinic receptor activation (by endogenously released acetylcholine) is a common denominator initiating neuroplasticity involved in the development of amphetamine, as well as cocaine-induced sensitization...
  30. ncbi Involvement of dopamine D1 and D2 receptors in the nucleus accumbens core and shell in inhibitory response control
    Tommy Pattij
    Department of Anatomy and Neurosciences, Research Institute Neurosciences Vrije Universiteit, Center for Neurogenomics and Cognitive Research, VU Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    Psychopharmacology (Berl) 191:587-98. 2007
    ..Impaired inhibitory control over behavior is a key feature in various psychiatric disorders, and recent studies indicated an important role for dopamine D(1) and D(2) receptors and the nucleus accumbens (Acb) in this respect...
  31. ncbi Relapse to cocaine- and heroin-seeking behavior mediated by dopamine D2 receptors is time-dependent and associated with behavioral sensitization
    Taco J de Vries
    Research Institute Neurosciences Vrije Universiteit, Drug Abuse Program, Department of Medical Pharmacology, VU Medical Center, Amsterdam, The Netherlands
    Neuropsychopharmacology 26:18-26. 2002
    ..Thus, it appears that dopamine D2 receptors have a time-dependent role in relapse to cocaine and heroin seeking which is strongly associated with a behaviorally sensitized state...

Research Grants1

  1. Social play behavior in periadolescent rats in relation to later drug abuse
    LOUK VANDERSCHUREN; Fiscal Year: 2007
    ....